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| 1 | H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘 | Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen | 2017 | Cell Research2017，27，12： | 70 |
| 2 | Transplantation of neurotrophin-3-transfected bone marrow mesenchymal stem cells for the repair of spinal cord injury显示文摘Bone marrow mesenchymal stem cell transplantation has been shown to be therapeutic in the repair of spinal cord injury. However, the low survival rate of transplanted bone marrow mesenchymal stem cells in vivo remains a problem. Neurotrophin-3 promotes motor neuron survival and it is hypothesized that its transfection can enhance the therapeutic effect. We show that in vitro transfection of neurotrophin-3 gene increases the number of bone marrow mesenchymal stem cells in the region of spinal cord injury. These results indicate that neurotrophin-3 can promote the survival of bone marrow mesenchymal stem cells transplanted into the region of spinal cord injury and potentially enhance the therapeutic effect in the repair of spinal cord injury. | Yuzhen Dong Libin Yang Lin Yang Hongxing Zhao Chao Zhang Dapeng Wu | 2014 | Neural Regeneration Research2014，9，16： | 16 |
| 3 | Carbon dioxide emissions from cities in China based on high resolution emission gridded data显示文摘Based on the China high resolution emission gridded data(1 km spatial resolution), this article is aimed to create a Chinese city carbon dioxide(CO_2) emission data set using consolidated data sources as well as normalized and standardized data processing methods. Standard methods were used to calculate city CO_2 emissions, including scope 1 and scope 2. Cities with higher CO_2 emissions are mostly in north, northeast, and eastern coastal areas. Cities with lower CO_2 emissions are in the western region. Cites with higher CO_2 emissions are clustered in the Jing-Jin-Ji Region(such as Beijing, Tianjin, and Tangshan), and the Yangtze River Delta region(such as Shanghai and Suzhou).The city per capita CO_2 emission is larger in the north than the south. There are obvious aggregations of cities with high per capita CO_2 emission in the north. Four cities among the top 10 per capita emissions(Erdos, Wuhai, Shizuishan, and Yinchuan) cluster in the main coal production areas of northern China. This indicates the significant impact of coal resources endowment on city industry and CO_2 emissions. The majority(77%) of cities have annual CO_2 emissions below 50 million tons. The mean annual emission, among all cities, is 37 million tons. Emissions from service-based cities, which include the smallest number of cities, are the highest. Industrial cities are the largest category and the emission distribution from these cities is close to the normal distribution. Emissions and degree of dispersion, in the other cities(excluding industrial cities and service-based cities), are in the lowest level. Per capita C02 emissions in these cities are generally below 20 t/person(89%) with a mean value of 11 t/person. The distribution interval of per capita CO_2 emission within industrial cities is the largest among the three city categories. This indicates greater differences among per capita CO_2 emissions of industrial cities. The distribution interval of per capita CO_2 emission of other cities is the lowest, indicating smaller differences of per capita CO_2 emissions among this city category. Three policy suggestions are proposed: first, city CO_2 emission inventory data in China should be increased,especially for prefecture level cities. Second, city responsibility for emission reduction, and partitioning the national goal should be established, using a bottom-up approach based on specific CO_2emission levels and potential for emission reductions in each city. Third, comparative and benchmarking research on city CO_2 emissions should be conducted, and a Top Runner system of city CO_2emission reduction should be established. | Bofeng Cai Jinnan Wang Shuying Yang Xianqiang Mao Libin Cao | 2017 | Chinese Journal of Population,Resources and Environment2017，15，1： | 10 |
| 4 | Development strategies for the sea cucumber industry in China显示文摘The sea cucumber, Apostichopus japonicus, is an important marine aquaculture species in China. After nearly thirty years of development, the production of A. japonicus has become commercially lucrative and successful. In this report, current advances in sea cucumber industry are addressed in terms of the basic biology, culturing methods, and health care bene?ts. Next, the challenges restricting development of the sea cucumber industry are discussed, including weaknesses in the basic biological research, the problem of germplasm degradation, environmental stress caused by global climate change, and food safety problems. Finally, several strategies are presented that might contribute to sustainable development of the sea cucumber industry. These strategies include advances in genome studies, behavioral studies, selective breeding, ecological culture technologies, reforms in food safety management, and the development of health care functions based on contemporary medical practices. Thus, our work provides new insights into how to explore the sustainable development of the sea cucumber industry in the future. | RU Xiaoshang ZHANG Libin LI Xiaoni LIU Shilin YANG Hongsheng | 2019 | Journal of Oceanology and Limnology2019，37，1： | 10 |
| 5 | Nanoparticles carrying neurotrophin-3-modified Schwann cells promote repair of sciatic nerve defects显示文摘Schwann cells and neurotrophin-3 play an important role in neural regeneration,but the secretion of neurotrophin-3 from Schwann cells is limited,and exogenous neurotrophin-3 is inactived easily in vivo.In this study,we have transfected neurotrophin-3 into Schwann cells cultured in vitro using nanoparticle liposomes.Results showed that neurotrophin-3 was successfully transfected into Schwann cells,where it was expressed effectively and steadily.A composite of Schwann cells transfected with neurotrophin-3 and poly(lactic-co-glycolic acid) biodegradable conduits was transplanted into rats to repair 10-mm sciatic nerve defects.Transplantation of the composite scaffold could restore the myoelectricity and wave amplitude of the sciatic nerve by electrophysiological examination,promote nerve axonal and myelin regeneration,and delay apoptosis of spinal motor neurons.Experimental findings indicate that neurotrophin-3 transfected Schwann cells combined with bridge grafting can promote neural regeneration and functional recovery after nerve injury. | Haibin Zong Hongxing Zhao Yilei Zhao Jingling Jia Libin Yang Chao Ma Yang Zhang Yuzhen Dong | 2013 | Neural Regeneration Research2013，8，14： | 7 |
| 6 | Kinematics and trajectory planning of a cucumber harvesting robot manipulator显示文摘In order to reduce cucumber harvesting cost and improve economic benefits,a cucumber harvesting robot was developed.The cucumber harvesting robot consists of a vehicle,a 4-DOF articulated manipulator,an end-effector,an upper monitor,a vision system and four DC servo drive systems.The Kinematics of the cucumber harvesting robot manipulator was constructed using D-H coordinate frame model.And the inverse kinematics which provides a foundation for trajectory planning has been solved with inverse transform technique.The cycloidal motion,which has properties of continuity and zero velocity and acceleration at the ports of the bounded interval,was adopted as a feasible approach to plan trajectory in joint space of the cucumber harvesting robot manipulator.Moreover,hardware and software based on CAN-bus communication between the upper monitor and the joint controllers have been designed.Experimental results show that the upper monitor communicates with the four joint controllers efficiently by CAN-bus,and the integrated errors of four joint angles do not exceed four degrees.Probable factors resulting in the errors were analyzed and the corresponding solutions for improving precision are proposed. | Zhang Libin Wang Yan Yang Qinghua Bao Guanjun Gao Feng Xun Yi | 2009 | International Journal of Agricultural and Biological Engineering2009，2，1： | 7 |
| 7 | Abrogation of Hn RNP L enhances anti-PD-1 therapy efficacy via diminishing PD-L1 and promoting CD8^(+) T cell-mediated ferroptosis in castration-resistant prostate cancer显示文摘Owing to incurable castration-resistant prostate cancer(CRPC)ultimately developing after treating with androgen deprivation therapy(ADT),it is vital to devise new therapeutic strategies to treat CRPC.Treatments that target programmed cell death protein 1(PD-1)and programmed death ligand-1(PD-L1)have been approved for human cancers with clinical benefit.However,many patients,especially prostate cancer,fail to respond to anti-PD-1/PD-L1 treatment,so it is an urgent need to seek a support strategy for improving the traditional PD-1/PD-L1 targeting immunotherapy.In the present study,analyzing the data from our prostate cancer tissue microarray,we found that PD-L1 expression was positively correlated with the expression of heterogeneous nuclear ribonucleoprotein L(Hn RNP L).Hence,we further investigated the potential role of Hn RNP L on the PD-L1 expression,the sensitivity of cancer cells to T-cell killing and the synergistic effect with anti-PD-1 therapy in CRPC.Indeed,Hn RNP L knockdown effectively decreased PD-L1 expression and recovered the sensitivity of cancer cells to T-cell killing in vitro and in vivo,on the contrary,Hn RNP L overexpression led to the opposite effect in CRPC cells.In addition,consistent with the previous study,we revealed that ferroptosis played a critical role in T-cell-induced cancer cell death,and Hn RNP L promoted the cancer immune escape partly through targeting YY1/PD-L1 axis and inhibiting ferroptosis in CRPC cells.Furthermore,Hn RNP L knockdown enhanced antitumor immunity by recruiting infiltrating CD8^(+)T cells and synergized with anti-PD-1 therapy in CRPC tumors.This study provided biological evidence that Hn RNP L knockdown might be a novel therapeutic agent in PD-L1/PD-1 blockade strategy that enhanced anti-tumor immune response in CRPC. | Xumin Zhou Libin Zou Hangyu Liao Junqi Luo Taowei Yang Jun Wu Wenbin Chen Kaihui Wu Shengren Cen Daojun Lv Fangpeng Shu Yu Yang Chun Li Bingkun Li Xiangming Mao | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 4 |
| 8 | Pharmacological Activation of RXR-a Promotes Hematoma Absorption via a PPAR-y-dependent Pathway After Intracerebral Hemorrhage显示文摘Endogenously eliminating the hematoma is a favorable strategy in addressing intracerebral hemorrhage(ICH).This study sought to determine the role of retinoid X receptor-ot(RXR-a)in the context of hematoma absorption after ICH.Our results showed that pharmacologically activating RXR-a with bexarotene significantly accelerated hematoma clearance and alleviated neurological dysfunction after ICH.RXR-ot was expressed in microglia/macro-phages,neurons,and astrocytes.Mechanistically,bexarotene promoted the nuclear translocation of RXR-a and PPAR-y,as well as reducing neuroinflammation by modulating microglia/macrophage reprograming from the Ml into the M2 phenotype.Furthermore,all the beneficial effects of RXR-a in ICH were reversed by the PPAR-y inhibitor GW9662.In conclusion,the pharmacological activation of RXR-a confers robust neuroprotection against ICH by accelerating hematoma clearance and repolarizing microglia/macrophages towards the M2 phenotype through PPAR-y-related mechanisms.Our data support the notion that RXR-ot might be a promising therapeutic target for ICH. | Chaoran Xu Huaijun Chen Shengjun Zhou Chenjun Sun Xiaolong Xia Yucong Peng Jianfeng Zhuang Xiongjie Fu Hanhai Zeng Hang Zhou Yang Cao Qian Yu Yin Li Libin Hu Guoyang Zhou Feng Yan Gao Chen Jianru Li | 2021 | Neuroscience Bulletin2021，37，10： | 4 |
| 9 | Effects of acrous gramineus and its component, alpha-asarone, on apoptosis of hippocampal neurons after seizure in immature rats显示文摘BACKGROUND: α-asarone and acrous gramineus have been shown to play a necessary function in enhancing the reactivity and convulsant threshold to electric stimulation of immature rats. They have also been shown to effectively suppress epileptic seizures induced by pentylenetetrazol in young rats. However, the mechanisms for these roles have been still unclear. OBJECTIVE: To observe the effects in immature rats of acrous gramineus and α-asarone on apoptosis of hippocampal neurons after epileptic seizure at the protein level, and to analyze the mechanism for these effects. DESIGN: A randomized controlled animal experiment. SETTINGS: Department of Pediatrics, First Hospital of Jilin University; Department of Histology and Embryology, Norman Bethune Medical School of Jilin University; Department of Internal Medicine, Children's Hospital of Changchun City; Department of Neurology, First Clinical Hospital affiliated to Harbin Medical University. MATERIALS: Fifty 3-week old Wistar rats, 34-40 g, irrespective of gender, were provided by Gaoxin Research Center of Medical Animal Experiment, Changchun. The animals were treated according to the animal ethical standards. The following chemicals were used for this study: acrous gramineus powders or infusion (Batch No. 0307113, Tianjiang Medicine Company Limited, Jiangyin), α-asarone tablets (Batch No. 030219, Tianwei Pharmaceutical Factory, Shenyang), and phenobarbital sodium tablets (Batch No. 020608, Xinya Medicine Company Limited, Shanghai). The animals were divided into five groups randomly. First, ten rats were chosen as the normal controls. The remaining rats were treated with i.p. injections of pentylenetetrazol to stimulate an epileptic model. METHODS: The experiments were performed at the Neurological Laboratory of the First Hospital of Jilin University between October and December 2004. The rats were treated with i.p. injections of pentylenetetrazol (60 mg/kg) to establish an epileptic model. According to Racine' s standard, animals that reached stage 4 and 5 were chosen and randomly divided into 4 groups: model group, phenobarbital sodium, acrous gramineus, and α-asarone group. The normal control group was treated with an i.p. injection of physiological saline (0.5 mL). After modeling, the model groups were intragastrically administrated 0.5 mL saline. The phenobarbital sodium, acrous gramineus, and α -asarone groups were intragastrically administrated 18 mg/kg/d phenobarbital sodium, 2 350 mg/kg/d acrous gramineus and 29 mg/kg/d α -asarone, respectively. The course of treatment was twice a day for 7 days. The normal group received intragastric administration of 0.5 mL saline at the same time. The rats were sacrificed and brain sections were prepared for light microscopy and electron microscopy. MAIN OUTCOME MEASURES: ① Pathological changes of CA1 and CA3 hippocampal region neurons were observed by light microscopy and electronic microscopy. ② Neuronal apoptosis in the CA1 and CA3 region was measured by TUNEL staining. ③ Bcl-2 and Bax expression in CA1 and CA3 region neurons was detected by immunohistochemistry and a ratio of Bcl-2/Bax was calculated. RESULTS: All 50 immature rats were included in the final analysis. ① Pathological changes of CA1 and CA3 region hippocampal neurons: there were different pathological changes in all groups other than the normal control group. The number of damaged neurons in the model group was highest. The phenobarbital sodium, acrous gramineus, and α-asarone group exhibited different degrees of improvement. ② Neuronal apoptosis in the CA1 and CA3 regions: there were less TUNEL-positive cells in the CA1 and CA3 regions in the normal control group. One week after PTZ-induced seizure, numerous TUNEL-positive cells were detected in the CA1 and CA3 regions in the remaining four groups. There was a significant difference between the normal control group and the remaining four groups (t = 12.089-19.162, P < 0.01). The number of TUNEL-positive cells was less in the phenobarbital sodium, acrous gramineus, and α-asarone groupscompared to the model group (t = 4.707-6.268, P < 0.01). ③Bcl-2 and Bax expression of neurons in the CA1 and CA3 regions: The number of Bcl-2- and Bax-positive cells was less in the normal control group. The Bax-positive cells exhibited a normal shape and had large round nuclei that were predominant. One week after PTZ-induced epilepsy, the number of Bcl-2- and Bax-positive cells in the CA1 and CA2 regions was significantly increased in the remaining four groups compared to the normal control group (t = 11.606-27.042, P < 0.01). The Bax-positive cells exhibited a reduced size and nuclear pyknosis was predominant. However, there was no significant difference among the four groups (P > 0.05). The number of Bcl-2-positive cells in the phenobarbital sodium, acrous gramineus, and α -asarone groups were significantly increased compared to the model group (t = 4.051-6.404, P < 0.01). However, the number of Bax-positive cells was not significantly different among the four groups. The ratio of Bcl-2 to Bax expression was approximately 6.0 in the normal controls, 0.7 in the model group, and 1.0 in the remaining three groups. CONCLUSION: Acrous gramineus and α-asarone increased Bcl-2 expression and decreased Bax expression, and also reduced the number of apoptotic hippocampal neurons during PTZ-induced epileptic seizures in immature rats. | Libin Yang Shulei Li Yanzhi Huang Jianmin Liang Yuhong Wang | 2008 | Neural Regeneration Research2008，3，1： | 4 |
| 10 | Overview of research on agricultural robots in China显示文摘As the representation of new concept agricultural machinery,agricultural robots possess great advantages of improving agricultural productivity,enhancing production environment and solving the problem of labor shortage.Therefore,the strategy for application of agricultural robots and precision agriculture to improve the intelligence and information level of agriculture is the inevitable trend for China’s agriculture in the twentieth century.Based on the developmental status of agricultural robots in China,the agricultural robots are categorized and the performances,structures and characteristics of various agricultural robots such as vegetable grafting robots,transplanting robots,spraying robots,mowing robots,harvesting robots,grading and detecting robots are amply introduced.It can be seen that vegetable grafting robots,spraying robots,harvesting robots,grading and detecting robots have already been put into production while others are still at experimental stage.At present,there are several problems such as low popularization,great limitations,high cost and low intelligence,which greatly restrict the development of agricultural robots in China.Thus,open agricultural robot system with good expansibility,generality and flexibility should be developed and adopted to decrease its cost and shorten developing cycle.The mechanical structure of robots should also be designed as simply as possible.Finally,multi-robot system would become another important development direction of agricultural robots in the future. | Zhang Libin Yang Qinghua Bao Guanjun Wang Yan Qi Liyong Gao Feng Xu Fang | 2008 | International Journal of Agricultural and Biological Engineering2008，1，1： | 4 |
| 11 | Effects of acrous gramimeus and its main component alpha-asarone on the reactivity and convulsive threshold of immature rats to electric stimulation显示文摘BACKGROUND: The traditional Chinese medicine acrous gramimeus is the dry rhizome of Acrous gramimeus Soland, a kind of Araceae familial perennial herb, which has a sedation action, anticonvulsant and antiepileptic effect. Its effective component has not been known yet, and α-asarone, the major component of the volatile oil extracted from acrous gramineus, has been supposed to play a necessary role in it. OBJECTIVE: To explore the effects of acrous gramimeu and α-asarone on the reactivity and convulsive threshold to electric stimulation in immature rats, furthermore, attempt to definitize the anticonvulsant effect of αasarone. DESIGN: A randomized controlled study. SETTINGS: Department of Pediatrics, First Hospital of Jilin University; Department of Histology and Embryology, School of Basic Medical Sciences of Jilin University; Department of Neurology, First Clinical Hospital affiliated to Harbin Medical University; Department of Internal Medicine, Children’s Hospital of Changchun City. MATERIALS: Seventy 3-week immature Wistar rats (either males or females) of 34-40 g were used. Acrous gramimeu (1 g/bag, the content of α-asarone was 0.046 26%-0.070 16%) with the batch number of 0307113 was provided by Tianjiang Medicine Company Limited, Jiangyin City. α-asarone tablet (60 mg per tablet) with the batch number of 030219 was provided by Tianwei Pharmaceutical Factory, Shenyang City. α-asarone injectable preparation (2 mL per piece) with the batch number of 030105 was provided by Shuanghe Medicine Limited Company, Beijing City. METHODS: The experiments were carried out in the Neurological Laboratory of the First Hospital of Jilin University between August and October in 2004. ① The 70 rats were randomly divided into intragastric subset and intraperitoneal subset. The intragastric subset included four groups of control, phenobarbital sodium, acrous gramimeu and α-asarone; the intraperitoneal subset included three groups of control, phenobarbital sodium and α-asarone. There were 10 rats per group. ② In the intragastric subset, different group was treated with saline (1 mL for each time, phenobarbital sodium (18 mg/kg per day), acrous gramineu (2 350 mg/kg per day) and α-asarone (29 mg/kg per day) respectively twice every day for 5 days. In the intraperitoneal subset, different group was treated with saline (0.5 mL), phenobarbital sodium (29 mg/kg) and α-asarone (2.9 mg/kg) respectively. ③ Before and after administration for 5 days in the intragastric subset as well as before and after administration for about 1 hour in the intraperitoneal subset respectively, the rats were given electric stimulation with the NIHOM KOMDEM multifunctional electrophysiological recorder, and the reactivity and convulsive threshold to electric stimulation of the rats were recorded. MAIN OUTCOME MEASURES: The reactivity and convulsive threshold to electric stimulation in immature rats were compared. RESULTS: All the rats were involved in the analysis of results. ① Results for intragastric administration: Before intragastric administration, there were no obvious differences in the reactivity and convulsive threshold to electric stimulation among the groups (P > 0.05). After intragastric administration for 5 days, the reactivity and convulsive threshold to the electric stimulation had no obvious changes in the control group, but those were significantly higher than before administration in the drug administration groups (t=3.317-7.401, P < 0.01), which were also obviously higher than those in the control group (t=3.027-8.941, P < 0.01), and those in the acrous gramimeu group and α-asarone group were not markedly different from those in the phenobarbital sodium group. ② Results for intraperitoneal injection: Before intraperitoneal injection, the reactivity and convulsive threshold to the electric stimulation had no obvious differences among the groups. After the intraperitoneal injection for 1 hour, the reactivity and convulsive threshold to the electric stimulation had no obvious change in the control group, but those were significantly higher than before administration in the drug administration groups (P < 0.01), which were also obviously higher than those in the control group (t=6.211-7.237, P < 0.01; t=4.085-5.633, P < 0.05), and there was no marked difference between α-asarone group and phenobarbital sodium group (P > 0.05). CONCLUSION: ① As effective anticonvulsants, both acrous gramineu and α-asarone can enhance the reactivity and convulsive threshold of immature rats to electric stimulation. ② As one of the major effective components against convulsion of acrous gramineu, α-asarone is equivalent to phenobarbital sodium. | Libin Yang Shulei Li Yuhong Wang Yanzhi Huang | 2006 | Neural Regeneration Research2006，1，1： | 3 |
| 12 | Comparison of pigment composition and melanin content among white,light-green,dark-green,and purple morphs of sea cucumber,Apostichopus japonicus显示文摘Sea cucumber, Apostichopus japonicus(Selenka), is a commercially important marine species in China. Among the differently colored varieties sold in China, white and purple sea cucumbers have the greatest appeal to consumers. Identification of the pigments that may contribute to the formation of different color morphs of sea cucumbers will provide a scientific basis for improving the cultivability of desirable color morphs. In this study,sea cucumbers were divided into four categories according to their body color: white, light green, dark green, and purple. The pigment composition and contents in the four groups were analyzed by high performance liquid chromatography(HPLC). The results show that the pigment contents differed significantly among the white, lightgreen, dark-green, and purple sea cucumbers, and there were fewer types of pigments in white sea cucumber than in the other color morphs. The only pigments detected in white sea cucumbers were guanine and pteroic acid.Guanine and pteroic acid are structural colors, and they were also detected in light-green, dark-green, and purple sea cucumbers. Every pigment detected, except for pteroic acid, was present at a higher concentration in purple morphs than in the other color morphs. The biological color pigments melanin, astaxanthin, β-carotene, and lutein were detected in light-green, dark-green, and purple sea cucumbers. While progesterone and lycopene,which are also biological color pigments, were not detected in any of the color morphs. Melanin was the major pigment contributing to body color, and its concentration increased with deepening color of the sea cucumber body. Transmission electron microscopy analyses revealed that white sea cucumbers had the fewest epidermal melanocytes in the body wall, and their melanocytes contained fewer melanosomes as well as non-pigmented pre-melanosomes. Sea cucumbers with deeper body colors contained more melanin granules. In the body wall of dark-green and purple sea cucumbers, melanin granules were secreted out of the cell. The results of this study provide evidence for the main factors responsible for differences in coloration among white, light-green, darkgreen, and purple sea cucumbers, and also provide the foundation for further research on the formation of body color in sea cucumber, A. japonicus. | XING Lili SUN Lina LIU Shilin LI Xiaoni MIAO Ting ZHANG Libin YANG Hongsheng | 2017 | Acta Oceanologica Sinica2017，36，12： | 3 |
| 13 | DC-CIK联合化疗治疗非小细胞肺癌的临床疗效评价(英文)显示文摘Objective: The aim of the study was to evaluate the safety and therapeutic effects of autologous dendritic cells co-cultured with cytokine-induced killer cells (DC-CIK) combined with chemotherapy in advanced non-small cell lung cancer (NSCLC) patients. Methods: Fifty patients with advanced NSCLC (stages III to IV), who had received therapies in our Center (Department of Biotherapy, Affiliated to Cancer Hospital of Shanxi Medical University, Taiyuan, China) from August 2008 to January 2010, were treated by DC-CIK + chemotherapy as the combined treatment group; fifty advanced NSCLC patients treated with chemotherapy at the same time served as controls. The immunologic function, short-term therapeutic effects, the 1-year survival rate, the life quality, the chemotherapy side effects were compared between the two groups, the safety and therapeutic effects of DC-CIK cells therapy were observed too. Results: There was no obvious change of subsets of T cells in peripheral blood before and after therapy in DC-CIK + chemotherapy group, and IFN-γ was improved after therapy in this group (P < 0.05); in chemotherapy alone group, the ratios of CD3+CD4+, CD3+CD8+, CD3-CD56+ cells and the secretion of IL-2, TNF-α decreased significantly after therapy (P < 0.05); the ratios of CD3+CD8+, CD3+CD56+ were improved after cell culture (P < 0.05). The disease control rate (DCR) of DC-CIK + chemotherapy group was higher than that in the chemotherapy alone group (78.0% vs 56.0%, P < 0.05); the 1-year survival rates of DC-CIK + chemotherapy group and chemotherapy alone group were 50% and 44% respectively, had no significant difference. Compared with chemotherapy alone group, the occurrence of chemotherapy side effects (including bone marrow suppression, nausea and vomiting, peripheral nerve toxicity) was less in the DC-CIK + chemotherapy group (P < 0.05). The physical and appetite were better in DC-CIK + chemotherapy group after therapy. Conclusion: To compare with simple chemotherapy, DC-CIK + chemotherapy for advanced NSCLC is safe and effective, and it can improve patients' life quality and remission rate, and prolong their survival time. | Junping Zhang Guanghua Mao Yaping Han Xiaoling Yang Huijing Feng Linzi Jia Ting Zhi Yan Xiao Libin Zhang Jiangtao Wang Tianliang Shi | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，2： | 3 |
| 14 | Delay model of signalized roundabouts显示文摘In order to evaluate the service level of roundaboutsintuitively, a new delay model of signalized roundabouts isestablished. According to traffic flow characteristics in thesignalized roundabout, vehicle delays on roundabouts aredivided into two parts: entrance delay and circulating lanedelay. Entrance delay is calculated by the delay model inHCM2010. Circulating lane delay is studied by analyzingconflict behavior in signalized roundabouts, and the delaymodels of traffic flows turning in different directions areestablished based on the motorcade analysis method. Finally,the simulation software Vissim, calibrated with field data, isused to verify the model. The simulation results show that theaverage relative error of the model is 10. 1%, meeting theaccuracy requirements. Therefore, the delay model properlyreflects the operation efficiency of a roundabout, and can thusorovide a scientific basis for the design of control schemes. | Liu Huanfeng Song Xianmin Zhang Libin Tao Pengfei Yang Qiujie | 2017 | Journal of Southeast University(English Edition)2017，33，3： | 2 |
| 15 | Occurrence and Epidemic Regularity of Wheat Stripe Rust in Nanchong City of Sichuan Province显示文摘In order to realize monitoring and early warning and comprehensive management of wheat stripe rust and to reduce its occurrence in Nanchong City,the occurrence and epidemic regularity of wheat stripe rust in Nanchong was studied by system monitoring and general survey,resistance identification,physiological race monitoring and meteorological data analysis. The initial occurrence location and spreading pathway of Puccinia striiformis f. sp. tritici( Pst) were first verified;there were two infection peaks of wheat stripe rust in Nanchong and one to three epidemic peaks in fields,in which the occurrence area of the first epidemic peak played a pivotal role in disease prevalence in that year; the cumulative occurrence area in late January was positively correlated with annual occurrence area,with the correlation coefficient of 0. 769; the prediction model for infected field rate,diseased plant rate and annual occurrence area was established. The internal reason for heavy occurrence and prevalence of wheat stripe rust in Nanchong was the decline or loss of wheat resistance against stripe rust,as well as the appearance of physiological races of Pst,which later became dominant races. Large fluctuation of temperature in warm winter and spring and more fog and dew days were external reasons responsible for prevalence of stripe rust. From 2002 to 2014,the accuracy rate of short-term prediction of wheat stripe rust reached 100%,while that of medium-term and long-term prediction reached over 98% and 95%,respectively,5%- 15% higher than that of the years before 1998. | Peng Changjia Bai Tikun Feng Libin Ding Pan Yang Yuheng | 2015 | Plant Diseases and Pests2015，6，6： | 2 |
| 16 | Fruit harvesting continuum manipulator inspired by elephant trunk显示文摘By combining the investigation of the biomechanics and behavior of elephant trunk in the performance of a wide range of dexterous manipulations,a novel approach in the design and kinematics modeling of a fruit harvesting continuum manipulator was proposed.By comparing the structure of two different species of elephant trunk,a new continuum structure which matched the key features of elephant trunk was designed.Based on analysis of the underlying elephant trunk’s grasping mode,a novel kinematics model was proposed.Contrast to traditional robot kinematics which focused on end effector’s position and posture,the proposed continuum manipulator kinematics focus on the center of manipulator’s position and posture,which is more effective when trunk robot realizing grasp and establishes the foundation for its application.Finally,three typical grasping experiments were implemented.The experiment results showed that the manipulator could conduct wrap/pinch manipulations effectively for both small objects and bigger ones. | Shao Tiefeng Zhang Libin Du Mingyu Bao Guanjun Yang Qinghua | 2015 | International Journal of Agricultural and Biological Engineering2015，8，1： | 2 |
| 17 | Zircon U-Pb geochronology,geochemistry and geological significance of Xiarihamu granodiorite in Eastern Kunlun orogenic belt,Qinghai显示文摘Zircon U-Pb geochronology and geochemistry of the granodiorites in Xiarihamu Cu-Ni mining area are studied to determine the formation age,genesis and tectonic setting. The results show that the granodiorites formed in the Middle Triassic with weighted average age of 242 ± 1 Ma. The granodiorites comprise of SiO_2 of 61. 34%--62. 54%,Al_2 O_3 of 16. 46%--16. 87%,MgO of 2. 37%--2. 66%,( Na_2 O + K_2 O) of 5. 39%--5. 74%with the Na2 O/K_2 O of 1. 46--1. 88,Mg~# of 47. 03--48. 04,and show metaluminous characteristics with A/CNK of 0. 94--0. 96,belonging to calc-alkaline I-type granites geochemically. The light and heavy rare earth elements in the rocks are distinctly fractionated and have ' right-inclined' distribution patterns with weak negative Eu anomalies( δEu = 0. 84--0. 91). Moreover,these samples show enrichments in LILEs( e. g.,Rb,Ba,K and Sr),especially in Sr [( 343--452) × 10^(-6)],and obvious depletions in HFSEs( e. g.,Nb,Ta,Ti and P),indicating geochemical characteristics similar to subduction-related magmatic rocks. According to the regional tectonic evolution,the Xiarihamu granodiorites were emplaced under an Andean-type active continental margin environment in the early Indosinian,possessing a crust-mantle mixing origin. | YANG Baorong MA Zhongxian ZHANG Libin WANG Xiaoyun YAN Zhengping | 2018 | Global Geology2018，21，4： | 1 |
| 18 | H7N9 Influenza Viruses Are Transmissible in Ferrets by Respiratory Droplet显示文摘 | Qianyi Zhang Jianzhong Shi Guohua Deng Jing Guo Xianying Zeng Xijun He Huihui Kong Chunyang Gu Xuyong Li Jinxiong Liu Guojun Wang Yan Chen Liling Liu Libin Liang Yuanyuan Li Jun Fan Jinliang Wang Wenhui Li Lizheng Guan Qimeng Li Huanliang Yang Pucheng Che | 2013 | Science2013，，6144： | 1 |
| 19 | New kinds of Dirac Energy Levels and their Crossing Regions显示文摘 | Yang Shuzheng Lin Libin | 2001 | Chin Phys Soc2001，10，11： | 1 |
| 20 | Genotyping of porcine circovirus type 2 from a variety of clinical conditions in China显示文摘 | Libin Wen Xin Guo Hanchun Yang | 2005 | Veterinary Microbiology2005，110，： | 1 |
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