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| 1 | Adaptive subsequence adjustment with evolutionary asymmetric path-relinking for TDRSS scheduling显示文摘Due to the limited transmission resources for data relay in the tracking and data relay satellite system(TDRSS), there are many job requirements in busy days which will be discarded in the conventional job scheduling model. Therefore, the improvement of scheduling efficiency in the TDRSS can not only help to increase the resource utilities, but also to reduce the scheduling failure ratio.A model of nonhomogeneous parallel machines scheduling problems with time window(NPM-TW) is firstly built up for the TDRSS,considering the distinct features of the variable preparation time and the nonhomogeneous transmission rates for different types of antennas on each tracking and data relay satellite(TDRS). Then,an adaptive subsequence adjustment(ASA) framework with evolutionary asymmetric path-relinking(Ev APR) is proposed to solve this problem, in which an asymmetric progressive crossover operation is involved to overcome the local optima by the conventional job inserting methods. The numerical results show that, compared with the classical greedy randomized adaptive search procedure(GRASP) algorithm, the scheduling failure ratio of jobs can be reduced over 11% on average by the proposed ASA with EvAPR. | Peng Lin Linling Kuang Xiang Chen Jian Yan Jianhua Lu Xiaojuan Wang | 2014 | Journal of Systems Engineering and Electronics2014，25，5： | 12 |
| 2 | Implications from protein uptake kinetics onto dextran-grafted Sepharose FF coupled with ion exchange and affinity ligands显示文摘Our previous studies have reported the presence of 'chain delivery' effects of protein adsorption onto ion exchangers with polymer-grafted ion-exchange groups, such as dextran-grafted and poly(ethylenimine)-modified Sepharose gels. However, it is unclear if the 'chain delivery' occurs on affinity adsorption with specific interactions. This work is designed to address this issue. A dextran-grafted Sepharose gel was prepared, and then the matrix was modified using diethylaminoethyl, a typical ion-exchange group, or octapeptide(FYCHWQDE), an affinity ligand for human immunoglobulin G(h Ig G) to prepare ion-exchange or affinity adsorbents, respectively.Results of h Ig G adsorption showed that the uptake rate represented by the effective diffusivity of h Ig G onto the dextran-grafted ion exchangers was obviously enhanced by the dextran grafting, indicating the presence of'chain delivery' of the bound proteins on the charged groups on the dextran chains. By contrast, the effective diffusivity of h Ig G changed little as ligand density increased on the dextran-grafted FYCHWQDE adsorbents.Their adsorption capacities decreased and effective diffusivities were not accelerated by the dextran grafting.Thus, this work clarified that grafted dextran could not accelerate h Ig G uptake rate on the affinity resins, or in other words, chain delivery did not occur on the specific interaction-based affinity adsorption. | Aiying Xue Linling Yu Yan Sun | 2017 | Chinese Journal of Chemical Engineering2017，25，7： | 10 |
| 3 | Protein adsorption onto diethylaminoethyl dextran modified anion exchanger:Effect of ionic strength and column behavior显示文摘Our previous studies on bovine serum albumin(BSA) adsorption to diethylaminoethyl dextran(DEAE dextran,DexD, grafting-ligand) and DEAE(D, surface-ligand) modified Sepharose FF resins found that all the grafted resins(FF-DexD and FF-D-DexD) exhibited extremely fast uptake rate(effective diffusivity, D_e, D_e/D_O> 1.4),which was six times greater than the ungrafted resins(D_e/D_O < 0.3). In this work, the influence of ionic strength(IS) on 6 typical DEAE dextran-grafted resins was investigated. Bath adsorption equilibria and kinetics, breakthrough, and linear gradient elution experiments were conducted. Commercial DEAE Sepharose FF was used for comparison. It is found that protein adsorption capacities on DEAE dextran-FF resins and the commercial resin decreased with increasing IS, but DEAE dextran-FF resins exhibited much higher capacity sensitivity to salt concentration. Besides, steeper decrease of adsorption capacities could be obtained at higher graftingligand or surface-ligand density. It is worth noting that the facilitating role of surface-ligand to the 'chain delivery' effect was weakened after adding salt, leading to the less improvement in uptake rate by increasing surface-ligand density at higher IS. Although the uptake rates of the DEAE dextran-FF resins increased first and then decreased with increasing IS, they kept the extremely high level of De values(D_e/D_O > 1.1) at the their working/binding IS range. Moreover, the DEAE dextran-FF resin displayed much higher adsorption capacities and De values than commercial ungrafted resin in their working condition. Furthermore, the column results of DEAE dextran-FF resins presented higher dynamic binding capacities than and similar elution ISs with DEAE Sepharose FF to achieve similar(or even higher) recoveries suggest the excellent chromatographic column performance of the DEAE dextran-FF resins. Finally, both high recovery and purity of BSA and γ-globulin could be easily achieved using the typical DEAE dextran-FF column, FF-D60-DexD160, to separate their binary mixtures,by step gradient elution. The research has provided new insights into the practical application of the series of DEAE-dextran grafted resins in protein chromatography and proved their superiority. | Shu Bai Lingli Gong Detao Han Yutong Li Linling Yu Yan Sun | 2018 | Chinese Journal of Chemical Engineering2018，26，2： | 5 |
| 4 | A novel secretagogin/ATF4 pathway is involved in oxidized LDL-induced endoplasmic reticulum stress and islet β-cell apoptosis显示文摘Excessive accumulation of cholesterol inβcells initiates endoplasmic reticulum(ER)stress and associated apoptosis.We have reported that excessive uptake of cholesterol by MIN6 cells decreases the expression of secretagogin(SCGN)and then attenuates insulin secretion.Here,we aimed to determine whether cholesterol-induced SCGN decrease is involved in the modulation of ER stress and apoptosis in pancreaticβcells.In this study,MIN6 cells were treated with oxidized low-density lipoprotein(ox-LDL)for 24 h,and then intracellular lipid droplets and cell apoptosis were quantified,and SCGN and ER stress markers were identified by western blot analysis.Furthermore,small interfer RNA(siRNA)-mediated SCGN knockdown and recombinant plasmid-mediated SCGN restoration experiments were performed to confirm the role of SCGN in ER stress and associated cell apoptosis.Finally,the interaction of SCGN with ATF4 was computationally predicted and then validated by a co-immunoprecipitation assay.We found that ox-LDL treatment increased the levels of ER stress markers,such as phosphorylated protein kinase-like endoplasmic reticulum kinase,phosphorylated eukaryotic initiation factor 2 alpha,activating transcription factor 4(ATF4),and transcription factor CCAAT-enhancer-binding protein homologous protein,and promoted MIN6 cell apoptosis;in addition,the expression of SCGN was downregulated.siRNA-mediated SCGN knockdown exacerbatedβ-cell ER stress by increasing ATF4 expression.Pretreatment of MIN6 cells with the recombinant SCGN partly antagonized ox-LDL-induced ER stress and apoptosis.Furthermore,a co-immunoprecipitation assay revealed an interaction between SCGN and ATF4 in MIN6 cells.Taken together,these results demonstrated that pancreaticβ-cell apoptosis induced by ox-LDL treatment can be attributed,in part,to an SCGN/ATF4-dependent ER stress response. | Li Wu Yuncheng Lv Ying Lv Sunmin Xiang Zhibo Zhao Ziqing Tang Linling Ou Bin Yan Xinhua Xiao Gebo Wen Renxian Cao Jing Yang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，1： | 2 |
| 5 | QoE-Driven Social Aware Caching Placement for Terrestrial-Satellite Networks显示文摘In remote terrestrial-satellite networks, caching is a very promising technique to alleviate the burden of space cloudlet(e.g., cache-enabled satellite user terminal) and to improve subscribers' quality of experience(Qo E) in terms of buffering delay and achievable video streaming rate. In this paper, we studied a Qo E-driven caching placement optimization problem for video streaming that takes into account the required video streaming rate and the social relationship among users. Social ties between users are used to designate a set of helpers with caching capability, which can cache popular files proactively when the cloudlet is idle. We model the utility function of Qo E as a logarithmic function. Then, the caching placement problem is formulated as an optimization problem to maximize the user's average Qo E subject to the storage capacity constraints of the helpers and the cloudlets. Furthermore, we reformulate the problem into a monotone submodular optimization problem with a partition matroid constraint, and an efficient greedy algorithm with 1-1 e approximation ratio is proposed to solve it. Simulation results show that the proposed caching placement approach significantly outperforms the traditional approaches in terms of Qo E, while yields about the same delay and hit ratio performance compare to the delay-minimized scheme. | Guiting Zhong Jian Yan Linling Kuang | 2018 | China Communications2018，15，10： | 2 |
| 6 | Expression patterns of an isoflavone reductase-like gene and its possible roles in secondary metabolism in Ginkgo biloba显示文摘 | Cheng Hua Li Linling Xu Feng Wang Yan Yuan Honghui Wu Conghua Wang Shaobing Liao Zhiqin Hua Juan Wang Yuping Cheng Shuiyuan Cao Fuliang | 2013 | Plant Cell Reports2013，，5： | 1 |
| 7 | LEO constellation design methodology for observing multi-targets显示文摘This paper is based on the second problem of the 8th China Space Trajectory Design Competition(CTOC8).The background is LEO constellation design strategy for monitoring discrete multi-targets with small stellite under J model.The difculty is that the small satellite is equipped with low-cost cameras with limited coverage ability and the targets are distributed separately in a key area,which result in long revisit time or large pumber of satelites based on traditional design method.In this paper,a speciflc LEO consellation design method is proposed to cope with the problems.First,grid search and numerical method are performed to construct a database consisting of repeating ground track orbits.Then several orbits are carefully selected by pruning method to visit each target.Finally,repeating ground track costellation is constructed to meet the maximun revisit time constraint.The present method provides a systematic constellation design methodology of remote sensing observation with limited coverage ability,and demonstrates the resulting constellation can obtain rapid revisit frequency over discrete multi-targets with the least number of satellites. | Chen Zhang Jin Jin Linling Kuang Jian Yan | 2018 | Astrodynamics2018，2，2： | 1 |
| 8 | Head-to-tail cyclization of a heptapeptide eliminates its cytotoxicity and significantly increases its inhibition effect on amyloid β-protein fibrillation and cytotoxicity显示文摘淀粉 --(A) 蛋白质聚集是 Alzheimers 疾病(广告) 的主要特点。纤维性颤动的抑制因此是广告的预防和处理的一条有希望的治疗学的途径。最近,我们设计了一个 heptapeptide 禁止者, LVFFARK (LK7 ) 。LK7 在纤维性颤动上显示出一个有希望的禁止的能力,但是对敏感自我装配并且显示高 cytotoxicity,它将妨碍它的实际申请。此处,我们由 head-to-tail 环合修改了 LK7 并且获得了周期的 LK7 (cLK7 ) 。cLK7 展览一不同自己组装从 LK7 的行为,并且比 LK7 和小 cytotoxicity 对解朊作用有更高的稳定性到 SHSY5Y 房间。热力学的分析表明 LK7 和 cLK7 能由静电的相互作用,氢结合和恐水病的相互作用绑在40,但是为40的 cLK7 的有约束力的亲密关系( K D = 4.96 mol/L )比 LK7 的高六倍( K D = 32.2 mol/L )。强壮的绑定使 cLK7 能稳定 40 的第二等的结构并且 potently 在广泛的集中范围禁止它的成核,纤维性颤动和 cytotoxicity,而 LK7 能仅仅中等在低集中禁止 A40 纤维性颤动和 cytotoxicity。调查结果显示肽环合是一条有希望的途径提高基于肽的淀粉的禁止者的表演。 | Shuai Ma Huan Zhang Xiaoyan Dong Linling Yu Jie Zheng Yan Sun | 2018 | Frontiers of Chemical Science and Engineering2018，12，2： | 1 |
| 9 | Characterization of novel mixed-mode protein adsorbents fabricated from benzoyl-modified polyethyleneimine-grafted Sepharose显示文摘 | Na Liu Ziyuan Wang Xiaoguang (Margaret) Liu Linling Yu Yan Sun | 2014 | Journal of Chromatography A2014，，： | 1 |
| 10 | Characteristics of alveolar macrophages in bronchioalveolar lavage fluids from active tuberculosis patients identified by single-cell RNA sequencing显示文摘Tuberculosis(TB),is an infectious disease caused by Mycobacterium tuberculosis(M.tuberculosis),and presents with high morbidity and mortality.Alveolar macrophages play an important role in TB pathogenesis although there is heterogeneity and functional plasticity.This study aimed to show the characteristics of alveolar macrophages from bronchioalveolar lavage fluid(BALF)in active TB patients.Single-cell RNA sequencing(scRNA-seq)was performed on BALF cells from three patients with active TB and additional scRNA-seq data from three healthy adults were established as controls.Transcriptional profiles were analyzed and compared by differential gene expression and functional enrichment analysis.We applied pseudo-temporal trajectory analysis to investigate correlations and heterogeneity within alveolar macrophage subclusters.Alveolar macrophages from active TB patients at the single-cell resolution are described.We found that TB patients have higher cellular percentages in five macrophage subclusters.Alveolar macrophage subclusters with increased percentages were involved in inflammatory signaling pathways as well as the basic macrophage functions.The TB-increased alveolar macrophage subclusters might be derived from M1-like polarization state,before switching to an M2-like polarization state with the development of M.tuberculosis infection.Cell-cell communications of alveolar macrophages also increased and enhanced in active TB patients.Overall,our study demonstrated the characteristics of alveolar macrophages from BALF in active TB patients by using scRNA-seq. | Qianqian Chen Chunmei Hu Wei Lu Tianxing Hang Yan Shao Cheng Chen Yanli Wang Nan Li Linling Jin Wei Wu Hong Wang Xiaoning Zeng Weiping Xie | 2022 | The Journal of Biomedical Research2022，36，3： | 1 |
| 11 | Mining and utilization of salinity tolerant legumes in tropical coastal agroecosystems: An overview显示文摘Coastal saline soils are increasing year by year caused by climate change and human activities.Most of the coastal saline soils are idle due to their high salinity level and few crops can grow normally.Salinity tolerant legumes are naturally tolerant to salt,which can ecologically cover the coastal saline soil,enhance soil fertility by symbiotic nitrogen fixation and increase the smallholder farmers’benefits in terms of forage,green manure,food or medicine.However,few reports are available for the systematic evaluation of salinity tolerant legumes.This review summarizes and evaluates currently available salinity tolerant legume species that could potentially be used and discusses their potential for integration into smallholder mixed coastal systems of the Asia-Pacific region.Fourty four salinity tolerant legumes were summarized,six of them showed a high level of salinity tolerance,17 of them showed a moderate level of salinity tolerance and 21 of them showed potential salinity tolerance but need to be further studied.Many gaps such as combined tolerance evaluation,nitrogen fixation efficiency,animal feeding experiments and salinity tolerant rhizobia screening/inoculants exist.Case studies demonstrate legumes could be used to reclaim coastal saline soils,but commitment and support from government and public services are necessary to address both seed system and extension needs,through the provision of adequate incentives,policies and development efforts. | Yiming Liu Mary Atieno Juan Andres Cardoso Hubiao Yang Bin Xu Rongshu Dong Linling Yan Chunqiong Huang Hengfu Huan Daogeng Yu Sabine Douxchamps Guodao Liu | 2022 | Grass Research2022，2，1： | 0 |
| 12 | Study on Saccharification of Saccharum spontaneum L. by Sulphuric Acid Hydrolysis显示文摘In order to improve the saccharification rate by acid hydrolysis in the technique for production of ethanol from biomass,in this study,Saccharum spontaneum L. was used as the experimental material to investigate the rules and technological conditions for two-step acid-hydrolysis saccharification by single factor experiment and orthogonal experiment. According to the results,concentrated sulfuric acid hydrolysis was the first step,with the liquid-solid ratio of 42∶ 1,sulfuric acid concentration of 70%,hydrolysis time of 20 min,and hydrolysis temperature of 55 ℃; dilute sulphuric acid hydrolysis was the second step,with the liquidsolid ratio of 115∶ 1,sulfuric acid concentration of 5. 5%,hydrolysis time of 155 min,and hydrolysis temperature of 100 ℃. In two-step acid hydrolysis process,the yield of reducing sugar was 48. 78%. The results indicated that two-step acid-hydrolysis saccharification required mild conditions,simple operation and low cost,and led to high reducing sugar yield,exhibiting a broad application prospect. | Jianle LIU Changjun BAI Linling YAN Qinglin JIA Yu ZHANG Hubiao YANG | 2014 | Agricultural Biotechnology2014，3，6： | 0 |
| 13 | Energy Productivity Potential Assessment of Saccharum spontaneum L. Germplasm Resources显示文摘[Objective]The energy productivity potential of Saccharum spontaneum L.germplasm resources as energy plants was discussed in this paper.[Method]The energy productivity potential of Saccharum spontaneum L.germplasm resources collected from the wild was assessed from the aspects of cellulose,semicellulose,lignin and crude ash contents and caloric value.[Result]The total content of cellulose and semicellulose ranged from 41.75%to 69.13%,the lignin content ranged from 2.16%to 11.75%,the crude ash content ranged from 4.79%to 9.34%and the caloric value ranged from 16.00 to 17.69 MJ/kg among the 30 Saccharum spontaneum L.germplasms.Compared to other plants,Saccharum spontaneum L.had higher contents of cellulose and semicellulose,a higher caloric value but lower contents of lignin and crude ash.[Conclusion]From the perspective of producing fuel ethanol with lignocellulose,Saccharum spontaneum L.has a great potential for development as an energy plant. | Jianle LIU Changjun BAI Linling YAN | 2014 | Agricultural Science & Technology2014，15，12： | 0 |
| 14 | A Comparative Study of Sister Carrie and Xiangzi Based on Environmental Determinism显示文摘Dreiser’s Sister Carrie and Lao She’s Camel Xiangzi are two classic novels.Both of them demonstrate the decisive influence of environmental factors on the characters’destiny.This paper tries to explore their tragic fates comparatively based on environmental determinism.Actually,the two protagonists of two novels were both dream chasers in social changes at first,and then they transformed into strugglers under the oppression of patriarchy and biological power,and eventually they became victims of the social values under the fateful role of the environment.Obviously,the fights between the two protagonists and the environment have certain enlightening effects on current human life and the process of urbanization. | HUANG Linling YAN Chunmei | 2021 | Sino-US English Teaching2021，18，9： | 0 |
| 15 | Nutritional Value Evaluation of Saccharum spontaneum L. Germplasm Resources显示文摘The contents of dry matter, crude fat, crude protein, neutral detergent fiber, acid detergent fiber, crude ash, Ca and P in 43 Saccharum spontaneum L.germplasms during the vegetative period were determined. Among them, the crude protein, crude fat, neutral detergent fiber, acid detergent fiber, P and Ca contents were treated as the judging indicators. The nutritional value evaluation was carried out with the analytic hierarchy process(AHP). The results showed A49(Guangxi)had the highest nutritional value. Its dry matter, crude protein, crude fat, crude ash,neutral detergent fiber, acid detergent fiber, Ca and P contents were 32.35%,7.20%, 4.06%, 8.07%, 75.81%, 50.72%, 0.23% and 0.16% respectively. While A3(Guangdong) had the lowest nutritional value. Its dry matter, crude protein, crude fat, crude ash, neutral detergent fiber, acid detergent fiber, Ca and P contents were32.24%, 4.62%, 0.51%, 6.38%, 46.40%, 40.02%, 0.15% and 0.09% respectively.The crude protein content differed significantly among different germplasms. A48 had the highest crude protein content(9.11%), and A14 had the lowest crude protein content(3.72%). Based on the evaluation results, the 43 Saccharum spontaneum L.germplasms were divided into 3 groups: high-nutritional value type, moderate-nutritional value type and low-nutritional value type. We hoped to provide a theoretical reference for the application of Saccharum spontaneum L. as a forage grass. | Jianle LIU Changjun BAI Linling YAN Shimeng CHEN Yu ZHANG Hubiao YANG | 2014 | Agricultural Science & Technology2014，15，11： | 0 |
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