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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | A correlation study of the expression of resistin and glycometabolism in muscle tissue after traumatic brain injury in rats显示文摘 | Jin Peng Zhu Lielie Zhang Jiasheng Xie Songling Pan Da Wen Hao Meng Weiyang Lin Luyang Chen Daqing | 2014 | Chinese Journal of Traumatology2014，17，3： | 5 |
| 3 | The correlation and overlaps between PD-L1 expression and classical genomic aberrations in Chinese lung adenocarcinoma patients: a single center case series显示文摘Objective:To investigate the correlation and overlaps between PD-L1 expression and classical genomic aberrations in Chinese lung adenocarcinoma(LADC)patients.Methods:We reviewed 428 consecutive,surgically resected cases of LADC from October 2015 to December 2016 from our center.PD-L1 expression was evaluated based on tumor proportion score(TPS).Correlation and co-occurrence of PD-L1 expression level with those of classical driver genes,such as EGFR,ALK,ROS-1,and KRAS and with clinical variables and disease-free survival(DFS)were analyzed.Results:Seventy of the 428 cases(16.4%)showed TPS≥1%,and 21 cases(4.9%)showed TPS≥50%.PD-L1 positive expression was significantly associated with male gender,smoking,advanced TNM stage,and solid histologic subtype.Both TPS≥1% and ≥50%were correlated with the absence of an EGFR mutation(P<0.001)and the presence of ALK rearrangement(P=0.024).KRAS mutation was associated with TPS≥50%(P=0.035).PD-L1 positivity commonly overlapped with the alterations of classical driver oncogenes(58.5%with TPS≥1% and 42.9% with TPS≥50%).Approximately three-quarters of PD-L1 positive cases co-occurred with classical therapeutic-gene aberrations in cases with stage III/IV cancer or cancer progression.LADC could be divided into four subgroups based on the expression profile of current routine biomarkers for potential therapeutic strategies.Conclusions:PD-L1 expression is not only closely correlated with classic gene alterations but also commonly overlaps with the aberrations of classical driver oncogenes in Chinese LADC patients.These findings provide a useful overview of clinical strategies that rely on the profile of routinely used molecular biomarkers. | Jianghua Wu Wei Sun Haiyue Wang Xiaozheng Huang Xinyu Wang Weiyang Jiang Ling Jia Ping Wang Qin Feng Dongmei Lin | 2019 | Cancer Biology & Medicine2019，16，4： | 5 |
| 4 | Blocking the JAK2/STAT3 and ERK pathways suppresses the proliferation of gastrointestinal cancers by inducing apoptosis显示文摘Dysregulated crosstalk between different signaling pathways contributes to tumor development,including resistance to cancer therapy.In the present study,we found that the mitogen-activated extracellular signal-regulated kinase(MEK)inhibitor trametinib failed to suppress the proliferation of PANC-1 and MGC803 cells by activating the Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3)signaling pathway,while the JAK2 inhibitor fedratinib failed to inhibit the growth of the PANC-1 cells upon stimulation of extracellular signal-regulated kinase(ERK)signaling.In particular,the most prominent enhancement of the anti-proliferative effect resulted from the concurrent blockage of the JAK2/STAT3 and ERK signaling pathways.Furthermore,the combination of the two inhibitors resulted in a reduced tumor burden in mice.Our evidence suggests novel crosstalk between JAK2/STAT3 and ERK signaling in gastric cancer(GC)and pancreatic ductal adenocarcinoma(PDAC)cells and provides a therapeutic strategy to overcome potential resistance in gastrointestinal cancer. | Xi WANG Chunyan DAI Yifei YIN Lin WU Weiyang JIN Yufei FU Zhe CHEN Ke HAO Bin LU | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，6： | 4 |
| 5 | Sub-nm ruthenium cluster catalyst for decomposition as an efficient and robust and synthesis of ammonia: Break the "size shackles"显示文摘 | Jinpeng Li Weiyang wang Wenxing Chen Qinmei Gong Jun Luo Ruoqian Lin Huolin Xin Hui Zhang Dingsheng wang Qing Peng Wei Zhu Chen Chen Yadong Li | 2018 | Nano Research2018，11，9： | 3 |
| 6 | Benefits of redundant channels in observer-based H∞ control for discrete-time switched linear systems显示文摘In this paper, the H∞ control problem is investigated for a class of discrete-time switched linear systems with modal persistent dwell-time(MPDT) switching. The redundant channels are considered to use in the data transmission to benefit the capability of overcoming the fragility of networks commonly configured by a single channel in the communication networks subject to random packet losses. In light of a new class of Lyapunov functions, the desired observer-based quasi-time-dependent controllers, which have less conservatism than the time-independent ones, are designed such that the resulting closed-loop system is exponentially mean-square stable with a guaranteed H_∞ disturbance attenuation performance. The MPDT can be minimized while ensuring the existence of such a class of observer-based controllers for a given period of persistence. An example of DC-DC boost converter is provided to verify the effectiveness of theoretical findings. | ZHU YanZheng ZHANG LiXian LIN WeiYang LI Zhan YU ShuYou | 2016 | Science China(Technological Sciences)2016，59，1： | 2 |
| 7 | Efficient adaptive-support association rule mining for recommender Systems显示文摘 | Lin Weiyang Alvarez S A Ruiz C | 2002 | Data Mining and Knowledge Discovery2002，6，： | 1 |
| 8 | A periodic DFT study on adsorption of small molecules(CH4,CO,H2O,H2S,NH3)on the WO3(001) surface-supported Au显示文摘Gas molecules(such as CH4,CO,H2O,H2S,NH_3)adsorption on the pure and Au-doped WO3(001)surface have been studied by Density functional theory calculations with generalized gradient approximation.Based on the the calculation of adsorption energy,we found the most stable adsorption site for gas molecules by comparing the adsorption energies of different gas molecules on the WO3(001)surface.We have also compared the adsorption energy of five different gas molecules on the WO3(001)surface,our calculation results show that when the five kinds of gases are adsorbed on the pure WO3(001)surface,the order of the surface adsorption energy is CO>H2S>CH4>H2O>NH3.And the results show that NH3 is the most easily adsorbed gas among the other four gases adsorbed on the surface of pure WO3(001)surface.We also calculated the five different gases on the Au-doped WO3(001)surface.The order of adsorption energy was found to be different from the previous calculation:CO>CH4>H2S>H2O>NH3.These results provide a new route for the potential applications of Au-doped WO3 in gas molecules adsorption. | Long Lin Jingtao Huang Weiyang Yu Chaozheng He Hualong Tao Yonghao Xu Linghao Zhu Pengtao Wang Zhanying Zhang | 2020 | Communications in Theoretical Physics2020，72，3： | 1 |
| 9 | Efficient adaptive-support association rule mining for recommender systems显示文摘 | Lin Weiyang | 2002 | Data Mining and Knowledge Discovery2002，6，： | 1 |
| 10 | Design of Research Platform on Telerobot System Based on Virtual Reality Technology显示文摘 | Chen Junjie Huang Weiyi Song Aiguo Xi Weiyang Lin Chun | 2004 | Journal of Southeast University (S1003-7985)2004，20，1： | 1 |
| 11 | Tumor-to-tumor metastasis: max- illary sinus adenoid cystic carcinoma metastasizing to double primary lung adenocarcinoma 显示文摘 | LIN Weiyang HSU W H | 2010 | Ann Thorac Surg2010，90，4： | 1 |
| 12 | Investigation of rotor–stator interaction broadband noise using a RANS-informed analytical method显示文摘A Reynolds-Averaged Navier Stokes(RANS)-information analytical method for predicting Rotor-Stator Interaction(RSI)broadband noise is established in this paper.First,the turbulence information is deduced from RANS simulation result.Then,the unsteady load on the stator blade is calculated using a strip theory approach based on LINearized SUBsonic unsteady flow in cascade(LINSUB)and 2-D equivalence method.In the end,the sound power of RSI broadband noise is calculated by coupling the unsteady load on the stator blade with acoustic analogy and annular duct mode.The broadband noise model part of the RANS-information analytical method is validated against the upstream sound power of an annular cascade experimental bench.Besides,the RANS-information analytical method is used in predicting RSI broadband noise of a single-stage axial fan acoustic experimental bench,the results illustrate that the RANS-information analytical method can accurately predict the RSI broadband noise in different fan working conditions.After simplification the Wave Leading Edge(WLE)stator blade,the effect of WLE stator blade on RSI broadband noise is studies.Although the simplification may bring some discrepancies,the results illustrate that the RANS-information analytical method has the capability for further studies on the broadband noise reduction with WLE stator blade. | Hang TONG Lin LI Liangfeng WANG Luqin MAO Weiyang QIAO | 2021 | Chinese Journal of Aeronautics2021，34，10： | 1 |
| 13 | Survival after radical cystectomy for bladder cancer:Multicenter comparison between minimally invasive and open approaches显示文摘Objective:To investigate oncological outcomes in patients with bladder cancer who underwent minimally invasive radical cystectomy(MIRC)or open radical cystectomy(ORC).Methods:We identified patients with bladder cancer who underwent radical cystectomy(RC)in 13 centers of the Chinese Bladder Cancer Consortium(CBCC).Perioperative outcomes were compared between MIRC and ORC.The influence of surgical approaches on overall survival(OS)and cancer-specific survival(CSS)in the entire study group and subgroups classified according to pathologic stage or lymph node(LN)status was assessed with the log-rank test.Multivariable Cox proportional hazard models were used to evaluate the association among OS,CSS and risk factors of interest.Results:Of 2098 patients who underwent RC,1243 patients underwent MIRC(1087 laparoscopic RC and 156 robotic-assisted RC,respectively),while 855 patients underwent ORC.No significant differences were noted in positive surgical margin rate and 90-day postoperative mortality rate.MIRC was associated with less estimated blood loss,more LN yield,higher rate of neobladder diversion,longer operative time,and longer length of hospital stay.There was no significant difference in OS and CSS according to surgical approaches(pZ0.653,and 0.816,respectively).Subgroup analysis revealed that OS and CSS were not significantly different regardless of the status of extravesical involvement or LN involvement.Multivariable Cox regression analyses showed that the surgical approach was not a significant predictor of OS and CSS.Conclusions:Our study showed that MIRC was comparable to conventional ORC in terms of OS and CSS. | Weibin Xie Junming Bi Qiang Wei Ping Han Dongkui Song Lei Shi Dingwei Ye Yijun Shen Xin Gou Weiyang He Shaogang Wang Zheng Liu Jinhai Fan Kaijie Wu Zhiwen Chen Xiaozhou Zhou Chuize Kong Yang Liu Chunxiao Liu Abai Xu Baiye Jin Guanghou Fu Wei Xue Haige Chen Tiejun Pan Zhong Tu Tianxin Lin Jian Huang | 2020 | Asian Journal of Urology2020，7，3： | 1 |
| 14 | Aivarez, Carolina Ruiz, Efficient adaptive-support association rule mining for recommender systems 显示文摘 | Weiyang Lin Sergio A | 2002 | Data Mining and Knowledge Discovery 62002，，： | 1 |
| 15 | Efficient Adaptive-Support Association Rule Mining for Recommender Systems显示文摘 | Weiyang Lin Sergio A. Alvarez Carolina Ruiz | 2002 | Data Mining and Knowledge Discovery2002，，1： | 1 |
| 16 | alvarez, Carolina Ruiz Efficient adap- tiveSupport Association Rule Mining for Recommender System 显示文摘 | Weiyang Lin Serglo A | 2004 | Data Miningand Knowledge Discovery2004，，6： | 1 |
| 17 | Evaporation of Intermediate-mass Fragments from Hot-nuclei Produced by 25MeV/u ^(40)Ar Bombarding ^(159)Tb Target显示文摘Evaporation of Intermediate-mass Fragments from Hot-nuclei Produced by 25MeV/u^(40)Ar Bombarding^(159)Tb Target￥JiangDongxing;... | Jiang Dongxing Qian Xing Qian Tao Hua Hui Lin Junsong Wu Enjiu Zheng Jiwen Jing Genming Yin Shuzhi Tan Jilin Jing Weiyang Song Mingtao Li Zuyu and He Zhiyong | 1994 | IMP & HIRFL Annual Report1994，，0： | 0 |
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