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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | 帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析显示文摘背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MDACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性NSCLC患者的免疫治疗应答。方法PEMBRO-RT和MDACC研究纳入标准:患者年龄≥18岁,患有转移性NSCLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。PEMBRO-RT研究纳入曾接受过化疗患者,MDACC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在PEMBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为<10年组和≥10年组)。MDACC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在PEMBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在MDACC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(ARR)、最佳射野外疾病控制率(ACR)、12周时ARR、12周时ACR、无进展生存期(PFS)和总生存期(OS)。2个研究的意向治疗(ITT)人群均纳入分析。PEMBRO-RT研究(NCT02492568)和MDACC研究(NCT02444741)均在ClinicalTrials.gov上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括PD-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳ARR分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,P=0.0039;最佳ACR分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,P=0.0071;PFS中位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,P=0.045;OS中位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,P=0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性NSCLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。 | 陈大卫(翻译) 于金明(校对) Willemijn S M E Theelen Vivek Verma Brian P Hobbs Heike M U Peulen Joachim G J V Aerts Idris Bahce Anna Larissa N Niemeijer Joe Y Chang Patricia M de Groot Quynh-Nhu Nguyen Nathan I Comeaux George R Simon Ferdinandos Skoulidis Steven H Lin Kewen He Roshal Patel John Heymach Paul Baas James W Welsh | 2021 | 中华肿瘤防治杂志2021，28，24： | 49 |
| 3 | Molecular and cellular characterization during chondrogenic differentiation of adipose tissue-derived stromal cells in vitro and cartilage formation in vivo显示文摘 | Lin Y Luo E Chen X Liu L Qiao J Yan Z Li Z Tang W Zheng X Tian W | 2006 | 中国生物学文摘2006，20，5： | 31 |
| 4 | Cerebral ischemia and neuroregeneration显示文摘Cerebral ischemia is one of the leading causes of morbidity and mortality worldwide. Although stroke(a form of cerebral ischemia)-related costs are expected to reach 240.67 billion dollars by 2030, options for treatment against cerebral ischemia/stroke are limited. All therapies except anti-thrombolytics(i.e., tissue plasminogen activator) and hypothermia have failed to reduce neuronal injury, neurological deficits, and mortality rates following cerebral ischemia, which suggests that development of novel therapies again st stroke/cerebral ischemia are urgently needed. Here, we discuss the possible mechanism(s) underlying cerebral ischemia-induced brain injury, as well as current and future novel therapies(i.e., growth factors, nicotinamide adenine dinucleotide, melatonin, resveratrol, protein kinase C isozymes, pifithrin, hypothermia, fatty acids, sympathoplegic drugs, and stem cells) as it relates to cerebral ischemia. | Reggie H.C.Lee Michelle H.H.Lee Celeste Y.C.Wu Alexandre Couto e Silva Harlee E.Possoit Tsung-Han Hsieh Alireza Minagar Hung Wen Lin | 2018 | Neural Regeneration Research2018，13，3： | 30 |
| 5 | Relationship of Helicobacterpylori eradication with gastric cancer and gastric mucosal histological changes: a 10-year follow-up study显示文摘 | Zhou Liya Lin Sanren Ding Shigang Huang Xuebiao Jin Zhu Cui Rongli Meng Lingmei Li Yuan Zhang Li Guo Changji Xue Yan Yan Xiu'e Zhang Jing | 2014 | Chinese Medical Journal2014，，8： | 28 |
| 6 | The impact of minimally invasive surgeries for the treatment of symptomatic benign prostatic hyperplasia on male sexual function: a systematic review显示文摘使随机化的控制试用和队研究的系统的评论被进行在男性功能上为征兆的良性的 prostatic 增生(BPH ) 的处理为最低限度地侵略的过程的效果评估数据。寻找的研究是与征兆的 BPH 注册了人的试用与激光手术,经尿道的微波治疗( TUMT ),前列腺(金枪鱼)的经尿道的针脱离,前列腺( TEAP )的经尿道的乙醇脱离和高紧张的频率超声( HIFU )被对待,与前列腺( TURP )或假冒的操作的传统的经尿道的切除术比较。72 研究的一个总数被识别,哪个 33 满足了包括标准。33 研究, 21 涉及了激光手术,六与 TUMT,四与金枪鱼并且二与包含信息考虑的 TEAP 男性功能。没有学习关于为男性功能上的 BPH 的 HIFU 的效果是可得到的。我们的分析证明为 BPH 的最低限度地侵略的手术在男可勃起的功能上 TURP 有可比较的效果到那些。一起,分别地,不到 15.4% 病人或 15.2% 将在激光过程, TUMT 和金枪鱼以后可勃起的功能有减少或增加。是与 TURP 观察了,射精的机能障碍(EjD ) 的高发生在有钬, potassium-titanyl-phosphate 和铥激光治疗的 BPH 的治疗以后是普通的(>33.6%) 。TUMT,金枪鱼和 neodymium:yttrium 铝石榴石为 BPH 的视觉激光脱离或空隙的激光凝结有更少的发生 EjD,而是这些过程为 BPH 治疗被认为更少有效什么时候与 TURP 相比。 | Ryan W. Frieben Hao-Cheng Lin Peter E Hinh Francesco Berardinelli Steven E. Canfield Run Wang | 2010 | Asian Journal of Andrology2010，12，4： | 13 |
| 7 | Nat Chem Biol:利用CRISPR-Cas9激活细菌中沉默的基因簇,有望发现新的药物显示文摘为了抵抗疾病,很多医药库中的武器是从细菌当中获得的。如今,利用CRISPR-Cas9基因编辑技术。研究人员揭示出沉默基因中隐藏着的更多潜在的宝藏。作为一类常见的细菌。链霉菌被用来产生很多作为抗生素、抗癌试剂和其他药物的化合物。在一项新的研究中。来自美国伊利诺伊大学和新加坡科技研究局的研究人员利用CRISPR-Cas9技术激活链霉菌中不表达的或者说沉默的基因簇。 | Mingzi M Zhang, Wan Lin Yeo, Ee Lui Ang, Huimin Zhao Fong Tian Wong, Elena Heng Yajie Wang, Shangwen Luo, Ryan E Cobb, Behnam Enghiad, Huimin Zhao Yee Hwee Lim | 2017 | 现代生物医学进展2017，17，17： | 12 |
| 8 | Grassland degradation in Northern Tibet based on remote sensing data显示文摘This study selected vegetation cover as the main evaluation index, calculated the grassland degradation index (GDI) and established the remote sensing monitoring and evaluation system for grassland degradation in Northern Tibet, according to the National Standard (GB19377-2003), based on the remote sensing data such as NDVI data derived from NOAA/AVHRR with a spatial resolution of 8 km of 1981-2000, from SPOT/VGT with a spatial resolution of 1 km of 2001 and from MODIS with a spatial resolution of 0.25 km of 2002-2004 respectively in this area, in combination with the actual condition of grassland degradation. The grassland degradation processes and their responses to climate change during 1981-2004 were discussed and analyzed in this paper. The result indicated that grassland degradation in Northern Tibet is very serious, and the mean value of GDI in recent 20 years is 2.54 which belongs to the serious degradation grade. From 1981 to 2004, the GDI fluctuated distinctly with great interannual variations in the proportion of degradation degree and GDI but the general tendency turned to severe-grade during this period with the grassland degradation grade changed from light degraded to serious degraded in Northern Tibet. The extremely serious degraded and serious degraded grassland occupied 1.7% and 8.0% of the study area, the moderate and light degraded grassland accounted for 13.2% and 27.9% respectively, and un-degraded grassland occupied 49.2% of the total grassland area in 2004. The grassland degradation was serious, especially in the conjunctive area of Naqu, Biru and Jiali counties, the headstream of the Yangtze River lying in the Galadandong snow mountain and glaciers, the area along the Qinghai-Tibet highway and railway, and areas around the Tanggula and Nianqingtanggula snow mountains and glaciers. So the snow mountains and glaciers as well as their adjacent areas in Northern Tibet were sensitive to climate change and the areas along the vital communication line with frequent human activities experienced relatively serious grassland degradation. | GAO Qingzhu LI Yu'e WAN Yunfan LIN Erda XIONG Wei JIANGCUN Wangzha WANG Baoshan LI Wenfu | 2006 | Journal of Geographical Sciences2006，16，2： | 10 |
| 9 | Effects of Glomus mosseae on the toxicity of heavy metals to Vicia faba显示文摘A glasshouse pot experiment was conducted to investigate effects of th e arbuscular mycorrhizal fungus Glomus mosseae on the growth of Vicia faba and t oxicity induced by heavy metals (HMs) (Cu, Zn, Pb and Cd) in a field soil contam inated by a mixture of these metals. There was also uninoculation treatment (NM) simultaneously. Mycorrhizal (GM) plants have significantly increased growth and tolerance to toxicity induced by heavy metals compared with NM plants. P uptake was significantly increased in GM plants. Mycorrhizal symbiosis reduced the tra nsportation of HMs from root to shoot by immobilizing HMs in the mycorrhizal, sh own by increasing the ratios of HMs from root to shoot. Oxidative stress, which can induce DNA damage, is an important mechanism of heavy metal toxicity. GM tre atment decreased oxidative stress by intricating antioxidative systems such as p eroxidases and non-enzymic systems including soluble protein. The DNA damage ind uced by heavy metals was detected using comet assay, which showed DNA damage in the plants was decreased by the GM treatment. | ZHANG Xu-hong LIN Ai-jun CHEN Bao-dong WANG You-shan SMITH Sally E SMITH F Andrew | 2006 | Journal of Environmental Sciences2006，18，4： | 10 |
| 10 | 勃起功能障碍(ED)的联合疗法显示文摘二十世纪九十年代末二十一世纪初,口服PDE5抑制剂(PDE5Is)的引入在很大程度上革新了性医学领域。目前PDE5I已经成为勃起功能障碍(ED)的首选单一疗法。然而,对一些复杂型ED患者来说,PDE5I单一疗法的疗效还不尽人意。目前越来越多不易治疗的ED病例开始采用联合疗法治疗,但还缺少对当前使用的联合疗法的严格评估。基于此,本综述在Pubmed和Cochrane Library数据库中进行了全面的文献检索.主要检索对象是1990年1月到2010年12月间研究PDE5I单一治疗失败后接受联合疗法的所有相关综述、随机对照试验、队列研究和回顾性研究。同时还对检索所得文献的参考文献进行了人工筛选,获得了其它一些相关的文献资料。目前发表的联合疗法主要包括PDE5I加真空吸引器(VED)、尿道给药、阴茎注射(ICI)、雄激素补充疗法、α-阻断剂,还有其它一些联合疗法。本综述发现,有些联合疗法的初步试验结果是有效的。然而,进行治疗时还是要谨慎,因为近十年来发表的大部分联合疗法相关文章的研究方法有很多问题,比如研究偏见和样本量小等。尽管如此,目前的研究结果还是在为将来复杂型ED的治疗研究方面奠定了坚实的基础。 | Rohit R Dhir Hao-Cheng Lin Steven E Canfield Run Wang | 2011 | Asian Journal of Andrology2011，13，3： | 7 |
| 11 | Tick-borne Pathogens in Shanxi Province, China显示文摘Ticks are recognized as one of the most important vectors that cause diseases in animals and humans,and have significant public health impacts worldwide[1].They have a wide range of hosts among terrestrial vertebrates,including mammals,birds,amphibians.The numerous zoonotic pathogens transmitted by ticks are the causative agents of Lyme disease,rickettsiosis,ehrlichioses,relapsing fever,Q fever,and tularemia.Cases of tick-borne diseases are increasing around the world and some emerging or re-emerging pathogens are being discovered,which pose great challenges for prevention and control. | YANG Xiao Na YANG Hui Jun ZHANG Lin HOU Xue Xia MIAO Guang Qing CAO Hong Bing HAO Rui E HAO Qin | 2021 | Biomedical and Environmental Sciences2021，34，5： | 4 |
| 12 | Characterization of the Yeast Transcriptome显示文摘 | Victor E Velculescu Lin Zhang Wei Zhou Jacob Vogelstein Munira A Basrai Douglas E Bassett Phil Hieter Bert Vogelstein Kenneth W Kinzler | 1997 | Cell1997，，2： | 4 |
| 13 | Highly sensitive solar-blind deep ultraviolet photodetector based on graphene/PtSe_(2)/β-Ga_(2)O_(3)2D/3D Schottky junction with ultrafast speed显示文摘There is an emerging need for high-sensitivity solar-blind deep ultraviolet(DUV)photodetectors with an ultra-fast response speed.Although nanoscale devices based on Ga_(2)O_(3)nanostructures have been developed,their practical applications are greatly limited by their slow response speed as well as low specific detectivity.Here,the successful fabrication of two-/three-dimensional(2D/3D)graphene(Gr)/PtSe2/β-Ga_(2)O_(3)Schottky junction devices for high-sensitivity solar-blind DUV photodetectors is demonstrated.Benefitting from the high-quality 2D/3D Schottky junction,the vertically stacked structure,and the superior-quality transparent graphene electrode for effective carrier collection,the photodetector is highly sensitive to DUV light illumination and achieves a high responsivity of 76.2 mA/W,a large on/off current ratio of~105,along with an ultra-high ultraviolet(UV)/visible rejection ratio of 1.8×104.More importantly,it has an ultra-fast response time of 12µs and a remarkable specific detectivity of~1013 Jones.Finally,an excellent DUV imaging capability has been identified based on the Gr/PtSe2/β-Ga_(2)O_(3)Schottky junction photodetector,demonstrating its great potential application in DUV imaging systems. | Di Wu Zhihui Zhao Wei Lu Lukas Rogée Longhui Zeng Pei Lin Zhifeng Shi Yongtao Tian Xinjian Li Yuen Hong Tsang | 2021 | Nano Research2021，14，6： | 4 |
| 14 | Parkin deficiency accentuates chronic alcohol intake-induced tissue injury and autophagy defects in brain,liver and skeletal muscle显示文摘Alcoholism leads to organ injury including mitochondrial defect and apoptosis with evidence favoring a role for autophagy dysregulation in alcoholic damage.Parkin represents an autosomal recessive in herited gene for Parkins on's disease and an important member of selective autophagy for mitoch on dria.The associati on between Parkins on's disease and alcoholic injury remains elusive.This study aimed to examine the effect of parki n deficiency on chr onic alcohol in takeinduced organ injury in brain,liver and skeletal muscle(rectus femoris muscle).Adult parkinknockout(PRK-/-)and wild-type mice were placed on Liber-De Carli alcohol liquid diet(4%)for 12 weeks prior to assessment of liver enzymes,intraperitoneal glucose toleranee,protein carbonyl content apoptosis,hematoxylin and eosin morphological staining,and mitochondrial respiration(cytochrome c oxidase,NADH:cytochrome c reductase and succinate:cytochrome c reductase).Autophagy protein markers were monitored by western blot analysis.Our data revealed that chronic alcohol intake imposed liver injury as evidenced by elevated aspartate aminotransferase and alanine transaminase,glucose intoleranee,elevated protein carbonyl formation,apoptosis,focal inflammation,necrosis,microvesiculation,autophagy/mitophagy failure and dampened mitochondrial respiration(complexⅣ,complexesⅠandⅢ,and complexesⅡandⅢ)in the brain,liver and rectus femoris skeletal muscle.Although parkin ablation itself did not generate any notable effects on liver enzymes,insulin sensitivity,tissue carbonyl damage,apoptosis,tissue morphology,autophagy or mitochondrial respiration,it accentuated alcohol intake-induced tissue damage,apoptosis,morphological change,autophagy/mitophagy failure and mitochondrial injury without affecting insulin sensitivity.These data suggest that parkin plays an integral role in the preservation against alcohol-induced organ injury,apoptosis and mitochondrial damage. | Hu Peng Xing Qin Sainan Chen Asli E Ceylan Maolong Dong Zhaofen Lin Jun Ren | 2020 | Acta Biochimica et Biophysica Sinica2020，52，6： | 3 |
| 15 | Ecological rebuilding and land reclamation in surface mines in Shanxi Province, China显示文摘It is well known that the mining industry produces a large amount of derelict land, and causes pollution of water loss and soil erosion as well as other environmental damage in China. As land is under pressure in China, it is now policy to restore or reclaim land despoiled by mining, the aim being to develop sustainable and healthy arable land ecosystems. This paper outlines the principles and approaches of ecological restoration, which have been adopted in Shanxi Province with reference to three typical surface mines. In the research, the principles of ecological engineering and ecological succession are considered as the critical theories of ecological restoration in mine degraded land. Meanwhile, the paper made a comparative research on main links of ecological rebuilding in three surface mines in Shanxi Province, which include new land construction, treatment of toxic substances, control of soil erosion, fertility management, irrigation, ecological planning and the establishment of legislation systems. As the research demonstrated, for successful restoration, new land construction is the fundamental framework, but it must be integrated with ecological engineering including ecological planning, the control of soil erosion and vegetation establishment and ecosystem creation in order to optimise land productivity and soil fertility. In addition, the establishment of the legislation systems and organization of administration are also indispensable aspects of ecological rebuilding in mined land. | MIAO Ze wei 1, BAI Zhong ke 2, GAO Lin 1 (1. Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China E\|mail: miaozewei@yahoo.com 2. Department of Soil Science, Shanxi Agricultural University Taigu, 03 | 2000 | Journal of Environmental Sciences2000，12，4： | 3 |
| 16 | Vitamin D levels do not predict the stage of hepatic fibrosis in patients with non-alcoholic fatty liver disease: A PRISMA compliant systematic review and meta-analysis of pooled data显示文摘AIM To investigate the relationship between 25-hydroxyvitamin D [25(OH)D] levels and fibrosis stage in patients with non-alcoholic fatty liver disease(NAFLD).METHODS Two individual reviewers identified relevant studies using the Pub Med, EMBASE, Cochrane, and Scopus databases. Inclusion criteria were as follows:(1) Studies that evaluated adults with NAFLD and serum or plasma 25(OH)D levels; and(2) assessed fibrosis stage using liver biopsy. A rigorous analysis yielded six articles as having sufficient data to employ in evaluating the association of serum vitamin D levels in patients with NAFLD based on their liver fibrosis stage by histopathological analysis. The lead investigators of each of the six studies were contacted and the data were collected. To meta-analyze vitamin D levels in F0-F2 vs F3-F4 fibrosis, a random-effects meta-analysis fit using restricted maximum likelihood was applied. To examine trends across each stage of fibrosis with respect to vitamin D levels, a meta-regression was performed. P < 0.05 was considered statistically significant. RESULTS A total of 937 subjects from six studies were included in the final analysis to evaluate the association of serum vitamin D levels in patients with NAFLD based on their liver fibrosis stage by histopathological analysis. The lead investigators of each of the six studies were contacted and the data were collected. First, the investigators performed a meta-analysis to compare serum vitamin D levels in patients with NAFLD with stage F0-F2 compared to F3-F4, which did not show significance [meta-estimate of the pooled mean difference =-0.86, P = 0.08(-4.17, 2.46)]. A metaregression evaluation of serum vitamin 25(OH)D levels across the individual stages(F0-F4) of fibrosis did not show an association for the six included studies.CONCLUSION Low vitamin D status is not associated with higher stages of liver fibrosis in patients with NAFLD. | Behnam Saberi Alia S Dadabhai Julie Nanavati Lin Wang Russell T Shinohara Gerard E Mullin | 2018 | World Journal of Hepatology2018，10，1： | 3 |
| 17 | Efficacy and Safety of Yanggan Jian in Hepatitis B Virusrelated Decompensated Cirrhosis:A Randomized,Doubleblind,Controlled Trial显示文摘Background and Aims:The aim was to evaluate the efficacy and safety of Yanggan Jian(YGJ)in HBV-infected patients with decompensated cirrhosis.Methods:This randomized,double-blind controlled trial enrolled 160 patients with HBV-related decompensated cirrhosis who were already receiving or about to start antiviral therapy.Patients were randomly assigned to receive YGJ or placebo for 24 weeks,and were followed-up to 36 weeks.The primary outcome was the proportion of patients with a≥2 point reduction in Child-Turcotte-Pugh(CTP)score from baseline at week 24.Secondary outcomes were CTP class and score,serum liver function indices,mortality,incidence of hepatocellular carcinoma and variceal bleeding.Results:The proportion of patients with a CTP score reduction≥2 was significantly greater in the YGJ than in the placebo group(p=0.009);the percentage of patients with CTP class C was significantly less than that in the placebo group(p<0.05),and the YGJ group had a significantly greater mean change from baseline in CTP score at week 24(p=0.034).The improvement in measured values and change from baseline of prothrombin time,serum albumin,platelets,cholinesterase,international normalized ratio,and activated partial thromboplastin time were significantly better with YGJ than with placebo.Between-group differences in cumulative rates of variceal bleeding,hepatocellular carcinoma,death,or the frequency of any adverse event(AE),AEs related to treatment,or discontinuation because of AEs were not significant.Conclusions:YGJ significantly improved CTP scores and hepatic synthetic and reserve function in patients with HBV-related decompensated cirrhosis,and was safe and well tolerated. | Long Chen Chaoqun Zhao Weili Yao Wei Liu Hua Zhang Yongping Mu Hong Cai Dongying Xue Chengbao Wang Wan’e Wang Yuehong Lin Jiamei Chen Ping Liu | 2023 | Journal of Clinical and Translational Hepatology2023，11，1： | 3 |
| 18 | Dexamethasone mediates protection against acute pancreatitis via upregulation of pancreatitis-associated proteins显示文摘AIM: To examine the influence of dexamethasone on pancreatitis-associated protein (PAP) gene expression using both in vitro and in vivo models of acute pancreati- tis and to study how PAP gene expression correlates with severity of pancreatitis. METHODS: In vitro, IL-6 stimulated pancreas acinar AR42J cells were cultured with increasing concentrations of dexamethasone and assayed for PAP expression (RT-PCR). In vivo , pancreatitis was induced in rats by retrograde injection of 40 g/L taurocholate into the pancreatic duct. Animals were pretreated with dexamethasone (2 mg/kg) daily or saline for 4 d. Pancreata and serum were harvested after 24 h and gene expression levels of PAPⅠ, Ⅱ and Ⅲ were measured by RT-PCR. Severity of pancreatitis was based on serum amylase, pancreatic wet weight, and histopathological score. RESULTS: In vitro, dexamethasone and IL-6 induced a marked transcription of PAPⅠ, Ⅱ and Ⅲ genes in AR42J cells at 24 h (P < 0.05 for all comparisons). In vivo, pancreas mRNA levels of PAPⅠ, Ⅱ or Ⅲ increased by 2.6-fold, 1.9-fold, and 1.3-fold respectively after dexa- methasone treatment, compared with saline treated ani- mals. Serum amylase levels and edema were significantly lower in the dexamethasone group compared with the saline group. Histopathologic evaluation revealed less inflammation and necrosis in pancreata obtained from dexamethasone treated animals (P < 0.05). CONCLUSION: Dexamethasone significantly decreases the severity of pancreatitis. The protective mechanism ofdexamethasone may be via upregulating PAP gene ex- pression during injury. | Emad Kandil Yin-Yao Lin Martin H Bluth Hong Zhang Gabriel Levi Michael E Zenilman | 2006 | World Journal of Gastroenterology2006，12，42： | 3 |
| 19 | Prospective and long-term evaluation of erect penile length obtained with inflatable penile prosthesis to that induced by intracavernosal injection显示文摘在有那的可膨胀的阴茎修复术(IPP ) 培植在外科前由 in-tracavernosal 注射(帝国化学工业公司) 导致了以后,我们比较了直立的阴茎长度。有充分勃起的 11 个病人的一个总数在阴茎颜色的时候由 Trimix (papaverine, phentolamine 和前列腺素 E1 ) 的 0.25 mL 的帝国化学工业公司导致了双 Doppler ultrasonography 在这研究被注册。病人随后为他们的可勃起的机能障碍(编辑) 作为最终的治疗经历了 IPP 培植。对 IPP 培植作为结果的直立的阴茎长度在 6 个星期被测量, 6 个月并且在在外科以后的 1 年。为男人(填隙用木片) 的性健康库存在 IPP 培植以后被管理在前,并且在 6 个月和 1 年。是导致了由树立阴茎长度(吝啬的 s.e ) 而与 IPP 达到的长度是 12.4,帝国化学工业公司是 13.2 0.4 厘米 0.3,在第六个星期,第六个月和 1 年的后续的 12.5 0.3 和 12.5 0.4 厘米分别地。有 0.83 0.25,分别地, 0.75 0.20 和 0.74 0.15 厘米在 IPP 培植以后在 6 个星期, 6 个月和 1 年在直立的阴茎长度减少什么时候与那相比在帝国化学工业公司以后(P < 0.05 ) 。没有抱怨,为报导更短的阴茎的病人的填隙用木片分数与为病人的那些一样(P > 0.05 ) 。到我们的知识,这是第一研究客观地在 IPP 培植以后在直立的阴茎长度看重要减少是否与那相比在帝国化学工业公司以后。然而,这减少没在对待编辑影响 IPP 的有效性。 | Run Wang Galen E Howard Anthony Hoang Jiu-Hong Yuan Hao-Cheng Lin Yu-Tian Dai | 2009 | Asian Journal of Andrology2009，11，4： | 3 |
| 20 | Involvement of acid-sensing ion channel 1a in gastric carcinoma cell migration and invasion显示文摘酸的微型环境,特别地酸察觉到的离子隧道 1a (ASIC1a ) ,被报导了象移植一样支持癌房间增长。在这研究,我们在胃的癌(GC ) 的移植和侵略上探索了 ASIC1a 的效果。ASIC1a 表示层次被 immunohistochemistry 从 16 个病人在配对的 GC 和邻近的正常纸巾检验。反向的抄写即时 PCR 和 immunoblotting 被进行与 ASIC1a 小发卡 RNA (shRNA ) 在 transfection 以后在 GC 房间线 AGS 估计 ASIC1a 表示层次。创伤愈合和 transwell 侵略试金被利用检测转移和侵略追随者 ASIC1a silencing。肿瘤形成被用来在 vivo 在 tumorigenicity 检测 ASIC1a 的角色。ASIC1a 表示水平在与非转移相比显示出手术后的转移的 GC 纸巾和非肿瘤纸巾是显著地更高的,这被发现。而且,有 shRNA 的 ASIC1a 的 silencing 显著地下面调整的 ASIC1a 表示和减少的 GC 房间移植和侵略。中等酸的细胞外的环境禁止了 GC 房间生存能力。而且, ASIC1a shRNA 在 vivo 引起了 tumorigenicity 的抑制。我们的学习是 attenuating 的第一份报告在 vitro 并且在由压制 ASIC1a 的 vivo 的 GC 的恶意的显型,并且建议一条新奇途径学习在 ASIC 和 GC 房间移植和侵略之间的关系。 | Xin Chen Xue Sun Zhe Wang Xiaojun Zhou Lu Xu Feng'e Li Xingding Zhang Ji'an Pan Lin Qi Haixin Qian Zhongqi Mao | 2018 | Acta Biochimica et Biophysica Sinica2018，50，5： | 3 |
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