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| 1 | Mesoporous silica nanoparticles for drug and gene delivery显示文摘Mesoporous silica nanoparticles(MSNs) are attracting increasing interest for potential biomedical applications. With tailored mesoporous structure, huge surface area and pore volume,selective surface functionality, as well as morphology control, MSNs exhibit high loading capacity for therapeutic agents and controlled release properties if modified with stimuli-responsive groups, polymers or proteins. In this review article, the applications of MSNs in pharmaceutics to improve drug bioavailability, reduce drug toxicity, and deliver with cellular targetability are summarized. Particularly,the exciting progress in the development of MSNs-based effective delivery systems for poorly soluble drugs, anticancer agents, and therapeutic genes are highlighted. | Yixian Zhou Guilan Quan Qiaoli Wu Xiaoxu Zhang Boyi Niua Biyuan Wu Ying Huang Xin Pan Chuanbin Wu | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 31 |
| 2 | Lifetime prediction based on Gamma processes from accelerated degradation data显示文摘Accelerated degradation test is a useful approach to predict the product lifetime at the normal use stress level, especially for highly reliable products. Two kinds of the lifetime prediction based on Gamma processes were studied. One was to predict the lifetime of the population from accelerated degradation data, and the other was to predict the lifetime of an individual by taking the accelerated degradation data as prior information. For an extensive application, the Gamma process with a time transformation and random effects was considered. A novel contribution is that a deducing method for determining the relationships between the shape and scale parameters of Gamma processes and accelerated stresses was presented. When predicting the lifetime of an individual, Bayesian inference methods were adopted to improve the prediction accuracy, in which the conjugate prior distribution and the non-conjugate prior distribution of random parameters were studied. The conjugate prior distribution only considers the random effect of the scale parameter while the non-conjugate prior distribution considers the random effects of both the scale and shape parameter. The application and usefulness of the proposed method was demonstrated by the accelerated degradation data of carbon-film resistors. | Wang Haowei Xu Tingxue Mi Qiaoli | 2015 | Chinese Journal of Aeronautics2015，28，1： | 23 |
| 3 | Integration of Metabolomics and Subcellular Organelle Expression Microarray to Increase Understanding the Organic Acid Changes in Post-harvest Citrus Fruit显示文摘Citric acid plays an important role in fresh fruit favor and its adaptability to post-harvest storage conditions.In order to explore organic acid regulatory mechanisms in post-harvest citrus fruit,systematic biological analyses were conducted on stored Hirado Buntan Pummelo(HBP;Citrus grandis)fruits.High-performance capillary electrophoresis,subcellular organelle expression microarray,real-time quantitative reverse transcription polymerase chain reaction,gas chromatography mass spectrometry(GC-MS),and conventional physiological and biochemical analyses were undertaken.The results showed that the concentration of organic acids in HBP underwent a regular fuctuation.GC-MS-based metabolic profling indicated that succinic acid,g-aminobutyric acid(GABA),and glutamine contents increased,but 2-oxoglutaric acid content declined,which further confrmed that the GABA shunt may have some regulatory roles in organic acid catabolism processes.In addition,the concentration of organic acids was signifcantly correlated with senescence-related physiological processes,such as hydrogen peroxide content as well as superoxide dismutase and peroxidase activities,which showed that organic acids could be regarded as important parameters for measuring citrus fruit post-harvest senescence processes. | Xiaohua Sun Andan Zhu Shuzhen Liu Ling Sheng Qiaoli Ma Li Zhang Elsayed Mohamed Elsayed Nishawy Yunliu Zeng Juan Xu Zhaocheng Ma Yunjiang Cheng Xiuxin Deng | 2013 | Journal of Integrative Plant Biology2013，55，11： | 14 |
| 4 | EGCG attenuates pro-inflammatory cytokines and chemokines production in LPS-stimulated L02 hepatocyte显示文摘内毒素 lipopolysaccharide (LPS ) 作为第二攻击在肝炎的煽动性的反应的加速起一个重要作用。能由指向 LPS 阻止发炎的混合物有潜在的治疗学的临床的申请。Epigallocatechin-3-gallate (EGCG ) 有有势力 hepatocyte 保护的效果和温和反肝炎病毒工作。这里,我们调查了 EGCG 是否在刺激 LPS 的 L02 hepatocytes 稀释了煽动性的反应的严厉。L02 hepatocytes 是有为 2 h 的 EGCG 的 pretreated,然后在 250 ng/ml 由 LPS 刺激了。 chemokine 的表示层次在表示并且藏匿的激活正常T房间( Rantes )和单核白血球之上调整了趋化性的 protein-1 ( MCP-1 ), 支持inflammatory cytokines 肿瘤坏死因素--(TNF-)并且干扰素--,粘附分子细胞间的粘附 molecule-1 ( ICAM-1 ),氧化剂压力分子氮的氧化物(没有),脉管的 endothelial 生长因素( VEGF ),和矩阵 metalloproteinase-2 ( MMP-2 )被连接酶的 immunosorbent 试金测试。全部的细胞外的调整信号的 kinase 1/2 (ERK1/2 ) 的表示, phospho-ERK1/2 (p-ERK1/2 ) , p-AKT,全部的 p38, phospho-p38 (p-p38 ) ,全部的 p65 和 phospho-p65 (p-p65 ) , IB, phospho-IB (p-IB ) 和 TNF 受体联系了因素 2 被西方的污点分析测试。我们的结果证明有 EGCG 的那个预告的处理能显著地减少 TNF- 的生产, Rantes, MCP-1, ICAM-1,不在以一种剂量依赖者方式的刺激 LPS 的 L02 hepatocytes 的 VEGF,和 MMP-2。EGCG 的效果可能与原子 factor-B (NF-B ) 和由 p-IB, p65, p-p65, p-p38, p-ERK1/2,和 p-AKT 的下面规定表明小径的激活 mitogen 的蛋白质 kinase (MAPK ) 的抑制有关。这些结果显示 EGCG 压制导致 LPS 的煽动性的反应和氧化剂应力并且由禁止 NF-B 和 MAPK 小径部分施加它的 hepatocyte 保护的活动。 | Qiaoli Liu Yun Qian Feng Chen Xiaoming Chen Zhi Chen Min Zhen | 2014 | Acta Biochimica et Biophysica Sinica2014，46，1： | 11 |
| 5 | Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development显示文摘Dear Editor,Previously,the Mendelian phe no types in huma n oocyte maturation arrest,fertilization failure and early embryonic arrest,are largely underestimated.In recent years,'missing'Men delian phe no types and genes in these processes are beginning to be uncovered by us and others(Huang et al.,2014;Alazami et al..2015;Feng et al.,2016;Xu et al.,2016;Chen et al.,2017;Sang et al.,2019).However,the genetic basis for majority of patients resulting from abnormalities in these phe no types remains to be elucidated. | Lin Zhao Songguo Xue Zhongyuan Yao Juanzi Shi Biaobang Chen Ling Wu Lihua Sun Yao Xu Zheng Yan Bin Li Xiaoyan Mao Jing Fu Zhihua Zhang Jian Mu Wenjing Wang Jing Du Shuai Liu Jie Dong Weijie Wang Qiaoli Li Lin He Li Jin Xiaozhen Liang Yanping Kuang Xiaoxi Sun Lei Wang Qing Sang | 2020 | Protein & Cell2020，11，12： | 10 |
| 6 | Pre-oxidation with KMnO4 changes extra-cellular organic matter's secretion characteristics to improve algal removal by coagulation with a low dosage of polyaluminium chloride显示文摘Microcystis aeruginosa was used to study the effect of KMnO4 pre-oxidation on algal removal through coagulation with polyaluminium chloride (PAC).KMnO4 pre-oxidation improved the coagulation efficiency of algal at a low dosage of PAC.The optimal KMnO4 feeding period was in the stationary growth phase of Microcystis aeruginosa.KMnO4 traumatized the algal cells and stimulated cellular release of organic matter,contributing to the pool of extra-cellular organic matter (EOM).KMnO4 also decomposed EOM,especially small molecular weight EOM.Lower concentrations of KMnO4,such as 2 mg/L,induced algae cells to produce moderate amounts of new EOM with molecular weights of 11,280,and 1500 kDa.These relatively large molecules combined easily with PAC,promoting coagulation and removal of algae.High concentrations of KMnO4 lysed algae cells and produced much high-molecular-weight EOM that did not enhance flocculation by PAC at lower dosages. | Lei Wang Junlian Qiao Yinghui Hu Lei Wang Long Zhang Qiaoli Zhou Naiyun Gao | 2013 | Journal of Environmental Sciences2013，25，3： | 10 |
| 7 | Electrochemical synthesis of silver nanoparticles-coated gold nanoporous film electrode and its application to amperometric detection for trace Cr(VI)显示文摘A simple and rapid approach for the electrochemical synthesis of Ag nanoparticles-coated gold nanoporous film (AgGNF) on a gold substrate was reported. The solid gold electrode (SGE) was directly anodized under a high potential of 5 V, and then reduced to obtain gold nanoporous film (AuNF) by freshly prepared ascorbic acid. The Ag nanoparticles (AgNPs) were grown on the AuNF electrode by potential-step electrodeposition. The resulting AgGNF composites electrodes were characterized by scanning electron microscopy (SEM), energy dispersive X-ray (EDX) spectroscopy and cyclic voltammetry (CV). As-prepared AgGNF electrode was used as a kind of superior sensor for Cr(VI) detection, which exhibited better electrocatalytic behavior than those of AuNF and SGE under identical conditions. Such a designed AgGNF nanocomposites electrode showed outstanding sensitivity (about 0.15 nA/ppb) and favorable reproducibility for Cr(VI) detection. The dependence of reduction current on Cr(VI) concentration is linear from 2 to 370 ppb with a low detection limit of 0.65 ppb. Interferences from other heavy metals ions (Cr3+, Cu2+, Pb2+, As3+ and Hg2+) associated with Cr(VI) analysis could be effectively diminished. The present method proves to be rapid, reliable, sensitive and low-cost. | XU He ZHENG QiaoLi YANG Ping LIU JianShe XING SuJie JIN LiTong | 2011 | Science China Chemistry2011，54，6： | 9 |
| 8 | An experimental study on thymus immune tolerance to treat surgical brain injury显示文摘 | Zheng Yongtao Kang Jianmin Liu Baolong Fan Weijia Wu Qiaoli Yan Hua | 2014 | Chinese Medical Journal2014，，4： | 8 |
| 9 | An integrated chemical mass balance and source emission inventory model for the source apportionment of PM2.5 in typical coastal areas显示文摘The source apportionment of PM2.5 is essential for pollution prevention.In view of the weaknesses of individual models,we proposed an integrated chemical mass balancesource emission inventory(CMB-SEI)model to acquire more accurate results.First,the SEI of secondary component precursors(SO2,NOx,NH3,and VOCs)was compiled to acquire the emission ratios of these sources for the precursors.Then,a regular CMB simulation was executed to obtain the contributions of primary particle sources and secondary components(SO4^2-,NO3^-3,NH4^+,and SOC).Afterwards,the contributions of secondary components were apportioned into primary sources according to the source emission ratios.The final source apportionment results combined the contributions of primary sources by CMB and SEI.This integrated approach was carried out via a case study of three coastal cities(Zhoushan,Taizhou,and Wenzhou;abbreviated WZ,TZ,and ZS)in Zhejiang Province,China.The regular CMB simulation results showed that PM2.5 pollution was mainly affected by secondary components and mobile sources.The SEI results indicated that electricity,industrial production and mobile sources were the largest contributors to the emission of PM2.5 gaseous precursors.The simulation results of the CMB-SEI model showed that PM2.5 pollution in the coastal areas of Zhejiang Province presented complex pollution characteristics dominated by mobile sources,electricity production sources and industrial production sources.Compared to the results of the CMB and SEI models alone,the CMB-SEI model completely apportioned PM2.5 to primary sources and simultaneously made the results more accurate and reliable in accordance with local industrial characteristics. | Nana Cheng Cheng Zhang Deji Jing Wei Li Tianjiao Guo Qiaoli Wang Sujing Li | 2020 | Journal of Environmental Sciences2020，32，6： | 8 |
| 10 | Isolation,Characterization,and Phylogenetic Analysis of Two New Crimean-Congo Hemorrhagic Fever Virus Strains from the Northern Region of Xinjiang Province,China显示文摘Crimean-Congo hemorrhagic fever(CCHF)caused by the CCHF virus(CCHFV)is a tick-borne natural focal disease with a mortality rate of approximately 50%.CCHFV is widely prevalent in Africa,southern Asia,the Middle East,and southeast Europe.CCHF outbreaks have been reported previously in Xinjiang province,China,especially in its southern region.Epidemiological surveys conducted on ticks and animals have revealed the presence of CCHFV strains in ticks,rodents,and infected individuals from cities and counties in southern Xinjiang.Phylogenetic analyses revealed that the Chinese CCHFV strains belong to one genotype,based on complete sequences of the S segments of its negative-stranded RNA genome.The present study reports two new CCHFV strains isolated from Hyalomma asiaticum asiaticum ticks collected from Fukang City and Wujiaqu City in the northern region of Xinjiang.Viral characteristics and their evolutionary relationships were analyzed through metagenomic and reverse-transcription PCR analyses;these analyses indicated that the genotype of both strains was different from that of other Chinese strains.Furthermore,previous reports of CCHFV in Xinjiang were reviewed and phylogenetic analyses were performed.CCHFV was found to prevail in Fukang City in Junggar Basin for more than 20 years,and that Fukang City and Wujiaqu City are considered natural reservoirs of different genotypes of CCHFV strains.Our findings facilitate the understanding of CCHFV distribution in Xinjiang province and provide insights into the evolutionary relationships among Chinese CCHFV strains. | Yanfang Zhang Shu Shen Yaohui Fang Jinliang Liu Zhengyuan Su Jinhao Liang Zhong Zhang Qiaoli Wu Cheng Wang Abulikemu Abudurexiti Zhihong Hu Yujiang Zhang Fei Deng | 2018 | Virologica Sinica2018，33，1： | 8 |
| 11 | Detection of geosmin and 2-methylisoborneol by liquid-liquid extraction-gas chromatograph mass spectrum (LLE-GCMS) and solid phase extraction-gas chromatograph mass spectrum (SPE-GCMS)显示文摘Two sample preparation methods were introduced and compared in this paper to establish a simple,quick and exact analysis of geosmin and 2-methylisoborneol.LC-18 column was employed in solid phase extraction(SPE),1.0 mL of hexane was adopted in liquid-liquid extraction(LLE),and the extracts were analyzed by gas chromatograph mass spectrum(GCMS)in selected ion mode.Mean recoveries of SPE were low for 2-methylisoborneol(2-MIB)and geosmin(GSM)with values below 50%.For LLE,the recoveries were satisfyingly above 50%for 2-MIB and 80%for GSM.Detection limits of the LLE method were as low as 1.0 ng/L for GSM and 5.0 ng/L for 2-MIB.A year-long investigation on odor chemicals of drinking water in Shanghai demonstrated that in the summer,there was a serious odor problem induced by a high concentration of 2-MIB.The highest concentration of 152.82 ng/L appeared in July in raw water,while GSM flocculation was minimal with concentrations below odor threshold. | MA Xiaoyan GAO Naiyun CHEN Beibei LI Qingsong ZHANG Qiaoli GU Guofen | 2007 | Frontiers of Environmental Science & Engineering2007，1，3： | 7 |
| 12 | Novel hydrogen storage properties of palladium nanocrystals activated by a pentagonal cyclic twinned structure显示文摘研究人员们看起来忽视了雏晶的一种特殊形式,五角的周期的 twinning,明显的二维的格子扩大在存在导致新奇 physicalchemical 性质在几何、电子的结构与变化联系了。在 Pd nanocrystals 把氢的存储和版本用作一根探针,我们发现了五角的周期的孪生的 Pd nanocrystals 有的那 icosahedral 不同的氢存储性质由于二维的格子扩大,与那些相当不同八面的单个水晶的对应物。另外,在五角的周期的孪生的 Pd nanocrystals 的二维的格子扩大在电子结构引起一个变化,它导致在 PdH x 五角的周期的孪生的 nanocrystals。 | Huang Huang Shixiong Bao Qiaoli Chen Yanan Yang Zhiyuan Jiang Qin Kuang Xiaoyin Wu Zhaoxiong Xie Lansun Zheng | 2015 | Nano Research2015，8，8： | 7 |
| 13 | A facile surfactant-free synthesis of Rh flower-like nanostructures constructed from ultrathin nanosheets and their enhanced catalytic properties显示文摘Rh 是广泛地在许多器官的反应被使用的重要催化剂。在最近的年里,许多努力集中了于由与控制尺寸和形态学制作催化剂 nanoparticles 改进它的催化效率。然而,也把有机化合物用作反应媒介或盖住代理人的经常采用的合成线路经常在催化剂表面上导致剩余分子,它急速地接着减少催化表演。此处,我们报导甲醛经由 Rh (acac )3 的热水的减小获得的新奇 Rh 象花的结构的灵巧的、水的、没有表面活化剂的合成。唯一的 Rh nanoflowers 从 ultrathin nanosheets 被构造,其基础表面包括了 { 111 } 有 ~ 的平均厚度的方面 1.1 nm。特定的表面区域由公司脱衣测量了 79.3 是 m 2 钟声到 134.4 食火鸟的浸透的磁化 ???? 愠汬祯湩吗?? | Yaqi Jiang Jingyun Su Yanan Yang Yanyan Jia Qiaoli Chen Zhaoxiong Xie Lansun Zheng | 2016 | Nano Research2016，9，3： | 7 |
| 14 | Effectiveness of Traditional Chinese Medicine (TCM) treatments on the cognitive functioning of elderly persons with mild cognitive impairment associated with white matter lesions显示文摘 | Songming HE Lijun LI Juying HU Qiaoli CHEN Weiqun SHU | 2015 | 上海精神医学2015，27，5： | 7 |
| 15 | Substrate stiffness modulates bone marrow-derived macrophage polarization through NF-κB signaling pathway显示文摘The stiffness of the extracellular matrix(ECM)plays an important role in regulating the cellular programming.However,the mechanical characteristics of ECM affecting cell differentiation are still under investigated.Herein,we aimed to study the effect of ECM substrate stiffness on macrophage polarization.We prepared polyacrylamide hydrogels with different substrate stiffness,respectively.After the hydrogels were confirmed to have a good biocompatibility,the bone marrow-derived macrophages(BMMs)from mice were incubated on the hydrogels.With simulated by the low substrate stiffness,BMMs displayed an enhanced expression of CD86 on the cell surface and production of reactive oxygen species(ROS)in cells,and secreted more IL-1βand TNF-αin the supernatant.On the contrary,stressed by the medium stiffness,BMMs expressed more CD206,produced less ROS,and secreted more IL-4 and TGF-β.In vivo study by delivered the hydrogels subcutaneously in mice,more CD68+CD86+cells around the hydrogels with the low substrate stiffness were observed while more CD68+CD206+cells near by the middle stiffness hydrogels.In addition,the expressions of NIK,phosphorylated p65(pi-p65)and phosphorylated IκB(pi-IκB)were significantly increased after stimulation with low stiffness in BMMs.Taken together,these findings demonstrated that substrate stiffness could affect macrophages polarization.Low substrate stiffness promoted BMMs to shift to classically activated macrophages(M1)and the middle one to alternatively activated macrophages(M2),through modulating ROS-initiated NF-κB pathway.Therefore,we anticipated ECM-based substrate stiffness with immune modulation would be under consideration in the clinical applications if necessary. | Mimi Chen Yu Zhang Pinghui Zhou Xingzhi Liu Huan Zhao Xichao Zhou Qiaoli Gu Bin Li Xuesong Zhu Qin Shi | 2020 | Bioactive Materials2020，5，4： | 7 |
| 16 | Identification of QTL and candidate genes involved in early seedling growth in rice via high-density genetic mapping and RNA-seq显示文摘Early seedling vigor(ESV)is a major breeding target in rice,especially under direct seeding.To identify quantitative trait locus(QTL)affecting ESV,a recombinant inbred line population derived from a cross between 02428 and YZX,two cultivars differing in vigor during early seedling growth,was used for QTL analysis.Nine traits associated with ESV were examined using a high-density map.Of 16 additive loci identified,three were detected in two generations and thus considered stable.Four epistatic interactions were detected,one of which was repeated in two generations.Further analysis of the pyramiding effect of the three stable QTL showed that the phenotypic value could be effectively improved with an increasing number of QTL.These results were combined with results from our previous QTL analysis of the germination index.The lines G58 and G182 combined all the favourable alleles of all three stable QTL for ESV and three QTL for germination speed.These two lines showed rapid germination and strong ESV.A total of 37 candidate differentially expressed genes were obtained from the regions of the three stable QTL by analysis of the dynamic transcriptomic expression profile during the seedling growth period of the two parents.The QTL are targets for ESV breeding and the candidate genes await functional validation.This study provides a theoretical basis and a genetic resource for the breeding of directseeded rice. | Jing Yang Zhenhua Guo Lixin Luo Qiaoli Gao Wuming Xiao Jiafeng Wang Hui Wang Zhiqiang Chen Tao Guo | 2021 | The Crop Journal2021，9，2： | 6 |
| 17 | Effect of Er-Xian decoction(二仙汤) on autoimmune premature ovarian failure in mice显示文摘OBJECTIVE:To investigate the therapeutic effect of Er-Xian decoction(二仙汤,EXD)on the autoimmune premature ovarian failure(POF)in mice,and its regulatory mechanisms.METHODS:Female BALB mice were treated with a single intraperitoneal injection of zona pellucida 3(ZP3).One week later,mice received low(5 g/kg),moderate(10 g/kg)and high(20 g/kg)doses of EXD by gastrogavage once daily for 90 d.Premarin(0.03 mg/kg)served as the positive control group.Serum levels of estradiol(E2),follicle stimulating hormone(FSH)and luteinizing hormone(LH)were measured by enzyme-linked immunosorbent assay,lymphocyte subtypes were analyzed,and follicular structure differences were observed by hematoxylin andeosin staining.The main mechanisms of POF was investigated by immunohistochemical analysis.RESULTS:Serum E2 levels in POF model mice were decreased,whereas FSH and LH levels were dramatically increased.Serum levels of LH and FSH were reduced in POF model mice treated with EXD(moderate and high doses)and premarin,while serum level of E2 were increased after POF model mice had been treated with EXD and premarin.The CD3+T,CD4+T,CD4+T/CD8+T ratio of mice in the positive control group and high and medium dose groups of EXD increased(P<0.05),and the number of CD8+T cells decreased significantly(P<0.05)when compared with the model group.Bone morphogenetic protein 15(BMP15)and Akt were repressed in autoimmune POF model mice,whereas high expression was observed in control mice and those treated with EXD(moderate and high doses)and premarin.CONCLUSION:EXD is effective in treating ZP3-induced POF in mice and increased expression of BMP-15,and Akt is represented in the mechanism accounting for this therapeutic effect. | ZHANG Xiaoli LI Jing ZHOU Xiaolin CHEN Qiaoli | 2021 | Journal of Traditional Chinese Medicine2021，41，5： | 6 |
| 18 | Cloning, Characterization, and Expression Patterns of Three Sarco/Endoplasmic Reticulum Ca^2+-ATPase Isoforms from Pearl Oyster (Pinctada fucata)显示文摘大量钙被要求因为 molluskbiomineralization.Sarco/endoplasmic 蜂窝胃 Ca^(2+)-ATPase (SERCA ) 是有支撑钙动态平衡的功能的著名蛋白质。怎么它可能在珍珠牡蛎简历矿化作用的过程工作?三 SERCA isoforms ,也就是, PSERA , PSERB ,和 PSERC 从珍珠牡蛎被克隆,三 isoforms 的 Pinctada fucata.The cDNAs 被reversetranscription聚合酶链反应( RT-PCR )和编码 1007 氨基酸的 3568 bp 的 cDNA ends.PSERAconsisted 的快速的扩大孤立, PSERB 包括了编码 1024 氨基酸的 3953 bp ,由编码 1000 氨基酸的 3450 bp 组成的 andPSERC 。三 isoforms 从另外的种类与 SERCA 显示出高相同(65%-87%) 。与从另外的无脊椎动物的结果一致, DNA 印迹分析表明三 isoforms 从麝猫帽子也与脊椎动物的 SERCA1, SERCA2,和 SERCA3 有关的一个单身者发源。 threeisoforms 的拼接的机制类似于脊椎动物 SERCA3.Semiquantitative RT-PCR 的 isoforms 的被执行学习结果显示出的三 isoforms.The 的表示模式那 PSERB 无所不在地在所有测试纸巾被表示并且是潜在的“家务” SERCA isoform ;在内转肌肌肉表示的 PSERAwas 并且脚并且是可能的是肌肉特定的 isoform ,除了内转肌肌肉或脚, andPSERC 在鳃和披风与最高的表示层次在另外的纸巾被表示,显示它是 non-muscle-specific isoform 和力量在珍珠牡蛎简历矿化作用期间涉及钙动态平衡。 | Weimin FAN Changzhong LI Shuo LI Qiaoli FENG Liping XIE Rongqing ZHANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，9： | 4 |
| 19 | Characterization and immunogenicity of bone marrow-derived mesenchymal stem cells under osteoporotic conditions显示文摘Mesenchymal stem cells(MSCs)are characterized by their multilineage potential and low immunogenicity.However,the properties of MSCs under pathological conditions are unclear.The current study investigated the differentiation potential and immunological characteristics of bone marrow-derived MSCs from ovariectomized-osteoporotic rats(OP-BMSCs).Although the expression of cell morphology-and stemness-related surface markers was similar between OP-BMSCs and BMSCs from healthy rats(H-BMSCs),the proliferation rate was significantly decreased compared with that of H-BMSCs.Regarding multilineage potential,osteogenesis and chondrogenesis abilities of OP-BMSCs decreased,but the adipogenesis ability was significantly enhanced compared with that of H-BMSCs.As expected,decreased osteogenesis following osteogenic induction resulted in reduced expression ofβ-catenin,osteocalcin,and runt-related transcription factor 2 in OP-BMSCs.Remarkably,the expression of the co-stimulatory proteins CD40 and CD80 was significantly higher,whereas the expression of the negative costimulatory molecule programmed cell death ligand 1 was significantly lower in the OP-BMSCs than that in H-BMSCs.Consequently,H-BMSCs inhibited the proliferation and secretion of inflammatory cytokines from anti-CD3 antibody-activated T cells,whereas OP-BMSCs did not.These results indicate that decreased osteogenesis and increased immunogenicity of OPBMSCs contribute to bone loss in osteoporosis. | Yingkang Huang Yin Yin Yanzheng Gu Qiaoli Gu Huilin Yang Zhengyu Zhou Qin Shi | 2020 | Science China(Life Sciences)2020，63，3： | 4 |
| 20 | All-fiber passively mode-locked laser using nonlinear multimode interference of step-index multimode fiber显示文摘We experimentally demonstrate for the first time, to the best of our knowledge, an all-fiber passively mode-locked laser operation based on the nonlinear multimode interference of step-index multimode fiber. Such a structure couples the light in and out of the multimode fiber via single-mode fibers, and its physical mechanisms for saturable absorption have been analyzed theoretically based on the third-order nonlinear Kerr effect of multimode fiber. Using the nonlinear multimode interference structure with 48.8 mm length step-index multimode fiber, the modulation depth has been measured to be ~5%. The passively mode-locked laser output pulses have a central wavelength of 1596.66 nm, bandwidth of 2.18 nm, pulsewidth of ~625 fs, and fundamental repetition rate of8.726 MHz. Furthermore, the influence of total cavity dispersion on the optical spectrum, pulse width, and output power is investigated systematically by adding different lengths of single-mode fiber and dispersion compensation fiber in the laser cavity. | TAO CHEN QIAOLI ZHANG YAPING ZHANG XIN LI HAIKUN ZHANG WEI XIA | 2018 | Photonics Research2018，，11： | 4 |
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