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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | The role of cyclooxygenase-2 inhibition for the prevention and treatment of prostate carcinoma 显示文摘 | Lin DW Nelson PS | 2003 | Clin Prostate Cancer2003，2，2： | 1 |
| 3 | RAS signaling pro- motes resistance to JAK inhibitors by suppressing BAD-mediat- ed apoptosis显示文摘 | Winter PS Sarosiek KA Lin KH | 2014 | Sci Signal2014，7，357： | 1 |
| 4 | Diethylstilbestrol and docetaxel:a PhaseⅡ study of tubulin active agents in patents with metastatic,androgen-independent prostate cancer显示文摘 | Montgomery RB Nelson PS lin D Ryan CW Garzotto M Beer TM | 2007 | Cancer2007，110，5： | 1 |
| 5 | The influence of the smearedlayer upon dentinal tubule penetration by plastic filling materials显示文摘 | White RR Goldman M Lin PS | 1984 | J Endod1984，10，12： | 1 |
| 6 | Dysregulation of leptin and testosterone production and their receptor expression in the human placenta with gestational diabetes mellitus 显示文摘 | Uzelac PS Li X Lin J et at | 2010 | Placenta2010，31，： | 1 |
| 7 | Interactions of tubulin with potent natural and synthetic analogs of the antimitotic agent combretastatin:a structure-activity study显示文摘 | Lin CM Singh SB Chu PS | | 0，，02： | 1 |
| 8 | Low levels of high-density lip- oprotein cholesterol in patients with atherosclerotic stroke: a pro- spective cohort study 显示文摘 | Yeh PS Yang CM Lin SH | 2013 | Atherosclerosis2013，228，2： | 1 |
| 9 | The current status of surgical staging of ovarian serous borderline tumor 显示文摘 | Lin PS Gershenson DM Bevels MW | 1999 | Cancer1999，85，4： | 1 |
| 10 | Adenovirus-mediated overexpression of dominant negative epidermal growth factor receptor-CD533 as a gene therapeutic approach radiosensitizes human carcinoma and malignant glioma cells 显示文摘 | Lammering G Lin PS Contessa JN | 2001 | Int J Radiation Oncology Biol Phys2001，51，3： | 1 |
| 11 | The inhibition of the estrogenic effects of pesticides and environmental chemicals by curcumin and isoflavonoids显示文摘 | Verma SP Goldin BR Lin PS | 1998 | Environ Health Perspect1998，106，12： | 1 |
| 12 | Neurotrophie effects of vascular endothelial growth factor and neurotrophins on cultured major pelvic ganglia显示文摘 | Lin G Chen KC Hsieh PS | 2003 | BJU Int2003，92，6： | 1 |
| 13 | Use of a single-tube nested real-time PCR assay to facilitate the early diagnosis of acute Q fever显示文摘 | Hou MY Hung MN Lin PS | 2011 | Japanese Journal of Infectious Diseases2011，64，2： | 1 |
| 14 | Effect of GAS6 and AXLGene Polymorphisms on Adiposity, Systemic Inflammation,and Insulin Resistance in Adolescents显示文摘 | Hsiao FC Lin YF Hsieh PS | 2014 | Int J Endocrinol2014，2014，67： | 1 |
| 15 | The inhibition of the estrogenic effects of pesticides and environmental chemicals by curcumln and isoflavonoids显示文摘 | Verma SP Goldin BR Lin PS | 1998 | Environ Health Perspect1998，106，12： | 1 |
| 16 | Radiosensitization of malignant glioma cells through overexpression of dominant-negative epidermal growth factor receptor 显示文摘 | Lammering G Valerie K Lin PS | 2001 | Clin Cancer Res2001，7，： | 1 |
| 17 | Radiation-inducedactivation of a common variant of EGFR confers enhancedradioresistance显示文摘 | Lammering G Valerie K Lin PS | 2004 | Radiother Oncol2004，72，3： | 1 |
| 18 | An investigation of epidemic enterovirus 71 infection in Taiwan, 2008: clinical, virologic, and serologic features 显示文摘 | Lee Ms Lin TY Chiang PS | 2010 | Pediate Infect Dis J2010，29，11： | 1 |
| 19 | Simmunophenotyping of angioimmunoblastic T- cell lymphomas by multiparameter flowcytometry显示文摘 | Lee PS Lin C N ChuangS | 2003 | Pathol Res Pract2003，199，8： | 1 |
| 20 | Dietary flavonoids inter-act with trace metals and affect metallothionein level in humanintestinal cells 显示文摘 | KUO S M LEAVITT PS LIN C P | 2001 | Biological Trace Element Research2001，62，3： | 1 |
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