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| 1 | Rational Operation for Primary Gastric Carcinoma with Liver Metastasis显示文摘OBJECTIVE To investigate the prognosis of advanced gastric carcinoma patients with liver metastasis,and provide a foundation for rational opera- tions. METHODS The operations and prognosis of 102 primary gastric carci- noma patients with liver metastasis were studied retrospectively. RESULTS In gastric carcinoma patients with H1 metastasis who under- went a resection operation,the 6-month,1-and 2-year post-operative sur- vival rates were 61%,42%and 7%.There was a statistically significant dif- ference in survival between resected and non-resected patients(P=0.000) In gastric carcinoma cases with H2 metastasis,resection operations resulted in 54%,16%and 8%respective survival rates,with no significant difference compared to patients not receiving a resection(P=0.132).Gastric carcinoma patients with H3 metastasis who received a resection operation showed 25%,13%and 0%respective survivals with no significantly better prognosis compared to the non-resected cases(P=0.135).There was no statistical y significant difference in survival between the cases with or without peritoneal metastasis(P=0.152). CONCLUSION A resection operation provides a better prognosis for gas- tric carcinoma patients with H1 metastasis independent of peritoneal metas- tasis,but resection has no benefit for gastric carcinoma cases with H2 or H3 metastasis.Peritoneal metastases are not the significant influencing factor for the prognosis of gastric cancer with liver metastasis. | Caigang Liu Ping Lu Jinsong Gu Junqing Chen | 2007 | Chinese Journal of Clinical Oncology2007，4，2： | 3 |
| 2 | 中国家族性胃癌的研究(英文)显示文摘Objective:The aim of the study was to investigate the influence of gastric cancer family history in the gastric cancer (GC) patients. Methods: Gastric cancer family histories within second degree relatives and clinicopathological features were obtained for 497 patients. Results:Of the 497 probands,235 probands were incorporated into familial gastric cancer (FGC) group (there were at least two GC members in the family); 262 probands were included in the non-FGC group (relatives only affected with non-GCs). Of 614 tumors in relatives,GC was the most frequent,followed by lung cancer,esophageal cancer,hepatocellular cancer,colorectal cancer,urogenital cancer,breast cancer,and pancreatic cancer. Most affected members aggregated within first-degree relatives. The ratio of males to females in affected first-degree relatives was usually higher in male probands. Paternal history of GC was a strong risk for GC in males,while risk of GC by maternal history of GCs was increased in females. Difference in tumor histological types between the two groups was derived from an excess of diffuse GC in non-FGC male probands. The lower site was the most frequent tumor location in all subgroups. Conclusion:Distribution of associated non-GCs in a family history of GC may vary with geographic areas. GC may have different genetic and/or environmental etiology in different families,and a certain subtype may be inherited in a male-influenced fashion. | Binbin Wang Zhijuan Li Caigang Liu Huimian Xu Feng Jin Ping Lu | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，6： | 2 |
| 3 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5h96bc5np9pnox6bop.ffgz.tsg.suse.edu.cn/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 4 | Clinical Implications of HER-2 and P53 in Taxane-Based and Anthracycline-Based Neoadjuvant Chemotherapy in Breast Cancer显示文摘OBJECTIVE To evaluate the predictive value of humanepidermal growth factor receptor-2 (HER-2) and P53 in taxane-based and anthracycline-based neoadjuvant chemotherapy (NAC)in breast cancer.METHODSSixty-two patients with breast cancer wereincluded in this study.Twenty-two patients were treated withtaxane-based (taxane group) and 40 with anthracycline-based(anthracycline group).ER,PR,c-erbB2 and P53 were detected byimmunohistochemistry staining before NAC,and FluorescenceIn Situ Hybridization(FISH) was used to detect the HER-2 geneamplification for the cases with the expression of c-erbB2 proteinas (++) or (+++).The efficacy of the regimens was evaluated afterNAC.RESULTS In the anthracycline group,objective response (OR)was observed in 30 out of 40 patients (75%),whereas no response(NR) was observed in 10 patients (25%).In the taxane group,ORwas observed in 15 patients out of 22 patients (68.2%),whereasNR was observed in 7 patients (31.8%).HER-2-negative status wascorrelated with a high OR in both taxane-based and anthracycline-based NAC (P = 0.023 and P = 0.029),whereas P53-negative statuswas correlated with high OR rate in anthracycline-based NAC (P= 0.041).The significant difference of the CR rates was observedbetween the patients took<4 cycles and>4 cycles NAC (4.65% vs.21.05%,P<0.05).CONCLUSION The patients with HER-2 gene non-amplicationmay be sensitive to both taxane-based and anthracycline-basedchemotherapy;the patients without P53 overexpression maysuitable to select anthracycline-based chemotherapy;and properincreased NAC cycles may increase CR rates. | Xiaolan Wang Fan Yao Nan Liu Yunfei Wu Xinyu Zheng Jiguang Li Caigang Liu Xueshan Qiu Feng Jin | 2008 | Chinese Journal of Clinical Oncology2008，5，6： | 2 |
| 5 | 乳腺癌术后患者心理状态评估及干预策略改进(英文)显示文摘Objective: The aim of the study was to investigate the level of self-image of patients after breast cancer surgery, and explore factors influencing self-image among patients who have experienced different types of surgeries, and set out a foundation for the improvement of care strategies. Methods: The 538 patients with primary breast cancer who underwent surgery in the Department of Breast Surgery, First Hospital of China Medical University, Shenyang, China, from January 2004 to January 2009 were included in the study. The psychological status of the patients was evaluated by body image after breast cancer questionnaire (BIBCQ), social support rating scale (SSRS), self-rating anxiety scale (SRAS), depression rating scale (DRS), and general information questionnaire. The factors influencing the self-image were selected by a stepwise regression analysis. Results: The patients who underwent breast-conserving surgery were the most satisfied with their body image, followed by those underwent surgery of modified radical mastectomy with reconstruction. However, cases treated by modified radical mastectomy without reconstruction had negative outcomes. Regardless of operation type, the self-image was influenced by anxiety, level of abuse by husband, and sexual satisfaction after operation. Conclusion: The self-image of patients who underwent different breast cancer surgeries was influenced by different factors, and individualized nursing should be offered in accordance with the specific situation. | Yanjun Zhang Caigang Liu Feng Jin | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，10： | 1 |
| 6 | Prognostic significance of subclassification of pT2 gastric cancer: A retrospective study of 847 patients显示文摘 | Yang Lu Caigang Liu Ruishan Zhang Hua Li Ping Lu Feng Jin Huimian Xu Shubao Wang Junqing Chen | 2008 | Surgical Oncology2008，，4： | 1 |
| 7 | Prevention and treatment of doxorubicin-induced cardiotoxicity by dexrazoxane and sehisandrin B in rabbits显示文摘 | Feifei C Yu L Caigang X | 2011 | International Journal of Toxicology2011，30，6： | 1 |
| 8 | Clinicopathologic Characteristics and Surgical Outcome of Gastric Cancer in Patients Younger than 36 Years of Age显示文摘OBJECTIVE This study was designed to determine theclinicopathologic features of young patients who underwentgastrectomy for gastric cancer and to improve the clinicalmanagement of this disease.METHODS From 1981 to 2000,among 1,830 gastric cancerpatients were admitted in our hospital for surgical treatment,66of them were<36 years of age.The clinicopathologic data of theseyoung patients were collected and reviewed.RESULTS The male:female ratio was 1.2:1.Most tumors werelocated in the lower third of the stomach(63.1%).The overall5-year survival rate of 66 cases was 28.7%.The 5-year survivalrates in the patients with early stages and with advanced stages ofgastric carcinoma were 77.8%(7/9)and 21.1%(12/57),respectively.Unfavorable prognostic factors associated with poor 5-yearsurvival included the degree of the invasion in the gastric wall(P<0.05),and curability of resection(non-curative vs.curative;P<0.05).CONCLUSION Gastric cancer in young adults tends to be moreadvanced presentation when diagnosed.However,young patientswith early gastric cancer can tolerate radical treatments well.Itis important to promptly make a precise diagnosis for gastriccarcinoma in young patients and to treat it in early stage. | Dapeng Lin Ping Lu Caigang Liu Huimian Xu ShubaoWang Junqing Chen | 2009 | Clinical oncology and cancer resexreh2009，6，4： | 1 |
| 9 | Clinicopathological Characteristics as Predictive Factrs for Lymph Node Metastasis in Submucosal Gastric Cancer显示文摘OBJECTIVE To identify clinicopathological characteristics as predictive factors for lymph node metastasis in submucosal gastric cancer, and in addi- tion to establish objective criteria as indications for endoscopic submucosal dissection (ESD). METHODS Data from 130 patients with submucosal gastric cancer were collected, and the relationship between their clinicopathological characteris- tics and the presence of lymph node metastasis was retrospectively analyzed by multivariate analysis. RESULTS In the multivariate logistic regression model, a tumor size of 2 cm or more and an undifferentiated histologic type were found to be inde- pendent risk clinicopathological characteristics for lymph node metastasis. Among 130 patients with submucosal carcinoma, no lymph node metastases were observed in 17 patients who showed neither of the two risk clinicopath- ological characteristics. Lymph node metastasis occurred in 61.1% (22/36) of the patients who had both risk clinicopathological characteristics. CONCLUSION A tumor size of 2 cm or more and an undifferentiated histologic type were significantly and independently related to lymph node metastasis in submucosal gastric cancer. It is rational for the paitients with neither of these two independent risk clinicopathological characteristics to undergo an ESD. | Caigang Liu Ping Lu Yang Lu Lua Li Ruishan Zhang Huimian Xu Shubao Wang Junqing Chen | 2007 | Chinese Journal of Clinical Oncology2007，4，4： | 1 |
| 10 | Source-Generated Noise Suppression Using the Singular Value Decomposition显示文摘Source-generated noise, such as air, refracted, guided waves, near-surface multiples, and radial ground roll, is one of the most challenging problems in the land seismic method. The interference of the noise with reflection events often results in a distorted representation of the subsurface and gives rise to interpretation uncertainties. To suppress the noise, geophysicists have devised various techniques in both acquisition and processing stages. Conventional processing methods, such as high-pass, f - k and hyperbolic velocity filters, however, have certain disadvantages when handling actual seismic data. In this study, we present a new hybrid method combining singular value decomposition (SVD) with a special linear transformation of the common-shot gather. The method is aimed at effectively removing the noise while minimizing harm to the signal. As compared with other methods, the SVD-based one gives a denser approximation to source-generated noise before its subtraction from the seismic data, due to the use of more appropriate basis functions. The special transformation applied in advance to the data is intended to align the source-generated noise events horizontally and thus to benefit the subsequent SVD. The effectiveness of the method in suppressing source-generated noise is demonstrated with a synthetic data set. Emphasis is put on the comparison of the performance of the method with that of conventional f - k filtering. | YuriyK.Tyapkin NaumYa.Marmalyevskyy ZenonV.Gomyak CaiGang | 2005 | Petroleum Science2005，2，2： | 1 |
| 11 | Predictive factors of lymph node metastasis in undifferentiated early gastric cancers and application of endoscopic mucosal resection显示文摘 | Hua Li Ping Lu Yang Lu Caigang Liu Huimian Xu Shubao Wang Junqing Chen | 2010 | Surgical Oncology2010，，4： | 1 |
| 12 | Clinicopathological Analysis as Predictive Factors for Recurrence in Early Gastric Cancer显示文摘OBJECTIVE To identify clinicopathological characteristics as predictive factors for recurrence in early gastric cancer(EGC),and to determine which lesions should be removed by gastrectomy by means other than endoscopic mucosal resection(EMR). METHODS Data from 249 patients with EGC were collected and the relationship between their clinicopathological characteristics and postoperative recurrence was retrospectively analyzed by univariate analysis. RESULTS Of the 249 patients a er gastrectomy,19 cases(7.6%) experienced a recurrence.The postoperative recurrence rate was 18.9%(7/37)in patients with lymph node metastasis,and 5.7% (12/212)in those without.Lymph node metastases were found to be significantly related to recurrence in EGC(P=0.005). CONCLUSION Lymph node metastases were the only predictive factor for recurrence in EGC.However,this was not the determining factor for performing gastrectomy rather than EMR.Although after gastrectomy with lymphadenectomy of EGC,patients with lymph node metastasis should be considered as candidates for adjuvant treatment.For lymph-node metastatic EGCs,adjuvant therapy is recommended following gastrectomy with lymphadenectomy. | Hua Li Ping Lu Caigang Liu Huimian Xu Shubao Wang Junqing Chen | 2008 | Chinese Journal of Clinical Oncology2008，5，2： | 1 |
| 13 | FSIP1 enhances the therapeutic sensitivity to CDK4/6 inhibitors in triple-negative breast cancer patients by activating the Nanog pathway显示文摘CDK4/6 inhibitors are routinely recommended agents for the treatment of advanced HR+HER2-breast cancer.However,their therapeutic effectiveness in triple-negative breast cancer(TNBC)remains controversial.Here,we observed that the expression level of fibrous sheath interacting protein 1(FSIP1)could predict the treatment response of TNBC to CDK4/6 inhibitors.High FSIP1 expression level was related to a poor prognosis in TNBC,which was associated with the ability of FSIP1 to promote tumor cell proliferation.FSIP1 downregulation led to slowed tumor growth and reduced lung metastasis in TNBC.FSIP1knockout caused cell cycle arrest at the G0/G1 phase and reduced treatment sensitivity to CDK4/6 inhibitors by inactivating the Nanog/CCND1/CDK4/6 pathway.FSIP1 could form a complex with Nanog,protecting it from ubiquitination and degradation,which may facilitate the rapid cell cycle transition from G0/G1 to S phase and exhibit enhanced sensitivity to CDK4/6 inhibitors.Our findings suggest that TNBC patients with high FSIP1 expression levels may be suitable candidates for CDK4/6 inhibitor treatment. | Guanglei Chen Lisha Sun Xi Gu Liping Ai Jie Yang Zhan Zhang Pengjie Hou Yining Wang Xunyan Ou Xiaofan Jiang Xinbo Qiao Qingtian Ma Nan Niu Jinqi Xue Hao Zhang Yongliang Yang Caigang Liu | 2023 | Science China(Life Sciences)2023，66，12： | 1 |
| 14 | Clinical implications of ERβ methylation on sporadic breast cancers in Chinese women显示文摘 | Lin Zhao Zhaojin Yu Yunan Li Xiaoyan Wen Wenfeng Ma Lin Wang Jie Ren Caigang Liu Miao He Xuefeng Bai Mingli Sun Zhihong Zheng Xiaoyi Mi Enhua Wang Olufunmilayo I. Olopade Feng Jin Minjie Wei | 2012 | Medical Oncology2012，，3： | 1 |
| 15 | Tension-free vaginal tape-obturator in the treatment of stress urinary incontinence: a prospective study with five-year follow-up显示文摘 | Dali Cheng Caigang Liu | 2012 | European Journal of Obstetrics and Gynecology2012，，2： | 1 |
| 16 | Does D3 surgery offer a better survival outcome compared to D1 surgery for gastric cancer? A result based on a hospital population of two decades as taking D2 surgery for reference显示文摘 | Zhang Hao Liu Caigang Wu Di | 2010 | BMC Cancer2010，10，： | 1 |
| 17 | Alternations of ER, PR, HER-2/neu, and 1?53 protein expression in ductal breast carcinomas and clinical implications 显示文摘 | Caigang Liu Hao Zhang Chen Shuang | 2010 | Med Oncol2010，27，9： | 1 |
| 18 | 显示文摘 | WANGYun ZHAOFa-zhan CAIGang etal(王贽 赵发展 蔡纲 等) | | 水文地质工程地质0，，： | 1 |
| 19 | PDGF在子宫内膜癌中的表达及其与血管生成的关系(英文)显示文摘Objective:To investigate the expression of platelet-derived endothelial growth factor(PDGF) and its effect in angiogenesis in endometrial cancer(EC),in order to investigate the mechanism of tumorigenesis and lay a foundation for the management of EC.Methods:We selected 40 cases with EC,20 endometrium,and 20 normal endometrium.All specimens were stained immunohistochemically for CD34 and PDGF identified immunohistochemically with specific antibodies.Results:The expression of PDGF was significantly higher in EC than normal endometrium and atypical hyperplasia of endometrium(P < 0.05),however,no significant difference was found between normal endometrium and atypical hyperplasia of endometrium(P > 0.05).The expression of PDGF was lower in well differentiated than moderately and poorly differentiated EC(P < 0.05).In cases with muscular invasion tumors,it was higher than in normal endometrium(P < 0.05).After Spearman correlation analysis,MVD was significantly influenced by PDGF,r = 0.848(P = 0.000).Conclusion:There was positive correlation between microvessel density(MVD) and PDGF in earlier stage of EC,it illustrate that PDGF may take part in angiogenesis of EC. | Shuang Chen Caigang Liu (Co-first author) Yonglai Wang Song Gao | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，10： | 0 |
| 20 | Protection of a cytidine deaminase gene gainst toxicity of high dose chemotherapy in mice显示文摘探索 transfecting cytidine (CD ) 的可行性的目的基因进老鼠骨髓房间以便观察高剂量 Ara-C 的药抵抗并且改进 myelosuppression 追随者联合化疗的忍耐。方法人的 cytidine 基因是进由制动火箭的老鼠骨髓房间的 transfected 病毒的向量。抵抗形成殖民地的单位 granulocyte 巨噬细胞(CFU 美国通用汽车公司) 试金在 Ara-C 对待的 transfected 老鼠骨髓房间以后被执行。DNA 从老鼠骨髓房间被提取。这药在在 transfection 以后的老鼠骨髓房间的抵抗基因被 PCR 检测。与病毒的制片人房间显示出的制动火箭有教养的施主鼠标的结果骨髓房间这药抵抗殖民地和电阻到 Ara-C,那么确实接受了与 CD 基因移植的鼠标(施主鼠标的 CFU 美国通用汽车公司是 52% , χ
2= 124.62, P <
0.01;接受老鼠是 54% , χ
2= 126.26, P <
0.01,与对比组相比) 。动物幸存率比控制的在基因 transfected 组是显著地更高的(χ
2= 7.42, P <
0.01 ) 。transfected 骨髓房间的 CD 基因被 PCR 证实。结论 CD 基因能高效地是进老鼠的骨髓房间的 transfected 并且增加药抵抗到 Ara-C。 | Bo Chen Caigang Liu Yang Lu Ping Lu Feng Jin Fan Yao Ruishan Zhang Jinlong Liu Shicheng Zhao | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，6： | 0 |
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