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| 1 | Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion显示文摘The recent outbreak of coronavirus disease(COVID-19)caused by SARS-CoV-2 infection in Wuhan,China has posed a serious threat to global public health.To develop specific anti-coronavirus therapeutics and prophylactics,the molecular mechanism that underlies viral infection must first be defined.Therefore,we herein established a SARS-CoV-2 spike(S)protein-mediated cell-cell fusion assay and found that SARS-CoV-2 showed a superior plasma membrane fusion capacity compared to that of SARS-CoV.We solved the X-ray crystal structure of six-helical bundle(6-HB)core of the HR1 and HR2 domains in the SARS-CoV-2 S protein S2 subunit revealing that several mutated amino acid residues in the HR1 domain may be associated with enhanced interactions with the HR2 domain.We previously developed a pan-coronavirus fusion inhibitor,EK1,which targeted the HR!domain and could inhibit infection by divergent human coronaviruses tested,including SARS-CoV and MERS-CoV.Here we generated a series of lipopeptides derived from EK1 and found that EK1C4 was the most potent fusion inhibitor against SARS-CoV-2 S protein-mediated membrane fusion and pseudovirus infection with IC50s of 1.3 and 15.8 nM,about 241-and 149-fold more potent than the original EK1 peptide,respectively.EK1C4 was also highly effective against membrane fusion and infection of other human coronavirus pseudoviruses tested,including SARS-CoV and MERS-CoV,as well as SARSr-CoVs,and potently inhibited the replication of 5 live human coronaviruses examined,including SARS-CoV-2.Intranasal application of EK1C4 before or after challenge with HCoV-OC43 protected mice from infection,suggesting that EK1C4 could be used for prevention and treatment of infection by the currently circulating SARS-CoV-2 and other emerging SARSr-CoVs. | Shuai Xia Meiqin Liu Chao Wang Wei Xu Qiaoshuai Lan Siliang Feng Feifei Qi Linlin Bao Lanying Du Shuwen Liu Chuan Qin Fei Sun Zhengli Shi Yun Zhu Shibo Jiang Lu Lu | 2020 | Cell Research2020，30，4： | 81 |
| 2 | Progress in Nanocellulose Preparation and Application显示文摘Nanocellulose is a biodegradable, renewable, nonmeltable polymeric material that is insoluble in most solvents due to hydrogen bonding and crystallinity. Nanocellulose has attracted considerable attention in recent decades owing to its environmental friendliness, wide availability, good biocompatibility, high crystallinity, and high Young's modulus. This review presents the recent achievements in preparation and applications of nanocellulose, including a discussion of the advantages and disadvantages of various preparation methods and a summary of the applications of nanocellulose in composite materials research. Finally, we examine the mounting evidence of more widespread potential applications of nanocellulose. | HaiQuan Mao YongYang Gong YuanLi Liu ShiQi Wang LinLin Du Chun Wei | 2017 | Paper And Biomaterials2017，2，4： | 19 |
| 3 | Step-wise synthesis of work exchange networks involving heat integration based on the transshipment model显示文摘Due to the deterioration of serious energy dilemma,energy-conservation and emission–reduction have been the strategic target in the past decades,thus people have identified the vital importance of higher energy efficiency and the influence of lower carbon development.Since work exchange network is a significant part of energy recovery system,its optima design will have dramatically significant effect on energy consumption reduction in chemical process system.With an extension of the developed transshipment model in isothermal process,a novel step-wise methodology for synthesis of direct work exchange network(WEN)in adiabatic process involving heat integration is first proposed in this paper,where a nonlinear programming(NLP)model is formulated by regarding the minimum utility consumption as objective function and optimizing the initial WEN in accordance with the presented matching rules to get the optimized WEN configuration at first.Furthermore,we focus on the work exchange network synthesis with heat integration to attain the minimal total annual cost(TAC)with the introduction of heat-exchange equipment that is achieved by the following strategies in sequence:introducing heat-exchange equipment directly,adjusting the work quantity of the adjacent utility compressors or expanders,and approximating upper/lower pressure limits consequently to obtain considerable cost savings of expanders or compressors and work utility.Finally,a case taken from the literature is studied to illustrate the feasibility and effectiveness of the proposed method. | Yu Zhuang Linlin Liu Qilei Liu Jian Du | 2017 | Chinese Journal of Chemical Engineering2017，25，8： | 7 |
| 4 | Adenosine A 2A R modulates cardiovascular function by activating ERK1/2 signal in the rostral ventrolateral medulla of acute myocardial ischemic rats显示文摘 | Meiyan Jiang Chengrong Zhang Jin Wang Jun Chen Chunmei Xia Dongshu Du Na Zhao Yinxiang Cao Linlin Shen Danian Zhu | 2011 | Life Sciences2011，，5： | 4 |
| 5 | Targeting slug-mediated non-canonical activation of c-Met to overcome chemo-resistance in metastatic ovarian cancer cells显示文摘Metastasis-associated drug resistance accounts for high mortality in ovarian cancer and remains to be a major barrier for effective treatment. In this study, SKOV3/T4, a metastatic subpopulation of ovarian cancer SKOV3 cells, was enriched to explore potential interventions against metastaticassociated drug resistance. Quantitative genomic and functional analyses were performed and found that slug was significantly increased in the SKOV3/T4 subpopulation and contributed to the high resistance of SKOV3/T4. Further studies showed that slug activated c-Met in a ligand-independent manner due to elevated levels of fibronectin and provoked integrin α V function, which was confirmed by the significant correlation of slug and p-Met levels in 121 ovarian cancer patient samples. Intriguingly,c-Met inhibitor(s) exhibited greatly enhanced anti-cancer effects in slug-positive ovarian cancer models both in vitro and in vivo. Additionally, IHC analyses revealed that slug levels were highly correlated with reduced survival of ovarian cancer patients. Taken together, this study not only uncovers the critical roles of slug in drug resistance in ovarian cancer but also highlights a promising therapeutic strategy by targeting the noncanonical activation of c-Met in slug-positive ovarian cancer patients with poor prognosis. | Linlin Chang Yan Hu Yingying Fu Tianyi Zhou Jun You Jiamin Du Lin Zheng Ji Cao Meidan Ying Xiaoyang Dai Dan Su Qiaojun He Hong Zhu Bo Yang | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 3 |
| 6 | Synthesis of indirect work exchange networks considering both isothermal and adiabatic process together with exergy analysis显示文摘In this paper, an efficient methodology for synthesizing the indirect work exchange networks(WEN) considering isothermal process and adiabatic process respectively based on transshipment model is first proposed. In contrast with superstructure method, the transshipment model is easier to obtain the minimum utility consumption taken as the objective function and more convenient for us to attain the optimal network configuration for further minimizing the number of units. Different from division of temperature intervals in heat exchange networks,different pressure intervals are gained according to the maximum compression/expansion ratio in consideration of operating principles of indirect work exchangers and the characteristics of no pressure constraints for stream matches. The presented approach for WEN synthesis is a linear programming model applied to the isothermal process, but for indirect work exchange networks with adiabatic process, a nonlinear programming model needs establishing. Additionally, temperatures should be regarded as decision variables limited to the range between inlet and outlet temperatures in each sub-network. The constructed transshipment model can be solved first to get the minimum utility consumption and further to determine the minimum number of units by merging the adjacent pressure intervals on the basis of the proposed merging methods, which is proved to be effective through exergy analysis at the level of units structures. Finally, two cases are calculated to confirm it is dramatically feasible and effective that the optimal WEN configuration can be gained by the proposed method. | Yu Zhuang Linlin Liu Lei Zhang Jian Du | 2018 | Chinese Journal of Chemical Engineering2018，26，8： | 2 |
| 7 | Phase group synchronization between any signals and its physical characteristics显示文摘The phase group synchronization between any signals is further revealed,which is based on proposing the new concepts of the greatest common factor frequency,the least common multiple period,quantized phase shift resolution,equivalent phase comparison frequency and so on.Then the problem of phase comparison and processing between different frequency signals is solved and shown in detail.Using the basic principle and the variation law of group phase difference,the frequency stability better than 10-14/s can be easily obtained in the time&frequency measurement and control domain,and experimental results also show the phase relations between atomic energy level transition signal and the locked crystal oscillator signal in an active hydrogen atomic clock are strict phase group synchronization,and locked precision with 10-13/s can be reached based on phase group synchronization.The phase group synchronization can provide technical support to frequency linking among radio frequency,microwave and light frequency. | DU BaoQiang SHI LinLin CHEN YaoMing DONG ShaoFeng YANG ZhiGang CAO LingZhi GUO ShuTing | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，4： | 2 |
| 8 | Heat exchanger network synthesis integrated with flexibility and controllability显示文摘Over the last three decades,flexibility and controllability considerations for heat exchanger networks(HENs)have received great attention,respectively.However,they should be simultaneously incorporated in HEN synthesis to allow the economic performance to be achievable in a practical operating environment.This paper proposes a method for simultaneous synthesis of flexible and controllable HEN by considering their coupling.The key idea is to add the bypasses with optimized initial fractions and positions to explore such coupling,and consequently enabling HENs to be operated successfully over a range of disturbance variations.These are implemented by identifying and quantifying disturbance propagations,and then examining the sensitivity of bypasses to the entire HEN.In this way,the superstructurebased mixed integer non-linear programming(MINLP)with objective function of minimizing the total annual cost is formulated.A case study is used to demonstrate the application of the proposed method.Quantitative measures and dynamic simulation show the ability to provide the satisfactory flexibility and controllability of the obtained HEN. | Siwen Gu Linlin Liu Lei Zhang Yiyuan Bai Shaojing Wang Jian Du | 2019 | Chinese Journal of Chemical Engineering2019，27，7： | 2 |
| 9 | Estimation of amphetamine and methamphetamine uses in Beijing through sewage-based analysis 显示文摘 | LI Jing HOU Linlin DU Peng | 2014 | Science of the Total Environment2014，490，： | 1 |
| 10 | Dietary quercetin combining intratumoral doxorubicin injection synergistically induces rejection of established breast cancer in mice显示文摘 | Gangjun Du Haihong Lin Yiming Yang Shuo Zhang Xianchuang Wu Mei Wang Liyan Ji Linlin Lu Lijuan Yu Guang Han | 2010 | International Immunopharmacology2010，，7： | 1 |
| 11 | Study of bonding wire failure effects on external measurable signals of IGBT module显示文摘 | Wei Kexin Du Mingxing Xie Linlin | 2014 | IEEE Journals Magazines2014，14，1： | 1 |
| 12 | Up-regulation of microRNA-1290 impairs cytokinesis and affects the reprogramming of colon cancer cells显示文摘 | Jia Wu Xiaowei Ji Linlin Zhu Qiaoli Jiang Zhenzhen Wen Song Xu Wei Shao Jianting Cai Qin Du Yongliang Zhu Jianshan Mao | 2012 | Cancer Letters2012，，： | 1 |
| 13 | Monitoring of ground deformation in Liulin district,China using InSAR approaches显示文摘Coalbed methane(CBM)exploration generally refers to a technique that extracts natural gas from coal beds.The development of CBM in Liulin,China,has experienced a significantly growth period during the past two decades.Previous research mainly focused on the coal geological background or CBM technique itself,while time series InSAR(TS-InSAR)technique was conducted in this work to study the potential land deformation induced by CBM extraction from 2003 to 2011.In total,21 ALOS-1 PALSAR images(acquired from 22 December 2006 to 2 January 2011)and 14 ENVISAT ASAR scenes(captured between 29 October 2003 and 7 November 2007)were used.The TS-InSAR outcome revealed that the annual deformation rates were ranging from 15 to−40 mm yr−1 over the study region.Then the time series deformation evolutions were analysed over 8 CBM sites(No.4 coal seam)out of 20,and the subsidence rates between 1.9 and−6.5 mm yr−1 were derived.In addition,the average subsidence rate and standard deviation among these eight measurements were−3.0 and 2.6 mm yr−1 respectively,suggesting that these CBM extraction sites were quite stable and no obvious subsidence had been observed during this eight-year period. | Zheyuan Du Linlin Ge Alex Hay-Man Ng Xiaojing Li Liyuan Li | 2018 | International Journal of Digital Earth2018，11，3： | 1 |
| 14 | A robust template tracking algorithm with weighted active drift correction显示文摘 | Fan Baojie Du Yingkui Zhu Linlin | 2011 | Pattern Recogni- tion Letters2011，32，9： | 1 |
| 15 | A neural network-based production process modeling and variable importance analysis approach in corn to sugar factory显示文摘Corn to sugar process has long faced the risks of high energy consumption and thin profits.However,it’s hard to upgrade or optimize the process based on mechanism unit operation models due to the high complexity of the related processes.Big data technology provides a promising solution as its ability to turn huge amounts of data into insights for operational decisions.In this paper,a neural network-based production process modeling and variable importance analysis approach is proposed for corn to sugar processes,which contains data preprocessing,dimensionality reduction,multilayer perceptron/convolutional neural network/recurrent neural network based modeling and extended weights connection method.In the established model,dextrose equivalent value is selected as the output,and 654 sites from the DCS system are selected as the inputs.LASSO analysis is first applied to reduce the data dimension to 155,then the inputs are dimensionalized to 50 by means of genetic algorithm optimization.Ultimately,variable importance analysis is carried out by the extended weight connection method,and 20 of the most important sites are selected for each neural network.The results indicate that the multilayer perceptron and recurrent neural network models have a relative error of less than 0.1%,which have a better prediction result than other models,and the 20 most important sites selected have better explicable performance.The major contributions derived from this work are of significant aid in process simulation model with high accuracy and process optimization based on the selected most important sites to maintain high quality and stable production for corn to sugar processes. | Yi Tong Mou Shu Mingxin Li Yingwei Liu Ran Tao Congcong Zhou You Zhao Guoxing Zhao Yi Li Yachao Dong Lei Zhang Linlin Liu Jian Du | 2023 | Frontiers of Chemical Science and Engineering2023，17，3： | 1 |
| 16 | Advances in 4D printed shape memory composites and structures:Actuation and application显示文摘Shape memory polymer composites(SMPCs)are a type of smart material that can change shapes under the stimulation of the external environment,and they have great potential in aerospace,biomedical,robotics,and electronic devices due to their advantages of high strength and toughness,lightweight,impact resistance,corrosion resistance,and aging resistance.4D printing technology has provided new opportunities for the further development of smart materials.The addition of various fillers enriches the variety of printable materials and provides composites with different properties and functions.The combination of SMPCs and printing technologies realizes the structure-function integration.This paper introduces the emergence and development of 4D printing technologies,the preparation methods and properties of SMPCs for 4D printing;as well as the research progress and potential application of 4D printable SMPCs in recent years in terms of thermal,electrical,magnetic,and optical driving.Finally,the existing problems and future development of 4D printable SMPCs are discussed. | WANG LinLin ZHANG FengHua DU ShanYi LENG JinSong | 2023 | Science China(Technological Sciences)2023，66，5： | 1 |
| 17 | Structural basis of interaction between the hepatitis C virus p7 channel and its blocker hexamethylene amiloride显示文摘 | Linlin Zhao Shuqing Wang Lingyu Du Jyoti Dev Liujuan Zhou Zhijun Liu James J. Chou Bo OuYang | 2016 | Protein & Cell2016，7，4： | 1 |
| 18 | Study of Bonding Wire Failure Effects on External Measurable Signals of IGBT Module显示文摘 | Kexin Wei Mingxing Du Linlin Xie Jian Li | | 0，，： | 1 |
| 19 | Development of SYBR G reen I ‐Based One‐Step Real Time RT ‐ PCR Assay for Quantifying S outhern rice black‐streaked dwarf virus in Rice显示文摘 | Tong Zhou Linlin Du Ying Lan Feng Sun Yongjian Fan Yijun Zhou | 2014 | J Phytopathol2014，，1： | 1 |
| 20 | Reverse transcription loop-mediated isothermal amplification of RNA for sensitive and rapid detection of southern rice black-streaked dwarf virus显示文摘 | Tong Zhou Linlin Du Yongjian Fan Yijun Zhou | 2011 | Journal of Virological Methods (-)2011，，1： | 1 |
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