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| 1 | Three-dimensional Finite Element Analysis of the Mechanical Properties of Helical Thread Connection显示文摘Conventional analytical and numerical methods for the mechanical properties of helical threads are relied on many assumptions and approximations and thus hardly yield satisfied results. A parameterized 3D finite element model of bolted joints with real helical thread geometry is established and meshed with refined hexahedral elements. The Von Mises plasticity criterion, kinematic hardening rule of materials and interfacial contacts are employed to make it possible for the suggested model be able to approach real assembly conditions. Then, the mechanical properties of bolted joints with different thread pitches, thread numbers and modular ratios are investigated, including the contact pressure distribution at joint interfaces, the axial load distribution and stress concentration in screw threads during the loading and unloading process. Simulation results indicate that the load distribution in screw threads produced by the suggested model agrees well the results from CHEN's photoelastic tests. In addition, an interesting phenomenon is found that tightening the bolt with a large preload first and then adjusting the clamping force by unloading can make the load distribution more uniform and reduce the maximum residual equivalent stress in thread roots by up to 40%. This research provides a simple and practical approach to constructing the 3D finite element model and predicting the mechanical properties of helical thread connection. | YANG Guoqing HONG Jun ZHU Linbo LI Baotong XIONG Meihua WANG Fei | 2013 | Chinese Journal of Mechanical Engineering2013，26，3： | 19 |
| 2 | Multi-scale object detection by top-down and bottom-up feature pyramid network显示文摘While moving ahead with the object detection technology, especially deep neural networks, many related tasks, such as medical application and industrial automation, have achieved great success. However, the detection of objects with multiple aspect ratios and scales is still a key problem. This paper proposes a top-down and bottom-up feature pyramid network(TDBU-FPN),which combines multi-scale feature representation and anchor generation at multiple aspect ratios. First, in order to build the multi-scale feature map, this paper puts a number of fully convolutional layers after the backbone. Second, to link neighboring feature maps, top-down and bottom-up flows are adopted to introduce context information via top-down flow and supplement suboriginal information via bottom-up flow. The top-down flow refers to the deconvolution procedure, and the bottom-up flow refers to the pooling procedure. Third, the problem of adapting different object aspect ratios is tackled via many anchor shapes with different aspect ratios on each multi-scale feature map. The proposed method is evaluated on the pattern analysis, statistical modeling and computational learning visual object classes(PASCAL VOC)dataset and reaches an accuracy of 79%, which exhibits a 1.8% improvement with a detection speed of 23 fps. | ZHAO Baojun ZHAO Boya TANG Linbo WANG Wenzheng WU Chen | 2019 | Journal of Systems Engineering and Electronics2019，30，1： | 11 |
| 3 | The crosstalk between autophagy and ferroptosis:what can we learn to target drug resistance in cancer?显示文摘Autophagy is a conserved intracellular degradation system that plays a dual role in cell death;thus,therapies targeting autophagy in cancer are somewhat controversial.Ferroptosis is a new form of regulated cell death featured with the iron-dependent accumulation of lethal lipid ROS.This pathway is morphologically,biochemically and genetically distinct from other forms of cell death.Accumulating studies have revealed crosstalk between autophagy and ferroptosis at the molecular level.In this review,we summarize the mechanisms of ferroptosis and autophagy,and more importantly,their roles in the drug resistance of cancer.Numerous connections between ferroptosis and autophagy have been revealed,and a strong causal relationship exists wherein one process controls the other and can be utilized as potential therapeutic targets for cancer.The elucidation of when and how to modulate their crosstalk using therapeutic strategies depends on an understanding of the fine-tuned switch between ferroptosis and autophagy,and approaches designed to manipulate the intensity of autophagy might be the key. | Yulu Zhou Yong Shen Cong Chen Xinbing Sui Jingjing Yang Linbo Wang Jichun Zhou | 2019 | Cancer Biology & Medicine2019，16，4： | 9 |
| 4 | Cancer-associated fibroblasts in breast cancer:Challenges and opportunities显示文摘The tumor microenvironment is proposed to contribute substantially to the progression of cancers,including breast cancer.Cancer-associated fibroblasts(CAFs)are the most abundant components of the tumor microenvironment.Studies have revealed that CAFs in breast cancer originate from several types of cells and promote breast cancer malignancy by secreting factors,generating exosomes,releasing nutrients,reshaping the extracellular matrix,and suppressing the function of immune cells.CAFs are also becoming therapeutic targets for breast cancer due to their specific distribution in tumors and their unique biomarkers.Agents interrupting the effect of CAFs on surrounding cells have been developed and applied in clinical trials.Here,we reviewed studies examining the heterogeneity of CAFs in breast cancer and expression patterns of CAF markers in different subtypes of breast cancer.We hope that summarizing CAFrelated studies from a historical perspective will help to accelerate the development of CAF-targeted therapeutic strategies for breast cancer. | Dengdi Hu Zhaoqing Li Bin Zheng Xixi Lin Yuehong Pan Peirong Gong Wenying Zhuo Yujie Hu Cong Chen Lini Chen Jichun Zhou Linbo Wang | 2022 | Cancer Communications2022，42，5： | 9 |
| 5 | Fucoxanthin induces growth arrest and apoptosis in human bladder cancer T24 cells by up-regulation of p21 and down-regulation of mortalin显示文摘Fucoxanthin,自然类胡萝卜素,被报导了在人的结肠癌房间,人的前列腺癌症房间,人的白血病房间,和人的上皮的颈的癌症房间举办反癌症活动。这研究被承担把 fucoxanthin 的分子的机制与人的膀胱癌症 T24 房间线作比较。 MTT 分析结果证明 5 和 10 M fucoxanthin 在生长拘捕在 G 0/G1伴随的一个剂量依赖者和时间依赖者举止禁止了 T24 房间的增长房间周期的阶段,被 p21 的起来规定调停,cyclin依赖的 kinase ( CDK )禁止的蛋白质和 CDK-2 , CDK-4 , cyclin D1 ,和 cyclin E 的下面规定。另外, 20 和 40 M fucoxanthin 由 mortalinp53 建筑群的废除和原子变异类型的 p53 的复活导致了 T24 房间的 apoptosis,它也让肿瘤 suppressor 作为野类型的 p53 工作。所有这些结果证明 T24 房间上的 fucoxanthin 的反癌症活动被 p21 的起来规定经由在 mortalin ,它是的表示水平,一个压力管理者和热的一个成员震惊的减少在低剂量和 apoptosis 在 G 0/G1阶段与房间周期拘捕联系蛋白质 70 ,在高剂量由劈开的 caspase-3 的起来规定列在后面。 | Linbo Wang Yang Zeng Ye Liu Xuansheng Hu Shuhong Li Yuepeng Wang Ling Li Zhongfang Lei Zhenya Zhang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，10： | 5 |
| 6 | Copper partitioning between granitic silicate melt and coexisting aqueous fluid at 850°C and 100 MPa显示文摘Experiments on the partitioning of Cu between different granitic silicate melts and the respective coexisting aqueous fluids have been performed under conditions of 850 °C, 100 MPa and oxygen fugacity(f O_2) buffered at approaching Ni–Ni O(NNO). Partition coefficients of Cu(DCu= cfluid/cmelt) were varied with different alumina/alkali mole ratios [Al_2O_3/(Na_2O·K_2O), abbreviated as Al/Alk], Na/K mole ratios, and Si O_2 mole contents. The DCu increased from 1.28 ± 0.01 to 22.18 ± 0.22 with the increase of Al/Alk mole ratios(ranging from 0.64 to 1.20)and Na/K mole ratios(ranging from 0.58 to 2.56). The experimental results also showed that DCuwas positively correlated with the HCl concentration of the starting fluid.The DCuwas independent of the Si O_2 mole content in the range of Si O_2 content considered. No DCuvalue was less than 1 in our experiments at 850 °C and 100 MPa, indicating that Cu preferred to enter the fluid phase rather than the coexisting melt phase under most conditions in the melt-fluid system, and thus a significant amount of Cu could be transported in the fluid phase in the magmatichydrothermal environment. The results indicated that Cu favored partitioning into the aqueous fluid rather than themelt phase if there was a high Na/K ratio, Na-rich, peraluminous granitic melt coexisting with the high Cl-fluid. | Shuilong Wang Hui Li Linbo Shang Xianwu Bi Xinsong Wang Wenlin Fan | 2016 | Acta Geochimica2016，35，4： | 3 |
| 7 | Cycle-by-Cycle Queue Length Estimation for Signalized Intersections Using Multi-Source Data显示文摘In order to estimate vehicular queue length at signalized intersections accurately and overcome the shortcomings and restrictions of existing studies especially those based on shockwave theory,a new methodology is presented for estimating vehicular queue length using data from both point detectors and probe vehicles. The methodology applies the shockwave theory to model queue evolution over time and space. Using probe vehicle locations and times as well as point detector measured traffic states,analytical formulations for calculating the maximum and minimum( residual) queue length are developed. The proposed methodology is verified using ground truth data collected from numerical experiments conducted in Shanghai,China. It is found that the methodology has a mean absolute percentage error of 17. 09%,which is reasonably effective in estimating the queue length at traffic signalized intersections. Limitations of the proposed models and algorithms are also discussed in the paper. | Zhongyu Wang Qing Cai Bing Wu Yinhai Wang Linbo Li | 2015 | Journal of Harbin Institute of Technology(New Series)2015，22，2： | 3 |
| 8 | Involucre fossils of Carpinus,a northern temperate element,from the Miocene of China and the evolution of its species diversity in East Asia显示文摘East Asia has long been recognized as a major center for temperate woody plants diversity.Although several theories have been proposed to explain how the diversity of these temperate elements accumulated in the region,the specific process remains unclear.Here we describe six species of Carpinus,a typical northern hemisphere temperate woody plant,from the early Miocene of the Maguan Basin,southwestern China,southern East Asia.This constitutes the southernmost,and the earliest occurrence that shows a high species diversity of the genus.Together with other Carpinus fossil records from East Asia,we show that the genus had achieved a high diversity in East Asia at least by the middle Miocene.Of the six species here described,three have become extinct,indicating that the genus has experienced apparent species loss during its evolutionary history in East Asia.In contrast,the remaining three species closely resemble extant species,raising the possibility that these species may have persisted in East Asia at least since the early Miocene.These findings indicate that the accumulation of species diversity of Carpinus in East Asia is a complex process involving extinction,persistence,and possible subsequent speciation. | Li Xue Linbo Jia Gi-soo Nam Yongjiang Huang Shitao Zhang Yuqing Wang Zhuo Zhou Yongsheng Chen | 2020 | Plant Diversity2020，42，3： | 2 |
| 9 | Construction and identification of an RNA interference lentivirus vector targeting the Ras homology C gene of melanoma cells显示文摘 | Wang Qiying Wang Ximei Zhai Xiaomei Zhang Jianwen Chen Minjing Liu Linbo | 2014 | Chinese Medical Journal2014，，7： | 2 |
| 10 | Lin28 promotes Her2 expression and Lin28/Her2 predicts poorer survival in gastric cancer显示文摘 | Qinchuan Wang Jichun Zhou Jufeng Guo Rongyue Teng Jianguo Shen Yasheng Huang Shuduo Xie Qun Wei Wenhe Zhao Wenjun Chen Xiaoming Yuan Yongxia Chen Linbo Wang | 2014 | Tumor Biology2014，，11： | 1 |
| 11 | Experimental investigation of Z-pinch radiation source for indirect drive inertial confinement fusion显示文摘Z-pinch dynamic hohlraums(ZPDHs)could potentially be used to drive inertial confinement fusion targets.Double-or multishell capsules using the technique of volume ignition could exploit the advantages of ZPDHs while tolerating their radiation asymmetry,which would be unacceptable for a central ignition target.In this paper,we review research on Z-pinch implosions and ZPDHs for indirect drive targets at the Institute of Nuclear Physics and Chemistry,China Academy of Engineering Physics.The characteristics of double-shell targets and the associated technical requirements are analyzed through a one-dimensional computer code developed from MULTI-IFE.Some key issues regarding the establishment of suitable sources for dynamic hohlraums are introduced,such as soft X-ray power optimization,novel methods for plasma profile modulation,and the use of thin-shell liner implosions to inhibit the generation of prior-stagnated plasma.Finally,shock propagation and radiation characteristics in a ZPDH are presented and discussed,together with some plans for future work. | Zhenghong Li Zhen Wang Rongkun Xu Jianlun Yang Fan Ye Yanyun Chu Zeping Xu Faxin Chen Shijian Meng Jianmin Qi Qinyuan Hu Yi Qin Jiaming Ning Zhanchang Huang Linbo Li Shuqing Jiang | 2019 | Matter and Radiation at Extremes2019，4，4： | 1 |
| 12 | Evaluation of urban redevelopment impact on non-motorized traffic显示文摘As an important component of city evolution,urban land redevelopment has an impact on transportation system.The current traffic impact analysis(TLA) is lack of a comprehensive component for non-motorized transportation under redevelopment.For a better guidance of land redevelopment and non-motorized transportation planning,it is necessary to evaluate the negative impact of redevelopment on non-motorized traffic in the TIA.In this paper,an evaluation framework for the impact analysis is built up.We organized the procedures and components of impact evaluation,and proposed the corresponding qualitative and quantitative evaluation indicators for non-motorized traffic under redevelopment.Level of service(LOS) and its criterion are employed for external impact evaluation,and level of safety,convenience,independence,and comfort which are four aspects of quality of service(QOS) are proposed to analyze the internal impact.The framework is applied to a redevelopment study in Shanghai,China.The case study results indicate that the redevelopment from a residential area to a mixed commercial area has a significant impact on non-motorized traffic.The potential negative impact from both external and internal traffic can be minimized by reasonable improvements in the internal land use design. | Yanli Wang Liang Li Xiaoyu Zhu Bing Wu Linbo Li | 2015 | Journal of Traffic and Transportation Engineering(English Edition)2015，2，3： | 1 |
| 13 | Synthesis of ZSM-5 with the silica source from industrial hexafluorosilicic acid as transalkylation catalyst显示文摘A new effective process to improve the utilization of industrial fluorosilicic acid of phosphate fertilizer by-product has been investigated to comprehensive application of the silicon and fluorine source. Two-step ammoniation was applied to recover high-quality silica. The recovered silica can be used to hydrothermal synthesize ZSM-5 zeolite without impurity phase contamination, which was confirmed by XRD, TG, SEM, BET and EDS characteristic techniques. It was found that with the increase of SiO_2/Al_2O_3 ratio and the extension of reaction time, the crystal type transform from the orthorhombic to the monoclinic phase. The impurity fluorine content of the recovered SiO_2 from H_2SiF_6 has great influence on the hydrothermal process for ZSM-5 crystal structure formation.Moreover, the increase of fluorine ions content in the hydrothermal process can control the crystal morphology and size of synthesized ZSM-5. Catalytic properties of synthesized HZSM-5 with different SiO_2/Al_2O_3 ratio in transalkylation of toluene and 1,2,4-trimethylbenzene show good and stable catalytic performance. The ZSM-5 synthesized with recovered silica source exhibits similar catalyst life as the performance of small particle size HZSM-5, because the ZSM-5 synthesized with the silica source from industrial hexafluorosilicic acid prefers a thin disk crystal along the b axis direction, which shortens the diffusion distance of generated products. | Fang Jin Xianqiao Wang Tieliang Liu Linbo Xiao Ming Yuan Yangchun Fan | 2017 | Chinese Journal of Chemical Engineering2017，25，9： | 1 |
| 14 | In vivo chondrogenesis of adult bone-marrow-derived autologous mesenchymal stem cells显示文摘 | Jinwu Chen Changyong Wang Shuanghong Lü Junzheng Wu Ximin Guo Cuimi Duan Lingzhi Dong Ying Song Junchuan Zhang Dianying Jing Linbo Wu Jiandong Ding Dexue Li | 2005 | Cell and Tissue Research2005，，3： | 1 |
| 15 | Exploring a particle-size-reduction strategy of YAG:Ce phosphor via a chemical breakdown method显示文摘Particle size reduction of Y_(3)Al_(5)O_(12):Ce(YAG:Ce) phosphor is highly needed for micro-LED display applications.In this work,size control of YAG:Ce phosphor particles is achieved via carbon coating and further heat treatment.A thin layer of carbon is deposited on the surface of YAG:Ce by chemical vapor deposition.During the heat treatment,carbon reacts with oxygen element in the phosphor and escapes from phosphor particles.The reaction results in the phosphor breaking into smaller particles.The phosphors were characterized by laser light scattering for particle size distribution,scanning electron microscopy(SEM),transmission electron microscopy for morphologies,X-ray diffraction refinements for crystal structure and electron energy-loss spectroscopy for elemental analysis.It is demonstrated that the median diameter(D_(50)) of the phosphor particle size is significantly reduced from 19.1 to 0.96 μm yet the photoluminescent properties have little changes.The carbon coating and further heat treatment method show potential application in size control of phosphors. | Hongren Chen Licheng Ju Li Zhang Xin Wang Linbo Zhang Xin Xu Lin Gao Kehui Qiu Liangjun Yin | 2021 | Journal of Rare Earths2021，39，8： | 1 |
| 16 | Lymphatic mapping and sentinel node biopsy in gastric cancer显示文摘 | Xiangyang Song Linbo Wang Wenjun Chen | 2004 | Am J Surg2004，187，2： | 1 |
| 17 | Application of a low pressure economizer for waste heat recovery from the exhaust flue gas in a 600 MW power plant显示文摘 | Chaojun Wang Boshu He Shaoyang Sun Ying Wu Na Yan Linbo Yan Xiaohui Pei | 2012 | Energy2012，，1： | 1 |
| 18 | Isolation,Screening and Identification of Antagonistic Actinomycetes against Ustilago scitaminea Syd显示文摘[Objectives] This study was conducted to obtain actinomycetes strains having antagonistic effect on Ustilago scitaminea Syd. [Methods]At first,actinomycetes strains were isolated from 22 soil samples in Hainan sugarcane regions. Then,antagonistic actinomycetes against U. scitaminea were screened by confrontation culture. Finally,the taxonomic status of antagonistic actinomycetes was determined using 16 S rD NA. [Results] From the 22 samples,984 actinomycetes strains were isolated. From all the isolated strains,23 antagonistic actinomycetes strains were obtained through primary screening,and one strains with better antagonistic effect was then obtained through secondary screening,and designated FAS. 16 S rD NA identification showed that strain FAS shared 99% sequence similarity with Streptomyces cealestis US24. A phylogenetic tree was built with MAGE 7. 0 software,and the results showed that strain FAS had the shortest genetic distance with S. caelestis US24. Therefore,the actinomycetes FAS was determined as S. caelestis. [Conclusions]This study provides a new biocontrol method for the biological control of sugarcane smut,thereby ensuring sustainable development of sugarcane industry and sugar industry. | Gengfeng ZHAO Guoru XIONG Wenzhi WANG Linbo SHEN Shuzhen ZHANG | 2018 | Agricultural Biotechnology2018，7，4： | 1 |
| 19 | Lin28 Mediates Paclitaxel Resistance by Modulating p21,Rb and Let-7a miRNA in Breast Cancer Cells显示文摘 | Kezhen Lv Liqun Liu Linbo Wang | 2012 | PLoS ONE2012，7，： | 1 |
| 20 | Formulation and pharmacokinetic studies of acyclovir cotrolled release capluses 显示文摘 | Jiasheng Tu Linbo Wang Jing Yang | 2001 | Drug Development and Industral Pharmacy2001，27，7： | 1 |
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