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| 1 | Transplantation of neurotrophin-3-transfected bone marrow mesenchymal stem cells for the repair of spinal cord injury显示文摘Bone marrow mesenchymal stem cell transplantation has been shown to be therapeutic in the repair of spinal cord injury. However, the low survival rate of transplanted bone marrow mesenchymal stem cells in vivo remains a problem. Neurotrophin-3 promotes motor neuron survival and it is hypothesized that its transfection can enhance the therapeutic effect. We show that in vitro transfection of neurotrophin-3 gene increases the number of bone marrow mesenchymal stem cells in the region of spinal cord injury. These results indicate that neurotrophin-3 can promote the survival of bone marrow mesenchymal stem cells transplanted into the region of spinal cord injury and potentially enhance the therapeutic effect in the repair of spinal cord injury. | Yuzhen Dong Libin Yang Lin Yang Hongxing Zhao Chao Zhang Dapeng Wu | 2014 | Neural Regeneration Research2014，9，16： | 16 |
| 2 | DISTRIBUTION AND CHARACTERIZATION OF POLYCYCLIC AROMATIC HYDROCARBON COMPOUNDS IN AIRBORNE PARTICULATES OF EAST ASIA显示文摘A review is presented on the distribution and characterization of polycyclic aromatic hydrocarbons (PAHs) and their derivatives, including nitro-PAHs and hydro-PAHs, on atmospheric particulates of East Asia. Generally, PAH compounds with two or three aromatic rings are released mainly into the gas phase, while those containing three or more aromatic rings are associated with particulate matter (PM) emission. Particle-associated PAHs are primarily adsorbed on fine particles, and little associated with coarse particles. Investigation into the concentration level of PAHs in different areas can serve not only to reflect the pollutant status and sources but also to lead to the formulation of control strategies. The results of the present study show that China has more severe PAH pollution than such East Asian countries as Ja-pan and Korea. | Yan Liu Libin Liu Jin-Ming Lin Ning Tang Kazuichi Hayakawa | 2006 | China Particuology2006，4，6： | 14 |
| 3 | Detection and identification of Vibrio parahaemolyticus by multiplex PCR and DNA-DNA hybridization on a microarray显示文摘In this paper,we developed a rapid and accurate method for the detection of Vibrio parahaemalyticus strains,using multiplex PCR and DNA—DNA hybridization.Multiplex PCR was used to simultaneously amplify three diagnostic genes(tlh,tdh and fla) that serve as molecular markers of V.parahaemolyticus.Biotinylated PCR products were hybridized to primers immobilized on a microarray,and detected by chemiluminesce with avidin—conjugated alkaline phosphatase.With this method,forty-five samples were tested.Eight known virulent strains (tlh^+/tdh^+/fla^+) and four known avirulent strains(tlh^+/tdh^-/fla^+) of the V.parahaemolyticus were successfully detected,and no non-specific hybridization and cross-hybridization reaction were found from fifteen closely-related strains(tlh^-/tdh^-/fla^+) of the Vibrio spp.In addition,all the other eighteen strains of non-Vibrio bacteria(tlh^-/tdh^-/fla^-) gave negative results.The DNA microarray successfully distinguished V. parahaemolyticus from other Vibrio spp.The results demonstrated that this was an efficient and robust method for identifying virulent strains of V.parahaemolyticus. | Rongzhi Wang Jiadong Huang Wei Zhang Guangmei Lin Junwei Lian Libin Jiang Hongcong Lin Songfa Wang Shihua Wang | 2011 | Journal of Genetics and Genomics2011，38，3： | 11 |
| 4 | MgO晶体中F型色心的电子结构和光学吸收谱研究显示文摘运用嵌入原子簇的电荷自洽离散变分方法(SCC-DVM-Xα方法)对MgO晶体中F型色心的电子结构进行了计算,并利用能量最小原理优化了色心格点周围的Mg,O离子结构,得到了MgO晶体中 F,F+和 F2+心的能带,态密度,并讨论了色心的光学跃迁模式。计算结果表明,F,F+和 F2+心在 MgO晶体的禁带中引入了色心能级,F和 F+心的光学跃迁能分别是 4. 67eV和 4. 66eV,电子从色心激发态跃迁到导带底需要吸收大的光电子跃迁能量。计算结果与实验结果符合较好,说明计算结果是合理的。 | 陈军 LIN Libin 林理彬 何捷 卢勇 何维 | 2001 | 核技术2001，24，2： | 3 |
| 5 | Reduction effects in rutile induced by neutron irradiation 显示文摘 | LU Tiecheng LIN Libin WU Shaoyi | 2002 | Nucl Instrum Methods Phys Res Sect B2002，191，： | 1 |
| 6 | New kinds of Dirac Energy Levels and their Crossing Regions显示文摘 | Yang Shuzheng Lin Libin | 2001 | Chin Phys Soc2001，10，11： | 1 |
| 7 | Simultaneous adsorption of As(Ⅲ) and Pb(Ⅱ) by the iron-sulfur codoped biochar composite:Competitive and synergistic effects显示文摘Simultaneous elimination of As(Ⅲ) and Pb(Ⅱ) from wastewater is still a great challenge.In this work,an iron-sulfur codoped biochar (Fe/S-BC) was successfully fabricated in a simplified way and was applied to the remediate the co-pollution of As(Ⅲ) and Pb(Ⅱ).The positive enthalpy indicated that the adsorption in As-Pb co-pollution was an endothermic reaction.The mechanism of As(Ⅲ) removal could be illustrated by surface complexation,oxidation and precipitation.In addition to precipitation and complexation,the elimination mechanism of Pb(Ⅱ) also contained ion exchange and electrostatic interactions.Competitive and synergistic effects existed simultaneously in the co-contamination system.The suppression of As(Ⅲ) was ascribed to competitive complexation of the two metals on Fe/S-BC,while the synergy of Pb(Ⅱ) was attributed to the formation of the PbFe2(AsO_(4))2(OH)2.Batch experiments revealed that Fe/S-BC had outstanding ability to remove As(Ⅲ) and Pb(Ⅱ),regardless of pH dependency and interference by various coexisting ions.The maximum adsorption capacities of the Fe/S-BC for As(Ⅲ) and Pb(Ⅱ) were 91.2 mg/g and 631.7 mg/g,respectively.Fe/S-BC could be treated as a novel candidate for the elimination of As(Ⅲ)-Pb(Ⅱ) combined pollution. | Yijun Chen Qintie Lin Xiaoqing Wen Jin He Haoyu Luo Quanfa Zhong Libin Wu Jiaqi Li | 2023 | Journal of Environmental Sciences2023，，3： | 1 |
| 8 | Electron capture rates in strong electron screening显示文摘 | Luo Zhiquan Liu Menquan Lin Libin | 2006 | Chinese Astronomy and Astrophysics2006，30，1： | 1 |
| 9 | A joint call for actions to advance taxonomy in China显示文摘Taxonomy plays an important role in understanding the origin, evolution, and ecological functionality of biodiversity. There are large number of unknown species yet to be described by taxonomists, which together with their ecosystem services cannot be effectively protected prior to description. Despite this, taxonomy has been increasingly underrated insufficient funds and permanent positions to retain young talents. Further, the impact factordriven evaluation systems in China exacerbate this downward trend, so alternative evaluation metrics are urgently necessary. When the current generation of outstanding taxonomists retires,there will be too few remaining taxonomists left to train the next generation. In light of these challenges, all co-authors worked together on this paper to analyze the current situation of taxonomy and put out a joint call for immediate actions to advance taxonomy in China. | Chaodong Zhu Arong Luo Ming Bai Michael COrr Zhonge Hou Siqin Ge Jun Chen Yibo Hu Xuming Zhou Gexia Qiao Hongzhi Kong Limin Lu Xiaohua Jin Lei Cai Xinli Wei Ruilin Zhao Wei Miao Qingfeng Wang Zhongli Sha Qiang Lin Meng Qu Jianping Jiang Jiatang Li Jing Che Xuelong Jiang Xiaoyong Chen Lianming Gao Zongxin Ren Chunlei Xiang Shixiao Luo Donghui Wu Dong Liu Yanqiong Peng Tao Su Chenyang Cai Tianqi Zhu Wanzhi Cai Xingyue Liu Hu Li Huaijun Xue Zhen Ye Xuexin Chen Pu Tang Shujun Wei Hong Pang Qiang Xie Feng Zhang Feng Zhang Xianjin Peng Aibing Zhang Taiping Gao Changfa Zhou Chen Shao Libin Ma Zhaoming Wei Yunxia Luan Ziwei Yin Wu Dai Cong Wei Xiaolei Huang Jingxian Liu Xiangsheng Chen Tianci Yi Zhisheng Zhang Zhulidezi Aishan Qin Li Hongying Hu | 2022 | Zoological Systematics2022，47，3： | 1 |
| 10 | Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression显示文摘 | Zhengzhao Liu Peng Chen Hong Gao Yu Gu Jiao Yang Hong Peng Xingxing Xu Haifeng Wang Meiqiang Yang Xiaoying Liu Libin Fan Shiyao Chen Jian Zhou Yihong Sun Kangchen Ruan Shuqun Cheng Masaaki Komatsu Eileen White Lin Li Hongbin Ji Daniel Finley Ronggui Hu | 2014 | Cancer Cell2014，，： | 1 |
| 11 | Probabilistic stability analysis of Bazimen landslide with monitored rainfall data and water level fluctuations in Three Gorges Reservoir, China显示文摘Landslide is a common geological hazard in reservoir areas and may cause great damage to local residents’life and property.It is widely accepted that rainfall and periodic variation of water level are the two main factors triggering reservoir landslides.In this study,the Bazimen landslide located in the Three Gorges Reservoir(TGR)was back-analyzed as a case study.Based on the statistical features of the last 3-year monitored data and field instrumentations,the landslide susceptibility in an annual cycle and four representative periods was investigated via the deterministic and probabilistic analysis,respectively.The results indicate that the fluctuation of the reservoir water level plays a pivotal role in inducing slope failures,for the minimum stability coefficient occurs at the rapid decline period of water level.The probabilistic analysis results reveal that the initial sliding surface is the most important area influencing the occurrence of landslide,compared with other parts in the landslide.The seepage calculations from probabilistic analysis imply that rainfall is a relatively inferior factor affecting slope stability.This study aims to provide preliminary guidance on risk management and early warning in the TGR area. | Wengang ZHANG Libin TANG Hongrui LI Lin WANG Longfei CHENG Tingqiang ZHOU Xiang CHEN | 2020 | Frontiers of Structural and Civil Engineering2020，14，5： | 1 |
| 12 | Synthesis,characteriza-tion of hierarchical TS-1 and its catalytic performance for cyclohex-anone ammoximation 显示文摘 | Lin Junzhong Xin Feng Yang Libin | 2014 | Catalysis Communications2014，45，： | 1 |
| 13 | Influence of high-fluence neutron and/or proton irradiation on the optical properties and microstructure of rutile 显示文摘 | LU Tiecheng LIN Libin ZU Xiaotao | 2004 | Nucl Instrum Methods Phys Res Sect B2004，218，： | 1 |
| 14 | A new semiconductor-based SERS substrate with enhanced charge collection and improved carrier separation: CuO/TiO_(2) p-n heterojunction显示文摘In this paper, CuO/TiO_(2) p-n heterojunction was developed as a new surface enhanced Raman scattering(SERS) substrate to magnify Raman signal of 4-mercaptobenzoic acid(4-MBA) molecule. In the heterojunction-molecule system, CuO as an “electron capsule” can not only offer more electrons to inject into the surface state energy level of TiO_(2) and consequently bring additional charge transfer, but also improve photogenerated carrier separation efficiency itself due to strong interfacial coupling in the interface of heterojunction, which together boost SERS performance of the heterojunction substrate. As expected,owing to the enhanced charge collection capacity and the improvement of photogenerated carrier separation efficiency derived from internal electric field and strong interface coupling provided in the interface of heterojunction, this substrate exhibits excellent SERS detection sensitivity towards 4-MBA, with a detection limit as low as 1 × 10^(-10)mol/L and an enhancement factor of 8.87 × 10~6. | Dongxue Yu Lin Xu Huizhu Zhang Jia Li Weie Wang Libin Yang Xin Jiang Bing Zhao | 2023 | Chinese Chemical Letters2023，34，7： | 0 |
| 15 | Quantification of selected monohydroxy metabolites of polycyclic aromatic hydrocarbons in human urine显示文摘An analytical method was developed to quantitatively determine selected monohydroxy metabolites of polycyclic aromatic hydrocarbons(PAHs) in human urine. The procedure included enzymatic hydrolysis to cleave the conjugated metabolites, solid-phase microextraction enrichment, and gas chromatography-mass spectrometry analysis. The method proved to be sensitive enough to detect the selected PAH metabolites in human urine. | Libin Liu Yueping Luo Junping Bi Haifang Li Jin-Ming Lin | 2015 | Science China Chemistry2015，58，10： | 0 |
| 16 | Scanning for Genomic Regions Subject to Selective Sweeps Using SNP-MaP Strategy显示文摘Population genomic approaches, which take advantages of high-throughput genotyping, are powerful yet costly methods to scan for selective sweeps. DNA-pooling strategies have been widely used for association studies because it is a cost-effective alternative to large-scale individual genotyping. Here, we performed an SNP-MaP (single nucleotide polymorphism microarrays and pooling) analysis using samples from Eurasia to evaluate the efficiency of pooling strategy in genome-wide scans for selection. By conducting simulations of allelotype data, we first demonstrated that the boxplot with average heterozygosity (HET) is a promising method to detect strong selective sweeps with a moderate level of pooling error. Based on this, we used a sliding window analysis of HET to detect the large contiguous regions (LCRs) putatively under selective sweeps from Eurasia datasets. This survey identified 63 LCRs in a European population. These signals were further supported by the integrated haplotype score (iHS) test using HapMap II data. We also confirmed the European-specific signatures of positive selection from several previously identified genes (KEL, TRPV5, TRPV6, EPHB6). In summary, our results not only revealed the high credibility of SNP-MaP strategy in scanning for selective sweeps, but also provided an insight into the population differentiation. | Libin Deng Xiaoli Tang Wei Chen Jiari Lin Zhiqing Lai Zuoqi Liu Dake Zhang | 2010 | Genomics, Proteomics & Bioinformatics2010，8，4： | 0 |
| 17 | Gene2DGE: A Perl Package for Gene Model Renewal with Digital Gene Expression Data显示文摘For transcriptome analysis, it is critical to precisely define all the transcripts across the whole genome. More and more digital gene expression (DGE) scannings have indicated the presence of huge amount of novel transcripts in addition to the known gene models. However, almost all these studies still depend crucially on existing annotation. Here, we present Gene2DGE, a Perl software package for gene model renewal with DGE data. We applied Gene2DGE to the mouse blastomere transcriptome, and defined 98,532 read-enriched regions (RERs) by read clustering supported by more than four reads for each base pair. Taking advantage of this ab initio method, we refined 2,104 exonic regions (4% of a total of 48,501 annotated transcribed regions) with remarkable extension into un-annotated regions (>50 bp). For 5% of uniquely mapped reads falling within intron regions, we identified 13,291 additional possible exons. As a result, we renewed 4,788 gene models, which account for 39% of a total of 12,277 transcribed genes. Furthermore, we identified 12,613 intergenic RERs, suggesting the possible presence of novel genes outside the existing gene models. In this study, therefore, we have developed a suitable tool for re-newal of known gene models by ab initio prediction in transcriptome dissection. The Gene2DGE package is freely available at http://gffzz7910605137224006hkxfufcovfou06kbq.ffgz.tsg.suse.edu.cn/. | Xiaoli Tang Libin Deng Dake Zhang Jiari Lin Yi Wei Qinqin Zhou Xiang Li Guilin Li Shangdong Liang | 2012 | Genomics, Proteomics & Bioinformatics2012，10，1： | 0 |
| 18 | Genetic Flux Between H1 and H2 Haplotypes of the 17q21.31 Inversion in European Population显示文摘The chromosome 17q21.31 inversion is a 900-kb common structural polymorphism found primarily in European population.Although the genetic flux within inversion region was assumed to be considerable suppressed, it is still unclear about the details of genetic exchange between the H1(non-inverted sequence)and H2(inverted sequence) haplotypes of this inversion.Here we describe a refined map of genetic exchanges between pairs of gene arrangements within the 17q21.31 region.Using HapMap phase II data of 1,546 single nucleotide polymorphisms, we successfully deduced 96 H1 and 24 H2 haplotypes in European samples by neighbor-joining tree reconstruction. Furthermore, we identified 15 and 26 candidate tracts with reciprocal and non-reciprocal genetic exchanges, respectively.In all 15 regions harboring reciprocal exchange, haplotypes reconstructed by clone sequencing did not support these exchange events, suggesting that such signals of exchange between two sister chromosomes in certain heterozygous individual were caused by phasing error regions.On the other hand, the finished clone sequencing across 4 of 26 tracts with non-reciprocal genetic flux confirmed that this kind of genetic exchange was caused by gene conversion.In summary, as crossover between pairs of gene arrangements had been considerably suppressed, gene conversion might be the most important mechanism for genetic exchange at 17q21.31. | Libin Deng Xiaoli Tang Xiangwen Hao Wei Chen Jiari Lin Yangyu Yu Dake Zhang Changqing Zeng | 2011 | Genomics, Proteomics & Bioinformatics2011，9，3： | 0 |
| 19 | Effects of different flow velocities on behavior and TRPA1 expression in the sea cucumber Apostichopus japonicas显示文摘A water flow simulation device capable of adjusting flow velocity was designed in flow velocity range of 0–30 cm/s,with which an indoor experiment was conducted to simulate the movement and adhesive behaviors of different-sized Apostichopus japonicus under different flow velocities.Observation showed that,in slow flow(~5 cm/s),A.japonicus moved more distance than in still water,and hardly moved in the riptide(~30 cm/s);and the adhesive capacity of A.japonicus was related to the flow velocity and attachment time.A.japonicus were able to attach to the bottom after any attachment time in the slow flow,after 10 s in the medium flow(~15 cm/s),and after 60 s in the riptide(~30 cm/s).In addition,larger A.japonicus were stronger with adhesive ability than smaller ones.The transcriptome data showed that the expression of transient receptor potential cation channel subfamily A,member 1(TRPA1)in the tube feet was increased significantly in a flowing water,but those in the tentacles and tube feet were not significantly changed.Fluorescence in-situ hybridization results showed that TRPA1 was expressed around the watervascular of tentacles,tube feet,body wall,and spines.Therefore,tube feet were important for sea cucumbers to keep themselves stable in relatively swift flow with adhesion ability. | LIN Chenggang LIU Xiaolu SUN Lina LIU Shilin SUN Jingchun ZHANG Libin YANG Hongsheng | 2020 | Journal of Oceanology and Limnology2020，38，4： | 0 |
| 20 | 社工介入社区日间照料中心的养老服务研究显示文摘目前,我国已进入老龄化社会,社会养老保障的压力日趋增大。作为我国养老服务方式的有效补充,社区日间照料养老服务能够缓解养老压力。但是,随着社会经济的发展,传统的社区日间照料养老服务面临着严峻的挑战,而社工介入社区日间照料养老服务,可以弥补传统的社区日间照料养老服务的不足之处。通过对调查数据的统计分析,了解老年人的日常生活状况及日间照料中心的发展状况,明确社工介入社区日间照料中心所要扮演的角色和面临的困境,提高社会养老服务水平。 | 刘延利 刘鑫昆 杜照柳 LV Qiaona ZOU Libin SONG Lin WANG Chengdi | 2018 | 山东英才学院学报2018，0，1： | 0 |
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