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| 1 | Comparison of the effect and safety of Kuntai capsule and hormone replacement therapy in patients with perimenopausal syndrome:a systematic review and Meta-analysis显示文摘OBJECTIVE: To assess the effectiveness and safety of Kuntai capsule and hormone replacement therapy in treatment of perimenopausal syndrome.METHODS: Articles were retrieved from the databases Cochrane Database of Systematic Reviews,Pub Med, Chinese National Knowledge Infrastructure, China Science and Technology Journal Database, and Wanfang Database. Only randomized controlled trials were included; 15 trials involving1243 patients were identified from January 2005 to April 2015. A systemic review and Meta-analysis of publications was performed. The review was limit-ed to randomized controlled trials that compared Kuntai capsule and hormone replacement therapy to treat perimenopausal syndrome for at least 3months. The primary outcome assessed was the treatment efficacy at 3 months, including effective rate of Kupperman menopausal scores, Kupperman menopausal scores, and blood estradiol(E2) or blood follicle stimulating hormone(FSH) levels.Other outcomes assessed were safety or adverse events, such as gastrointestinal complaints, breast distending pain, or vaginal bleeding.RESULTS: Kupperman menopausal scores showed no significant difference in effective rate [odds ratio(OR): 1.05, 95% confidence intervals(CI): 0.71 to1.55] and changes in FSH level [mean difference(MD): 2.14, 95% CI:-2.36 to 6.65]. There was a significant statistical difference in Kupperman menopausal scores(MD:-1.14, 95% CI:-2.03 to-0.25)and changes in E2level(MD:-16.41, 95% CI:-18.83to-13.69). There were fewer adverse events in the Kuntai capsule group than in the hormone replacement therapy group(OR: = 0.35, 95% CI: 0.25 to0.48, P < 0.01).CONCLUSION: Compared with hormone replacement therapy, Kuntai capsule can improve perimenopausal symptoms and blood E2 levels, and reduce the incidence of adverse events. | Du Xiaoqin Xu Lin Wang Lijun Heng Mingli Bu Huaien Hao Yu Tian Jinhui | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 28 |
| 2 | Doping bioactive elements into a collagen scaffold based on synchronous self-assembly/mineralization for bone tissue engineering显示文摘Pure collagen is biocompatible but lacks inherent osteoinductive,osteoimmunomodulatory and antibacterial activities.To obtain collagen with these characteristics,we developed a novel methodology of doping bioactive elements into collagen through the synchronous self-assembly/mineralization(SSM)of collagen.In the SSM model,amorphous mineral nanoparticles(AMN)(amorphous SrCO3,amorphous Ag3PO4,etc.)stabilized by the polyampholyte,carboxymethyl chitosan(CMC),and collagen molecules were the primary components under acidic conditions.As the pH gradually increased,intrafibrillar mineralization occurred via the self-adaptive interaction between the AMNs and the collagen microfibrils,which were self-assembling;the AMNs wrapped around the microfibrils became situated in the gap zones of collagen and finally transformed into crystals.Srdoped collagen scaffolds(Sr-CS)promoted in vitro cell proliferation and osteogenic differentiation of rat bone marrow mesenchymal stromal cells(rBMSCs)and synergistically improved osteogenesis of rBMSCs by altering the macrophage response.Ag-doped collagen scaffolds(Ag-CS)exhibited in vitro antibacterial effects on S.aureus,as well as cell/tissue compatibility.Moreover,Sr-CS implanted into the calvarial defect of a rat resulted in improved bone regeneration.Therefore,the SSM model is a de novo synthetic strategy for doping bioactive elements into collagen,and can be used to fabricate multifunctional collagen scaffolds to meet the clinical challenges of encouraging osteogenesis,boosting the immune response and fighting severe infection in bone defects. | Huanhuan Liu Mingli Lin Xue Liu Ye Zhang Yuyu Luo Yanyun Pang Haitao Chen Dongwang Zhu Xue Zhong Shiqing Ma Yanhong Zhao Qiang Yang Xu Zhang | 2020 | Bioactive Materials2020，5，4： | 6 |
| 3 | Age-Related Reduction in Cortical Thickness in First-Episode Treatment-Na?ve Patients with Schizophrenia显示文摘Substantial evidence supports the neurodevelopmental hypothesis of schizophrenia.Meanwhile,progressive neurodegenerative processes have also been reported,leading to the hypothesis that neurodegeneration is a characteristic component in the neuropathology of schizophrenia.However,a major challenge for the neurodegenerative hypothesis is that antipsychotic drugs used by patients have profound impact on brain structures.To clarify this potential confounding factor,we measured the cortical thickness across the whole brain using highresolution T1-weighted magnetic resonance imaging in 145 first-episode and treatment-naive patients with schizophrenia and 147 healthy controls.The results showed that,in the patient group,the frontal,temporal,parietal,and cingulate gyri displayed a significant age-related reduction of cortical thickness.In the control group,age-related cortical thickness reduction was mostly located in the frontal,temporal,and cingulate gyri,albeit to a lesser extent.Importantly,relative to healthy controls,patients exhibited a significantly smaller age-related cortical thickness in the anterior cingulate,inferior temporal,and insular gyri in the right hemisphere.These results provide evidence supporting the existence of neurodegenerative processes in schizophrenia and suggest that these processes already occur in the early stage of the illness. | Yin Lin Mingli Li Yi Zhou Wei Deng Xiaohong Ma Qiang Wang Wanjun Guo Yinfei Li Lijun Jiang Xun Hu Nanyin Zhang Tao Li | 2019 | Neuroscience Bulletin2019，35，4： | 5 |
| 4 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 5 | Carboxymethyl chitosan as a polyampholyte mediating intrafibrillar mineralization of collagen via collagen/ACP self-assembly显示文摘The significant role of the polyelectrolytic nature of non-collagenous proteins (NCPs) in regulating the in vivo mineralization of collagen provides important insights for scientists searching for analogues of NCPs to achieve in vitro collagen mineralization. Polyampholyte carboxymethyl chitosan (CMC) has both carboxyl and amino groups, which allows it to act as a cationic or anionic polyelectrolyte below or above its isoelectric point (IP), respectively. In this study, CMC was employed as the analogue of NCPs to stabilize amorphous calcium phosphate (ACP) under acidic conditions (pH < 3.5) via the formation of CMC/ACP nanocomplexes. In the presence of both ACP nanoparticles and acid collagen molecules, ACP nanoparticles could be integrated into collagen fibrils during the process of collagen self-assembly and achieve intrafibrillar mineralization of collagen in vitro (i.e., synchronous self-assembly/mineralization (SSM) of collagen). This mode of mineralization is different from established mechanisms in which mineralization follows the self-assembly (MFS) of collagen. Thus, SSM provides a new strategy for developing materials from mineralized collagen scaffolds. | Mingli Lin Huanhuan Liu Jingjing Deng Ran An Minjuan Shen Yanqiu Li Xu Zhang | 2019 | Journal of Materials Science & Technology2019，35，9： | 4 |
| 6 | Effect of La_(2)O_(3) addition on the synthesis of tungsten nanopowder via combustion-based method显示文摘In this study, the influences of La_(2)O_(3) added on the phase, morphology and reduction process of tungsten oxide prepared by solution combustion synthesis(SCS) were investigated for the first time. And tungsten nanopowders with different La_(2)O_(3) doping amount(0.5~5.0 wt%) were successfully prepared by SCS and followed hydrogen reduction. The results showed that with the increase of La_(2)O_(3) addition,the product synthesized by SCS changed from needle-like W_(18) O_(49) to irregularly granulated H0.53 WO3 and the complete reduction temperature also increased form 700°C to 850°C. The densification behavior of as-prepared W nanopowders revealed that the densification inhibitory effect of La_(2)O_(3) was enhanced as the La_2O_3 addition increased. Nevertheless, due to the optimal size and distribution of La_(2)O_(3) particles,the sample with 2.0 wt% La_(2)O_(3) addition has a smallest grain size of 0.47 μm and a highest microhardness value of 739.3 Hv0.2, which are the best compared with the literature. | Zheng Chen Mingli Qin Junjun Yang Lin Zhang Baorui Jia Xuanhui Qu | 2020 | Journal of Materials Science & Technology2020，58，23： | 2 |
| 7 | Down‐regulation of ING4 is associated with initiation and progression of lung cancer显示文摘 | Qiu‐shiWang MingLi Lin‐youZhang YanJin Dan‐danTong YangYu JingBai QiHuang Fang‐LiLiu AnLiu Ki‐YoungLee Song‐binFu | 2010 | Histopathology2010，，2： | 2 |
| 8 | Genetic analysis of the VP1 region of enterovirus 71 reveals the emergence of genotype A in central China in 2008显示文摘 | Haiyang Yu Wei Chen Hongwei Chang Renshu Tang Jun Zhao Lin Gan Boyu Liu Jason Chen Mingli Wang | 2010 | Virus Genes2010，，1： | 1 |
| 9 | Removal of VOCs from suddenpolluted raw water by air stripping显示文摘 | Lin Mingli Yin Xiaotao Cui Fuyi | 2011 | Journal Donghua University2011，28，5： | 1 |
| 10 | Effects of initialchlorobenzene concentration,air flow rate and temperature on masstransfer of chlorobenzene by air stripping显示文摘 | Lin Mingli Zhao Zhiwei Cui Fuyi | 2012 | Desalination and WaterTreatment2012，40，： | 1 |
| 11 | Pressureless two-step sintering of ultrafine-grained refractory metals:Tungsten-rhenium and molybdenum显示文摘The challenge of sintering ultrafine-grained refractory metals and alloys to full density is hereby addressed by pressureless two-step sintering in tungsten-rhenium alloy and pure molybdenum. Using properly processed nano powders(~50 nm average particle size), we are able to sinter W-10Re alloy to 98.4% density below 1200 ℃ while maintaining a fine grain size of 260 nm, and sinter molybdenum to 98.3% density below 1120 ℃ while maintaining a fine grain size of 290 nm. Compared to normal sintering,two-step sintering offers record-fine grain sizes and better microstructural uniformity, which translates to better mechanical properties with higher hardness(6.3 GPa for tungsten-rhenium and 4.0 GPa for molybdenum, both being the highest in all pressurelessly sintered samples of the respective material system)and larger Weibull modulus. Together with our previous demonstration in tungsten, we believe that twostep sintering is a general effective method to produce high-quality fine-grained refractory metals and alloys, and the lessons learned here are transferable to other materials for powder metallurgy. | Zhongyou Que Zichen Wei Xingyu Li Lin Zhang Yanhao Dong Mingli Qin Junjun Yang Xuanhui Qu Ju Li | 2022 | Journal of Materials Science & Technology2022，，31： | 1 |
| 12 | Clinical implications of ERβ methylation on sporadic breast cancers in Chinese women显示文摘 | Lin Zhao Zhaojin Yu Yunan Li Xiaoyan Wen Wenfeng Ma Lin Wang Jie Ren Caigang Liu Miao He Xuefeng Bai Mingli Sun Zhihong Zheng Xiaoyi Mi Enhua Wang Olufunmilayo I. Olopade Feng Jin Minjie Wei | 2012 | Medical Oncology2012，，3： | 1 |
| 13 | Down‐regulation of ING4 is associated with initiation and progression of lung cancer显示文摘 | Qiu‐shiWang MingLi Lin‐youZhang YanJin Dan‐danTong YangYu JingBai QiHuang Fang‐LiLiu AnLiu Ki‐YoungLee Song‐binFu | 2010 | Histopathology2010，，2： | 1 |
| 14 | Genetic analysis of the VP1 region of enterovirus 71 reveals the emergence of genotype A in central China in 2008显示文摘 | Haiyang Yu Wei Chen Hongwei Chang Renshu Tang Jun Zhao Lin Gan Boyu Liu Jason Chen Mingli Wang | 2010 | Virus Genes2010，，1： | 1 |
| 15 | Hot deformation behavior of Co-base ODS alloys显示文摘 | Lin Zhang Xuanhui Qu Xinbo He Din Rafi-ud Mingli Qin Hongmin Zhu | 2011 | Journal of Alloys and Compounds2011，，1： | 1 |
| 16 | Microbial diversity and structure in the gastrointestinal tracts of two stranded short-finned pilot whales(Globicephala macrorhynchus)and a pygmy sperm whale(Kogia breviceps)显示文摘Information on the gut microbiome composition of different mammals could provide novel insights into the evolution of mammals and succession of microbial communities in different hosts.However,there is limited information on the gut microbiome composition of marine mammals,especially cetaceans because of sampling constraints.In this study,we investigated the diversity and composition of microbial communities in the stomach,midgut,and hindgut of 2 stranded short-finned pilot whales(Globicephala macrorhynchus)and hindgut of a stranded pygmy sperm whale(Kogia breviceps)by using 16S rRNA gene amplicon sequencing technology.On the basis of the 50 most abundant operational taxonomic units,principal coordinate analysis,and non-metric multidimensional scaling analysis,we confirmed that the gut microbial communities of the 3 whales were different.Our results revealed that the gut microbiome of 1 stranded short-finned pilot whale GM16 was dominated by Firmicutes(mainly Clostridium)and Fusobacteria;whereas that of the other pilot whale GM19 was composed of Gammaproteobacteria and Bacteroidetes(mainly Vibrio and Bacteroides,respectively),probably caused by intestinal disease and antibiotic treatment.The gut microbiome of the pygmy sperm whale was dominated by Firmicutes and Bacteroidetes.Moreover,different gastrointestinal tract regions harbored different microbial community structures.To our knowledge,this is the first report of the gut microbiome of short-finned pilot whales,and our findings will expand our current knowledge on microbial diversity and composition in the gastrointestinal tract of cetaceans. | Shijie BAI Peijun ZHANG Mingli LIN Wenzhi LIN Zixin YANG Songhai LI | 2021 | Integrative Zoology2021，16，3： | 1 |
| 17 | Change of Low-level Jet in a Heavy Rainstorm Process of Xiangtan in July 2016显示文摘Based on the previous research on the model of rainstorm weather with low-level jet in Xiangtan,using the classification result of radar echo characteristics,the wind profile data provided by new generation of weather radar in Changsha and hourly rainfall data,a thorough study of the heavy rainfall from 2 to 5 July 2016 in Xiangtan was conducted. It was concluded that heavy precipitation had the characteristics of the WPSH pattern of rainstorm with low-level jet at early stage,and then it converted to cold shear jet pattern in latter stage. When low-level southwest jet began to have momentum download,that is to say,there was more than 12 m/s of southwest jet below 1 km,and it rapidly strengthened and expanded downward,it was conducive to the occurrence of short-term rainstorm. The low-level jet would not immediately cause a strong precipitation when it reached the station,with a certain lag. A positive correlation existed between the increase of low-level jet index and precipitation intensity,and low-level jet index could predict the occurrence of heavy rainfall and rain intensity. | Dai Jin He Ning Chen Si Lin Mingli | 2019 | Meteorological and Environmental Research2019，10，2： | 1 |
| 18 | Preparation of TiN nanopowder by carbothermal reduction of a combustion synthesized precursor显示文摘 | Aimin Chu Mingli Qin Xuezhi Jiang Lin Zhang Baorui Jia Huifeng Lu Yajuan Chen Xuanhui Qu | 2013 | Materials Characterization2013，，： | 1 |
| 19 | Impact of preoperative therapy on surgical outcomes of laparoscopic total gastrectomy for gastric/gastroesophageal junction cancer显示文摘Objective: As laparoscopic surgery is widely applied for primarily treated gastric cancer(GC)/gastroesophageal junction cancer(GEJC) and gains many advantages, the feasibility of laparoscopic total gastrectomy(LTG) for GC/GEJC patients who have received preoperative therapy(PT) has come to the fore. This study aims to analyze the safety and feasibility of LTG after PT for GC/GEJC patients.Methods: We retrospectively analyzed the data of 511 patients with GC/GEJC undergoing LTG, of which 405received LTG(LTG group) and 106 received PT+LTG(PT-LTG group) at Nanfang Hospital between June 2018and September 2022. The surgical outcomes were compared between the two groups.Results: The surgical duration was significantly longer in the PT-LTG group(P<0.001), while the incidence of intraoperative complications(P=1.000), postoperative complications(LTG group vs. PT-LTG group: 26.2% vs.23.6%, P=0.587), the classification of complication severity(P=0.271), and postoperative recovery was similar between two groups. Notably, the incidence of anastomotic complications of esophagojejunostomy was also comparable between the two groups(LTG group vs. PT-LTG group: 5.9% vs. 5.7%, P=0.918). The univariate and multivariate analysis confirmed that positive proximal margin [positive vs. negative: odds ratio(OR)=14.094, 95%confidence interval(95% CI): 2.639-75.260, P=0.002], rather than PT, has an impact on anastomotic complications after LTG(OR=0.945, 95% CI: 0.371-2.408, P=0.905).Conclusions: PT did not increase the surgical risk of LTG for GC/GEJC. Therefore, considering the positive effect of PT on long-term survival, the broader application of PT and LTG for GC/GEJC is supported by our findings. | Yuehong Chen Zhijing Yang Mingli Zhao Chuanjin Xu Yuxuan Zhu Huimin Zhang Huilin Huang Yanmei Peng Yanfeng Hu Tian Lin Tao Chen Hao Chen Liying Zhao Hao Liu Guoxin Li Jiang Yu Xinhua Chen | 2023 | Chinese Journal of Cancer Research2023，35，4： | 0 |
| 20 | Investigation of nanostructure of konjac-based water absorbents with atomic force microscopy显示文摘Atomic force microscopy technology is gradually spreading to almost all aspects,including food science and technology,since it was first invented in 1986.In this study,this powerful instrument was applied to image nanostructures of three water absorbents-original konjac powder,konjac powder grafted with acrylic acid using^(60)Coγ-irradiation and regenerated grafted powder.Water absorption capacities and the rates of the three absorbents were also determined in this work.Original konjac powder could only absorb 60 times(w/w)of water,while 270 times for the grafted absorbent and 360 times for the regenerated absorbent.The initial water absorption rates in both tap and distilled water were high,but the rate decreased steeply as time elapsed.After 20 min,the absorbent was close to saturated status.These physical properties were in accordance with the nanostructures of these three water absorbents. | Shengrong GENG Ruotai LIN Mingli CHEN Shaoyang LIU Yifen WANG | 2009 | Frontiers of Chemical Science and Engineering2009，3，4： | 0 |
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