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| 1 | The Hardy Rubber Tree Genome Provides Insights into the Evolution of Polyisoprene Biosynthesis显示文摘Eucommia ulmoides,也叫的强壮的橡胶树,是一棵经济地重要的树;然而,它的染色体顺序的缺乏 ?限制基本生物研究和这植物种的应用研究。这里,我们在场它的 1.2-Gb 染色体的一个高质量的集会(支架 N50 ?=? 1.88 Mb ) 与至少 26 ? 为 E 的 723 预言的基因。ulmoides,顺序 Garryales 的首先定序的染色体,它用联合定序的 Illumina 的综合策略被获得,定序的 PacBio,和印射的 BioNano。作为到 lamiids 和 campanulids 的姐妹 taxon, E。ulmoides 经历了三倍由核心 eudicots 而是没有进一步整个染色体的复制分享了的一个古老的染色体 ? 在最后 1.25 亿年里。E。ulmoides 为涉及压力回答和第二等的代谢物的生合成的多重基因展出高表达式层次或基因数字扩大,它可以说明它的可观的环境适应性。与橡胶树(Hevea brasiliensis ) 相对照,它生产 cis 聚异式戊二我烯, E。ulmoides 演变综合经由 farnesyl diphosphate synthases (FPS ) 的长链的 trans 聚异式戊二我烯。而且, FPS 和橡胶延伸 factor/small 橡胶粒子蛋白质基因家庭从 H 独立地被扩展。brasiliensis 系。这些结果提供新卓见进 E. 的生物学 ? ulmoides 和聚异式戊二我烯生合成的起源。 | Ta-na Wuyun Lin Wang Huimin Liu Xuewen Wang Liangsheng Zhang Jeffrey L. Bennetzen Tiezhu Li Lirong Yang Panfeng Liu Lanying Du Lu Wang Mengzhen Huang Jun Qing Iili Zhu Wenquan Bao Hongguo Li Qingxin Du Jingle Zhu Hong Yang Shuguang Yang Hui Liu Hui Yue Jiang Hu Suoliang Yu Yu Tian Fan Liang Jingjing Hu Depeng Wang Ruiwen Gao Dejun Li Hongyan Du | 2018 | Molecular Plant2018，11，3： | 24 |
| 2 | The Y.D.and climate abrupt events in the early and middle Holocene:Stalagmite oxygen isotope record from Maolan,Guizhou,China显示文摘The isotope records which range from 3.9 kaBP to 15.7 kaBP with an average resolution of 90 a have been obtained from 45 cm to 193.6 cm of the upper part of D4 stalagmite from Dongguo Cave in Libo, Guizhou, by using system TIMS U-series dating and carbon and oxygen stable isotope analyses.The study indicates that the last cold event, the YD (Younger Dryas) event, of the last glacial period was apparently shown in D4 record, which started from 12.80 kaBP and ended in 11.58 kaBP, with a great range of drop in temperature. The end of the last glacial period was consistent with the termination I in oceanic isotope records and was with time limit of 11.3 kaBP. The three most distinct cold events in the early and middle Holocene occurred respectively in 10.91 kaBP, 8.27 kaBP and 4.75 kaBP, with a range of drop in tem- perature reaching 2—5℃. The climate abrupt events in thousand and hundred years scale re- corded in stalagmite δ O can be compared to those in GISP2 ice cores from Greenland in their 18 happening time and the range of their lasting time. The cold events in 8.27 kaBP and 4.75 kaBP can also be compared to CC3 stalagmite records in Ireland, which indicate that climate changes of short range in China monsoon areas, western Europe and polar regions, have the same driv- ing factor. This has a global significance. In addition, the trend of record curves in some time- stages is apparently different, which reflects probably the difference between environment in monsoon climate areas and in polar regions. | QIN Jiaming1, YUAN Daoxian1, CHENG Hai2, LIN Yushi1, ZHANG Meiliang1, WANG Fuxing1, R. L. Edwards2, WANG Hua1 & RAN Jingcheng3 1. The Karst Dynamic Laboratory, IKG, CAGS, Guilin 541004, China 2. Geology and Geophysics Department, Minnesota University, MN55455, USA 3. The Management of Maolan National Nature Reserve, Libo 558400, China | 2005 | Science China Earth Sciences2005，48，4： | 23 |
| 3 | Functional Variant in microRNA-196a2 Contributes to the Susceptibility of Congenital Heart Disease in a Chinese Population显示文摘 | XU , J. Hu, Z.B. Xu, Z.F. Gu, H.Y Yi, L. Cao, H. L. Chen, J. P. Tian, T. Liang, J. Lin, Y. Qiu, W. S. Ma, H.X. Shen, H. B Chen, Y. J. | 2009 | 南京医科大学学报(自然科学版)2009，29，11： | 20 |
| 4 | An Improved Frequency Domain Technique for Determining Soil Water Content显示文摘For many years a soil water content sensor with low cost, reliability and sufficient accuracy has been desirable. Thus, an improved measurement method based on the frequency domain (FD) principle for determining soil water content was considered. Unlike other measurement principles, a new measurable index, η, which was independent of the output impedance and the amplitude of the oscillator while relying on the electrical impedance of a multi-pin probe, was pro- posed. Moreover, a model for processing the impedance of the multi-pin soil probe was developed, and several important electrical parameters for establishing their operating ranges applicable to this probe were evaluated. In order to confirm the theoretical analysis, an experiment was conducted with a 4-pin probe. Using the developed model, the relationship between the proposed index η and soil volumetric water content was shown to be linear (R2 = 0.9921). Thus, as the measurable index, η seemed satisfactory. | SUN Yu-Rui MA Dao-Kun LIN Jian-Hui P. SCHULZE LAMMERS L. DAMEROW | 2005 | Pedosphere2005，15，6： | 13 |
| 5 | Cesarean scar pregnancy: issues in management显示文摘 | K.‐M.Seow L.‐W.Huang Y.‐H.Lin M.Yan‐Sheng Lin Y.‐L.Tsai J.‐L.Hwang | 2004 | Ultrasound Obstet Gynecol2004，，3： | 12 |
| 6 | Kevlar对位芳纶浆粕增强橡胶的研究显示文摘研究Kevlar对位芳纶浆粕和精切短纤维对天然橡胶胶料的补强效果。结果表明:随着纤维用量的增大,Kevlar对位芳纶浆粕补强的胶料储能模量增加幅度大于损耗模量增加幅度,损耗角和损耗因子随着浆粕用量的增大而降低,这种效果有利于低滚动阻力轮胎或其他轮胎部件的胶料配方设计,在提高胶料定伸模量的同时不会增加滞后生热;Kevlar对位芳纶浆粕表现出的一种独特手风琴效应可能是低滞后生热的原因。 | Jeffery S. Downey Constantine W. Tsimpris Andrew L. Pollard Chloe F. Wilson Jocelyn Willis-Papi Christiane K. Hohenwarter Qin Lin 黎学东 | 2012 | 轮胎工业2012，32，7： | 11 |
| 7 | First dark matter search results from the PandaX-Ⅰ experiment显示文摘We report on the first dark-matter(DM)search results from PandaX-I,a low threshold dual-phase xenon experiment operating at the China JinPing Underground Laboratory.In the 37-kg liquid xenon target with 17.4 live-days of exposure,no DM particle candidate event was found.This result sets a stringent limit for low-mass DM particles and disfavors the interpretation of previously-reported positive experimental results.The minimum upper limit,3.7×10-44cm2,for the spin-independent isoscalar DM-particle-nucleon scattering cross section is obtained at a DM-particle mass of 49 GeV/c2at 90%confidence level. | XIAO MengJiao XIAO Xiang ZHAO Li CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HU Jie HUANG XingTao JI XiangDong JU YongLin LEI SiAo LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing STEPHENSON Scott TAN AnDi TARL Greg WANG HongWei WANG JiMin WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIE PengWei YOU YingHui ZENG XiongHui ZHANG Hua ZHANG Tao ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 10 |
| 8 | PandaX: a liquid xenon dark matter experiment at CJPL显示文摘PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay search.The central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton scale.The experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,China.The detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional scintillation.In this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented. | CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO MengJiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao ZHAO HaiYing ZHAO Li ZHOU XiaoPeng ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，8： | 9 |
| 9 | Multiple Chromatographic and Chemometric Methods for Quality Standardization of Chinese Herbal Medicines显示文摘Quality standardization of complementary medicine is fundamental for industry and practice as it underpins the quality,safety and efficacy of Chinese herbal medicines.Current herbal standardizations are often based on the quantitative analysis of a single compound,which may not reflect the total characteristic,bioactive and toxic nature of the herbs or products.Therefore,there is a need to establish an internationally recognized methodology for quality standardization of Chinese herbal medicines.The analytical methods reviewed in this article are pharmacognosy,TLC,HPLC,LCMS,CE and chemo-metrics.This article also covers the developments and applications of these methods in quality standardization.Recent advances show that a combination of these methods creates an overall chemical profile of each herb.This is supported by results reviewed in this article and obtained in our laboratory tests on medicinal herbs including Hypericum perforatum,Morinda officinalis and Centella asiatica.Significant variations in active components have been observed between herbal samples and products.It is proposed that the identification of active components,pharmacological activities and eventual clinical applications are required for a comprehensive quality standardization system.Our findings indicate that the combination of various chromatographic and chemometric methods will advance the methodology of quality standardization and enhance the overall confidence in herbal medicine for the health practitioner and the public. | Valentina Razmovski-Naumovski Wannit Tongkao-on Benjamin Kimble Vincent L. Qiao Bei-lun Lin Kong M. Li Basil Roufogalis Depo Yang Meicun Yao George Q. Li | 2010 | 世界科学技术-中医药现代化2010，12，1： | 5 |
| 10 | Cancer treatment and survivorship statistics, 2014显示文摘 | Carol E. DeSantis Chun Chieh Lin Angela B. Mariotto Rebecca L. Siegel Kevin D. Stein Joan L. Kramer Rick Alteri Anthony S. Robbins Ahmedin Jemal | 2014 | CA: A Cancer Journal for Clinicians2014，，4： | 4 |
| 11 | Prevalence of polycystic ovary syndrome in women in China: a large community-based study显示文摘 | Rong Li Qiufang Zhang Dongzi Yang Shangwei Li Shulan Lu Xiaoke Wu Zhaolian Wei Xueru Song Xiuxia Wang Shuxin Fu Jinfang Lin Yimin Zhu Yong Jiang Huai L. Feng Jie Qiao | 2013 | Human Reproduction2013，，9： | 4 |
| 12 | Characteristics of Some Heavy Metals in Acid Sulfate Topsoils, Eastern Australia显示文摘Forty-five acid sulfate topsoil samples (depth < 0.5 m) from 15 soil cores at 11 locations along the New South Wales coast, Australia, were selected to investigate the chemical behavior of Zn, Mn, Cr, Co and Pb in these soils. The amount of HCI-extractable Mn was much smaller than the mean value of the total Mn documented for other soils. This may be attributed to enhanced mobilization of Mn from the soils under the extremely acidic and seasonally flooded conditions encountered in the investigated soils. The pH-dependency of soluble Zn and Mn was strongly affected by the availability of acid reactive Zn and Mn compounds. There were fairly good relationships between soluble Zn and acid reactive Zn compounds, and between soluble Mn and acid reactive Mn compounds. Soluble Zn and soluble Mn concentrations were important controls on exchangeable Zn and Mn concentrations, respectively. In contrast to the suggestion by other authors that adsorption of Co was closely associated with Mn oxides present in soils, the exchangeable Co in the investigated acid sulfate soils was not clearly related to the abundance of Mn minerals. In addition to the fact that there are few Mn minerals present in the soils, this might also be because the availability of canon exchange sites on the crystal surfaces of Mn oxides was reduced under extremely acidic conditions. | C. LIN, D. MCCONCHIE, R. T. BUSH, L. A. SULLIVAN and M. ROSICKY (School of Resource Science and Management, Southern Cross University, Lismore, NSW (Australia)) | 2001 | Pedosphere2001，11，1： | 4 |
| 13 | A Sustained Virologic Response Is Durable in Patients With Chronic Hepatitis C Treated With Peginterferon Alfa-2a and Ribavirin显示文摘 | Mark G. Swain Ming–Yang Lai Mitchell L. Shiffman W. Graham E. Cooksley Stefan Zeuzem Douglas T. Dieterich Armand Abergel Mário G. Pess?a Amy Lin Andreas Tietz Edward V. Connell Moisés Diago | 2010 | Gastroenterology2010，，5： | 3 |
| 14 | Indole methylation protects diketopiperazine configuration in the maremycin biosynthetic pathway显示文摘The maremycin biosynthetic gene cluster has been identified in Streptomyces sp. B9173. Comparative metabolic profiling with knockout mutant strains led to the identification of new products correlated to the maremycin biosynthesis, in particular the'demethyl'-maremycins with an unexpected D-tryptophan unit. A biosynthetic pathway for the maremycins is proposed and plausible reasoning for tryptophan epimerization in the demethylmaremycin biosynthesis is also provided. | Yingxia Lan Yi Zou Tingting Huang Xiaozheng Wang Nelson L. Brock Zixin Deng Shuangjun Lin | 2016 | Science China Chemistry2016，59，9： | 3 |
| 15 | Cirrhotic patients at increased risk of peptic ulcer bleeding: a nationwide population‐based cohort study显示文摘 | J.‐C. Luo H.‐B. Leu M.‐C. Hou C.‐C. Huang H.‐C. Lin F.‐Y. Lee F.‐Y. Chang W.‐L. Chan S.‐J. Lin J.‐W. Chen | 2012 | Aliment Pharmacol Ther2012，，6： | 3 |
| 16 | Herpes Simplex Virus Type 2 Risks in Female Sex Workers in the China-vietnam Border County of Hekou显示文摘Objective To survey the prevalence and risk factors of HSV-2 among Chinese and Vietnamese female sex workers (FSW) in the border county of Hekou, Yunnan Province, China. Methods A cross-sectional survey was conducted on demographics, sexual behavior, medical history, and drug use among FSWs. Laboratory samples were obtained to test for HSV-2 and other STIs such as HIV, Syphilis, Trichomonas vaginalis, Neisseria gonorrhoeae, Chlamydia trachomatis, Bacterial vaginosis, and Yeast infections. Cervicitis and genital warts were also diagnosed. Results Of the 345 FSWs who participated in this study, 112 (32.5%) were ethnic Chinese and 233 (67.5) were Vietnamese. Among FSWs in Hekou, the prevalence rates were 58.3% for HSV-2, 5.5% for HIV, and 4.1% for bacterial vaginosis (BV). Age <21 (OR: 0.5; 95% CI: 0.3, 0.8), duration of commercial sex work ≤3 months (OR: 0.5; 95% CI: 0.3, 0.8), oral and vaginal sex with the last client (as opposed to only vaginal sex) (OR: 1.6; 95% CI: 1.0, 2.7), HIV (OR: 11.4; 95% CI: 1.5, 87.2), and bacterial vaginosis (BV) (OR: 5.6; 95% CI: 1.2, 26.9) were significantly correlated with HSV-2 infection. Conclusion Multivariate analysis showed that several factors were significantly correlated with the high prevalence of HSV-2 in FSWs in the border area between China and Vietnam. Further studies and interventions are needed for HSV-2 epidemiology in the border area. | WANG Jun Jie ZHU Zhi Bin YANG Xi WU Jing WANG Hai BO FENG Lin DING Guo Wei Jessie L. NORRIS WANG Ning | 2012 | Biomedical and Environmental Sciences2012，25，6： | 3 |
| 17 | Iron Monosulfide Distribution in Three Coastal Floodplain Acid Sulfate Soils, Eastern Australia显示文摘The distribution of iron monosulfide (quantified as acid volatile sulfur: SAV) was compared with geo- chemical properties that are known to affect its formation and accumulation in three coastal Holocene acid sulfate soils (ASS) at Tuckean Swamp, McLeods Creek and Bungawalbyn Swamp respectively. These properties included PH, reactive iron (FeR), pore-water sulfate (SO:42-) and organic carbon (OC). Iron monosulfide was concentrated at the oxic/anoxic boundary. The Tuckean Swamp and McLeods Creek sites are Holocene sediments, whereas the Bungawalbyn Swamp is a Holocene peat. The concentration of SAV averaged 0.2 g kg-l in a 0.5 m thick soil layer at the Tuckean Swamp, but was an order of magnitude lower in the oxic/anoxic transition layers at McLeods Creek and Bungawalbyn Swamp. The SAV mineral greigite (Fe3S4) was identified in the Tuckean Swamp by X-ray diffraction and scanning electron microscopy with quantitative energy dispersive X-ray analysis (SEM-EDX). Very small concentrations of greigite were also observed in the McLeods Creek, based on crystal morphology and elemental composition. The concentration of SAV was a small fraction of the total reduced sulfur, representing at most 3% of the Pyrite sulfur. However, the presence of this highly reactive sulfide mineral, distributed within pores where oxygen diffusion is most rapid, has important implications to the potential rate of acid production from these sediments. | R. T. BUSH, L. A. SULLIVAN and C. LIN School of Resource Science and Management, Southern Cross University, Lismore, NSW 2480 (Australia) | 2000 | Pedosphere2000，10，3： | 3 |
| 18 | Clear lens extraction in angle-closure glaucoma patients显示文摘AIM: To describe the results of 5 consecutive cases of clear lens extraction in angle closure patients for the treatment of elevated intraocular pressure (IOP). ·METHODS: Retrospective observational case series. All angle closure patients were on two or more topical glaucoma medications and had prior laser iridotomy. Eyes underwent clear lens extraction by phacoemu - lsification with intraocular lens implantation. ·RESULTS: All five patients in this case series carried the diagnosis of angle -closure glaucoma and had uncontrolled IOP prior to surgery despite topical medications. After clear lens extraction three of the cases had good IOP control (IOP <22mmHg) without the need for topical medications. In one case the IOP was better controlled after surgery, however, topical medications were required. The desired IOP was not met in one case despite restarting maximum topical therapy. ·CONCLUSION: This case series suggests that there may be a role for therapeutic clear lens extraction in select cases of angle-closure glaucoma. | Diego T. Q. Barbosa Ashleigh L. Levison Shan C. Lin | 2013 | International Journal of Ophthalmology(English edition)2013，6，3： | 3 |
| 19 | Generating oxidation-resistant variants of Bacillus kaustophilus leucine aminopeptidase by substitution of the critical methionine residues with leucine显示文摘 | Chi, M. C. Chou, W. M. Wang, C. H. Chen, W. L. Hsu, W. H. Lin, L. L. | 2007 | 中国生物学文摘2007，21，1： | 3 |
| 20 | Risk factors and outcomes in postpancreaticoduodenectomy pancreaticocutaneous fistula显示文摘 | John W. Lin M.D. M. Eng. John L. Cameron M.D. Charles J. Yeo M.D. Taylor S. Riall M.D. Keith D. Lillemoe M.D | 2004 | Journal of Gastrointestinal Surgery2004，，8： | 2 |
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