|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Progress of Jinping Underground laboratory for Nuclear Astrophysics(JUNA)显示文摘Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given. | WeiPing Liu ZhiHong Li JiangJun He XiaoDong Tang Gang Lian Zhu An JianJun Chang Han Chen QingHao Chen XiongJun Chen ZhiJun Chen BaoQun Cui XianChao Du ChangBo Fu Lin Gan Bing Guo GuoZhu He Alexander Heger SuQing Hou HanXiong Huang Ning Huang BaoLu Jia LiYang Jiang Shigeru Kubono JianMin Li KuoAng Li Tao Li YunJu Li Maria Lugaro XiaoBing Luo HongYi Ma ShaoBo Ma DongMing Mei YongZhong Qian JiuChang Qin Jie Ren YangPing Shen Jun Su LiangTing Sun WanPeng Tan Isao Tanihata Shuo Wang Peng Wang YouBao Wang Qi Wu ShiWei Xu ShengQuan Yan LiTao Yang Yao Yang XiangQing Yu Qian Yue Sheng Zeng HuanYu Zhang Hui Zhang LiYong Zhang NingTao Zhang QiWei Zhang Tao Zhang XiaoPeng Zhang XueZhen Zhang ZiMing Zhang Wei Zhao Zuo Zhao Chao Zhou | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，4： | 3 |
| 2 | 96-Week Treatment of Tenofovir Amibufenamide and Tenofovir Disoproxil Fumarate in Chronic Hepatitis B Patients显示文摘Background and Aims:Tenofovir amibufenamide(TMF)is a novel phosphoramidated prodrug of tenofovir with nonin-ferior efficacy and better bone and renal safety to tenofovir disoproxil fumarate(TDF)in 48 weeks of treatment.Here,we update 96-week comparison results.Methods:Patients with chronic hepatitis B were assigned(2:1)to receive either 25 mg TMF or 300 mg TDF with matching placebo for 96 weeks.The virological suppression was defined as HBV DNA levels<20 IU/mL at week 96.Safety was evaluated thoroughly with focusing on bone,renal,and metabolic pa-rameters.Results:Virological suppression rates at week 96 were similar between TMF and TDF group in both HBeAg-positive and HBeAg-negative populations.Noninferior efficacy was maintained in the pooled population,while it was first achieved in patients with HBV DNA≥7 or 8 log10 IU/mL at baseline.Non-indexed estimated glomerular filtration rate for renal safety assessment was adopted,while a smaller decline of which was seen in the TMF group than in the TDF group(p=0.01).For bone mineral density,patients receiv-ing TMF displayed significantly lower reduction levels in the densities of spine,hip,and femur neck at week 96 than those receiving TDF.In addition,the lipid parameters were stable after week 48 in all groups while weight change still showed the opposite trend.Conclusions:TMF maintained similar efficacy at week 96 compared with TDF with continued superior bone and renal safety profiles(NCT03903796). | Zhihong Liu Qinglong Jin Yuexin Zhang Guozhong Gong Guicheng Wu Lvfeng Yao Xiaofeng Wen Zhiliang Gao Yan Huang Daokun Yang Enqiang Chen Qing Mao Shide Lin Jia Shang Huanyu Gong Lihua Zhong Huafa Yin Fengmei Wang Peng Hu Qiong Wu Chao Pan Wen Jia Chuan Li Chang’an Sun Junqi Niu Jinlin Hou TMF Study Group | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 3 |
| 3 | Micro/nanodevices for assessment and treatment in stomatology and ophthalmology显示文摘Micro/nanodevices have been widely applied for the real-time monitoring of intracellular activities and the delivery of exogenous substances in the past few years.This review focuses on miniaturized micro/nanodevices for assessment and treatment in stomatology and ophthalmology.We first summarize the recent progress in this field by examining the available materials and fabrication techniques,device design principles,mechanisms,and biosafety aspects of micro/nanodevices.Following a discussion of biochemical sensing technology from the cellular level to the tissue level for disease assessment,we then summarize the use of microneedles and other micro/nanodevices in the treatment of oral and ocular diseases and conditions,including oral cancer,eye wrinkles,keratitis,and infections.Along with the identified key challenges,this review concludes with future directions as a small fraction of vast opportunities,calling for joint efforts between clinicians and engineers with diverse backgrounds to help facilitate the rapid development of this burgeoning field in stomatology and ophthalmology. | An’an Sheng Long Lin Jia Zhu Jian Zhuang Jian Li Lingqian Chang Huanyu Cheng | 2021 | Microsystems & Nanoengineering2021，7，1： | 3 |
| 4 | Surveillance of pine wilt disease by high resolution satellite显示文摘Pine wilt disease caused by the pinewood nematode Bursaphelenchus xylophilus has led to the death of a large number of pine trees in China.This destructive disease has the characteristics of bring wide-spread,fast onset,and long incubation time.Most importantly,in China,the fatality rate in pines is as high as 100%.The key to reducing this mortality is how to quickly find the infected trees.We proposed a method of automatically identifying infected trees by a convolution neural network and bounding box tool.This method rapidly locates the infected area by classifying and recognizing remote sensing images obtained by high resolution earth observation Satellite.The recognition accuracy of the test data set was 99.4%,and the remote sensing image combined with convolution neural network algorithm can identify and determine the distribution of the infected trees.It can provide strong technical support for the prevention and control of pine wilt disease. | Hongwei Zhou Xinpei Yuan Huanyu Zhou Hengyu Shen Lin Ma Liping Sun Guofei Fang Hong Sun | 2022 | Journal of Forestry Research2022，33，4： | 2 |
| 5 | Zbed3 contributes to malignant phenotype of lung cancer via regulating β‐catenin and P120‐catenin 1显示文摘 | Chuifeng Fan Guiyang Jiang Xiupeng Zhang Yuan Miao Xuyong Lin Lan Luan Zhonghai Xu Yijun Zhang Huanyu Zhao Di Liu Enhua Wang | 2015 | Carcinog2015，，1： | 1 |
| 6 | A Per- sonalized Learning Content Adaptation Mechanism to Meet Diverse User Needs in Mobile Learning Environments显示文摘 | Su Junming Tseng Shian-Shyong Lin Huanyu | 2011 | User Modeling and User-adapted Interaction2011，21，12： | 1 |
| 7 | Annual Operation Status of SECRAL in 2009显示文摘 | Lu Wang Sun Liangting Feng Yucheng Guo Xiaohong Zhang Xuezheng Li Jingyu Cao Yun Wang Hui Ma Baohua Shang Yong Sha Shan Ma Hongyi Li Xixia Lin Shuhao Zhang Wenhui Jin Tao Zhao Huanyu Zhao Hongwei | 2009 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2009，，1： | 1 |
| 8 | Operation of LECR3显示文摘 | Feng Yueheng Ma Baohua Wang Hui Li Jinyu Cao Yun Shang Yong Lu Wang Sha Shan Ma Hongyi Zhang Wenhui Lin Shuhao Li Xixia Zhao Huanyu Miao Tingting Guo Xiaohong Zhang Xuezhen Sun Liangting | 2009 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2009，，1： | 1 |
| 9 | A personalized learning content adaptation mechanism to meet diverse user needs in mobile learning environments显示文摘 | Su Junming Tseng Shian-Shyong Lin Huanyu | 2011 | User Modeling and User-adapted Interaction2011，21，12： | 1 |
| 10 | Integrated analysis of gene expression and methylation profiles of novel pancreatic cancer cell lines with highly metastatic activity显示文摘Pancreatic cancer is one of the most lethal human malignancies, partly because of its propensity for metastasis. However, highly metastatic human pancreatic cancer cell lines suitable for studies of metastasis are currently lacking. Here we established two highly metastatic human pancreatic cancer cell lines, MIA PaCa-2 In8 and Panc-1 In8, by Matrigel induction assay. The cell lines were further characterized both in vitro and in vivo. MIA PaCa-2 In8 and Panc-1 In8 cells demonstrated increased migration and invasion compared with their respective parental cells. Following injection into nude mice, MIA PaCa-2 In8 and Panc-1 In8 cells resulted in more pulmonary metastases compared with the parental cells. Furthermore, analyses of m RNA, long non-coding RNA, micro RNA, and methylation profiling revealed that these factors were aberrantly regulated in the highly metastatic cells,indicating that they probably affected metastasis. We thus established and characterized two highly metastatic human pancreatic cell lines that could be used as valuable tools for future investigations into the pathogenesis, metastasis, and potential treatment of human pancreatic cancer. | Gang Yang Huanyu Wang Mengyu Feng Lei You Lianfang Zheng Taiping Zhang Lin Cong Yupei Zhao | 2019 | Science China(Life Sciences)2019，62，6： | 1 |
| 11 | 6 - 18 Operation Status of On-line Ion Sources in 2012显示文摘 | FengYucheng Lu Wang Li Jinyu Zhang Wenhui Ma Hongyi Ma Baohua Wang Hui Li Jiaqing Lin Shuhao Cao Yun Sha Shan W u Qi Guo Junwei Fang Xing Yang Yao Li Xixia Zhang Hengjuan Zhao Huanyu Zhang Xuezhen Sun Liangting Zhao Hongwei | 2012 | IMP & HIRFL Annual Report2012，，1： | 1 |
| 12 | Direct visualization of percolating metal-insulator transition in V_(2)O_(3) using scanning microwave impedance microscopy显示文摘Using the extensively studied V_(2)O_(3) as a prototype system, we investigate the role of percolation in metal-insulator transition(MIT). We apply scanning microwave impedance microscopy to directly determine the metallic phase fraction p and relate it to the macroscopic conductance G, which shows a sudden jump when p reaches the percolation threshold. Interestingly, the conductance G exhibits a hysteretic behavior against p, suggesting two different percolating processes upon cooling and warming. Based on our image analysis and model simulation, we ascribe such hysteretic behavior to different domain nucleation and growth processes between cooling and warming, which is likely caused by the decoupled structural and electronic transitions in V_(2)O_(3) during MIT. Our work provides a microscopic view of how the interplay of structural and electronic degrees of freedom affects MIT in strongly correlated systems. | Weiyan Lin Huanyu Zhang Yoav Kalcheim Xinchen Zhou Fubao Yang Yang Shi Yang Feng Yihua Wang Jiping Huang Ivan KSchuller Xiaodong Zhou Jian Shen | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，9： | 0 |
| 13 | Discovery of 4-cyclopropyl-3-(2-((1-cyclopropyl-1H-pyrazol-4-yl) amino) quinazolin-6-yl)-N-(3-(trifluoromethyl) phenyl) benzamides as potent discoidin domain receptor inhibitors for the treatment of idiopathic pulmonary fibrosis显示文摘Idiopathic pulmonary fibrosis(IPF)is a chronic fatal lung disease with a median survival time of 3–5 years.Inaccurate diagnosis,limited clinical therapy and high mortality together indicate that the development of effective therapeutics for IPF is an urgent need.In recent years,it was reported that DDRs are potential targets in anti-fibrosis treatment.Based on previous work we carried out further structure modifications and led to a more selective inhibitor 47 by averting some fibrosis-unrelated kinases,such as RET,AXL and ALK.Extensive profiling of compound 47 has demonstrated that it has potent DDR1/2 inhibitory activities,low toxicity,good pharmacokinetic properties and reliable in vivo anti-fibrosis efficacy.Therefore,we confirmed that discoidin domain receptors are promising drug targets for IPF,and compound 47 would be a promising candidate for further drug development. | Qi Wang Bixi Tang Dandan Sun Ying Dong Yinchun Ji Huanyu Shi Liwei Zhou Yueyue Yang Menglan Luo Qian Tan Lin Chen Yue Dong Cong Li Rongrong Xie Yi Zang Jingkang Shen Bing Xiong Jia Li Danqi Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 0 |
| 14 | Smart bioadhesives for wound healing and closure显示文摘The high demand for rapid wound healing has spurred the development of multifunctional and smart bioadhesives with strong bioadhesion,antibacterial effect,real-time sensing,wireless communication,and on-demand treatment capabilities.Bioadhesives with bio-inspired structures and chemicals have shown unprecedented adhesion strengths,as well as tunable optical,electrical,and bio-dissolvable properties.Accelerated wound healing has been achieved via directly released antibacterial and growth factors,material or drug-induced host immune responses,and delivery of curative cells.Most recently,the integration of biosensing and treatment modules with wireless units in a closed-loop system yielded smart bioadhesives,allowing real-time sensing of the physiological conditions(e.g.,pH,temperature,uric acid,glucose,and cytokine)with iterative feedback for drastically enhanced,stage-specific wound healing by triggering drug delivery and treatment to avoid infection or prolonged inflammation.Despite rapid advances in the burgeoning field,challenges still exist in the design and fabrication of integrated systems,particularly for chronic wounds,presenting significant opportunities for the future development of next-generation smart materials and systems. | Jia Zhu Honglei Zhou Ethan Michael Gerhard Senhao Zhang Flor Itzel Parra Rodríguez Taisong Pan Hongbo Yang Yuan Lin Jian Yang Huanyu Cheng | 2023 | Bioactive Materials2023，，1： | 0 |
| 15 | Comparative study of LiNiO_2, LiNi_(0.8)Co_(0. 2)O_2 and LiNi_(0.75)Al_(0.25)O_2 for lithium-ion batteries显示文摘The comparative study of LiNi0.8Co0.2O2 and LiNi0.75Al0.25O2 was carried out by X-ray diffraction (XRD) and electrochemical methods. The results show that Co and Al doping suppress the phase transition during charge-discharge. The experiments indicate that LiNi0.75Al0.25O2 has the better cycle-ability and over-charge resistance comparing with LiNi0.8Co0.2O2. The interfacial behavior was studied by use of electrochemical impedance spectroscopy (EIS). The results show that LiNi0.75Al0.25O2 has a slightly larger polarization character than LiNi0.8Co0.2O2. | Chuangang Lin, Weihua Qiu, Zhimin Li, Jialing Hong, Huanyu Hu, and Zhongqin LuLaboratory on Solid State Ionics, University of Science and Technology Beijing, Beijing 100083, China | 2002 | Journal of University of Science and Technology Beijing2002，9，6： | 0 |
| 16 | Nudging sustainable consumption of residential energy use:A behavioral economics perspective显示文摘1 Introduction How to achieve economic development while minimizing the negative impact on the environment is the challenge faced by policy makers.CO_(2)emissions in 2022,released by the International Energy Agency in March 2023,showed that global energy-related CO_(2)emissions increased by 0.9%or 321 million tons to a record high of over 36.8 billion tons in 2022. | Boqiang LIN Huanyu JIA | 2023 | Frontiers of Engineering Management2023，10，3： | 0 |
| 17 | Hub genes associated with immune cell infiltration in breast cancer, identified through bioinformatic analyses of multiple datasets显示文摘Objective:The aim of this study was to identify hub genes associated with immune cell infiltration in breast cancer through bioinformatic analyses of multiple datasets.Methods:Nonparametric(NOISeq)and robust rank aggregation-ranked parametric(EdgeR)methods were used to assess robust differentially expressed genes across multiple datasets.Protein-protein interaction network,GO,KEGG enrichment,and subnetwork analyses were performed to identify immune-associated hub genes in breast cancer.Immune cell infiltration was evaluated with the CIBERSORT,XCELL,and TIMER methods.The association between the hub gene-based risk signature and survival was determined through Kaplan–Meier survival analysis,multivariate Cox analysis,and a nomogram with external verification.Results:We identified 163 robust differentially expressed genes in breast cancer through applying both nonparametric and parametric methods to multiple GEO(n=2,212)and TCGA(n=1,045)datasets.Integrated bioinformatic analyses further identified 10 hub genes:CXCL10,CXCL9,CXCL11,SPP1,POSTN,MMP9,DPT,COL1A1,ADAMDEC1,and RGS1.The 10 hub-gene-based risk signature significantly correlated with the prognosis of patients with breast cancer.Moreover,these hub genes were strongly associated with the extent of infiltration of CD4+T cells,CD8+T cells,neutrophils,macrophages,and myeloid dendritic cells into breast tumors.Conclusions:Integrated analyses of multiple databases led to the discovery of 10 robust hub genes that together may serve as a risk factor characteristic of the immune microenvironment in breast cancer. | Huanyu Zhao Ruoyu Dang Yipan Zhu Baijian Qu Yasra Sayyed Ying Wen Xicheng Liu Jianping Lin Luyuan Li | 2022 | Cancer Biology & Medicine2022，19，9： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员