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| 1 | MicroRNA-548 down-regulates host antiviral response via direct targeting of IFN-λ1显示文摘Interferon(IFN)-mediated pathways are a crucial part of the cellular response against viral infection.Type III IFNs,which include IFN-λ1,2 and 3,mediate antiviral responses similar to Type I IFNs via a distinct receptor complex.IFN-λ1 is more effective than the other two members.Transcription of IFN-λ1 requires activation of IRF3/7 and nuclear factor-kappa B(NF-κB),similar to the transcriptional mechanism of Type I IFNs.Using reporter assays,we discovered that viral infection in-duced both IFN-λ1 promoter activity and that of the 3′-untranslated region(UTR),indicating that IFN-λ1 expression is also regulated at the post-transcriptional level.After analysis with microRNA(miRNA)prediction programs and 3′UTR targeting site assays,the miR-NA-548 family,including miR-548b-5p,miR-548c-5p,miR-548i,miR-548j,and miR-548n,was identified to target the 3′UTR of IFN-λ1.Further study demonstrated that miRNA-548 mimics down-regulated the expression of IFN-λ1.In contrast,their inhibitors,the complemen-tary RNAs,enhanced the expression of IFN-λ1 and IFN-stimulated genes.Furthermore,miRNA-548 mimics promoted infection by enterovirus-71(EV71)and ve-sicular stomatitis virus(VSV),whereas their inhibitors significantly suppressed the replication of EV71 and VSV.Endogenous miRNA-548 levels were suppressed during viral infection.In conclusion,our results sug-gest that miRNA-548 regulates host antiviral response via direct targeting of IFN-λ1,which may offer a poten-tial candidate for antiviral therapy. | Yongkui Li Jiajia Xie Xiupeng Xu Jun Wang Fang Ao Yushun Wan Ying Zhu | 2013 | Protein & Cell2013，4，2： | 22 |
| 2 | Late Mesozoic-Cenozoic dcollement structure and its deep geological background in western Shandong,China显示文摘Data from seismic reflection profiles, drilling, stratigraphy, structural deformation studies and physical rock properties reveal the existence of dcol1ement structures in both shallow and deep levels in western Shandong, China. The most outstanding shallow dcol1ement structures occur along the regional unconformity surface between the Cambrian and Archean, and the disconformity surface between the Carboniferous and Ordovician. The dcollement structure surface manifests as a fault zone with cataclastic rocks and asymmetrical folds. Some of the cataclastic rocks underwent dynamic metamorphism and hydrothermal alteration, including silicification, marbleization and specularite mineralization. Above the dcol1ement structure, the bottom of the Cambrian might be missing or overprinted because of dcollement. The striations, asymmetrical folds and boudinage structures indicate the direction of the main dcollement to the NNW and NNE. A deep level dcollement structure occurs at a depth of 12-22 km and up to 30 km distance to the south. The early Cretaceous and Eocene are two main periods of activity, with the Cretaceous dcollement probably initiated by mantle upwelling derived from subduction and collision of the Yangtze Plate with the North China Plate along the Tancheng-Lujiang Fault in the late Triassi-early Jurassic. This circumstance implies a multidirection of subduction and collision of these two plates in the early late Mesozoic. | Li, Li Zhong, Dalai Shi, Xiupeng Tang, Zibo Hu, Qiuyuan Xu, Yi Li, Zhiwei | 2009 | Progress in Natural Science:Materials International2009，19，5： | 12 |
| 3 | Non-contact cylindrical rotating triboelectric nanogenerator for harvesting kinetic energy from hydraulics显示文摘Hydraulics provide a unique and widely existed mechanical energy source around us,such as in water or oil pipes,and sewers.Here,a non-contact cylindrical rotating triboelectric nanogenerator(TENG)was developed to harvest the mechanical energy from water flows.Operation of the TENG was based on the non-contact free-rotating between a curved Cu foil and a flexible nanostructured fluorinated ethylene propylene(FEP)polymer film.The free-standing distance between two rotating interfaces avoided abrading of electrode materials.The TENG was able to effectively convert mechanical energy of the water flow into electricity.When driven by water flow,the output voltage and current of the TENG reached 1,670 V and 13.4 uA,respectively.Without any energy storage component,the produced electricity could instantaneously power 12 white light emitting diodes(LEDs)bulbs and a digital timer.This non-contact rotating TENG would provide new opportunities for harvesting energy from many types of hydraulics as a self-sustainable power source for sensing,detection,and protection. | Nan Zhang Cheng Qin Tianxing Feng Jun Li Zhirui Yang Xiupeng Sun Erjun Liang Yanchao Mao Xudong Wang | 2020 | Nano Research2020，13，7： | 4 |
| 4 | Arsenic concentration in peripheral blood is correlated with efficacy of a Traditional Chinese Medicine regimen containing realgar for the treatment of myelodysplastic syndromes显示文摘OBJECTIVE:To explore the relationship between the efficacy of realgar for the treatment of myelodysplastic syndromes with multilineage dysplasia(MDS-MLD)and arsenic concentration in the peripheral blood of patients.METHODS:In this prospective study,a total of 50 MDS-MLD patients were treated with traditional Chinese drugs containing realgar for 3 months in Xiyuan Hospital from March 2018 to January 2019.Routine blood examination as well as liver and kidney function were monitored before and after treatment.The concentration of arsenic in the peripheral blood was measured using an atomic fluorescence spectrometer after treatment.The correlation between clinical effect and arsenic concentration was analyzed by Spearman’s method.RESULTS:The treatment response rate was 54%.Two patients(4%)achieved complete remission,50%(25 of 50)showed hematologic improvement,and 23 patients had stable disease(23%).No disease progression was observed.Arsenic concentration in the peripheral blood ranged from 14.60 to 85.96μg/L.Clinical efficacy was positively correlated with arsenic concentration(P<0.05).The incidence of mild adverse reactions was 16%.CONCLUSION:A relatively high concentration of arsenic in the peripheral blood may improve the clinical efficacy of realgar in MDS-MLD patients. | WANG Dexiu XU Yonggang DU Yu WANG Hongzhi LI Liu HU Xiaomei YANG Xiupeng MA Rou ZHOU Qingbing | 2021 | Journal of Traditional Chinese Medicine2021，41，4： | 3 |
| 5 | A Concept Discussion on Northeast Asia Power Grid Interconnection显示文摘Northeast Asia is one of world’s major economic and energy consumption centers.Countries in this region are undergoing rapid economic and social development,and energy security and greenhouse gas emission reduction have become prominent issues.In this region,clean energy resources including hydro,wind,and solar are concentrated in Russia,Mongolia,and Northeast China,whilst electricity load centers are in East China,Korea and Japan.Currently,an energy and electricity model has been developed to project electricity demand through 2030 for each country.Based on the idea of a Global Energy Interconnection,this article proposes to establish a Northeast Asia Grid Interconnection(NEAG),connecting Mongolia,China,Korea,Japan,and Russia with large volumes of transmission lines,in an effort to facilitate optimized resource allocation.The NEAG would be accomplished step by step along with identification of key interconnectors.China is set to play an important role in establishing the NEAG by providing a strong sending grid and necessary technological equipment.Tremendous economic,environmental,and social benefits are expected to be generated by the NEAG. | Zhenya Liu Gesong Chen Xiupeng Guan Qiankun Wang Wei He | 2016 | CSEE Journal of Power and Energy Systems2016，2，4： | 3 |
| 6 | Characterization of the imprinting and expression patterns of ZAG2 in maize endosperm and embryo显示文摘ZAG2 has been identified as a maternally expressed imprinted gene in maize endosperm.Our study revealed that paternally inherited ZAG2 alleles were imprinted in maize endosperm and embryo at 14 days after pollination(DAP), and consistently imprinted in endosperm at 10, 12, 16, 18, 20, 22, 24, 26, and 28 DAP in reciprocal crosses between B73 and Mo17. ZAG2 alleles were also imprinted in reciprocal crosses between Zheng 58 and Chang7-2 and between Huang C and 178. ZAG2 alleles exhibited differential imprinting in hybrids of 178 × Huang C and B73 × Mo17, while in other hybrids ZAG2 alleles exhibited binary imprinting. The tissue-specific expression pattern of ZAG2 showed that ZAG2 was expressed at a high level in immature ears, suggesting that ZAG2 plays important roles in not only kernel but ear development. | Chaoxian Liu Jiuguang Wang Xiupeng Mei Xiaojing Deng Tingting Yu Xiaoli Liu Guoqiang Wang Zhizhai Liu Yilin Cai | 2015 | The Crop Journal2015，3，1： | 3 |
| 7 | 调强适形放疗在乳腺癌保乳术后应用的系统评价(英文)显示文摘Objective:The aim of this study was to assess the long-term effect of breast conservation with breast intensitymodulated radiotherapy (IMRT) for early-stage breast cancers.Methods:Pub Med,EMBASE,Cochrane Library,Chinese Biomedical Literature Database were searched to identify relevant original published trails,and the references of eligible studies were manually screened.Randomized controlled trails reported in any language,comparing breast IMRT with conventional radiotherapy (RT) in patients with early-stage breast cancer were eligible for inclusion.Two investigators independently assessed the quality of included trials and extracted data.The RevMan 5.0 software was used for statistical analysis.Results:Four trials involving 1440 patients were included.The results showed that in the IMRT group,the occurrence of acute moist dermatitis,the edema of the mammary gland and the occurrence of hyperpigmentation were lower than those of RT group,the pooled risk ratio value and 95% confidence interval were 0.28 (0.17-0.48),0.03 (0.00-0.21) and 0.06 (0.02-0.15) respectively.The use of IMRT did not correlate with pain and quality of life,but the presence of moist desquamation did significantly correlate with pain and reduced quality of life.Conclusion:The currently available evidence showed that IMRT significantly reduces the occurrence of moist acute dermatitis anywhere in the breast and alleviates the suffering of patients and improves the quality of life of patients.Future large-scale,high-quality,double-blind trials are needed. | Xiupeng Ye Ling Su Xiaohu Wang Kehu Yang inhui Tian Qiuning Zhang Qiang Wang Xiaojun Li Yuqing Kang Liyun Guo Ruifeng Liu Shifang Feng | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，12： | 2 |
| 8 | SUSTAINABLE SUGARCANE CROPPING IN CHINA显示文摘Demand for sugar is projected to grow in China for the foreseeable future.However,sugarcane production is unlikely to increase due to increasing production cost and decreasing profit margin.The persisting sugarcane yield plateau and the current cropping system with fertilizer overuse,soil acidification and pests and diseases remain the major productivity constraints.Sugarcane agriculture supports the livelihood of about 28 million farmers in South China;hence,sustaining it is a socioeconomic imperative.More compellingly,to meet the ever-increasing Chinese market demand,annual sugar production must be increased from the current 10 Mt to 16 Mt by 2030 of which 80% to 90% comes from sugarcane.Therefore,increasing sugar yield and crop productivity in an environmentally sustainable way must be a priority.This review examines the current Chinese sugarcane production system and discuss options for its transition to a green,sustainable cropping system,which is vital for the long-term viability of the industry.This analysis shows that reducing chemical inputs,preventing soil degradation,improving soil health,managing water deficit,provision of clean planting material,and consolidation of small farm holdings are critical requirements to transform the current farming practices into an economically and environmentally sustainable sugarcane cropping system. | Ting LUO Prakash LAKSHMANAN Zhongfeng ZHOU Yuchi DENG Yan DENG Linsheng YANG Dongliang HUANG Xiupeng SONG Xihui LIU Wen-Feng CONG Jianming WU Xinping CHEN Fusuo ZHANG | 2022 | Frontiers of Agricultural Science and Engineering2022，9，2： | 1 |
| 9 | Zbed3 contributes to malignant phenotype of lung cancer via regulating β‐catenin and P120‐catenin 1显示文摘 | Chuifeng Fan Guiyang Jiang Xiupeng Zhang Yuan Miao Xuyong Lin Lan Luan Zhonghai Xu Yijun Zhang Huanyu Zhao Di Liu Enhua Wang | 2015 | Carcinog2015，，1： | 1 |
| 10 | Synthesis and characterization of hierarchically macroporous and mesoporous CaO–MO–SiO 2 –P 2 O 5 (M显示文摘 | Xiupeng Wang Xia Li Atsuo Ito Yu Sogo | 2011 | Acta Biomaterialia2011，，10： | 1 |
| 11 | Control of crystallinity of hydrated products in a calcium phosphate bone cement显示文摘 | Wang Xiupeng Ye Jiandong Wang Yingjun | 2007 | J Biomed Mater Res Part A2007，81，4： | 1 |
| 12 | BMP-2 and ALP gene expression induced by a BMP-2 gene–fibronectin–apatite composite layer显示文摘 | Xiupeng Wang Ayako Oyane Hideo Tsurushima Yu Sogo Xia Li Atsuo Ito | 2011 | Biomedical Materials2011，，4： | 1 |
| 13 | Prediction of methane production in wastewater treatment facility:a data-min- ing approach 显示文摘 | Andrew Kusiak Xiupeng Wei | 2014 | Annals of Operations Research2014，216，1： | 1 |
| 14 | Zinc-containing apatite layers on external fixation rods promoting cell activity显示文摘 | Xiupeng Wang Atsuo Ito Yu Sogo Xia Li Ayako Oyane | 2009 | Acta Biomaterialia2009，，3： | 1 |
| 15 | Hydration mechanism of a novel PCCP?+?DCPA cement system显示文摘 | Xiupeng Wang Jiandong Ye Yingjun Wang | 2008 | Journal of Materials Science: Materials in Medicine2008，，2： | 1 |
| 16 | Sharing Economy in Local Energy Markets显示文摘With an increase in the electrification of end-use sectors,various resources on the demand side provide great flexibility potential for system operation,which also leads to problems such as the strong randomness of power consumption behavior,the low utilization rate of flexible resources,and difficulties in cost recovery.With the core idea of“access over ownership”,the concept of the sharing economy has gained substantial popularity in the local energy market in recent years.Thus,we provide an overview of the potential market design for the sharing economy in local energy markets(LEMs)and conduct a detailed review of research related to local energy sharing,enabling technologies,and potential practices.This paper can provide a useful reference and insights for the activation of demand-side flexibility potential.Hopefully,this paper can also provide novel insights into the development and further integration of the sharing economy in LEMs. | Zhaoyuan Wu Jianxiao Wang Haiwang Zhong Feng Gao Tianjiao Pu Chin-Woo Tan Xiupeng Chen Gengyin Li Huiru Zhao Ming Zhou Qing Xia | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，3： | 1 |
| 17 | Fine mapping of quantitative trait loci for acid phosphatase activity in maize leaf under low phosphorus stress显示文摘 | Hongbo Qiu Xiupeng Mei Chaoxian Liu Jiuguang Wang Guoqiang Wang Xu Wang Zheng Liu Yilin Cai | 2013 | Molecular Breeding2013，，3： | 1 |
| 18 | Mapping delta- ic depositional systems using seismic sedimentology显示文摘 | Li Xiupeng Zeng Hongliu Zha Ming | 2008 | Journal of Chengdu University of Technology: Science & Technology Edition2008，35，6： | 1 |
| 19 | Effect of Additives on the Morphology of the Hydrated Product and Physical Properties of a Calcium Phosphate Cement显示文摘与几通常使用的添加剂做的含水的磷酸钙水泥(CPC ) 的形态学被扫描电子显微镜学(SEM ) 调查,水泥的压缩强度在这研究是坚定的。没有添加剂的 CPC 的含水的产品是像杆的 hydroxyapatite (哈) 谷物与在在长度的 2-5 亩 m 和在宽度的 100 nm 附近。Sr 的增加显然减少了包含碳酸盐,骨胶原和明胶的像杆的 grains.CPCs 的晶体大小显示出像薄片的水晶 morphology.Crylic 酸包含的 CPC 介绍像绒球的结构。并且苹果酸酸包含的 CPC 展出了面向的像薄片的结构。X 光检查衍射(XRD ) 分析证明在这研究使用的添加剂没改变水泥的水和产品。压缩强度测试显示有像杆的形态学的水泥的压缩强度哈晶体比有像薄片的形态学的水泥的高得多哈有面向的像薄片的形态学的晶体,和水泥哈晶体展出了最差的压缩强度。 | Xiupeng WANG Jiandong YE Yingjun WANG | 2008 | Journal of Materials Science & Technology2008，24，2： | 1 |
| 20 | 放疗联合手术治疗胃癌的Meta-分析(英文)显示文摘Objective:We carried out a meta-analysis to assess the effectiveness and safety of radiotherapy combined with surgery for gastric cancer.Methods:Randomized Clinical Trials (RCTs) in which radiotherapy (preoperative,intraoperative and postoperative),was compared with surgery alone in resectable gastric cancer were identified by searching Cochrane Library (Issue 2,2009),PubMed (Jan 1966-Jun 2009),EMBASE (Jan 1974-Jun 2009),Chinese Biomedical Literature Database (Jan 1978-Jun 2009),Chinese Science and Technology Periodicals Database (Jan 1989-Jun 2009),China National Knowledge Infrastructure (Jan 1994-Jun 2009) and Wanfang database (Jan 1997-Jun 2009) in English and Chinese languang.Two researchers assessed the quality of included randomized controlled trials (RCT) extracted data independently.The RevMan 5.0 software was used for meta-analysis.Our researchers assessed the quality of included randomized controlled trials (RCT) extracted data independently.The RevMan 5.0 software was used for meta-analysis.Results:Nine randomized controlled trials of 1 548 patients were selected for meta-analysis.Five randomized controlled trials were related with comparison of preoperative radiotherapy plus surgery with single surgery.Two randomized controlled trials were the comparative studies between surgery plus postoperative and single surgery.The meta-analysis results showed that:(1) compared with surgery alone,preoperative radiotherapy combined with surgery can increase 3 years (OR=1.78;95% CI 1.14-2.78,P=0.01),5 years (OR=1.67;95% CI 1.22-2.29,P=0.001),10 years (OR=1.64;95% CI 1.03-2.60,P=0.04) survival rate and resection rate (OR=2.15;95% CI 1.31-3.54,P=0.003);reduce the of tumor recurrence rate (OR=0.59;95% CI 0.37-0.92,P=0.02) and metastasis rate (OR=0.44;95% CI 0.27-0.73,P=0.001);(2) The tumor recurrent rates (OR=0.19,95% CI 0.03-1.14,P=0.07) and tumor metastasis rate (OR=0.09;95% CI 0.00-1.77,P=0.11) had no difference between single surgery group and peri-operative radiotherapy plus surgery group;(3) Postoperative radiotherapy compared with surgery alone had no significant effects on 1 year (OR=0.83;95% CI 0.60-1.15,P=0.26) and 3 years (OR=0.75;95% CI 0.51-1.11,P=0.15) survival rate compared with single surgery,but the 5-year survival rates (OR=0.57;95% CI 0.34-0.95,P=0.03) of the patients who received surgery alone was higher than those who received combined therapy.No difference of the tumor recurrence rate (OR=0.59;95% CI 0.33-1.05,P=0.07),tumor metestasis rate (OR=0.90;95% CI 0.51-1.59,P=0.71) and anastomotic leak (OR=0.98;95% CI 0.25-3.65,P=0.98) were observed between the two groups.Conclusion:Preoperative radiotherapy combined surgery is more rational and effective than surgery alone of gastric cancer.However,in terms of the clinical effects of perioperarive or postoperative radoiotherapy combined with surgery,much multicenter,largescale,high-quality,double-blind and rigorously designed studies would be needed than currently available in the future. | Liyun Guo Xiaohu Wang Bin Ma Kehu Yang Qjuning Zhang Xiupeng Ye Hongtao Luo Ruifeng Liu | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，8： | 1 |
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