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| 1 | USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy显示文摘Macrophage polarization to proinflammatory M1-like or anti-inflammatory M2-like cells is critical to mount a host defense or repair tissue.The exact molecular mechanisms controlling this process are still elusive.Here,we report that ubiquitin-specific protease 19(USP19)acts as an anti-inflammatory switch that inhibits inflammatory responses and promotes M2-like macrophage polarization.USP19 inhibited NLRP3 inflammasome activation by increasing autophagy flux and decreasing the generation of mitochondrial reactive oxygen species.In addition,USP19 inhibited the proteasomal degradation of inflammasome-independent NLRP3 by cleaving its polyubiquitin chains.USP19-stabilized NLRP3 promoted M2-like macrophage polarization by direct association with interferon regulatory factor 4,thereby preventing its p62-mediated selective autophagic degradation.Consistent with these observations,compared to wild-type mice,Usp19−/−mice had decreased M2-like macrophage polarization and increased interleukin-1βsecretion,in response to alum and chitin injections.Thus,we have uncovered an unexpected mechanism by which USP19 switches the proinflammatory function of NLRP3 into an anti-inflammatory function,and suggest that USP19 is a potential therapeutic target for inflammatory interventions. | Tao Liu Liqiu Wang Puping Liang Xiaojuan Wang Yukun Liu Jing Cai Yuanchu She Dan Wang Zhi Wang Zhiyong Guo Samuel Bates Xiaojun Xia Junjiu Huang Jun Cui | 2021 | Cellular & Molecular Immunology2021，18，10： | 15 |
| 2 | The role of β18-β19 loop structure in insecticidal activity of Cry1Ac toxin from Bacillus thuringiensis显示文摘The β18-β19 loop in domain III of Cry1Ac toxin is unique among Bacillus thuringiensis Cry proteins. In this study, the role of the loop structure in insecticidal activity of Cry1Ac toxin was investigated. Alanine scanning mutations within the loop were initially generated and most mutants were over-expressed and reduced toxicity at different degrees, except mutant N546A that showed almost 2 times enhanced toxicity against Helicoverpa armigera larvae. Further mutagenic analysis of N546 revealed that a charged amino acid in this position would cause very unfavorable influence on insecticidal activity. In addition, the deletion of N546 led to protein instability because of destruction of the loop integrity. Besides, mutant W544F was much more toxic than W544Y, indicating that hydrophobic nature of the position was important for maintaining the stability and activity of Cry1Ac protein. These findings are the first biological evidence for a structural function of β18-β19 loop in insecticidal activity of the Cry1Ac toxin. | XIA LiQiu WANG FaXiang DING XueZhi ZHAO XinMin FU ZuJiao QUAN MeiFang YU ZiNiu | 2008 | Chinese Science Bulletin2008，53，20： | 4 |
| 3 | A biomass carbon material with microtubule bundling and natural O-doping derived from goldenberry calyx and its electrochemical performance in supercapacitor显示文摘A promising biomass carbon material,manufactured by the carbonation of Physalis peruviana L.calyx at 700℃,is presented in this wo rk.Morphology characterization shows that the carbon material possesses long microtubule bundling and above 30%natural O-atom component on the surface.After KOH chemical etching,the materials maintain the oxygen content but exhibit more micropores and higher specific surface area up to 1732.6 m^2/g.Using as an electrode material for supercapacitor,the active carbon material exhibits high specific capacitance up to 339.7 F/g at 0.5 A/g in 3 mol/L KOH aqueous solution through three-electrode system.The active carbon material also exhibits excellent cycling stability(97%retention)by 10,000 cycles at 10 A/g.The outstanding electrochemical performances are attributing to the unique long microtubule bundling with much more pores and the abundant Oelement on the surface.This biomass carbon material with excellent electrochemical properties could be a useful material for multiple applications. | Yang Liu Mengyi Zhang Liqiu Wang Yajuan Hou Chenxiao Guo Haiying Xin Shuang Xu | 2020 | Chinese Chemical Letters2020，31，3： | 4 |
| 4 | Metagenome analysis reveals potential microbial functions in topsoil of wheat-maize rotation system with five-year application of fertilizers显示文摘Fertilization mode affects soil quality and ecological health.The effects of four fertilization regimens on lignocellulose content,readily degradable carbohydrate decomposition,and potential microbial functions in the topsoil of a wheat-maize rotation system between 2012 and 2017 were investigated.The fertilization regimens of control(control NFNB),high chemical fertilizer(HCF),high biochar plus low chemical fertilizer(HBLCF),and biochar-based fertilizer(BBF)were compared on soil fundamental properties,microbial structure,and potential function in soil carbohydrate degradation based on metagenome analysis.The diversity of carbohydrate-active enzyme genes in the topsoil microbial consortia in the four trials was primarily distributed within the ten ecologically most dominant phyla.Application of BBF was associated with the lowest decline in total nitrogen and P2O5(2012-2017:6.5%and 28.1%,respectively)and the most effective carbohydrate decomposition(2015-2017:67.0%for cellulose and 59.9%for readily degradable carbohydrate).Carbohydrate transport and metabolism accounted for 6.0%of reads assigned functional classification under the BBF regimen.These findings reveal the ecologically functional diversity of topsoil microorganisms and suggest BBF application as a promising strategy for sustainable agriculture and beneficial to soil health. | Yujun Shen Lixin Zhao Haibo Meng Hongsheng Cheng Jingtao Ding Jiarui Wang Shanshan Dong Xi Zhang Liqiu Song Shengwei Zheng | 2019 | International Journal of Agricultural and Biological Engineering2019，12，6： | 3 |
| 5 | Synthesis and thermal conductivity of microfluidic copper nanofluids显示文摘A microfluidic chemical solution method is developed for the synthesizing Cu nanofluids. The method replaces batch-based macroreactors in the conventional chemical solution method by continuous-flow microfluidic microreactors, thereby enabling the synthesis of nanofluids with various microstructures. The Cu nanofluids synthesized by this technology show a better stability, remaining stable even after more than 100 h standing. The measured thermal conductivity shows that the presence of nanoparticles can either upgrade or downgrade fluid conductivity, a phenomenon predicted by the recent thermal-wave theory of nanofluids. | Xiaohao Wei Liqiu Wang | 2010 | Particuology2010，8，3： | 3 |
| 6 | Investigation and analysis of the linkage mechanism and whole process cost of livestock manure organic fertilizer显示文摘In recent years,the utilization of manure resources for livestock and poultry farming has attracted a widespread attention,and manure resources utilization models suitable for different regional characteristics have formed gradually.Among them,the production of organic fertilizer from animal manure is a vital utilization method.However,there are still some problems such as high production costs,difficult sales,and the unwillingness of farmers to use organic fertilizers which have affected the breeding cycle and the sustainability of manure treatment in livestock and poultry breeding.This article selected 371 organic fertilizer plants,related farms and farmers in China,focusing on the main links of the entire process of livestock manure-organic fertilizer-farm application,and studied the mode of animal manure collection by organic fertilizer plants.The costs of organic fertilizer production and farmland application were discussed.Moreover,suggestions were made for the promotion and implementation of large-scale organic fertilizers to make good utilization of manure resources in livestock and poultry farming. | Shanshan Dong Bin Sui Yujun Shen Haibo Meng Lixin Zhao Jingtao Ding Haibin Zhou Xi Zhang Hongsheng Cheng Jian Wang Ran Li Liqiu Song Pengxiang Xu Ji Li | 2020 | International Journal of Agricultural and Biological Engineering2020，13，2： | 2 |
| 7 | FIBRED MAGNESIUM HYDROXIDE AND FLAME-RESISTANT POLYENE MATERIAL显示文摘The fibred mangesiun hydroxide from the bracite was treated with a surface active agent. The modified fibred magesium hydroxide as flame-retardant, boric acid, barium stearate, polydimethyl siloxane fluid, vinyltriethoxysilane as synergists of the flame-retardant were added to polyene resin. The flame-resistance polyene material prepared meets the requirements of EWCZ-6287-1. | Zhang, Jin'an Wang, Liqiu Li, Qingshan
| 1999 | Journal of Wuhan University of Technology(Materials Science)1999，14，2： | 2 |
| 8 | Prediction of Dynamic Wellbore Pressure in Gasified Fluid Drilling显示文摘The basis of designing gasified drilling is to understand the behavior of gas/liquid two-phase flow in the wellbore. The equations of mass and momentum conservation and equation of fluid flow in porous media were used to establish a dynamic model to predict wellbore pressure according to the study results of Ansari and Beggs-Brill on gas-liquid two-phase flow. The dynamic model was solved by the finite difference approach combined with the mechanistic steady state model. The mechanistic dynamic model was numerically implemented into a FORTRAN 90 computer program and could simulate the coupled flow of fluid in wellbore and reservoir. The dynamic model revealed the effects of wellhead back pressure and injection rate of gas/liquid on bottomhole pressure. The model was validated against full-scale experimental data,and its 5.0% of average relative error could satisfy the accuracy requirements in engineering design. | Wang Zhiming Ping Liqiu Zou Ke | 2007 | Petroleum Science2007，4，4： | 2 |
| 9 | Phase Evolution of BaTiO3 Nanoparticles:An Identification of BaTi20 IntermediatePhasein Calcined Stearic Acid Gel显示文摘 | Wang Liqiu Kang Hongmin Xue Dongfeng | 2008 | Journal of Physical Chemistry C2008，112，7： | 1 |
| 10 | Thermal vibration phenomenon of single phase lagging heat conduction and its thermodynamic basis显示文摘In the present work it is shown that the single phase lagging heat conduction not only avoids the infinite heat propagation speed assumed by the conventional Fourier law, but also complies with Galilean principle of relativity. Therefore it is more advantageous than the Cattaneo-Vernotte model. Based on the single-phase-lagging heat conduction model, the condition for the occurrence of thermal vibration of heat conduction is established. In order to resolve the contradiction that the thermal vibration violates the second law of thermodynamics, the extended irreversible thermodynamics is improved and a generalized entropy definition is introduced. In the framework of the newly-developed extended irreversible thermodynamics the thermal vibration phenomena are consistent with the second law of thermodynamics. | CHENG Lin XU MingTian WANG LiQiu | 2008 | Chinese Science Bulletin2008，53，22： | 1 |
| 11 | Evolution of core - shell structure: from emulsion to ultrafine emulsion electrospun fibers 显示文摘 | Chong Wang Liqiu Wang Min Wang | 2014 | Materia/s Letters2014，124，： | 1 |
| 12 | Formation of Nanoliter Droplets in a Confined Microfluidic T - Shaped Junc- tion: Formation Time and Droplet Volume 显示文摘 | Yuxiang Zhang Jing Fan Liqiu Wang | 2009 | Current Nano- science2009，，5： | 1 |
| 13 | A novel approach to the convexity control of interpolant curves显示文摘 | Duan Qi Wang Liqiu Twizell E h | 2003 | Commun Numer Meth Engng2003，19，： | 1 |
| 14 | Gradient wettability induced by deterministically patterned nanostructures显示文摘We report a large-scale surface with continuously varying wettability induced by ordered gradient nanostructures.The gradient pattern is generated from nonuniform interference lithography by utilizing the Gaussian-shaped intensity distribution of two coherent laser beams.We also develop a facile fabrication method to directly transfer a photoresist pattern into an ultraviolet(UV)-cured high-strength replication molding material,which eliminates the need for high-cost reactive ion etching and e-beam evaporation during the mold fabrication process.This facile mold is then used for the reproducible production of surfaces with gradient wettability using thermal-nanoimprint lithography(NIL).In addition,the wetting behavior of water droplets on the surface with the gradient nanostructures and therefore gradient wettability is investigated.A hybrid wetting model is proposed and theoretically captures the contact angle measurement results,shedding light on the wetting behavior of a liquid on structures patterned at the nanoscale. | Siyi Min Shijie Li Zhouyang Zhu Wei Li Xin Tang Chuwei Liang Liqiu Wang Xing Cheng Wen-Di Li | 2020 | Microsystems & Nanoengineering2020，6，1： | 1 |
| 15 | Wear-resistance comparison of carbon nanotubes and conventional silicon-probes for atomic force microscopy显示文摘 | GUO Liqiu WANG Rui XU Huaming | 2005 | Wear2005，258，1112： | 1 |
| 16 | Seasonal variation in blood pressure and its relationship with outdoor temperature in 10 diverse regions of China: the China Kadoorie Biobank显示文摘 | Sarah Lewington Liming Li Paul Sherliker Yu Guo Iona Millwood Zheng Bian Gary Whitlock Ling Yang Rory Collins Junshi Chen Xianping Wu Shaojie Wang Yihe Hu Li Jiang Liqiu Yang Ben Lacey Richard Peto Zhengming Chen | 2012 | Journal of Hypertension2012，，7： | 1 |
| 17 | Heavy metals and community structure of microorganism changes during livestock manure composting with inoculation of effective microorganisms显示文摘Effective microorganisms(EM)is usually used in composting to improve the composting process.However,the effect of EM on heavy metals evolution was still unclear.This study was performed to illustrate the microbial community changes that occur during composting with the addition of EM and to determine the evolution of heavy metal speciation during this process.The requirement of harmlessness for pig manure was met after the addition of EM at a dosage of 0.5%,with a germination index of 96.42%.The bacterial and fungal diversity were both found to decrease during the composting process.Additionally,the bioavailability of Cu and Pb decreased significantly during composting.Significant correlations were observed between the microbial composition and the percentage of different heavy metals fractions;however,the mechanism responsible for this correlation requires further investigation.This study has the potential to contribute to control of heavy metal contamination during the process of recycling pig manure through the controlled addition of EM. | Haibin Zhou Yujun Shen Ran Li Haibo Meng Xi Zhang Jian Wang Hongsheng Cheng Shanshan Dong Liqiu Song Jingtao Ding Qiongyi Cheng | 2020 | International Journal of Agricultural and Biological Engineering2020，13，6： | 1 |
| 18 | Small-signal stability studies of a 270V DC more-electric aircraft power system显示文摘 | Liqiu Han Jiabin Wang David Howe | 2006 | IEEE Aerospace and Electronic Systems Magazine2006，，： | 1 |
| 19 | Adaptive Geovisualization: An Approach towards the Design of Intelligent Geovisualization Systems 显示文摘 | WANG Y LIU Y CHEN X CHEN Y LIQIU M | 2001 | Journal of Geographical Sciences2001，，11： | 1 |
| 20 | Photocatalytic activity of Zr: SrTiO3 under UV illumination显示文摘 | CHEN Liang ZHANG Shouchen WANG Liqiu | 2009 | Journal of Crystal Growth2009，311，： | 1 |
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