|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A study of preoperative methionine-depleting parenteral nutrition plus chemotherapy in gastric cancer patients显示文摘AIM To investigate the interference ofmethionine.free parenteral nutrition plus 5-Fu(-MetTPN+5-Fu)in gastric cancer cell kineticsand the side effects of the regimen.METHODS Fifteen patients with advancedgastric cancer were randomly divided into twogroups,7 patients were given preoperatively aseven-day course of standard parenteralnutrition in combination with a five-day courseof chemotherapy(sTPN+5-Fu),while the other8 patients were given methionine-deprivedparenteral nutrition and 5-Fu(-MetTPN+5-Fu).Cell cycles of gastric cancer and normal mucosawere studied by flow cytometry(FCM).Bloodsamples were taken to measure the serumprotein,methionine(Met)and cysteine(Cys)levels,and liver and kidney functions.RESULTS As compared with the resultsobtained before the treatment,the percentage ofG0/G1 tumor cells increased and that of S phasedecreased in the-MetTPN+5-Fu group,while thecontrary was observed in the sTPN+5-Fu group.Except that the ALT,AST and AKP levels wereslightly increased in a few cases receiving-MetTPN+5-Fu,all the other biochemicalparameters were within normal limits.Serum Cys level decreased slightly after the treatmentin both groups.Serum Met level of patientsreceiving sTPN+5-Fu was somewhat higher aftertreatment than that before treatment;however,no significant change occurred in the -MetTPN+5-Fu group,nor operative complications in bothgroups.CONCLUSION -MetTPN+5-Fu exerted asuppressive effect on cancer cell proliferation,probably through a double mechanism ofcreating a state of'Met starvation'adverse tothe tumor cell cycle,and by allowing 5-Fu to killspecifically cells in S phase.Preoperative short-term administration of -MetTPN+5-Fu had littleundesirable effect on host metabolism. | Cao WX Cheng QM Fei XF Li SF Yin HR Lin YZ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 2 | Risk factors for ICU mortality in critically ill patients 显示文摘 | Chen YC Lin SF Liu CJ | 2001 | Fomos Med Assoc2001，100，10： | 1 |
| 3 | Effect of HPMC and carbopol on the release and floating properties of gastric floating drug delivery system using factorial design显示文摘 | Li SF Lin SS Dagg BP | 2003 | Int J Pharm2003，253，12： | 1 |
| 4 | Phenolic aporphine-benzylisoquinoline alkaloids from Thalictrum faberi显示文摘 | LIN LZ HU SF CHU M | 1999 | Phytochemistry1999，50，5： | 1 |
| 5 | Nonsurgical endodontic treatment of dens invaginatus with large periradicular lesion: a case report 显示文摘 | Pai SF Yang SF Lin LM | 2004 | J Endod2004，30，8： | 1 |
| 6 | Knowledge, attitudes and practices (KAP) related to the pandemic (H1N1)2009 among Chinese general population:a telephone survey 显示文摘 | Lin Y Huang L Nie SF | 2011 | BMC Infectious Dis- eases2011，11，： | 1 |
| 7 | C-shaped root canals in mandibular second molars in a Chinese population显示文摘 | Yang ZP Yang SF Lin YC | 1988 | Endod Dent Traumatol1988，4，4： | 1 |
| 8 | Duodenal versus gastric feeding in medical intensive care unit patients= a prospective, random- ized,clinical study显示文摘 | Hsu CW Sun SF Lin SL | 2009 | Crit Care Med2009，37，6： | 1 |
| 9 | Combined neuromuscular electrical stimulation (NMES) with fiberoptic endoscopic evaluation of swal- lowing (FEES) and traditional swallowing reha- bilitation in the treatment of stroke-related dys- phagia显示文摘 | Sun SF Hsu CW Lin HS | 2013 | Dysphagia2013，28，： | 1 |
| 10 | Analysis of adverse drug reactions using drug and drug target interactions and graph-based metheds显示文摘 | Lin SF Xiao KT Huang YT | 2010 | Artificial Intelligence in Medicine2010，48，23： | 1 |
| 11 | Microsurgical tissue transfers for head and neck reconstruction in patients with alcohol-induced mental disorder显示文摘 | Kuo YR Jeng SF Lin KM | 2008 | Ann Surg Oncol2008，15，1： | 1 |
| 12 | TNF- α signals through PKC ζ /NF- K B to alter the tight junction complex and increase retinal endothelial cell permeability显示文摘 | Aveleira CA Lin CM Abcouwer SF | 2010 | Diabetes2010，59，11： | 1 |
| 13 | Predicting long-term care institution utilization among post-rehabilitation stroke patients in Taiwan:a medical centre-based study显示文摘 | Lin JH Hsieh CL Hsiao SF | 2001 | Disabil Rehabil2001，23，： | 1 |
| 14 | Diabetic ketoasidosis: comparisons of patient characteristics, clinical presentations and outcomes today and 20 years ago 显示文摘 | Lin SF Lin JD Huang YY | 2005 | Chang Gung Mcd J2005，28，1： | 1 |
| 15 | Lercanidipine inhibits vascular smooth muscle cell proliferation and neointimal formation via reducing intracellular reactive oxygen species and inactivating Ras-ERK1/2 signaling显示文摘 | Wu JR Liou SF Lin SW | | 0，，： | 1 |
| 16 | Prolongation of cardiac allograft survival in rats by anti-TNF and cyclosporine combination therapy显示文摘 | Bolling SF Kunkel SL Lin H | 1992 | Transplantation1992，53，2： | 1 |
| 17 | Impact of obesity on medical problems and quality of life in Taiwan 显示文摘 | Tsai WL Yang CY Lin SF | 2004 | American Journal of Epidemiology2004，160，6： | 1 |
| 18 | C-shaped root canals in mandibular second molars in Chinese population显示文摘 | Yang ZP Yang SF Lin YL | 1988 | Endod Dent Traumatol1988，4，16： | 1 |
| 19 | Inflammatory cytokine and cell response in surgery显示文摘 | LIN E CALVANO LOWRY SF | 2000 | Surgery2000，127，2： | 1 |
| 20 | Prognosis of Multifocal Papillary Thyroid Carcinoma显示文摘 | Kuo SF Lin SF Chao TC | 2013 | Int J Endocrinol2013，2013，80： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员