|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Perturbed Solving Method for Interdecadal Sea-air Oscillator Model显示文摘A coupled system of the interdecadal sea-air oscillator model is studied.The El Nio-southern oscillation(ENSO) atmospheric physics oscillation is an abnormal phenomenon involved in the tropical Pacific ocean-atmosphere interactions.The oscillator model is involved with the variations of both the eastern and western Pacific anomaly pat-terns.This paper proposes an ENSO atmospheric physics model using a method of the perturbation theory.The aim is to create an asymptotic solving method for the ENSO model.Employing the perturbed method,the asymptotic solution of corresponding problem is obtained,and the asymptotic behaviour of the solution is studied.Thus we can obtain the prognoses of the sea surface temperature anomaly and related physical quantities. | MO Jiaqi LIN Yihua LIN Wantao CHEN Lihua | 2012 | Chinese Geographical Science2012，22，1： | 38 |
| 2 | Large eddy simulation of a planar jet flow with nanoparticle coagulation显示文摘易于在一口平面喷气的大协调结构的 nanoparticles 的凝结和生长被使用大旋涡模拟探索了。粒子地被一片刻采用方法接近获得 nanoparticle 将军动态方程。在直径包含 1 nm 的粒子的不可压缩的液体被投射进一没有粒子周围。当喷气发展,结果证明协调结构统治 nanoparticle 数字紧张直径和多分散性分布的进化。另外,当配对的旋涡引起粒子分布成为制服时,增加粒子的散开的协调结构行为,和旋涡滚动起来做更不规则地散布的粒子。当喷气下游地旅行,平均时间的粒子数字集中在郊区在喷气核心并且更高变得更低,而在全部流动地上的平均时间的粒子团维持未改变,,并且他们的最大值在喷气区域的接口上并且周围。 | Mingzhou Yu Jianzhong Lin Lihua Chen Tatleung Chan | 2006 | Acta Mechanica Sinica2006，22，4： | 25 |
| 3 | Intercropping with Solanum nigrum and Solanum photeinocarpum from Two Ecoclimatic Regions Promotes Growth and Reduces Cadmium Uptake of Eggplant Seedlings显示文摘Soil contamination by heavy metals is a serious environmental problem worldwide, and reduction of heavy metal accumulation in vegetables grown on contaminated land is a matter of urgency. A pot experiment was conducted to study the effects of intercropping with the Cd hyperaccumulators Solanum nigrum and Solanum photeinocarpum from two ecoclimatic regions, Ya'an and Chengdu,Sichuan Province, China, on the growth and cadmium(Cd) uptake of eggplant(Solanum melongena L.). The biomass, photosynthetic pigment contents, and activities of antioxidant enzymes of eggplant were enhanced by intercropping. The biomass of eggplant was the highest after intercropping with S. photeinocarpum from Ya'an, but did not differ significantly from that after intercropping with S. nigrum from Chengdu. The shoot Cd content of eggplant was significantly reduced by intercropping with the hyperaccumulators,which ranked as follows: S. nigrum from Chengdu > S. nigrum from Ya'an > S. photeinocarpum from Chengdu > S. photeinocarpum from Ya'an, with the decreases being 19.60%, 14.36%, 9.66%, and 6.42%, respectively, as compared with the control. The lowest shoot Cd content and translocation factor of eggplant were attained after intercropping with S. nigrum from Chengdu. Therefore, it was feasible to intercrop eggplant with S. nigrum and S. photeinocarpum on Cd-contaminated soil. | TANG Yi HE Juan YU Xuena XIE Yongdong LIN Lijin SUN Guochao LI Huanxiu LIAO Mingan LIANG Dong XIA Hui WANG Xun ZHANG Jing LIU Zejing TU Lihua LIU Li | 2017 | Pedosphere2017，27，3： | 17 |
| 4 | Determination of Taurine in Biological Samples by High-Performance Liquid Chromatography Using 4-Fluoro-7-Nitrobenzofurazan as a Derivatizing Agent显示文摘Objective A highly sensitive and rapid high‐performance liquid chromatography method with pre‐column derivatization with 4‐fluoro‐7‐nitrobenzofurazan was developed for determination of taurine in biological samples,including plasma,brain,and liver.Methods The optimum derivatization reaction temperature was 70℃,and at this temperature the reaction was complete within 3 min.The derivatized taurine was separated using phosphate buffer (0.02 mol/L,pH 6.0):acetonitrile (84:16,v/v) as the mobile phase at a flow rate of 1.0 mL/min,and a column temperature of 25℃.The taurine derivatives were separated within 20 min (tR:14.5 min) and fluorometrically detected at 530 nm with excitation at 470 nm.Results The intra‐ and the inter‐day coefficients of variation for the method were 5.3% and 7.7%,respectively.The calibration curve was linear from 0.1 μmol/L to 30.0 μmol/L with a correlation coefficient of 0.9995.Conclusion This method can be used to determine the taurine contents in plasma,brain,and liver from normal rats and human plasma. | WANG XiFeng CHI DeFeng SU GuanMin LI Lin SHAO LiHua | 2011 | Biomedical and Environmental Sciences2011，24，5： | 13 |
| 5 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 6 | Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development显示文摘Dear Editor,Previously,the Mendelian phe no types in huma n oocyte maturation arrest,fertilization failure and early embryonic arrest,are largely underestimated.In recent years,'missing'Men delian phe no types and genes in these processes are beginning to be uncovered by us and others(Huang et al.,2014;Alazami et al..2015;Feng et al.,2016;Xu et al.,2016;Chen et al.,2017;Sang et al.,2019).However,the genetic basis for majority of patients resulting from abnormalities in these phe no types remains to be elucidated. | Lin Zhao Songguo Xue Zhongyuan Yao Juanzi Shi Biaobang Chen Ling Wu Lihua Sun Yao Xu Zheng Yan Bin Li Xiaoyan Mao Jing Fu Zhihua Zhang Jian Mu Wenjing Wang Jing Du Shuai Liu Jie Dong Weijie Wang Qiaoli Li Lin He Li Jin Xiaozhen Liang Yanping Kuang Xiaoxi Sun Lei Wang Qing Sang | 2020 | Protein & Cell2020，11，12： | 10 |
| 7 | Coupling of wave and current numerical model with unstructured quadtree grid for nearshore coastal waters显示文摘This paper presents 2D wave-current interaction model for evaluating nearly horizontal wave-induced currents in the surf-zone and coastal waters.The hydrodynamic model is the two-dimensional depth-averaged nonlinear shallow water equations by using an unstructured non-staggered and multiple-level quadtree rectangular mesh,this mesh information is stored in simple data structures and it is easy to obtain a locally high resolution for important region.The intercell fluxes are computed based on the HLL(Harten-Lax-van Leer) approximate Riemann solver with shock capturing capability for computing the dry-to-wet interface of coastal line.The effects of pressure and gravity are included in source term in the model,this treatment can simplify the computation and eliminate numerical imbalance between source and flux terms.The wave model readily provides the radiation stresses that represent the shortwave-averaged forces in a water column for the hydrodynamic model and the wave model takes into account the effect of wave-induced nearshore currents and water level.The coupling model is applied to verify different experimental cases and real life case of considering the wave-current interaction.The calculated results agree with analytical solution,experimental and field data.The results show that the modeling approach presented herein should be useful in simulating the nearshore processes in complicated natural coastal domains. | ZHANG MingLiang WU WeiMing LIN LiHua YU JiangNan | 2012 | Science China(Technological Sciences)2012，55，2： | 10 |
| 8 | Efficient elimination of multidrug-resistant bacteria using copper sulfide nanozymes anchored to graphene oxide nanosheets显示文摘Antibacterial nanomaterials have attracted growing interest for bacterial infection therapy.However,most nanomaterials eliminate bacteria either physically or chemically,which hampers their efficacy when dealing with multidrug-resistant bacteria.To overcome this,we integrated copper sulfide(CuS)nanoparticles with active graphene oxide nanosheets(GO NSs)to synthesize a superior nanocomposite(CuS/GO NC)that acts both physically and chemically on the bacteria.CuS/GO NC was produced using a facile hydrothermal method,whereby the CuS nanoparticles grew and were uniformly dispersed on the GO NSs in situ.We found that the CuS/GO NC possesses a unique needle-like morphology that physically damages the bacterial cell membrane.CuS/GO NC also exhibits high oxidase-and peroxidase-like activity,ensuring efficient generation of the reactive oxygen species•OH from H2O2,which kills bacteria chemically.These features endow the CuS/GO NC with excellent antibacterial capabilities to kill multidrug-resistant bacteria such as methicillin-resistant Staphylococcus aureus(MRSA)with only a single dose.Additionally,it was found that the CuS/GO NC accelerated the healing of infected wounds in vivo owing to its good biocompatibility as well as facilitation of cell migration and collagen secretion.This study provides a new strategy to combine the physical and chemical antibacterial modes of nanomaterials to develop more effective therapies to combat multidrug-resistant bacterial infections. | Wanshun Wang Binglin Li Huili Yang Zefeng Lin Lingling Chen Zhan Li Jiayuan Ge Tao Zhang Hong Xia Lihua Li Yao Lu | 2020 | Nano Research2020，13，8： | 8 |
| 9 | Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis显示文摘 | Xu Xiaojie Fan Zhongyi Kang Lei Han Juqiang Jiang Chengying Zheng Xiaofei Zhu Ziman Jiao Huabo Lin Jing Jiang Kai Ding Lihua Zhang Hao Cheng Long Fu Hanjiang Song Yi Jiang Ying Liu Jiahong Wang Rongfu Du Nan Ye Qinong | 2013 | Journal of Clinical Investigation2013，，2： | 7 |
| 10 | Advertisement Call Variability in the Black-spined Toad Bufo melanostictus (Anura: Bufonidae) during the Breeding Season in Lishui, Zhejiang, China显示文摘Advertisement calls play an important role in influencing female mate choice and are regarded as one of the key characters responsible for reproductive isolation and speciation events in frogs and toads. The black-spined toad, Bufo melanostictus, is one of the most common amphibians in Southeast Asia and is frequently observed in human habitations throughout its distributional range. The advertisement calls of the toad have not been well described. Here, we report the advertisement calls of this species from Lishui, Zhejiang, China during its breeding season. The advertisement calls of B. melanostictus are composed of single notes with a single harmonic frequency emitted sporadically. The call parameters recorded in this study were highly variable across recording times and with different body sizes. Dominant frequency was negatively correlated with body size. Comparing the calls of the B. melanostictus population from Lishui with the populations from five other localities(Bangkok, Thailand; Coorg, India; Burma, Myanmar; Bali, Indonesia; Halimun-Salak National Park, Indonesia), we found that call structure was similar among five different populations with no harmonics, while the Halimun-Salak National Park population contained two clear harmonics. Dominant frequency was similar between Bali(1.56 kHz) and Coorg(1.6 kHz) populations, while it was highly variable among other populations. Besides call duration, call interval and pulse/call rate may also be significantly different among the comparing populations. Pooling the available data, we observed some similarities and differences in call parameters among the six populations. | Li WEI Lihua ZHAO Xiaohao MA Xiaoli FAN Xiaomei MA Zhihua LIN | 2012 | Asian Herpetological Research2012，3，2： | 6 |
| 11 | Responses of ammonia-oxidizing microorganisms to biochar and compost amendments of heavy metals-polluted soil显示文摘Heavy metal pollution affects soil ecological function.Biochar and compost can effectively remediate heavy metals and increase soil nutrients.The effects and mechanisms of biochar and compost amendments on soil nitrogen cycle function in heavy-metal contaminated soils are not fully understood.This study examined how biochar,compost,and their integrated use affected ammonia-oxidizing microorganisms in heavy metal polluted soil.Quantitative PCR was used to determine the abundance of ammonia-oxidizing archaea(AOA)and bacteria(AOB).Ammonia monooxygenase(AMO)activity was evaluated by the enzymelinked immunosorbent assay.Results showed that compost rather than biochar improved nitrogen conversion in soil.Biochar,compost,or their integrated application significantly reduced the effective Zn and Cd speciation.Adding compost obviously increased As and Cu effective speciation,bacterial 16 S rRNA abundance,and AMO activity.AOB,stimulated by compost addition,was significantly more abundant than AOA throughout remediation.Correlation analysis showed that AOB abundance positively correlated with NO_(3)^(-)-N(r=0.830,P<0.01),and that AMO activity had significant correlation with EC(r=-0.908,P<0.01)and water-soluble carbon(r=-0.868,P<0.01).Those seem to be the most vital factors affecting AOB community and their function in heavy metal-polluted soil remediated by biochar and compost. | Mingyue Li Jiachao Zhang Xiao Yang Yaoyu Zhou Lihua Zhang Yuan Yang Lin Luo Qingyun Yan | 2021 | Journal of Environmental Sciences2021，33，4： | 5 |
| 12 | Structure insights into mechanisms of ATP hydrolysis and the activation of human heat-shock protein 90显示文摘分子的女伴热吃惊蛋白质 90 的激活(Hsp90 ) 依赖于 ATP 绑定和水解作用,它发生在蛋白质的 N 终端域。这里,我们与 ATP 和 ATP 类似物在土著人并且在建筑群决定了人的 Hsp90 的 N 终端领域的三水晶结构,提供由 Hsp90 的 ATP 水解作用的催化机制的一个清楚的看法。另外, ATP 的绑定导致 N 终端领域是能被用来部分解释 Hsp90 的孤立的 N 终端领域为什么举办很弱的 ATP hydrolytic 活动的一个中间的状态。 | Jian Li Lihua Sun Chunyan Xu Feng Yu Huan Zhou Yanlong Zhao Jian Zhang Jianhua Cai Cheney Mao Lin Tang Yechun Xu Jianhua He | 2012 | Acta Biochimica et Biophysica Sinica2012，44，4： | 5 |
| 13 | Differential expression of immune-related genes between healthy volunteers and type 2 diabetic patients with spleen-deficiency pattern显示文摘OBJECTIVE: To investigate the clinical differentiation of spleen-deficiency pattern(SDP), a group of symptoms and signs defined in terms of Traditional Chinese Medicine for its clinical practice.METHODS: Peripheral venous blood(> 3 m L) was collected from each of six type 2 diabetes mellitus(T2DM)-SDP patients and six healthy volunteers. After the isolation of peripheral white blood cells(PWBCs), total RNA was extracted, and quality control was performed on all RNA samples. Microarray experiments were conducted using the Agilent human whole genome gene chip, and genes demonstrating differential expression were screened. Bioinformatics analysis was conducted on these genes using several online databases.RESULTS: We screened a total of 175 differentially expressed genes(DEGs), of which 111(63%) were down-regulated and 64(37%) were up-regulated in T2DM-SDP patients compared with healthy controls. Among the 175 genes, 158 had biological function annotations: 46(29%) were directly related to an individual's immune regulation or response, 25(16%) were associated with substance and energy metabolism of PWBCs which could also indirectly influence immunity, and the remaining87(55%) were involved in a variety of PWBC biological processes that might eventually influence the immune function. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis revealed that the DEGs were predominantly enriched in seven immune-related pathways. Hierarchical cluster analysis identified gene expression patterns that were distinguishable between the two study groups.CONCLUSION: Our results suggest that T2DM-SDP patients experience significant hypoimmunity and/or immune dysfunctions, and possess a specific gene expression profile. These findings offer new insights into SDP and the clinical pattern differentiation of T2DM-SDP. | Chen Longhui Yang Zemin Chen Weiwen Li Ruliu Lin Chuanquan Guan Lihua Zhu Zhangzhi Chen Ruifang Li Saimei Zhao Lingbo Zeng Jinhao Wang Jianhua | 2015 | Journal of Traditional Chinese Medicine2015，35，6： | 5 |
| 14 | An Experimental Study on Optimization of Large-volume Airgun Source Excitation Conditions in a Reservoir显示文摘Through manual pickup of seismic phases,the number of recording stations,the farthest observation distance of station and received energy are determined,then optimal operating condition processing software is developed to evaluate the excitation effect of operating conditions. The optimal operating conditions in the Mianhuatan Reservoir are determined using this software. They are: optimal water depth 25 m,airgun array sink depth 9m and airgun array size 7m × 7m. At the same time,accumulative stacking results for every 10 times are analyzed for 300 fixed-point excitations. It is concluded that the excitation effect shows a rapidly rising trend at 10 to 90 times stacking,a slowly rising trend at 100 to 150 times stacking,a rapidly rising trend at 160 to 240 times stacking,and a slowly rising trend at 250 to 300 times stacking. As the number of stacking increases,the propagation distance and the number of recording stations also increase gradually. | Chen Huifang Lin Binhua Jin Xing Wu Lihua Cai Huiteng | 2016 | Earthquake Research in China2016，30，3： | 4 |
| 15 | Effects of different carbon sources on the removal of ciprofloxacin and pollutants by activated sludge:Mechanism and biodegradation显示文摘This research investigated the effects of ciprofloxacin(CIP)(0.5,5,and 20 mg/L)on SBR systems under different carbon source conditions.Microbial community abundance and structure were determined by quantitative PCR and high-throughput sequencing,respectively.The biodegradation production of CIP and possible degradation mechanism were also studied.Results showed that CIP had adverse effects on the nutrient removal from wastewater.Compared with sodium acetate,glucose could be more effectively used by microorganisms,thus eliminating the negative effects of CIP.Glucose stimulated the microbial abundance and increased the removal rate of CIP by 18%–24%.The mechanism research indicated that Proteobacteria and Acidobacteria had a high tolerance for CIP.With sodium acetate as a carbon source,the abundance of nitrite-oxidizing bacterial communities decreased under CIP,resulting in the accumulation of nitrite and nitrate.Rhodanobacter and Microbacterium played a major role in nitrification and denitrification when using sodium acetate and glucose as carbon sources.Dyella and Microbacterium played positive roles in the degradation process of CIP and eliminated the negative effect of CIP on SBR,which was consistent with the improved removal efficiency of pollutants. | Yixiang Cai Zhiyong Yan Yingjuan Ou Boshang Peng Lihua Zhang Jihai Shao Yiqing Lin Jiachao Zhang | 2022 | Journal of Environmental Sciences2022，34，1： | 4 |
| 16 | CXCL16 deficiency attenuates acetaminopheninduced hepatotoxicity through decreasing hepatic oxidative stress and inflammation in mice显示文摘Chemokine C-X-C ligand 16 (CXCL16 ) ,一种单个通行证的类型我属于 CXC chemokine 家庭的膜蛋白质,与在肝损害的煽动性的反应有关。在现在的学习,我们调查了 CXCL16 的 pathophysiological 角色,唯一的膜界限 chemokine,在导致的 acetaminophen (APAP ) 在老鼠的 hepatotoxicity。老鼠与 APAP 被注射,并且血和织物样品在不同时间点被收获。浆液高活动性的组盒子 1 并且 CXCL16 层次被三明治免疫分析确定。肝织物节与 hematoxylin 曙红或与染色的 dihydroethidium 被染色。CXCL16 和另外的 cytokines 的表情被即时聚合酶链反应检验。Ly6-B, p-jun N 终端 kinase (p-JNK ) ,和 JNK 表情被西方的污点分析测量。细胞内部的谷胱甘肽,反应的氧种类,和 malondialdehyde 层次也被测量。APAP 服药过量增加了肝的 CXCL16 mRNA 和浆液 CXCL16 蛋白质层次。CXCL16 缺乏的老鼠显著地展出了更少的肝损害和肝的坏死,以及更低的死亡比野类型(WT ) 响应 APAP 服药过量处理的老鼠。提高的 APAP 在 WT 老鼠的呼吸的链激活,它是强烈在 CXCL16 大美人老鼠颠倒了的氧化应力和减少的 mitochondrial 的生产。另外, CXCL16 缺乏禁止了嗜中性的渗入和 APAP 服药过量处理触发的 proinflammatory cytokines 的生产。我们的学习表明 CXCL16 是对导致 APAP 的 hepatotoxicity 的肝免疫者反应的一个批评管理者,因此由指向 CXCL16 为导致药的尖锐的肝失败的处理提供潜在的策略。 | Hong Wang Yihui Shao Saisai Zhang Anqi Xie Yanna Ye Lihua Shi Leigang Jin Xuebo Pan Zhuofeng Lin Xiaokun Li Shulin Yang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，6： | 4 |
| 17 | Optimum Tilt Angle of Flow Guide in Steam Turbine Exhaust Hood Considering the Effect of Last Stage Flow Field显示文摘Heat transfer and vacuum in condenser are influenced by the aerodynamic performance of steam turbine exhaust hood. The current research on exhaust hood is mainly focused on analyzing flow loss and optimal design of its structure without consideration of the wet steam condensing flow and the exhaust hood coupled with the front and rear parts. To better understand the aerodynamic performance influenced by the tilt angle of flow guide inside a diffuser, taking a 600 MW steam turbine as an example, a numerical simulator CFX is adopted to solve compressible three-dimensional(3D) Reynolds time-averaged N-S equations and standard k-e turbulence model.And the exhaust hood flow field influenced by different tilt angles of flow guide is investigated with consideration of the wet steam condensing flow and the exhaust hood coupled with the last stage blades and the condenser throat.The result shows that the total pressure loss coefficient and the static pressure recovery coefficient of exhaust hood change regularly and monotonously with the gradual increase of tilt angle of flow guide. When the tilt angle of flow guide is within the range of 30° to 40°, the static pressure recovery coefficient is in the range of 15.27% to 17.03% and the total pressure loss coefficient drops to approximately 51%, the aerodynamic performance of exhaust hood is significantly improved. And the effectiveenthalpy drop in steam turbine increases by 0.228% to 0.274%. It is feasible to obtain a reasonable title angle of flow guide by the method of coupling the last stage and the condenser throat to exhaust hood in combination of the wet steam model, which provides a practical guidance to flow guide transformation and optimal design in exhaust hood. | Lihua CAO Aqiang LIN Yong LI Bin XIAO | 2017 | Chinese Journal of Mechanical Engineering2017，30，4： | 3 |
| 18 | Comprehensive profiling of EBV gene expression in nasopharyn- geal carcinoma through paired-end transcriptome sequencing显示文摘在鼻咽的癌(NPC ) 的 Epstein-Barr 病毒(EBV ) 基因的潜伏的表示模式广泛地被调查了,并且在 NPC 的几 lysin 的基因的表示被报导了。然而,通过在 NPC 的 EBV transcriptome 分析的全面信息是有限的。我们执行了对结束 RNA-seq 到系统地并且包括地在 NPC 织物和 C666-1 NPC 房间线描绘 EBV 基因的表示,它一致地带 EBV。除了限制打 II 潜伏感染,类型 III 潜伏 EBNA3s 基因和lysin 的基因的一个实质的数字的抄本,例如 BZLF1 , BRLF1 ,和 BMRF1 ,通过 RNA-seq 被检测并且进一步通过也执行的实时 PCR.We 在 C666-1 房间和 NPC 织物被验证聚类分析以 EBV 基因表示分类 NPC 耐心的组,它介绍了 NPC 样品的二种子类型。结果在 NPC 病人揭示了 EBV 基因表示的有趣的模式。这个聚类与 heterotrimeric G 蛋白质发信号有关与许多发信号的小径被相关,例如那些,发炎由 chemokine 并且 cytokine 发信号调停了,核糖体,蛋白质新陈代谢,流行性感冒感染,和 ECM 受体相互作用。我们的联合调查结果建议在 NPC 的 EBV 基因的表示被限制不仅打 II 潜伏基因而且打 III 潜伏和 lysin 的基因。这研究在 NPC 的发展提供了进一步的卓见进 EBV 的潜在的角色。 | Lijuan Hu Zhirui Lin YanhengWu Juqin Dong Bo Zhao Yanbing Cheng Peiyu Huang Lihua Xu Tianliang Xia Dan Xiong Hongbo Wang Manzhi Li Ling Guo Elliott Kieff YixinZeng | 2016 | Frontiers of Medicine2016，10，1： | 3 |
| 19 | 96-Week Treatment of Tenofovir Amibufenamide and Tenofovir Disoproxil Fumarate in Chronic Hepatitis B Patients显示文摘Background and Aims:Tenofovir amibufenamide(TMF)is a novel phosphoramidated prodrug of tenofovir with nonin-ferior efficacy and better bone and renal safety to tenofovir disoproxil fumarate(TDF)in 48 weeks of treatment.Here,we update 96-week comparison results.Methods:Patients with chronic hepatitis B were assigned(2:1)to receive either 25 mg TMF or 300 mg TDF with matching placebo for 96 weeks.The virological suppression was defined as HBV DNA levels<20 IU/mL at week 96.Safety was evaluated thoroughly with focusing on bone,renal,and metabolic pa-rameters.Results:Virological suppression rates at week 96 were similar between TMF and TDF group in both HBeAg-positive and HBeAg-negative populations.Noninferior efficacy was maintained in the pooled population,while it was first achieved in patients with HBV DNA≥7 or 8 log10 IU/mL at baseline.Non-indexed estimated glomerular filtration rate for renal safety assessment was adopted,while a smaller decline of which was seen in the TMF group than in the TDF group(p=0.01).For bone mineral density,patients receiv-ing TMF displayed significantly lower reduction levels in the densities of spine,hip,and femur neck at week 96 than those receiving TDF.In addition,the lipid parameters were stable after week 48 in all groups while weight change still showed the opposite trend.Conclusions:TMF maintained similar efficacy at week 96 compared with TDF with continued superior bone and renal safety profiles(NCT03903796). | Zhihong Liu Qinglong Jin Yuexin Zhang Guozhong Gong Guicheng Wu Lvfeng Yao Xiaofeng Wen Zhiliang Gao Yan Huang Daokun Yang Enqiang Chen Qing Mao Shide Lin Jia Shang Huanyu Gong Lihua Zhong Huafa Yin Fengmei Wang Peng Hu Qiong Wu Chao Pan Wen Jia Chuan Li Chang’an Sun Junqi Niu Jinlin Hou TMF Study Group | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 3 |
| 20 | Study of magneto-optical effects in γ-Fe_2O_3/ZnFe_2O_4 nanoparticle ferrofluids, using circularly polarized light显示文摘When circularly polarized light travels through a ferrofluid film in the presence of an applied magnetic field, the transmitted light will behave as elliptically polarized light, because of magnetic birefringence and dichroism. The angular distribution o the relative intensity of the transmitted light can be obtained using a polarizer, so that the ratio of both the long and short ax es-as well as the orientation angle of the ellipse, corresponding to the direction of the applied magnetic field-can be deter mined, and whether the ferrofluids samples are stable during the measurement can be directly judged from the shape of the distribution curves. Thus, the ratio of the amplitudes Ax/Ay and the added phase difference can be resolved in the elliptically polarized light, and information on both the magnetic birefringence n and the dichroism k can be deduced for the ferrofluid sample. From the orientation angles of both right-handed and left-handed elliptically polarized transmitted light, the direction of the applied magnetic field can be accurately determined. Using circularly polarized light, the magnetic birefringence and dichroism of pure γ-Fe2O3 ferrofluids and γ-Fe2O3/ZnFe2O4 binary ferrofluids were studied. For the binary ferrofluids, a mod ulating effect on the magnetic birefringence and dichroism was revealed. | FU Jun LI Jian LIN YueQiang LIU XiaoDong MIAO Hua LIN LiHua | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，8： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员