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| 1 | Vitamin D levels do not predict the stage of hepatic fibrosis in patients with non-alcoholic fatty liver disease: A PRISMA compliant systematic review and meta-analysis of pooled data显示文摘AIM To investigate the relationship between 25-hydroxyvitamin D [25(OH)D] levels and fibrosis stage in patients with non-alcoholic fatty liver disease(NAFLD).METHODS Two individual reviewers identified relevant studies using the Pub Med, EMBASE, Cochrane, and Scopus databases. Inclusion criteria were as follows:(1) Studies that evaluated adults with NAFLD and serum or plasma 25(OH)D levels; and(2) assessed fibrosis stage using liver biopsy. A rigorous analysis yielded six articles as having sufficient data to employ in evaluating the association of serum vitamin D levels in patients with NAFLD based on their liver fibrosis stage by histopathological analysis. The lead investigators of each of the six studies were contacted and the data were collected. To meta-analyze vitamin D levels in F0-F2 vs F3-F4 fibrosis, a random-effects meta-analysis fit using restricted maximum likelihood was applied. To examine trends across each stage of fibrosis with respect to vitamin D levels, a meta-regression was performed. P < 0.05 was considered statistically significant. RESULTS A total of 937 subjects from six studies were included in the final analysis to evaluate the association of serum vitamin D levels in patients with NAFLD based on their liver fibrosis stage by histopathological analysis. The lead investigators of each of the six studies were contacted and the data were collected. First, the investigators performed a meta-analysis to compare serum vitamin D levels in patients with NAFLD with stage F0-F2 compared to F3-F4, which did not show significance [meta-estimate of the pooled mean difference =-0.86, P = 0.08(-4.17, 2.46)]. A metaregression evaluation of serum vitamin 25(OH)D levels across the individual stages(F0-F4) of fibrosis did not show an association for the six included studies.CONCLUSION Low vitamin D status is not associated with higher stages of liver fibrosis in patients with NAFLD. | Behnam Saberi Alia S Dadabhai Julie Nanavati Lin Wang Russell T Shinohara Gerard E Mullin | 2018 | World Journal of Hepatology2018，10，1： | 3 |
| 2 | 欧洲和中国的心脏与肾脏远程缺血预适应研究:一项随机对照试验显示文摘远程缺血预适应(remote ischemic preconditioning,RIPC)对经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后造影剂肾病(contrast-induced nephropathy,CIN)的潜在保护作用尚待确定。该研究为双盲、随机、安慰剂对照的多中心研究,纳入年龄〈85岁,肾清除率为30~60mL/(min·1.73m^2)的有临床适应证的患者,除了直接PCI外均按1∶1给予RIPC或标准治疗。主要终点是CIN的发生率。次要终点是围手术期心肌梗死(peri-procedural myocardial infarction,PMI)的发生率。 | 刘青 叶鹏 Moretti C Cerrato E Cavallero E Lin S Rossi ML Picchi A Sanguineti F Ugo F Palazzuoli A Bertaina M Presbitero P Shao-Liang C Pozzi R Giammaria M Limbruno U Lefèvre T Gasparetto V Garbo R OmedèP Sheiban I Escaned J Biondi-Zoccai G Gaita F Perl L D'Ascenzo F | 2018 | 中华高血压杂志2018，26，4： | 3 |
| 3 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 4 | A concise survey of scheduling with time-dependent processing times显示文摘 | Cheng T C E Ding Q Lin B M T | 2004 | European Journal of Operational Research2004，152，： | 1 |
| 5 | Antioxidant and free radical scavenging effects of baicalein,baicalin and wogonin显示文摘 | SHIEH D E LIU L T LIN C C | 2000 | Anticancer Res2000，20，5： | 1 |
| 6 | Advances in digital video content protection显示文摘 | LIN E T ESKICIOGLU A M LAGENDIJK R L | 2005 | Proceedings of IEEE2005，93，1： | 1 |
| 7 | Acute respiratory symp- toms in adults in general practice显示文摘 | Hong C Y Lin R T 'Fan E S | 2004 | Faro Pract2004，21，3： | 1 |
| 8 | Mortality risk after preoperative versus postoperative chemotherapy and radiotherapy in lymph node-positive rectal cancer显示文摘 | Seery T E Ziogas A Lin B S | 2013 | Journal of Gastrointestinal Surgery2013，17，2： | 1 |
| 9 | Novel carboxyl-amine bonding methods for poly(dimethylsiloxane)-based devices 显示文摘 | Ouellet E Yang C W T Lin T | 2010 | Langmuir2010，26，11： | 1 |
| 10 | Food as a form of destination identity: A tourism destination brand perspective 显示文摘 | Lin Y C Pearson T E Cai L P | 2011 | Tourism and Hospitality Research2011，1，1： | 1 |
| 11 | An efficient, classification-based approach for grouping pen strokes into objects 显示文摘 | Stahovich T F Peterson E J Lin H | 2014 | Computers & Graphics (S0097-8493)2014，42，8： | 1 |
| 12 | A concise survey of scheduling with time-dependent processing times显示文摘 | Cheng T C E Ding Q Lin B M T | 2004 | European Journal of Operational Research2004，152，： | 1 |
| 13 | Somatic mutations and altered expression of the candidate tumor suppressors CSNK1 epsilon,DLG1, and EDD/hHYD in mamumary ductal carcinoma显示文摘 | Fuja T J Lin F Osann K E Bryant P J | 2004 | Cancer Res2004，64，3： | 1 |
| 14 | Strategies for enantioseparations of catecholamines and structurally related compounds by capillary zone electrophoresis using sulfated β - cyclodextrins as chiral selectors 显示文摘 | LIN C E CHENG H T FANG I J | 2006 | Electrophoresis2006，27，： | 1 |
| 15 | A concise survey of scheduling with time-dependent processing times显示文摘 | Cheng T C E Ding Q Lin B M T | 2004 | European Journal of Operational Research2004，152，1： | 1 |
| 16 | Fabrication and Assembly Scheduling in a Two-machine Flow Shop显示文摘 | Lin B M T Cheng T C E | 2002 | lIE Transactions2002，34，11： | 1 |
| 17 | Targeting bone al eviates osteoarthritis in osteopenic mice and modulates cartilage catabolism显示文摘 | Funck-Brentano T Lin H Hay E | | 0，，03： | 1 |
| 18 | Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin 显示文摘 | Shieh D E Liu L T Lin C C | 2000 | Anticancer Res2000，20，5： | 1 |
| 19 | Role of interferon regula- tory factor-1 in the induction of biliary glycoprotein (Cell CAM-I) by interferon-T显示文摘 | CHEN C J LIN T T SHIVELY J E | 1996 | The Journal of Biological Chemistry1996，45，28： | 1 |
| 20 | Digital Watermarking of Low Bit- rate Advanced Simple Profile MPEG- 4 Compressed Video 显示文摘 | Alattar A M Lin E T Celik M U | 2003 | IEEE Transactions on Circuits and Systems for Video Technology2003，13，8： | 1 |
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