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| 1 | H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘 | Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen | 2017 | Cell Research2017，27，12： | 70 |
| 2 | Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors显示文摘Multipotent 神经干细胞为房间治疗保持大诺言。到导致的 pluripotent 干细胞以及成熟神经原的成纤维细胞的 reprogramming 建议可能性没有首先建立 pluripotency,把一个严重地区分的体的房间变换成一个 multipotent 状态。这里,我们证明房间从中层导出的那 Sertoli 能直接被变换成拥有神经干细胞性质的一个 multipotent 状态。导致的神经干细胞(iNSCs ) 表示多重 NSC 特定的标记,展出类似于正常 NSC 的全球基因表示侧面,并且能够自强并且区分功能的神经原进神经胶质并且 electrophysiologically。为酷氨酸 hydroxylase (TH ) 积极的导出 iNSC 的神经原污点, γ -aminobutyric 酸,和胆碱 acetyltransferase。另外, iNSCs 能熬过并且产生跟随移植进有牙齿的回转的触处。iNSCs 的产生可以为疾病建模和再生药有重要含意。 | Chao Sheng Qinyuan Zheng Jianyu Wu Zhen Xu Libin Wang Wei Li Haijiang Zhang Xiao-Yang Zhao Lei Liu Ziwei Wang Changlong Guo Hua-Jun Wu Zhonghua Liu Liu Wang Shigang He Xiu-Jie Wang Zhiguo Chen Qi Zhou | 2012 | Cell Research2012，22，1： | 31 |
| 3 | A Novel Rice bHLH Transcription Factor, DTD, Acts Coordinately with TDR in Controlling Tapetum Function and Pollen Development显示文摘Dear Editor, Male reproductive development is an essential biological process for flowering plants and crucial for crop seed production.Formation of the male reproductive organ,the anther,involves a number of developmental events,including stamen meristem specification,generation of sporogenous cells and their differentiation into microspore mother cells (MMCs),meiosis,microspore (pollen) maturation,and pollination (Ma,2005).The formation of microspores and their development into mature pollen grains require cooperative interactions between gametophytic (microspores) and sporophytic (anther wall) cells,with the innermost cell layer,the tapetum,playing the most crucial role (Ma,2005).Tapetal cells undergo degeneration by programmed cell death (PCD). | Chonghui Ji Heying Li Libin Chen Min Xie Fengping Wang Yuanling Chen Yao-Guang Liu | 2013 | Molecular Plant2013，6，5： | 14 |
| 4 | DISTRIBUTION AND CHARACTERIZATION OF POLYCYCLIC AROMATIC HYDROCARBON COMPOUNDS IN AIRBORNE PARTICULATES OF EAST ASIA显示文摘A review is presented on the distribution and characterization of polycyclic aromatic hydrocarbons (PAHs) and their derivatives, including nitro-PAHs and hydro-PAHs, on atmospheric particulates of East Asia. Generally, PAH compounds with two or three aromatic rings are released mainly into the gas phase, while those containing three or more aromatic rings are associated with particulate matter (PM) emission. Particle-associated PAHs are primarily adsorbed on fine particles, and little associated with coarse particles. Investigation into the concentration level of PAHs in different areas can serve not only to reflect the pollutant status and sources but also to lead to the formulation of control strategies. The results of the present study show that China has more severe PAH pollution than such East Asian countries as Ja-pan and Korea. | Yan Liu Libin Liu Jin-Ming Lin Ning Tang Kazuichi Hayakawa | 2006 | China Particuology2006，4，6： | 14 |
| 5 | Generation of dopaminergic neurons directly from mouse fibroblasts and fibroblast-derived neural progenitors显示文摘 | Chao Sheng Qinyuan Zheng Jianyu Wu Zhen Xu Lisi Sang Libin Wang Changlong Guo Wanwan Zhu Man Tong Lei Liu Wei Li Zhong-Hua Liu Xiao-Yang Zhao Liu Wang Zhiguo Chen Qi Zhou | 2012 | Cell Research2012，22，4： | 12 |
| 6 | Effects of baicalein on pancreatic cancer stem cells via modulation of sonic Hedgehog pathway显示文摘 | Libin Song Xiangyuan Chen Peng Wang Song Gao Chao Qu Luming Liu | 2018 | Acta Biochimica et Biophysica Sinica2018，50，6： | 10 |
| 7 | Development strategies for the sea cucumber industry in China显示文摘The sea cucumber, Apostichopus japonicus, is an important marine aquaculture species in China. After nearly thirty years of development, the production of A. japonicus has become commercially lucrative and successful. In this report, current advances in sea cucumber industry are addressed in terms of the basic biology, culturing methods, and health care bene?ts. Next, the challenges restricting development of the sea cucumber industry are discussed, including weaknesses in the basic biological research, the problem of germplasm degradation, environmental stress caused by global climate change, and food safety problems. Finally, several strategies are presented that might contribute to sustainable development of the sea cucumber industry. These strategies include advances in genome studies, behavioral studies, selective breeding, ecological culture technologies, reforms in food safety management, and the development of health care functions based on contemporary medical practices. Thus, our work provides new insights into how to explore the sustainable development of the sea cucumber industry in the future. | RU Xiaoshang ZHANG Libin LI Xiaoni LIU Shilin YANG Hongsheng | 2019 | Journal of Oceanology and Limnology2019，37，1： | 10 |
| 8 | Revisiting ovarian cancer microenvironment: a friend or a foe?显示文摘 | Boyi Zhang Fei Chen Qixia Xu Liu Han Jiaqian Xu Libin Gao Xiaochen Sun Yiwen Li Yan Li Min Qian Yu Sun | 2018 | Protein & Cell2018，9，8： | 6 |
| 9 | PCN-Fe(Ⅲ)-PTX nanoparticles for MRI guided high efficiency chemo-photodynamic therapy in pancreatic cancer through alleviating tumor hypoxia显示文摘As nanomedicine-based clinical strategies have continued to develop,the possibility of combining chemotherapy and singlet oxygen-dependent photodynamic therapy(PDT)to treat pancreatic cancer(PaC)has emerged as a viable therapeutic modality.The efficacy of such an approach,however,is likely to be constrained by the mechanisms of drug release and tumor oxygen levels.In the present study,we developed an Fe(Ⅲ)-complexed porous coordination network(PCN)which we then used to encapsulate PTX(PCN-Fe(Ⅲ)-PTX)nanoparticles(NPs)in order to treat PaC via a combination of chemotherapy and PDT.The resultant NPs were able to release drug in response to both laser irradiation and pH changes to promote drug accumulation within tumors.Furthermore,through a Fe(Ⅲ)-based Fenton-like reaction these NPs were able to convert H2O2 in the tumor site to O2,thereby regulating local hypoxic conditions and enhancing the efficacy of PDT approaches.Also these NPs were suitable for use as a T1-MRI weighted contrast agent,making them viable for monitoring therapeutic efficacy upon treatment.Our results in both cell line and animal models of PaC suggest that these NPs represent an ideal agent for mediating effective MRI-guided chemotherapy-PDT,giving them great promise for the clinical treatment of PaC. | Tao Zhang Zhenqi Jiang Libin Chen Chunshu Pan Shan Sun Chuang Liu Zihou Li Wenzhi Ren Aiguo Wu Pintong Huang | 2020 | Nano Research2020，13，1： | 4 |
| 10 | Proteasomal deubiquitinase UCH37 inhibits degradation of β-catenin and promotes cell proliferation and motility显示文摘The ubiquitin–proteasome system degrades most cellular proteins in eukaryotes.UCH37,also known as UCH-L5,is a deubiquitinase binding to Rpn13,a receptor for ubiquitinated substrates in the 26 S proteasome.But,it remains unclear how UCH37 influences the proteasomal degradation of the ubiquitinated substrates.Because deletion of UCH37 is embryonically lethal in mice,this study aims to investigate the role of UCH37 in proteasomal degradation by constructing the UCH37-deficient cell lines using CRISPR/Cas9 technology.Our results demonstrated that deletion of UCH37 decreased the levels of proteasomal Rpn13,implying that UCH37 might facilitate incorporation of Rpn13 into the proteasome.Meanwhile,deletion of UCH37 decreased the levels of β-catenin and the early endosomal protein Rab8.β-Catenin interacts with TCF/LEF to control transcription,and is involved in development,tissue homeostasis and tumorigenesis.We further found that deletion of UCH37 increased the levels of the ubiquitinated β-catenin and accelerated the hydrogen peroxide-stimulated degradation of β-catenin.Deletion of UCH37 also down-regulated the transcription of c-Myc,a downstream effector of β-catenin,and inhibited cell proliferation and motility.These results raise the possibility that UCH37 maintains the homeostasis of proteasomal degradation reciprocally by assisting the recruitment of the ubiquitin receptor Rpn13 into the proteasome and by reversing ubiquitination of certain critical substrates of the 26 S proteasome. | Zijian Li Luming Zhou Tianxia Jiang Libin Fan Xiaoying Liu Xiaobo Qiu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，3： | 4 |
| 11 | TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2显示文摘Tripartite motif(TRIM)family proteins are important effectors of innate immunity against viral infections.Here we identified TRIM35 as a regulator of TRAF3 activation.Deficiency in or inhibition of TRIM35 suppressed the production of type I interferon(IFN)in response to viral infection.777m35-deficient mice were more susceptible to influenza A virus(IAV)infection than were wild-type mice.TRIM35 promoted the RIG-Imediated signaling by catalyzing Lys63-linked polyubiquitination of TRAF3 and the subsequent formation of a signaling complex with VISA and TBK1.IAV PB2 polymerase countered the innate antiviral immune response by impeding the Lys63-linked polyubiquitination and activation of TRAF3.TRIM35 mediated Lys48-linked polyubiquitination and proteasomal degradation of IAV PB2,thereby antagonizing its suppression of TRAF3 activation.Our in vitro and in vivo findings thus reveal novel roles of TRIM35,through catalyzing Lys63-or Lys48-linked polyubiquitination,in RIG-I antiviral immunity and mechanism of defense against IAV infection. | Nan Sun Li Jiang Miaomiao Ye Yihan Wang Guangwen Wang Xiaopeng Wan Yuhui Zhao Xia Wen Libin Liang Shujie Ma Liling Liu Zhigao Bu Hualan Chen Chengjun Li | 2020 | Protein & Cell2020，11，12： | 4 |
| 12 | STRUCTURE DESIGN OF THE BEIJING SPECTROMETERⅢBEAM PIPE显示文摘The Beijing spectrometerⅢ(BESⅢ)beam pipe is in the center of the BESⅢ,which is the detector of the upgrade project of Beijing electron and positron collider(BEPCⅡ).Electrons and positrons collide in the BESⅢbeam pipe.According to the demands of the BEPCⅡ,a key program of Chinese Academy of Sciences,the BESⅢbeam pipe is designed based on the finite elements analysis.The BESⅢbeam pipe is installed in the inner cylinder of the BESⅢdrift chamber.As a vacuum tube,the BESⅢbeam pipe is designed as 1000 mm in length,63 mm in inner diameter and 114 mm in outer diameter,respectively.The BESⅢbeam pipe consists of a central beryllium pipe cooled by EDM-1,the oil No.1 for electric discharge machining,and two extended copper pipes cooled by deionized water(DW).The three parts are jointed by vacuum welding.Factors taken into account in the design are as follows.①The wall thickness of the central beryllium pipe should be designed as small as possible to reduce the multi-scattering and improve the particle momentum resolution.And the wall thickness of the extended copper pipe should be designed as large as possible to protect the detectors from the backgrounds.②The BESⅢbeam pipe must be sufficiently cooled to avoid the damage and prevents its influence to the BESⅢdrift chamber(DC)operation.The inner surface temperature of the DC inner cylinder must be maintained at 293±2 K.③The magnetic permeability of the materials used in the BESⅢbeam pipe must be less than 1.05 H/m to avoid large magnetic field distortions.④The static pressure of the vacuum chamber of the BESⅢbeam pipe must be less than 800μPa.The simulating results show that the designed structure oftbe BESⅢbeam pipe satisfies the requirements mentioned above.The structure design scheme is evaluated and adopted by the headquarters of BEPCⅡ. | ZHENG Lifang JI Quan WANG Li LI xunfeng XU Shaowang DONG Sujun ZHAO Libin LIU Jianping | 2008 | Chinese Journal of Mechanical Engineering2008，21，3： | 3 |
| 13 | Designing high-strength titanium alloy using pseudo-spinodal mechanism through diffusion multiple experiment and CALPHAD calculation显示文摘This study used the pseudo-spinodal mechanism to obtain the ultrafineαphase for designing highstrength titanium alloy.Diffusion multiple experiments were designed to find the composition range of TM-x Mo-y V alloy(TM:Ti-4.5 Al-2 Cr-2.5 Nb-2 Zr-1 Sn)for obtaining ultrafineαphase.CALPHAD results confirm that when the alloy composition is located near the intersection of theαandβphase free energy curves,the alloy will undergo pseudo-spinodal transformation and obtain the ultrafineαphase.The designed TM-6 Mo-3 V alloy has a yield strength of 1411 MPa and an elongation of 6.5%.The strength of the alloy depends on the thickness,fraction of theαphase and the solid solution strengthening effect of the alloying elements.The deformation mechanism of the alloy is the dislocation slip of theαandβphases and the twin deformation of theαphase.The large number ofα/βinterfaces produced by the fineαphase is the main reason for limiting the ductility of the alloy.The use of the pseudo-spinodal mechanism combined with diffusion multiple experiments and CALPHAD is an effective method for designing high-strength titanium alloys. | Di Wu Libin Liu Lijun Zeng Wenguang Zhu Wanlin Wang Xiaoyong Zhang Junfeng Hou Baoliang Liu Jiafeng Lei Kechao Zhou | 2021 | Journal of Materials Science & Technology2021，，15： | 3 |
| 14 | Low carbon storage of woody debris in a karst forest in southwestern China显示文摘The properties of woody debris(WD) vary across different forests under various soil conditions.Owing to the relatively shallow and low amounts of soils on karst terrains, it is necessary to determine the WD carbon inventory of karst forests. In this study, we recorded WD with a basal diameter for standing snags and the largeend diameter for fallen logs of ≥ 1 cm. The carbon density of WD in a secondary karst mixed evergreen and deciduous broad-leaved forest that had been clear-cut 55 years ago in southwestern China were inventoried in a 2 ha plot. Woody debris carbon density calculated using specific gravity and carbon concentration was 4.07 Mg C ha^-1. Woody debris with diameters ≥ 10 cm(coarse WD) constituted 53.8% of total carbon storage whereas WD < 10 cm in diameters(fine WD) accounted for more pieces of WD(89.9%).Lithocarpus confinis contributed the most WD carbon(26.5%). Intermediate decayed WD was relatively more abundant, but WD with final decay contributed the least to the total pieces of WD(6.7%). The contribution of WD to carbon storage of karst forest was low compared to other forests worldwide. Significant positive correlations were found between WD carbon and biodiversity(R^2= 0.035,p < 0.01) and elevation(R^2= 0.047, p < 0.01) and negative correlations was found in outcrop coverage(R^2= 0.034, p <0.01). Further studies are needed to elucidate the ecological functions of WD to better understand their roles in maintaining biodiversity, enhancing productivity, and controlling vegetation degradation in karst forest ecosystems. | Yangyang Wu Libin Liu Chunzi Guo Zhonghua Zhang Gang Hu Jian Ni | 2019 | Acta Geochimica2019，38，4： | 3 |
| 15 | Comparison of pigment composition and melanin content among white,light-green,dark-green,and purple morphs of sea cucumber,Apostichopus japonicus显示文摘Sea cucumber, Apostichopus japonicus(Selenka), is a commercially important marine species in China. Among the differently colored varieties sold in China, white and purple sea cucumbers have the greatest appeal to consumers. Identification of the pigments that may contribute to the formation of different color morphs of sea cucumbers will provide a scientific basis for improving the cultivability of desirable color morphs. In this study,sea cucumbers were divided into four categories according to their body color: white, light green, dark green, and purple. The pigment composition and contents in the four groups were analyzed by high performance liquid chromatography(HPLC). The results show that the pigment contents differed significantly among the white, lightgreen, dark-green, and purple sea cucumbers, and there were fewer types of pigments in white sea cucumber than in the other color morphs. The only pigments detected in white sea cucumbers were guanine and pteroic acid.Guanine and pteroic acid are structural colors, and they were also detected in light-green, dark-green, and purple sea cucumbers. Every pigment detected, except for pteroic acid, was present at a higher concentration in purple morphs than in the other color morphs. The biological color pigments melanin, astaxanthin, β-carotene, and lutein were detected in light-green, dark-green, and purple sea cucumbers. While progesterone and lycopene,which are also biological color pigments, were not detected in any of the color morphs. Melanin was the major pigment contributing to body color, and its concentration increased with deepening color of the sea cucumber body. Transmission electron microscopy analyses revealed that white sea cucumbers had the fewest epidermal melanocytes in the body wall, and their melanocytes contained fewer melanosomes as well as non-pigmented pre-melanosomes. Sea cucumbers with deeper body colors contained more melanin granules. In the body wall of dark-green and purple sea cucumbers, melanin granules were secreted out of the cell. The results of this study provide evidence for the main factors responsible for differences in coloration among white, light-green, darkgreen, and purple sea cucumbers, and also provide the foundation for further research on the formation of body color in sea cucumber, A. japonicus. | XING Lili SUN Lina LIU Shilin LI Xiaoni MIAO Ting ZHANG Libin YANG Hongsheng | 2017 | Acta Oceanologica Sinica2017，36，12： | 3 |
| 16 | Sources of organic matter and paleo-environmental implications inferred from carbon isotope compositions of lacustrine sediments at Inexpressible Island, Ross Sea, Antarctica显示文摘The carbon isotopic composition of organic matter(δ^(13)C_(org)) was determined in two sediment cores(IIL1 and IIL9) recovered from Inexpressible Island, Ross Sea, Antarctica, and analyzed to identify the sources of that organic matter. The δ^(13)C_(org) values of sediments of IIL9 were found to vary between-14.6‰ and-11.6‰, with a mean of-13.4‰(n=48). These values were significantly higher than those of IIL1 sediments which varied between-23.2‰ and-20.4‰, with a mean of-21.8‰(n=55). The variation in δ^(13)C_(org) values in these two sediment cores indicate different sources of organic matter. The relatively high δ^(13)C_(org) values in IIL9 are in accordance with a source from algae, while the low δ^(13)C_(org) values in IIL1 evince significant influence from penguin guano with algae as the secondary source. Compared with the reference data from other high-latitude lake sediments and plants, the δ^(13)C_(org) values in IIL9 were extremely high, a result likely related to intense competition for CO_2 assimilation among algal species during the growing season in this relatively shallow pond. These results indicate that sedimentary δ^(13)C_(org) is a reliable proxy for paleo-primary productivity in ponds at Inexpressible Island. | WEI Yangyang JIN Jing NIE Yaguang CHEN Xin WU Libin FU Pingqing LIU Xiaodong Steven D.Emslie | 2016 | Advances in Polar Science2016，27，4： | 2 |
| 17 | Change of Organic δ^(13)C in Ornithogenic Sediments of the Xisha Archipelago,South China Sea and its Implication for Ecological Development显示文摘Organic carbon isotopes in sediments have been frequently used to identify the source of organic matter.Here we present a study of organic δ^(13)C on two sediment profiles influenced by guano from Guangjin and Jinqing islands in the Xisha Archipelago,South China Sea.Organic matter from ornithogenic coral sand sediments has two main sources,guano pellets and plant residues,and their organic δ^(13)C(δ^(13)C_(OM)) are significantly different.Organic carbon δ^(13)C_(guano) is much higher thanδ^(13)C_(plants),and δ^(13)C_(OM)of bulk samples is intermediate.Based on a two-end-member mixing model,the proportions of guano-and plant-derived organic matter in the bulk samples were reconstructed quantitatively.The results showed that seabirds began to inhabit the islands around approximately1200-1400 AD,and that guano pellets have been an important source of soil organic matter since then.With the accumulation of guano-derived nutrients,plants began to develop prosperously on the islands in the last 200 years,which is reflected by the significant increase of plant-derived organic matter in the upper sediment layer.However,guano-derived organic matter decreased greatly in recent decades,indicating a rapid decrease in seabird population.Our results show that organic δ^(13)C can be effectively used to quantitatively determine different source contributions of OM to bulk ornithogenic coral sand sediments. | WU Libin LIU Xiaodong XU Liqiang | 2017 | Acta Geologica Sinica(English Edition)2017，91，3： | 2 |
| 18 | Delay model of signalized roundabouts显示文摘In order to evaluate the service level of roundaboutsintuitively, a new delay model of signalized roundabouts isestablished. According to traffic flow characteristics in thesignalized roundabout, vehicle delays on roundabouts aredivided into two parts: entrance delay and circulating lanedelay. Entrance delay is calculated by the delay model inHCM2010. Circulating lane delay is studied by analyzingconflict behavior in signalized roundabouts, and the delaymodels of traffic flows turning in different directions areestablished based on the motorcade analysis method. Finally,the simulation software Vissim, calibrated with field data, isused to verify the model. The simulation results show that theaverage relative error of the model is 10. 1%, meeting theaccuracy requirements. Therefore, the delay model properlyreflects the operation efficiency of a roundabout, and can thusorovide a scientific basis for the design of control schemes. | Liu Huanfeng Song Xianmin Zhang Libin Tao Pengfei Yang Qiujie | 2017 | Journal of Southeast University(English Edition)2017，33，3： | 2 |
| 19 | 3 - 43 Effects on Seedling Growth and Antioxidant Enzymes Activity of Oil-sunflower Irradiated by Carbon Ion Beams显示文摘 | Liu Qingfang Li Wenjian Qu Ying Zhou Libin Yu Lixia Du Yan | 2010 | IMP & HIRFL Annual Report2010，，1： | 2 |
| 20 | Diagnosis Technology for the Icing Status of Wind Turbine Blades Based on Vibration Detection显示文摘对不同覆冰状态下的风力机叶片动力特性进行了模拟实验研究,定义叶片覆冰状态参数,包括覆冰区域起点参数、覆冰区域长度参数和覆冰厚度参数。利用人工环境实验室和模态分析系统建立风力机叶片覆冰振动测试实验台,对风力机模拟叶片在不同覆冰状态下进行模态分析,从叶片的曲率模态参数中提取判断风力机叶片覆冰参数的特征值指标,从实验结果获得的特征值较准确地诊断出风力机模拟叶片覆冰状态。通过仿真计算得到叶片结构的质量变化率和抗弯刚度变化率重合点。上述仿真及实验结果表明风力机叶片覆冰诊断理论方法以及技术具备正确性与可行性。 | LIU Shengxian LI Luping Yu Tao LEI Libin LI Mangmang | 2013 | 中国电机工程学报2013，33，32： | 2 |
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