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| 1 | From Golden Rice to aSTARice:Bioengineering Astaxanthin Biosynthesis in Rice Endosperm显示文摘Carotenoids are important phytonutrients with antioxidant properties,and are widely used in foods and feedstuffs as Supplements.Astaxanthin,a red-colored ketocarotenoid,has strong antioxidant activity and thus can benefit human health.However,astaxanthin is not produced in most higher plants.Here we report the bioengineering of astaxanthin biosynthesis in rice endosperm by introducing four synthetic genes,sZmPSY1,sPaCrtl,sCrBKT,and sHpBHY,which encode the enzymes phytoene synthase,phytoene desaturase,β-carotene ketolase,and β-carotene hydroxylase,respectively.Transgneic overexpression of two (sZmPSY1 and sPaCrtl),three (sZmPSY1,sPaCrtl and sCrBKT),and all these four genes driven by rice endosperm-specific promoters established the Carotenoid/ketocarotenoid/astaxanthin biosynthetic pathways in the endosperm and thus resulted in various types of germplasm,from the yellow-grained β-caro- tene-enriched Golden Rice to orange-red-grained Canthaxanthin Rice and Astaxanthin Rice,respectively. Grains Of Astaxanthin Rice were enriched with astaxanthin in the endosperm and had higher antioxidant activity.These results proved that introduction of a minimal set of four transgenes enables de novo biosynthesis of astaxanthin in therice endosperm.This work provides a Successful example for synthetic biology in plants and biofortification in crops;the biofortified rice products generated by this study could be consumed as health-promoting foods and processed tO produce dietary supplements. | Qinlong Zhu Dongchang Zeng Suize Yu Chaojun Cui Jiamin Li Heying Li Junyu Chen Runzhao Zhang Xiucai Zhao Letian Chen Yao-Guang Liu | 2018 | Molecular Plant2018，11，12： | 35 |
| 2 | Coal and gas outburst dynamic system显示文摘Coal and gas outburst is an extremely complex dynamic disaster in coal mine production process which will damage casualties and equipment facilities, and disorder the ventilation system by suddenly ejecting a great amount of coal and gas into roadway or working face. This paper analyzed the interaction among the three essential elements of coal and gas outburst dynamic system. A stress-seepage-damage coupling model was established which can be used to simulate the evolution of the dynamical system, and then the size scale of coal and gas outburst dynamical system was investigated. Results show that the dynamical system is consisted of three essential elements, coal-gas medium(material basis), geology dynamic environment(internal motivation) and mining disturbance(external motivation). On the case of C13 coal seam in Panyi Mine, the dynamical system exists in the range of 8–12 m in front of advancing face. The size scale will be larger where there are large geologic structures. This research plays an important guiding role for developing measures of coal and gas outburst prediction and prevention. | Fan Chaojun Li Sheng Luo Mingkun Du Wenzhang Yang Zhenhua | 2017 | International Journal of Mining Science and Technology2017，27，1： | 19 |
| 3 | A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30显示文摘Mitochondrial 熔化是为正常 mitochondrial 功能和 mitochondrial DNA 继承混合并且统一 mitochondrial 分隔空间的一个高度协调的过程。Dysregulated mitochondrial 熔化原因 mitochondrial 破碎,反常 mitochondrial 生理学和继承,并且有原因地与很多 neuronal 疾病被连接了。这里,我们识别了 potently 导致了 mitochondrial 熔化在在 Mfn1 或 Mfn2 是缺乏的房间恢复 mitochondrial 网络和氧化呼吸的 diterpenoid 衍生物 15-oxospiramilactone (S3 ) 。线粒体局部性的 deubiquitinase USP30 是 S3 的一个目标。由 S3 的 USP30 的抑制导致 Mfn1/2 的 non-degradative ubiquitination 的增加,它提高 Mfn1 和 Mfn2 活动并且支持 mitochondrial 熔化。通过 USP30 的一个禁止者的使用,因此,我们的学习揭开在支持 mitochondrial 的 Mfns 的 non-degradative ubiquitination 的异乎寻常的功能熔化。 | Wen Yue Ziheng Chen HaiYang Li Chen Yan Ming Chen Du Feng Chaojun Yan Hao Wu Lei Du Yueying Wang Jinhua Liu Xiaohu Huang Laixin Xia Lei Liu Xiaohui Wang Haijing Jin Jun Wang Zhiyin Song Xiaojiang Hao Quan Chen | 2014 | Cell Research2014，24，4： | 18 |
| 4 | Characteristics of China’s oil and gas pool formation in latest geological history显示文摘The structural activities took place extensively in the Asia continent during the Cenozoic era owing to the strong continent-to-continent collision and continuous compression between the India Plate and the Eurasia Plate. Huang Jiqing called such structural activities Himalayan movement. China’s sedimentary basins developed and took shape mainly during the Himalayan movement period. It is also the main period for formation and development of the oil and gas reservoirs. Of 366 large and medium-sized oil and gas fields currently found in China, 212 reservoirs were formed in the Neo- gene-Quaternary period. The proportion is as high as 68.2%. The oil and gas migration and accumu- lation in the latest geological period, which were controlled by the times, properties, styles and strength of the Himalayan movement, took place mainly in eight regions, such as the low uplift area of Bohai Sea, the onshore faulted sag area of Bohai Bay, anticlinorium zone in Daqing, the foreland fold-and-thrust belt in West China, the tilted structural zone in West China, the cratonic palaeohigh in the Tarim Basin, the zone of fault and fold belt in the East Sichuan Basin, and the biological gas zone in the East Qaidam Basin. The oil and gas pool formations in those regions have their own charac- teristics. With the great potential and broad prospect, those regions are the main exploration areas in China in the future. | JIA Chengzao HE Dengfa SHI Xin YANG Geng ZHANG Chaojun | 2006 | Science China Earth Sciences2006，49，9： | 16 |
| 5 | T-cell receptor-engineered T cells for cancer treatment: current status and future directions显示文摘T 房间受体(TCR ) 设计了 T 房间为采纳房间治疗的一种新奇选择为癌症的几种先进形式的治疗被使用。用设计 TCR 的 T 房间的工作超过二十年以前开始了,与证明如此的房间能调停的众多的现出症状之前的潜的研究肿瘤细胞溶解和根除。这些试用的成功为临床的试用提供了基础,包括用到目标纽约食道的有鳞的房间癌(NY-ESO-1 ) 的设计 TCR 的 T 房间的最近的临床的成功。这些成功表明这条途径的潜力治疗癌症。在这评论,我们为癌症的治疗在设计 TCR 的 T 房间的现在和将来的应用上提供一个观点。我们的摘要集中于 TCR 激活和设计 TCR 的 T 房间的现出症状之前的潜、临床的应用。我们也讨论怎么提高设计 TCR 的 T 房间的功能并且在肿瘤微型环境延长他们的长寿。 | Yu Ping Chaojun Liu Yi Zhang | 2018 | Protein & Cell2018，9，3： | 16 |
| 6 | Tectonic types and evolution of Ordovician proto-type basins in the Tarim region显示文摘The Ordovician system is an important target for exploration in the Tarim Basin. Restoration of the Ordovician tectono-depositional environment is a key basis for the study of the structural development history in Tarim block and the prediction of the favorable Ordovician reservoir belts (zones). Based on the surrounding tectonic settings, the litho-facies and sedimentary fill, the palaeo-geography, palaeoclimate and palaeo-ecology, and the structural deformation and magmatic eruptions, in this paper we combine the sedimentary fill in the basin with the development of the surrounding orogenic belts and re-build the proto-type basins of the different Ordovician periods. During the Ordovician period, the Tarim region was characterized by the composite of the interior cratonic depression with the peripheral cratonic depression. The interior cratonic depression in the central and western parts is mainly the depositional area of the platform facies while the peripheral cratonic depression in the eastern part is mainly the zone of deepwater basin facies, with the slope acting as the transition belt between them. During the Late Ordovician period, the closure of the Northern Kunlun Ocean and destruction of the trencharc-basin system in the Altyn Tagh region put the southern part of the Tarim block under compression and uplifting and turned the central and western parts of the carbonate platform into the mixed depositional continental shelf. The eastern region of the basin had the over-compensated flysch sedimentation with huge thickness, marking the drastic turn of the basin nature. The basin tectonic framework turned to the south-north differentiation of the Silurian period from the east-west differentiation of the Ordovician period. | HE DengFa ZHOU XinYuan ZHANG ChaoJun YANG XiaoFa | 2007 | Chinese Science Bulletin2007，52，A01： | 15 |
| 7 | Overexpression of cotton (Gossypium hirsutum) dirigentl gene enhances lignification that blocks the spread of Verticillium dahliae显示文摘Dirigent 总科在整个植物王国丰富,特别脉管的植物。阐明棉花(Gossypium hirsutum ) 的功能在木质化的 DIR 基因,编码通常认为的 dirigent 蛋白质的二 cDNAs (指明的 GhDIR1 和 GhDIR2 ) 从棉花 cDNA 图书馆被孤立。实时量的反向的抄写聚合酶链反应分析表明那个 GhDIR1 抄本优先地在棉花胚轴被积累,而 GhDIR2 主要在棉花纤维被表示。GhDIR1 基因的 Overexpression 导致了转基因的棉花植物的木质素内容的增加,与野类型的相比。组织化学的试金表明转基因的植物在外皮和脉管的捆比野类型的显示了更普遍的木质化。而且,转基因的棉花植物显示了更多的忍耐到 Verticillium dahliae 的感染。我们的数据建议 GhDIR1 可以涉及能堵住真菌的病原体 V 的传播的棉花木质化。dahliae。 | Haiyan Shi Zhihao Liu Li Zhu Chaojun Zhang Yun Chen Ying Zhou Fuguang Li Xuebao Li | 2012 | Acta Biochimica et Biophysica Sinica2012，44，7： | 12 |
| 8 | Comparative Proteome Analysis of Human Lung Squamous Carcinoma Tissue显示文摘客观:与高分辨率建立二维的电气泳动侧面;从人的肺的重制度有鳞的癌织物;配对的正常肿瘤邻近的支气管的上皮,;识别微分表示由使用 proteome 分析的联系肿瘤的蛋白质。方法:有 20 人的肺的比较 proteome 分析有鳞的癌纸巾;邻近肿瘤的配对的正常支气管的上皮被执行。人的肺的全部的蛋白质有鳞的癌织物;配对的正常肿瘤邻近的支气管的上皮借助于使不能调动的 pH 被分开基于坡度的二维的胶化电气泳动(2-DE ) ;染色的银。微分表示蛋白质被分析;然后到飞行团分光术(MALDI-TOF-MS ) 的帮助矩阵的激光解吸附作用 / 电离时间识别了。结果:(1 ) 人的肺的解决得好的、可再现的 2-DE 模式有鳞的癌;邻近的正常支气管的上皮被获得。为肿瘤织物, 3 胶化的平均的点是 1567 ± 4 6,;4 看到的 1436 ± 5 与 91.6% 的平均匹配率被匹配。为控制, 3 胶化的平均的点是 1349 ± 5 8,;5 看到的 1228 ± 3 与 91.03% 的平均匹配率被匹配。匹配的点的平均位置偏差是在 IEF 的 0.924 ± 0 .128 公里方向,;在 SDS 页方向的 1.022 ± 0 .205 公里;(2 ) 6 看到的 1178 ± 5 的一个总数在 20 人的肺的电泳地图之间被匹配有鳞的癌纸巾;配对正常肿瘤邻近的支气管的上皮。76 差别表示了蛋白质被屏蔽;(3 ) 68 微分蛋白质被 PMF 识别,一些蛋白质是 oncogenes 的产品,;涉及房间的规定的其它骑车;信号转导变异;(4 ) 以便验证识别结果的可靠性, 3 蛋白质 mdm2 的表示, c-jun;EGFR,它与肺被相关有鳞的癌,被免疫检测组织化学的染色;西方的污点分析。结果揭示了那 mdm2, c-jun;EGFR 在肺是起来调整的有鳞的癌而他们在邻近的正常支气管的上皮是下面调整的,正常的肺纸巾;煽动性的假肿瘤,它与我们的 proteome 分析一致结果。结论:人的肺的解决得好的、可再现的 2-DE 模式有鳞的癌;邻近的正常支气管的上皮被建立;68 微分蛋白质被成功地使用比较 proteome 分析描绘。这些结果将为屏蔽使用到 diagnose 的分子的简历标记提供科学基础;对待肺有鳞的癌,以及改进病人的预后;为肺的研究提供新线索有鳞的致癌机制。 | LI Cui TANG Can'e DUAN Chaojun YI Hong XIAO Zhiqiang CHEN Zhuchu | 2006 | The Chinese-German Journal of Clinical Oncology2006，5，4： | 11 |
| 9 | Experimental investigations on separation control and flow structure around a circular cylinder with synthetic jet显示文摘Circular cylinder separation control and flow structure influenced by the synthetic jet have been experimentally investigated in a water channel. The synthetic jet is- sues from a slot and ejects toward upstream from the front stagnation point of the cylinder. It has been found that, similar to the traditional synthetic jet which is po- sitioned near the separation point or inside the separation region, the present synthetic jet arrangement constitutes an efficient way to control flow separation of the circular cylinder, but with a different control mechanism. The present synthetic jet leads to an upstream displacement of the front stagnation point and the forma- tion of a vortex pair near both sides of the exit orifice. When ReU based on the synthetic jet average exit orifice velocity is about lower than 43, a closed envelope forms in front of the windward side of the cylinder during the blowing cycle of syn- thetic jet, which acts as an apparent modification for the cylinder configuration. When ReU is high enough, an open envelope forms upstream of the cylinder, and the flow around the cylinder becomes much energetic. Thus, regardless of ReU, the present synthetic jet can improve separation for flow around a circular cylinder. With regard to the leeward side, as ReU increases, the flow separation region be- hind the cylinder gradually disappears. The flow over cylinder may be fully attached when the open envelope forms upstream of the cylinder and ReU is greater than 344. Then, the flow past the cylinder will converge near the back stagnation point of the cylinder, where a new vortex pair shedding periodically is generated due to the high shear layer. | WANG JinJun FENG LiHao XU ChaoJun | 2007 | Science China(Technological Sciences)2007，50，5： | 9 |
| 10 | Studying the viscosity of lower crust of Qinghai-Tibet Plateau according to post-seismic deformation显示文摘The viscosity of lower crust of Qinghai-Tibet Plateau on earth should be determined. It has become a predominant problem in quantitative research on geodynamics. Its order of magnitude will have a great influence on the results of quantitative modeling. To obtain the viscosity of lower crust of Qinghai-Tibet Plateau, this parameter was calculated by three methods. The first is based on the estimation on the temperature state of Qinghai-Tibet Plateau in the deep part, and the viscosity of lower crust of northern Plateau was recomputed with strain rate derived from rheology law and GPS observation. Effective viscosity of middle crust in Kunlun region is between 1020 and 1022 Pa·s, and that of lower crust is be- tween 1019 and 1021 Pa·s; the second is based on three kinds of rheological models used to fit the post-seismic deformation recorded by cross-over fault GPS sites set after Ms8.1 Kunlun earthquake in 2001. The viscosity of lower crust obtained by this method is of 1017 Pa·s order of magnitude. However, higher viscosity is required to fit the data of south fault better, and the lower one is required to fit the data of north fault better. The viscosity of lower crust, which was obtained by fitting the cross-over fault post-seismic deformation after Ms7.6 Luhuo earthquake in 1973, is of 1019 Pa·s order of magnitude. Non-linear relationship between effective viscosity and strain rate is ignored in the former research of effective viscosity. This research shows the difference of effective viscosity obtained from laboratory experiment, and shorter and longer time post-seismic deformation after large earthquakes can be explained in phase. | ZHANG ChaoJun CAO JianLing SHI YaoLin | 2009 | Science China Earth Sciences2009，52，3： | 9 |
| 11 | Effect of shrub-grass vegetation coverage and slope gradient on runoff and sediment yield under simulated rainfall显示文摘Evaluating the benefits of sediment and runoff reduction in different vegetation types is essential for studying the mechanisms of soil and water conservation on the Loess Plateau.The experiment was conducted in shrub-grass plots with nine levels of mixed vegetation coverage from 0%to 70%,three slopes(10,15,and 20)and two rainfall intensities(1.0 and 2.5 mm/min).The results showed that the vegetation coverage and slope gradient significantly affect runoff and sediment yield.Shrub-grass vegetation coverage had a significant effect on the runoff start-time,runoff flow velocity,runoff rate,and soil erosion rate on hillslopes.Mixed vegetation coverage could effectively delay the runoff starttime and decrease the runoff flow velocity.However,the effects of the slope gradient on runoff and sediment yield are opposite to those of vegetation coverage.Shrub-grass vegetation coverage could effectively increase runoff and sediment yield reduction benefits,while their benefits were affected by the rainfall intensity.At the 1.0 mm/min rainfall intensity,the reduction in the sediment production rate was greater than that under the 2.5 mm/min intensity.However,when the shrub-grass vegetation coverage exceeded 42%,the runoff reduction benefit was more obvious at higher rainfall intensities.The cumulative sediment yield increased with increasing cumulative runoff,and the rate of increase in the cumulative runoff was greater than that of the cumulative sediment yield with increasing of shrub-grass vegetation coverage.Moreover,there was a power function relationship between cumulative sediment yield and cumulative runoff yield(P<0.05).Our paper is expected to provide a good reference on the ecological environment and vegetation construction on the Loess Plateau. | Dandan Han Jingcheng Deng Chaojun Gu Xingmin Mu Peng Gao Jianjian Gao | 2021 | International Journal of Sediment Research2021，36，1： | 8 |
| 12 | HY5-HDA9 Module Transcriptionally Regulates Plant Autophagy in Response to Light-to-Dark Conversion and Nitrogen Starvation显示文摘Light is arguably one of the most important environmental factors that determines virtually all aspects of plant growth and development,but the molecular link between light signaling and the autophagy pathway has not been elucidated in plants.In this study,we demonstrate that autophagy is activated during light-to-dark conversion though transcriptional upregulation of autophagy-related genes(ATGs).We showed that depletion of the ELONGATED HYPOCOTYL 5(HY5),a key component of light signaling,leads to enhanced autophagy activity and resistance to extended darkness and nitrogen starvation treatments,contributing to higher expression oiATGs.HY5 interacts with and recruits HISTONE DEACETYLASE 9(HDA9)to ATG5 and ATG8e loci to repress their expression by deacetylation of the Lys9 and Lys27 of histone 3.Furthermore,we found that both darkness and nitrogen depletion induce the degradation of HY5 via 26S proteasome and the concomitant disassociation of HDA9 from ATG5 and ATG8e loci,leading to their depression and thereby activated autophagy.Genetic analysis further confirmed that HY5 and HDA9 act synergistically and function upstream of the autophagy pathway.Collectively,our study unveils a previously unknown transcriptional and epigenetic network that regulates autophagy in response to light-to-dark conversion and nitrogen starvation in plants. | Chao Yang Wenjin Shen Lianming Yang Yun Sun Xibao Li Minyi Lai Juan Wei Chaojun Wang Yingchao Xu Faqiang Li Shan Liang Chengwei Yang Shangwei Zhong Ming Luo Caiji Gao | 2020 | Molecular Plant2020，13，3： | 8 |
| 13 | Distinctive effects of CD34- and CD133-specific antibody-coated stents on re-endothelialization and in-stent restenosis at the early phase of vascular injury显示文摘It is not clear what effects of CD34-and CD133-specific antibody-coated stents have on reendothelialization and in-stent restenosis(ISR)at the early phase of vascular injury.This study aims at determining the capabilities of different coatings on stents(e.g.gelatin,anti-CD133 and anti-CD34 antibodies)to promote adhesion and proliferation of endothelial progenitor cells(EPCs).The in vitro study revealed that the adhesion force enabled the EPCs coated on glass slides to withstand flow-induced shear stress,so that allowing for the growth of the cells on the slides for 48 h.The in vivo experiment using a rabbit model in which the coated stents with different substrates were implanted showed that anti-CD34 and anti-CD133 antibody-coated stents markedly reduced the intima area and restenosis than bare mental stents(BMS)and gelatin-coated stents.Compared with the anti-CD34 antibody-coated stents,the time of cells adhesion was longer and earlier present in the anti-CD133 antibody-coated stents and anti-CD133 antibody-coated stents have superiority in re-endothelialization and inhibition of ISR.In conclusion,this study demonstrated that anti-CD133 antibody as a stent coating for capturing EPCs is better than anti-CD34 antibody in promoting endothelialization and reducing ISR. | Xue Wu Tieying Yin Jie Tian Chaojun Tang Junli Huang Yinping Zhao Xiaojuan Zhang Xiaoyan Deng Yubo Fan Donghong Yu Guixue Wang | 2015 | Regenerative Biomaterials2015，2，2： | 7 |
| 14 | Synthesis of graphene materials by electrochemical exfoliation: Recent progress and future potential显示文摘Synthesis of structurally controlled graphene materials is critical for realizing their practical applications.The electrochemical exfoliation of graphite has emerged as a simple method to produce graphene materials.This review examines research progress in the last 5 years,from 2015 to 2019.Graphene material synthesis methods generally have a trade‐off between increasing production yield and achieving better material property control.The synthesis conditions for synthesizing pristine graphene,graphene oxide(GO),and graphene composites are significantly different.Thus,in this review,we first discuss synthesis methods for graphene materials with high C/O ratios from four aspects:graphite electrodes,equipment engineering,electrolytes,and additional reduction methods.Next,we survey synthesis methods for GO and examine how the pretreatment of the graphite electrodes,electrolytes,and operation parameters,such as applied voltages,electrolyte temperatures,and mechanical forces,affect the quality of GO.Further,we summarize electrochemical exfoliation methods used to dope graphene materials,introduce covalent functional groups,incorporate various nanoparticles,and assembly of graphene architectures.For all synthesis methods,we compare the properties of resulting graphene materials such as C/O ratios,lateral size,layer numbers,and quality characterized by Raman spectroscopy.Lastly,we propose our perspectives on further research.We hope this review stimulates more studies to realize the on‐demand production of graphene materials with desired properties using electrochemical exfoliation methods. | Fei Liu Chaojun Wang Xiao Sui Muhammad Adil Riaz Meiying Xu Li Wei Yuan Chen | 2019 | Carbon Energy2019，1，2： | 6 |
| 15 | Overexpressed BRH1, a RING finger gene, alters rosette leaf shape in Arabidopsis thaliana显示文摘Leaves are the most important plant parts for photosynthesis and respiration. Many genes are involved in determining leaf shape;however, little is known about the effects of brassinosteroid (BR) signaling-pathway genes on the development of leaf shape. Here, the brassinosteroid-responsive RING-H2 (BRH1) gene, which is suppressed by 24-epi-brassinolide treatment, was isolated from Arabidopsis thaliana. The amino acid sequence contained a highly conserved RING finger domain. In a phylogenetic analysis,BRH1 clustered closely with GLYMA11G02470.1. The leaves of brh1 mutant plants were not much different to those of the wild-type, while transgenic plants with high BRH1 expression levels had rounder rosette leaves. Mutants of the BR synthesis pathway also had a similar round leaf phenotype, and greater BRH1 expression levels. Moreover, the related marker genes KNAT1,AtHB13 and ROT4, which are known to control leaf shape, altered transcriptional levels in both transgenic BRH1 and BR-synthesis mutant lines. Thus, BRH1 may be involved in the BR signaling pathway and regulate the growth and development of rosette leaves. Research on BRH1 may prove valuable for understanding the regulatory mechanism of leaf shape and improving the leaf shapes of ornamental plants. | Xiaoqian Wang Eryong Chen Xiaoyang Ge Qian Gong HamamaIslam Butt Chaojun Zhang Zuoren Yang Fuguang Li Xueyan Zhang | 2018 | Science China(Life Sciences)2018，61，1： | 5 |
| 16 | Peripheral Lymphocyte Subsets as a Marker of Parkinson's Disease in a Chinese Population显示文摘In this study, we conducted a clinical analysis of lymphocyte subtypes in 268 patients with Parkinson's disease(PD) to assess their clinical impact as a potential marker of advanced PD in Chinese patients. The participants comprised 268 sporadic PD patients and 268 healthy controls. The numbers of natural killer(NK) cells and CD3+, CD3+CD4+, CD3+CD8+, and CD19+ lymphocytes from peripheral blood were determined by immunostaining and flow cytometric analysis and the percentages of these CD+ T cells were calculated. The ratio of regulatory T(Treg)/helper T 17(Th17) lymphocytes from 64 PD patients and 46 controls was determined by flow cytometric analysis.The results showed that the percentage of NK cells was higher in advanced PD patients than in controls(22.92% ±10.08% versus 19.76% ± 10.09%, P = 0.006), while CD3+ T cells are decreased(62.93% ± 9.27% versus65.75% ± 9.13%, P = 0.005). The percentage of CD19+B cells in male patients was lower(P = 0.021) than in female patients, whereas NK cells were increased(P \ 0.0001). The scores on the Unified Parkinson's Disease Rating Scale(UPDRS) and the Non-Motor Symptoms Scale in late-onset PD patients were significantly higher than those in earlyonset patients(P = 0.024 and P = 0.007, respectively). The percentage of CD19+ B cells in patients with UPDRS scores[24 was lower than in those with scores \24(10.17% ±4.19% versus 12.22% ± 5.39%, P = 0.009). In addition, the Treg/Th17 ratio in female patients was higher than that in female controls(13.88 ± 6.32 versus 9.94 ± 4.06, P =0.042). These results suggest that the percentages of NK cells,CD3+ T cells, and CD19+ B cells along with the Treg/Th17 ratio in peripheral blood may be used to predict the risk of PD in Chinese individuals and provide fresh avenues for novel diagnostic biomarkers and therapeutic designs. | Luan Cen Chaohao Yang Shuxuan Huang Miaomiao Zhou Xiaolu Tang Kaiping Li Wenyuan Guo Zhuohua Wu Mingshu Mo Yousheng Xiao Xiang Chen Xinling Yang Qinhui Huang Chaojun Chen Shaogang Qu Pingyi Xu | 2017 | Neuroscience Bulletin2017，33，5： | 5 |
| 17 | Transcriptome Profiling Reveals Auxin and Cytokinin Regulating Somatic Embryogenesis in Different Sister Lines of Cotton Cultivar CCRI24显示文摘在在棉花(Gossypium hirsutum L.) 位于体的 embryogenesis (SE ) 下面的分子的机制上得到一个更宽广的看法,棉花 transcriptome 动力学的全球分析用 RNA-Seq 在在不同姐妹线的 SE 期间被执行。204349 unigenes 的一个总数被 214977462 Illumina 的汇编读的 de novo 检测。量的反向的 transcriptionpolymerase 链反应(qRT-PCR ) 大小断然与几乎所有测试基因的 RNA-Seq 结果被相关(R2=0.841,关联在 0.01 水平是重要的) 。不同植物激素(植物生长素和细胞激动素) 在媒介和在在不同姐妹线的二个阶段的这二植物激素的内长的内容变化的集中比率在棉花 SE 期间建议了植物生长素和细胞激动素的角色。根据植物激素相关的基因的全球基因规定,从所有差别的众多的基因表示了抄本涉及植物生长素和细胞激动素生合成和信号 transduction 小径。差别的分析表示了涉及揭示的这些小径的基因在在二根姐妹线之间的基因类型和丰富的实质的变化。隔离,克隆并且在棉花 SE 期间揭示了显著起来表示或下面表示的基因是的 silencing/overexpressing 重要。而且,植物生长素和细胞激动素与对方或另外的因素遗体一起在 SE,而是潜在的串音起一个主要作用不清楚。 | Zhenzhen Xu Chaojun Zhang Xueyan Zhang Chuanliang Liu Zhixia Wu Zuoren Yang Kehai Zhou Xiaojie Yang Fuguang Li | 2013 | Journal of Integrative Plant Biology2013，55，7： | 5 |
| 18 | Coupled Model of Two-phase Debris Flow,Sediment Transport and Morphological Evolution显示文摘The volume fraction of the solid and liquid phase of debris flows,which evolves simultaneously across terrains,largely determines the dynamic property of debris flows. The entrainment process significantly influences the amplitude of the volume fraction. In this paper,we present a depth-averaged two-phase debris-flow model describing the simultaneous evolution of the phase velocity and depth,the solid and fluid volume fractions and the bed morphological evolution. The model employs the Mohr–Coulomb plasticity for the solid stress,and the fluid stress is modeled as a Newtonian viscous stress. The interfacial momentum transfer includes viscous drag and buoyancy. A new extended entrainment rate formula that satisfies the boundary momentum jump condition(Iverson and Ouyang,2015) is presented. In this formula,the basal traction stress is a function of the solid volume fraction and can take advantage of both the Coulomb and velocity-dependent friction models. A finite volume method using Roe's Riemann approximation is suggested to solve the equations. Three computational cases are conducted and compared with experiments or previous results. The results show that the current computational model and framework are robust and suitable for capturing the characteristics of debris flows. | HE Siming OUYANG Chaojun LIU Wei WANG Dongpo | 2016 | Acta Geologica Sinica(English Edition)2016，90，6： | 5 |
| 19 | Structure and deformation measurements of shallow overburden during top coal caving longwall mining显示文摘Mining induced pressures are strong and overburden failure areas are large in top coal caving longwall mining, which constrains high production and safety mining. By employing the combination of the full view borehole photography technique and the seismic CT scanner technique, the deformation and failure of overlying strata of fully mechanized caving face in shallow coal seam were studied and the failure development of overburden was determined. Results show that the full view borehole photography can reveal the characteristics of strata, and the seismic CT scanner can reflect the characteristics of strata between the boreholes. The combined measurement technique can effectively determine the height of fractured and caved zones. The top end of the caved zone in Yangwangou coal mine employing the top coal caving longwall mining was at the depth of 171 m and fractured zone was at the depth of 106-110 m. The results provide a theoretic foundation for controlling the overburden strata in the shallow buried top coal caving panel. | Li Sheng Fan Chaojun Luo Mingkun Yang Zhenhua Lan Tianwei Zhang Haifeng | 2017 | International Journal of Mining Science and Technology2017，27，6： | 4 |
| 20 | Optimization of control parameters of droplet density in citrus trees using UAVs and the Taguchi method显示文摘The control parameters of the unmanned aerial vehicle(UAV)should be carefully designed to improve UAV spraying performance on citrus trees.The present study investigated the optimal droplet distribution control parameters in citrus trees using a UAV and the Taguchi method,of which optimal results were observed with an inverted triangle citrus tree canopy shape,a spraying height of 1.40 m,and a flight speed of 1.0 m/s.Among the discussed control parameters,the flight speed presented the most significant effect with a contribution percentage of 74.0%.The established multiple regression model predicted an optimal spraying height of 1.27 m and a maximum droplet density of 35.39 droplets/cm2.In addition,the effects of individual control parameter on the droplet density of the lower layer of citrus trees were systematically analyzed,of which inverted triangle shape more significantly affected the droplet density of the lower layer and presented an 82.0%increase in droplet density as compared to the triangle shape.An improvement of 59.6%in the lower layer droplet density was observed at a spraying height of 1.40 m.In addition,the other spraying heights did not present significant differences in their coefficient of variation(CV)values. | Chaojun Hou Yu Tang Shaoming Luo Jintian Lin Yong He Jiajun Zhuang Weifeng Huang | 2019 | International Journal of Agricultural and Biological Engineering2019，12，4： | 4 |
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