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| 1 | Minimal invasive microscopic tooth preparation in esthetic restoration: a specialist consensus显示文摘By removing a part of the structure,the tooth preparation provides restorative space,bonding surface,and finish line for various restorations on abutment.Preparation technique plays critical role in achieving the optimal result of tooth preparation.With successful application of microscope in endodontics for>30 years,there is a full expectation of microscopic dentistry.However,as relatively little progress has been made in the application of microscopic dentistry in prosthodontics,the following assumptions have been proposed:Is it suitable to choose the tooth preparation technique under the naked eye in the microscopic vision?Is there a more accurate preparation technology intended for the microscope?To obtain long-term stable therapeutic effects,is it much easier to achieve maximum tooth preservation and retinal protection and maintain periodontal tissue and oral function health under microscopic vision?Whether the microscopic prosthodontics is a gimmick or a breakthrough in obtaining an ideal tooth preparation should be resolved in microscopic tooth preparation.This article attempts to illustrate the concept,core elements,and indications of microscopic minimally invasive tooth preparation,physiological basis of dental pulp,periodontium and functions involved in tool preparation,position ergonomics and visual basis for dentists,comparison of tooth preparation by naked eyes and a microscope,and comparison of different designs of microscopic minimally invasive tooth preparation techniques.Furthermore,a clinical protocol for microscopic minimally invasive tooth preparation based on target restorative space guide plate has been put forward and new insights on the quantity and shape of microscopic minimally invasive tooth preparation has been provided. | Haiyang Yu Yuwei Zhao Junying Li Tian Luo Jing Gao Hongchen Liu Weicai Liu Feng Liu Ke Zhao Fei Liu Chufan Ma Juergen MSetz Shanshan Liang Lin Fan Shanshan Gao Zhuoli Zhu Jiefei Shen Jian Wang Zhimin Zhu Xuedong Zhou | 2019 | International Journal of Oral Science2019，11，4： | 25 |
| 2 | Study on the HPHT synthetic diamond crystal from Fe-C(H) system and its significance显示文摘Investigations of crystal habit, micro-topographic imaging, micro-composition and micro-structural analysis of HPHT synthetic diamonds from the Fe-C(H) system indicate that most of them have an oc-tahedral habit. The crystals grow mainly layer-to-layer from center to periphery. HPHT synthetic dia-mond is smaller in size than natural diamond because it only goes through nucleation and growth in the early stage. In the middle and late stages, due to the coalescence of diamond grains related to dif-ferences of surface energy, the growth of HPHT synthetic diamond is limited. The active energy (E) of transforming single nitrogen into a nitrogen-pair is lowered and the time of transforming single nitro-gen into a nitrogen-pair is shortened because of the existence of hydrogen. Therefore, aggregate ni-trogen (A-centers) may exist in synthetic diamond from HPHT and explosive detonation processes. It needs further discussion on a worldwide view that the time of natural diamond formation extracted from nitrogen aggregation is some hundred million years. Consideration of the way in which surface energy influences the growth of diamond can help to understand some of the remaining issues (e.g. growth mechanism, etc.) in the HPHT synthetic process and effectively explain the formation of natural diamond in terms of HPHT thermodynamic theory. Especially, it is important to pay more attention to the influence of hydrogen on surface energy in that hydrogen may be a 'bridge' for explaining the formation of HPHT synthetic and natural diamond. | YANG ZhiJun LI HongZhong PENG MingSheng CHEN Jun LIN Feng SU YuWei | 2008 | Chinese Science Bulletin2008，53，1： | 15 |
| 3 | Next generation patient-derived prostate cancer xenograft models显示文摘对为前列腺癌症的更有效的治疗学的途径有批评需要。然而,在这个区域的研究被缺乏严重妨碍了临床上相关,在疾病的 vivo 模型试验性。这评论特别地基于 patients’ 的 subrenal 囊 grafting 集中于前列腺癌症异种皮移植模型的发展;进 nonobese 糖尿病 / 严重的肿瘤组织联合了 immunodeficient (NOD/SCID ) 老鼠。这种技术允许可移植的、导出病人的癌症织物异种皮移植线的成功的开发从不仅好攻击变形,而且从局部性的前列腺癌症纸巾。异种皮移植被发现了保留原来的恶意的关键生物性质,包括组织病理学说、分子的特征,肿瘤异质,对雄激素脱离的反应和变形能力。因此,他们是高度临床上相关并且在细胞、分子的层次,为个性化的癌症治疗屏蔽的药和现出症状之前的潜的药为前列腺癌症前进的研究提供珍贵工具测试的功效;特别当模型的一块面板习惯于盖子时许多疾病。这些异种皮移植模型能因此被看作前列腺癌症的下一代的模型。 | Dong Lin Hui Xue Yuwei Wang Rebecca Wu Akira Watahiki Xin Dong Hongwei Cheng Alexander W Wyatt Colin C Collins Peter W Gout Yuzhuo Wang | 2014 | Asian Journal of Andrology2014，16，3： | 4 |
| 4 | Two-dimensional multimetallic sulfide nanosheets with multi-active sites to enhance polysulfide redox reactions in liquid Li2S6-based lithium-polysulfide batteries显示文摘The lithium-sulfur battery has attracted enormous attention as being one of the most significant energy storage technologies due to its high energy density and cost-effectiveness.However,the 'shuttle effect' of polysulfide intermediates represents a formidable challenge towards its wide applications.Herein,we have designed and synthesized two-dimensional Cu,Zn and Sn-based multimetallic sulfide nanosheets to construct multi-active sites for the immobilization and entrapment of polysulfides with offering better performance in liquid Li2S6-based lithium-polysulfide batteries.Both experimental measurements and theoretical computations demonstrate that the interfacial multi-active sites of multimetallic sulfides not only accelerate the multi-chained redox reactions of highly diffusible polysulfides,but also strengthen affinities toward polysulfides.By adopting multimetallic sulfide nanosheets as the sulfur host,the liquid Li2 S6-based cell exhibits an impressive rate capability with 1200 mAh/g and retains 580 mAh/g at 0.5 mA/cm^(2) after 1000 cycles.With high sulfur mass loading conditions,the cell with 2.0 mg/cm^(2) sulfur loading delivers a cell capacity of 1068 mAh/g and maintains 480 mAh/g with 0.8 mA/cm^(2) and 500 cycles.This study provides new insights into the multifunctional material design with multi-active sites for elevated lithium-polysulfide batteries. | Chenyang Zha Donghai Wu Yuwei Zhao Jun Deng Jinghua Wu Rong Wu Meng Yang Lin Wang Houyang Chen | 2021 | Journal of Energy Chemistry2021，30，1： | 3 |
| 5 | Principle and numerical demonstration of high power all-fiber coherent beam combination based on self-imaging effect in a square core fiber显示文摘The self-imaging effect in a square core fiber has been investigated, and an integrated all-fiber combiner has been proposed based on a large mode area double clad fiber, which can be employed to construct high power coherent beam combining sources in the all-fiber format. The influence of various parameters on beam quality(M^(2)) and efficiency of the all-fiber coherent beam combiner has been studied numerically, which reveals that the near diffraction-limited laser beam can be achieved. A principle demonstration of the self-imaging effect has been carried out experimentally in a square core fiber, which proves the feasibility of beam combining with the square fiber, and that it is a promising way to develop high power coherent beam combination sources. | Yuefang Yan Yu Liu Haoyu Zhang Yue Li Yuwei Li Xi Feng Donglin Yan Jianjun Wang Honghuan Lin Feng Jing Wenhui Huang Rumao Tao | 2022 | Photonics Research2022，10，2： | 2 |
| 6 | Neuro-regenerative imidazole-functionalized GelMA hydrogel loaded with hAMSC and SDF-1α promote stem cell differentiation and repair focal brain injury显示文摘Brain tissues that are severely damaged by traumatic brain injury(TBI)is hardly regenerated,which leads to a cavity or a repair with glial scarring.Stem-cell therapy is one viable option to treat TBI-caused brain tissue damage,whose use is,whereas,limited by the low survival rate and differentiation efficiency of stem cells.To approach this problem,we developed an injectable hydrogel using imidazole groups-modified gelatin methacrylate(GelMA-imid).In addition,polydopamine(PDA)nanoparticles were used as carrier for stromal-cell derived factor-1(SDF-1α).GelMA-imid hydrogel loaded with PDA@SDF-1αnanoparticles and human amniotic mesenchymal stromal cells(hAMSCs)were injected into the damaged area in an in-vivo cryogenic injury model in rats.The hydrogel had low module and its average pore size was 204.61±41.41 nm,which were suitable for the migration,proliferation and differentiation of stem cells.In-vitro cell scratch and differentiation assays showed that the imidazole groups and SDF-1αcould promote the migration of hAMSCs to injury site and their differentiation into nerve cells.The highest amount of nissl body was detected in the group of GelMA-imid/SDF-1α/hAMSCs hydrogel in the in-vivo model.Additionally,histological analysis showed that GelMA-imid/SDF-1α/hAMSCs hydrogel could facilitate the regeneration of regenerate endogenous nerve cells.In summary,the GelMA-imid/SDF-1α/hAMSCs hydrogel promoted homing and differentiation of hAMSCs into nerve cells,and showed great application potential for the physiological recovery of TBI. | Yantao Zheng Gang Wu Limei Chen Ying Zhang Yuwei Luo Yong Zheng Fengjun Hu Tymor Forouzanfar Haiyan Lin Bin Liu | 2021 | Bioactive Materials2021，6，3： | 2 |
| 7 | Clinical characteristics and risk factors for mortality in cancer patients with COVID-19显示文摘Patients with cancer are at increased risk of severe infections.From a cohort including 3060 patients with confirmed COVID-19,109(3.4%)cancer patients were included in this study.Among them,23(21.1%)patients died in the hospital.Cancer patients,especially those with hematological malignancies(41.6%),urinary carcinoma(35.7%),malignancies of the digestive system(33.3%),gynecological malignancies(20%),and lung cancer(14.3%),had a much higher mortality than patients without cancer.A total of 19(17.4%)cancer patients were infected in the hospital.The clinical characteristics of deceased cancer patients were compared with those of recovered cancer patients.Multivariate Cox regression analysis indicated that a Nutritional Risk Screening(NRS2002)score≥3(adjusted hazard ratio(HR)11.00;95%confidence interval(CI)4.60–26.32;P<0.001),high-risk type(adjusted HR 18.81;95%CI 4.21–83.93;P<0.001),tumor stage IV(adjusted HR 4.26;95%CI 2.34–7.75;P<0.001),and recent adjuvant therapy(<1 month)(adjusted HR 3.16;95%CI 1.75–5.70;P<0.01)were independent risk factors for in-hospital death after adjusting for age,comorbidities,D-dimer,and lymphocyte count.In conclusion,cancer patients showed a higher risk of COVID-19 infection with a poorer prognosis than patients without cancer.Cancer patients with high-risk tumor,NRS2002 score≥3,advanced tumor stage,and recent adjuvant therapy(<1 month)may have high risk of mortality. | Junnan Liang Guannan Jin Tongtong Liu Jingyuan Wen Ganxun Li Lin Chen Wei Wang Yuwei Wang Wei Liao Jia Song Zeyang Ding Xiao-ping Chen Bixiang Zhang | 2021 | Frontiers of Medicine2021，15，2： | 2 |
| 8 | Single cell analysis reveals inhibition of angiogenesis attenuates the progression of heterotopic ossification in Mkx^(−/−)mice显示文摘Tendon heterotopic ossification(HO)is characterized by bone formation inside tendon tissue,which severely debilitates people in their daily life.Current therapies fail to promote functional tissue repair largely due to our limited understanding of HO pathogenesis.Here,we investigate the pathological mechanism and propose a potential treatment method for HO.Immunofluorescence assays showed that the Mohawk(MKX)expression level was decreased in human tendon HO tissue,coinciding with spontaneous HO and the upregulated expression of osteochondrogenic and angiogenic genes in the tendons of Mkx^(−/−)mice.Single-cell RNA sequencing analyses of wild-type and Mkx^(−/−)tendons identified three cell types and revealed the excessive activation of osteochondrogenic genes during the tenogenesis of Mkx^(−/−)tendon cells.Single-cell analysis revealed that the gene expression program of angiogenesis,which is strongly associated with bone formation,was activated in all cell types during HO.Moreover,inhibition of angiogenesis by the small-molecule inhibitor BIBF1120 attenuated bone formation and angiogenesis in the Achilles tendons of both Mkx mutant mice and a rat traumatic model of HO.These findings provide new insights into the cellular mechanisms of tendon HO and highlight the inhibition of angiogenesis with BIBF1120 as a potential treatment strategy for HO. | Junxin Lin Yuwei Yang Wenyan Zhou Chao Dai Xiao Chen Yuanhao Xie Shan Han Huanhuan Liu Yejun Hu Chenqi Tang Varitsara Bunpetch Dandan Zhang Yishan Chen Xiaohui Zou Di Chen Wanlu Liu Hongwei Ouyang | 2022 | Bone Research2022，10，4： | 1 |
| 9 | An Indexed-Scaling Pipelined FFT Processor for OFDM-Based WPAN Applications显示文摘 | Chen Yuan Tsao Yuchi Lin Yuwei | 2008 | IEEE Transcations on Circuits and Systems-II:Express Briefs2008，55，2： | 1 |
| 10 | Atmospheric gaseous organic acids in winter in a rural site of the North China Plain显示文摘Organic acids are important contributors to the acidity of atmospheric precipitation,but their existence in the Chinese atmosphere is largely unclear.In this study,twelve atmospheric gaseous organic acids,including C_(1)-C_(9) alkanoic acids,methacrylic acid,pyruvic acid,and benzoic acid,were observed in the suburb of Wangdu,Hebei Province,a typical rural site in the northern China plain from 16^(th) December,2018 to 22^(nd) January,2019,using a Vocus■ Proton-Transfer-Reaction time-of-flight mass spectrometer(Vocus PTR-ToF).The quantification of C_(2)-C_(4) alkanoic acids by the Vocus PTR-ToF was calibrated according to the titration of a NaOH solution by C_(2)-C_(4) alkanoic acids from home-made permeation sources,and the other organic acids except for formic acid were quantified based on the k_(cap)-sensitivity linearity in the Vocus PTR-ToF,whereas formic acid was not quantified because our instrument setting led to a significant underestimation in its concentration.The average total concentration of eleven gaseous organic acids was 6.96±5.20 ppbv(parts per billion by volume).The average concentration of acetic acid was the highest(3.86±3.00 ppbv),followed by propanoic acid,butyric acid,and methacrylic acid.Domestic straw burning was likely the dominant source of the observed gaseous organic acids according to the good correlations between acetonitrile and organic acids and between particulate K+and organic acids,and traffic emissions could also have contributed.During episodes with continuously high concentrations of organic acids,short-distance transport dominated in Wangdu according to the backward trajectory analysis.Baoding,Shijiazhuang,and Hengshui areas were the main source areas based on potential source contribution function and concentration weighing track analysis. | Xiaoyu Hu Gan Yang Yiliang Liu Yiqun Lu Yuwei Wang Hui Chen Jianmin Chen Lin Wang | 2022 | Journal of Environmental Sciences2022，34，3： | 1 |
| 11 | Anti--tumor activity of the fermentation broth of Cordyceps militaris cultured in the medium of Radix astragali显示文摘 | Lin Yuwei Chiang Been Huang | 2008 | Process Biochemistry2008，43，3： | 1 |
| 12 | Overexpression of a maize WRKY58 gene enhances drought and salt tolerance in transgenic rice显示文摘 | Ronghao Cai Yang Zhao Yufu Wang Yongxiang Lin Xiaojian Peng Qian Li Yuwei Chang Haiyang Jiang Yan Xiang Beijiu Cheng | 2014 | Plant Cell, Tissue and Organ Culture (PCTOC)2014，，3： | 1 |
| 13 | High degree polymerized chitooligosaccharides synthesis by chitosanase in the bulk aqueous system and reversed micellar microreactors显示文摘 | Hsiao Yiehien Lin Yuwei Su Chiakai | 2008 | Process Biochemistry2008，43，： | 1 |
| 14 | Design of an FFT/IFFT Processor for MIMO OFDM Systems显示文摘 | Lin Yuwei Lee Chenyi | 2007 | IEEE Trans on Circuits and Systems2007，54，4： | 1 |
| 15 | Biology of Ageing and Role of Dietary Antioxidants显示文摘 | Cheng Peng Xiaobo Wang Jingnan Chen Rui Jiao Lijun Wang Yuk Man Li Yuanyuan Zuo Yuwei Liu Lin Lei Ka Ying Ma Yu Huang Zhen-Yu Chen Dina Bellizzi | 2014 | BioMed Research International2014，，： | 1 |
| 16 | Application of immersed boundary method in turbomachines显示文摘Simulating unsteady turbulent flow in turbomachines is still challenging due to the complexity of blade geometry and relative motion between rotor and stator.This study presents an Immersed Boundary Method(IBM)for high-Reynolds turbomachinery internal flows,and shows the advantage of the automatic grid generation techniques and flexible moving boundary treatments.The wall functions are used in the present method to alleviate the wall resolution restriction of turbulence simulation.The Two-Dimensional(2-D)IBM solver,which was previously developed and tested for a low-speed compressor,is further validated for a well-documented Low-Pressure Turbine(LPT)cascade.Both the blade loading and the total pressure losses in the wake are well captured by the present 2-D solver.The complex Three-Dimensional(3-D)effects in turbomachines motivate the further development of an extended 3-D IBM solver by using a curvilinear-coordinate system that facilitates the hub and casing boundary treatment.The good performance of the 3-D solver is demonstrated through comparison with CFX solver solutions for the rotor configuration of Advanced Noise Control Fan(ANCF).Further effects of the grid resolution on capturing the blade wake are discussed.The results indicate that the present 3-D solver is capable of reproducing the evolution of the blade wake with suitable computational grid. | Congcong CHEN Yuwei WANG Zhuo WANG Lin DU Xiaofeng SUN | 2023 | Chinese Journal of Aeronautics2023，36，5： | 1 |
| 17 | Design of an FFT/IFFT Processor for MIMO OFDM Systems显示文摘 | Lin Yuwei Lee Chen-yi | 2007 | IEEE Transactions on Circuits and Systems2007，54，4： | 1 |
| 18 | A Dynamic Scaling FFT Processor for DVB-T Applications显示文摘 | Lin Yuwei Liu Hsuan-yu Lee Chen-yi | 2004 | IEEE Journal of Solid-state Circuits2004，39，11： | 1 |
| 19 | ETV2 mediates endothelial transdifferentiation of glioblastoma显示文摘Glioblastoma multiforme(GBM)is characterized by extensive endothelial hyperplasia.Recent studies suggest that a subpopulation of endothelial cells originates via vasculogenesis by the transdifferentiation of GBM tumor cells into endothelial cells(endotransdifferentiation).The molecular mechanism underlying this process remains poorly defined.Here,we show that the expression of ETS variant 2(ETV2),a master regulator of endothelial cell development,is highly correlated with malignancy.Functional studies demonstrate that ETV2 is sufficient and necessary for the transdifferentiation of a subpopulation of CD133+/Nestin+GBM/neural stem cells to an endothelial lineage.Combinational studies of ChIP-Seq with gain-of-function RNA-Seq data sets suggest that ETV2,in addition to activating vascular genes,represses proneural genes to direct endo-transdifferentiation.Since endotransdifferentiation by ETV2 is VEGF-A independent,it likely accounts for the observed resistance of GBM tumor cells to antiangiogenesis therapy.Further characterization of the regulatory networks mediated by ETV2 in endo-transdifferentiation of GBM tumor cells should lead to the identification of more effective therapeutic targets for GBM. | Chengjian Zhao Gustavo AGomez Yuwei Zhao Yu Yang Dan Cao Jing Lu Hanshuo Yang Shuo Lin | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 0 |
| 20 | A chromosome-level genome assembly reveals that tandem-duplicated CYP706V oxidase genes control oridonin biosynthesis in the shoot apex of Isodon rubescens显示文摘The ent-kaurenoids(e.g.,oridonin and enmein)from the Isodon genus(Lamiaceae)are one class of diterpenoids with rich structural diversity and intriguing pharmaceutical activity.In contrast to the well-established gibberellin pathway,oxidative modifications diversifying the ent-kaurene skeleton in Isodon have remained undetermined for half a century.Here we report a chromosome-level genome assembly of I.rubescens,a well-recognized oridonin producer long favored by Asian people as a traditional herb with antitumor effects.The shoot apex was confirmed to be the actual region actively producing ent-kaurene diterpenoids.Through comparative genomics and phylogenetic analyses,we discovered a cluster of tandem-duplicated CYP706V oxygenase-encoding genes located on an ancient genomic block widely distributed in eudicots,whereas almost exclusively emerged in Isodon plants.In the shoot apex,IrCYP706V2 and IrCYP706V7 oxidized the ent-kaurene core in the initial stage of oridonin biosynthesis.Loss of CYP706Vs in other Lamiaceae plants offered an explanation for the specific kaurenoid production in Isodon plants.Moreover,we found that the Isodon genomes encode multiple diterpenoid synthases that are potentially involved in generating diterpenoid diversity.These findings provided new insights into the evolution of the lineage-specific diterpenoid pathway and laid a foundation for improving production of bioactive ent-kaurene-type diterpenoids by molecular breeding and synthetic biology approaches. | Yuwei Sun Jie Shao Haili Liu Hua Wang Guangyi Wang Jianhua Li Yaping Mao Zhuo Chen Ke Ma Lin Xu Yong Wang | 2023 | Molecular Plant2023，16，3： | 0 |
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