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| 1 | Establishment and Characterization of a Cell Based Artificial Antigen-Presenting Cell for Expansion and Activation of CD8^+ T Cells Ex Vivo显示文摘Artificial antigen-presenting cells are expected to stimulate the expansion and acquisition of optimal therapeutic features of T cells before infusion. Here CD32 that binds to a crystallizable fragment of IgG monoclonal antibody was genetically expressed on human K562 leukemia cells to provide a ligand for T-cell receptor. CD86 and 4-1BBL,which are ligands of co-stimulating receptors of CD28 and 4-1BB,respectively,were also expressed on K562 cells. Then we accomplished the artificial antigen-presenting cells by coupling K32/CD86/4-1BBL cell with OKT3 monoclonal antibody against CD3,named K32/CD86/4-1BBL/OKT3 cells. These artificial modified cells had the abilities of inducing CD8+ T cell activation,promoting CD8+ T cell proliferation,division,and long-term growth,inhibiting CD8+ T cell apoptosis,and enhancing CD8+ T cell secretion of IFN-γ and perforin. Furthermore,antigen-specific cytotoxic T lymphocytes could be retained in the culture stimulated with K32/CD86/4-1BBL/OKT3 cells at least within 28 days. This approach was robust,simple,reproducible and economical for expansion and activation of CD8+ T cells and may have important therapeutic implications for adoptive immunotherapy. | Weijuan Gong Mingchun Ji Zhengfeng Cao Liheng Wang Yayun Qian Maozhi Hu Li Qian Xingyuan Pan | 2008 | Cellular & Molecular Immunology2008，5，1： | 5 |
| 2 | A panel of monoclonal antibodies against the prion protein proves that there is no prion protein in human pancreatic ductal epithelial cells显示文摘Prion diseases are a group of neurodegenerative diseases that are fatal. The study of these unique diseases in China is hampered by a lack of resources. Amongst the most important resources for biological study are monoclonal antibodies. Here, we characterize a panel of monoclonal antibodies specific for cellular prion protein by enzyme-linked immunosorbent assay(ELISA), immunofluorescent staining, flow cytometry, and western blotting. We identify several antibodies that can be used for specific applications and we demonstrate that there is no prion protein expression in human pancreatic ductal epithelial cells(HPDC). | Liheng Yang Yan Zhang Lipeng Hu Ying Zhu Man-Sun Sy Chaoyang Li | 2014 | Virologica Sinica2014，29，4： | 3 |
| 3 | Phonon scattering and exciton localization: molding exciton flux in two dimensional disorder energy landscape显示文摘Two dimensional excitonic devices are of great potential to overcome the dilemma of response time and integration in current generation of electron or/and photon based systems.The ultrashort diffusion length of exciton arising from ultrafast relaxation and low carrier mobility greatly discounts the performance of excitonic devices.Phonon scattering and exciton localization are crucial to understand the modulation of exciton flux in two dimensional disorder energy landscape,which still remain elusive.Here,we report an optimized scheme for exciton diffusion and relaxation dominated by phonon scattering and disorder potentials in WSe2 monolayers.The effective diffusion coefficient is enhanced by>200%at 280 K.The excitons tend to be localized by disorder potentials accompanied by the steadily weakening of phonon scattering when temperature drops to 260 K,and the onset of exciton localization brings forward as decreasing temperature.These findings identify that phonon scattering and disorder potentials are of great importance for long-range exciton diffusion and thermal management in exciton based systems,and lay a firm foundation for the development of functional excitonic devices. | Pengfei Qi Yang Luo Beibei Shi Wei Li Donglin Liu Liheng Zheng Zhixin Liu Yanglong Hou Zheyu Fang | 2021 | eLight2021，1，1： | 3 |
| 4 | MOF-Like 3D Graphene-Based Catalytic Membrane Fabricated by One-Step Laser Scribing for Robust Water Purification and Green Energy Production显示文摘Increasing both clean water and green energy demands for survival and development are the grand challenges of our age.Here,we successfully fabricate a novel multifunctional 3D graphene-based catalytic membrane(3D-GCM)with active metal nanoparticles(AMNs)loading for simultaneously obtaining the water purification and clean energy generation,via a“green”one-step laser scribing technology.The as-prepared 3D-GCM shows high porosity and uniform distribution with AMNs,which exhibits high permeated fluxes(over 100 L m^(−2) h^(−1))and versatile super-adsorption capacities for the removal of tricky organic pollutants from wastewater under ultra-low pressure-driving(0.1 bar).After adsorption saturating,the AMNs in 3D-GCM actuates the advanced oxidization process to self-clean the fouled membrane via the catalysis,and restores the adsorption capacity well for the next time membrane separation.Most importantly,the 3D-GCM with the welding of laser scribing overcomes the lateral shear force damaging during the long-term separation.Moreover,the 3D-GCM could emit plentiful of hot electrons from AMNs under light irradiation,realizing the membrane catalytic hydrolysis reactions for hydrogen energy generation.This“green”precision manufacturing with laser scribing technology provides a feasible technology to fabricate high-efficient and robust 3D-GCM microreactor in the tricky wastewater purification and sustainable clean energy production as well. | Xinyu Huang Liheng Li Shuaifei Zhao Lei Tong Zheng Li Zhuiri Peng Runfeng Lin Li Zhou Chang Peng Kan-Hao Xue Lijuan Chen Gary J.Cheng Zhu Xiong Lei Ye | 2022 | Nano-Micro Letters2022，14，11： | 2 |
| 5 | Helically Grooved Gold Nanoarrows: Controlled Fabrication, Superhelix, and Transcribed Chiroptical Switching显示文摘Plasmonic chiroptical materials,coupled by chirality and surface plasmons,have been attracting great interest due to their potential applications,such as photonics,chiral recognition,asymmetric catalysis and biosensing.Herein,we constructed a new chiral plasmonic nanostructure—helically grooved gold nanoarrows(HeliGNAs)by introducing L-/Dcysteine(L-/D-Cys)during the growth of the gold nanoarrows(GNAs).The variation of the concentration of L-/D-Cys leads to the HeliGNAs with a tunable plasmonic circular dichroism(PCD). | Song Wang Liheng Zheng Wenjie Chen Lukang Ji Li Zhang Wensheng Lu Zheyu Fang Fucheng Guo Limin Qi Minghua Liu | 2021 | CCS Chemistry2021，3，9： | 2 |
| 6 | Oriented nano-structured hydroxyapatite from the template显示文摘 | Yuanjian Zhang Liheng Zhou Di Li Naicun Xue Xiudong Xu Jinghong Li | 2003 | Chemical Physics Letters2003，，3： | 1 |
| 7 | Brown remodeling of white adipose tissue by SirTl-dependent deacetylation of PPAR3'显示文摘 | Li Q Liheng W Ning K | 2012 | Cell2012，150，3： | 1 |
| 8 | Collaborative force and shape control for large composite fuselage panels assembly显示文摘This study proposed a force and shape collaborative control method that combined method of influence coefficients(MIC)and the elitist nondominated sorting genetic algorithm(NSGA-II)to reduce the shape deviation caused by manufacturing errors,gravity deformation,and fixturing errors and improve the shape accuracy of the assembled large composite fuselage panel.This study used a multi-point flexible assembly system driven by hexapod parallel robots.The proposed method simultaneously considers the shape deviation and assembly load of the panel.First,a multi-point flexible assembly system driven by hexapod parallel robots was introduced,with the relevant variables defined in the control process.In addition,the corresponding mathematical model was constructed.Subsequently,MIC was used to establish the prediction models between the displacements of actuators and displacements of panel shape control points,deformation loads applied by the actuators.Following the modeling,the shape deviation of the panel and the assembly load were used as the optimization objectives,and the displacements of actuators were optimized using NSGA-II.Finally,a typical composite fuselage panel case study was considered to demonstrate the effectiveness of the proposed method. | Zhanghao WANG Dongsheng LI Liheng SHEN Yi SUI Yunong ZHAI | 2023 | Chinese Journal of Aeronautics2023，36，7： | 1 |
| 9 | Enhanced Multi-phosphopeptide Enrichment and Nano LC-ESI-qTOF-MS Detection Strategy Using Click OEG-CD Matrix显示文摘 | ZHAO Yanyan WANG Liheng GUO Zhimou CHI Xiaofei MA Xiaochi QI Yan FANG Shinong LI Xiuling LIANG Xinmiao | 2015 | Chemical Research in Chinese Universities2015，31，1： | 1 |
| 10 | Clinical practice guideline for body composition assessment based on upper abdominal magnetic resonance images annotated using artificial intelligence显示文摘Introduction Upper abdominal magnetic resonance(MR)imaging is appropriate for body composition analysis.111 Especially for individuals with obesity,it is of great value to quantify the hepatic proton density fat fraction(PDFF)and the amount of abdominal adipose tissue during clinical evaluation and for research on obesity-related risks.Analytical results may be used to determine the optimal choice of surgical procedure and evaluate treatment outcomes.Multiple artificial intelligence(Al)algorithms and systems have been developed for the automated measurement of body composition.The basis of Al development and application is to have uniform standards for clinical data acquisition and management.The uneven quality ofMR images is one ofthe major obstacles to Al system development and analytical results.A standardized process of MR scanning and clinical data management is urgently needed. | Han Lv Mengyi Li Zhenchang Wang Dawei Yang Hui Xu Juan Li Yang Liu Di Cao Yawen Liu Xinru Wu He Jin Peng Zhang Liqin Zhao Rixing Bai Yunlong Yue Bin Li Nengwei Zhang Mingzhu Zou Jinghai Song Weibin Yu Pin Zhang Weijun Tang Qiyuan Yao Liheng Liu Hui Yang Zhenghan Yang Zhongtao Zhang National Clinical Research Center for Digestive Diseases in Beijing Friendship Hospital,Capital Medical University Beijing Quality Control and Improvement Center of Medical Imaging National Health Commission Capacity Building and Continuing Education Center,Chinese College of Metabolic and Bariatric Surgeons Beijing Quality Control and Improvement Center of Metabolic and Bariatric Surgery | 2022 | Chinese Medical Journal2022，，6： | 1 |
| 11 | Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ显示文摘 | Li Qiang Liheng Wang Ning Kon Wenhui Zhao Sangkyu Lee Yiying Zhang Michael Rosenbaum Yingming Zhao Wei Gu Stephen R. Farmer Domenico Accili | 2012 | Cell2012，，3： | 1 |
| 12 | Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ显示文摘 | Li Qiang Liheng Wang Ning Kon Wenhui Zhao Sangkyu Lee Yiying Zhang Michael Rosenbaum Yingming Zhao Wei Gu Stephen R. Farmer Domenico Accili | 2012 | Cell2012，，3： | 1 |
| 13 | Brown Re- modeling of White Adipose Tissue by SirT1 - De- pendent Deacetylation of Ppar 显示文摘 | Qiang Li Liheng Wang Ning Kon | 2012 | Cell2012，150，3： | 1 |
| 14 | A lean-zinc anode battery based on metal-organic framework-derived carbon显示文摘Improving zinc metal(Zn^(0))reversibility and minimizing the N/P ratio are critical to boosting the energy density of Zn^(0) batteries.However,in reality,an excess Zn source is usually adopted to offset the irreversible zinc loss and guarantee sufficient zinc cycling,which sacrifices the energy density and leads to poor practicability of Zn^(0) batteries.To address the above conundrum,here,we report a lean-Zn and hierarchical anode based on metal-organic framework(MOF)-derived carbon,where trace Zn^(0) is pre-reserved within the anode structure to make up for any irreversible zinc source loss.This allows us to construct low N/P ratio Zn^(0) full cells when coupling the lean-Zn anode with Zn-containing cathodes.Impressively,high Zn^(0) reversibility(average Coulombic efficiency of 99.4% for 3000 cycles)and long full-cell lifetime(92% capacity retention after 900 cycles)were realized even under the harsh lean-Zn condition(N/P ratio:1.34).The excellent Zn reversibility is attributed to the hierarchy structure that homogenizes zinc ion flux and electric field distribution,as confirmed by theoretical simulations,which therefore stabilizes Zn^(0) evolution.The lean-Zn anode design strategy will provide new insights into construction of high-energy Zn^(0) batteries for practical applications. | Chao Li Liheng Liang Xuhui Liu Ning Cao Qingguo Shao Peichao Zou Xiaobei Zang | 2023 | Carbon Energy2023，5，4： | 1 |
| 15 | Current Status and Analysis of Machine Learning in Hepatocellular Carcinoma显示文摘Hepatocellular carcinoma(HCC)is a common tumor.Although the diagnosis and treatment of HCC have made great progress,the overall prognosis remains poor.As the core component of artificial intelligence,machine learning(ML)has developed rapidly in the past decade.In particular,ML has become widely used in the medical field,and it has helped in the diagnosis and treatment of cancer.Different algorithms of ML have different roles in diagnosis,treatment,and prognosis.This article reviews recent research,explains the application of different ML models in HCC,and provides suggestions for follow-up research. | Sijia Feng Jianhua Wang Liheng Wang Qixuan Qiu Dongdong Chen Huo Su Xiaoli Li Yao Xiao Chiayen Lin | 2023 | Journal of Clinical and Translational Hepatology2023，11，5： | 1 |
| 16 | Giant nonlinear Hall effect in twisted bilayer WSe_(2)显示文摘The recently discovered nonlinear Hall effect(NHE)in a few non-interacting systems provides a novel mechanism for generating second-harmonic electrical Hall signals under time-reversal-symmetric conditions.Here,we introduce a new approach to engineering an NHE by using twisted moiréstructures.We found that the twisted WSe_(2)bilayer exhibited an NHE when the Fermi level was tuned to the moiréflat bands.When the first moiréband was half-filled,the nonlinear Hall signal exhibited a sharp peak with a generation efficiency that was at least two orders of magnitude greater than those obtained in previous experiments.We discuss the possible origins of the diverging generation efficiency in twisted WSe_(2)based on resistivity measurements,such as moiré-interface-induced correlation effects and mass-diverging-type continuous Mot transition.This study demonstrates not only how interaction effects can combine with Berry curvature dipoles to produce novel quantum phenomena,but also the potential of NHE measurements as a new tool for studying quantum criticality. | Meizhen Huang Zefei Wu Jinxin Hu Xiangbin Cai En Li Liheng An Xuemeng Feng Ziqing Ye Nian Lin Kam Tuen Law Ning Wang | 2023 | National Science Review2023，10，4： | 0 |
| 17 | Introduction to bioimaging-based spatial multi-omic novel methods显示文摘Background: Spatial multi-omics are demonstrated to be a powerful method to assist researchers on genetic studies. In this review, bioimaging-based spatial multi-omics techniques such as seqFISH+, merFISH, integrated DNA seqFISH+, DNA merFISH, and MINA are introduced along with each technique’s probe design, development, and imaging processes.Results: seqFISH employed 4–5 fluorophores to barcode and conducted multiple rounds of hybridization, in order that mRNA can be identified through color-coding. seqFISH+ added 60 pseudo-color and distributed them equally into three channels to enhance imaging power, in order that i.e., 24,000 genes can be imaged in total. merFISH utilized 4 out 16 Hamming distance to innovatively provide a robust error-detecting method. MINA, a methodology combining merFISH (multiplexed error-robust fluorescence in situ hybridization) and chromosomal tracing, enabled multiplexed genomic architecture imaged in mammalian single cells. Optical reconstruction of chromatin architecture (ORCA) a method that could conduct DNA path tracing in nanoscale manner with kilobase resolution, an FISH variation that improved genetic resolution, enable high-precision fiducial registration and sequential imaging, and utilized Oligopaint probe to hybridize the short genomic region ranging from 2 to 10 kilobase. ORCA then prescribes these short section primary probes with individual barcodes to attach fluorophore and to be imaged.Conclusion: This review concentrated on providing a comprehensive overview for these spatial-multi-omics techniques with the intention on helping researchers on selecting appropriate technique for their research. | Yan Yan Liheng Yang Leyuan Meng Haochen Su Cheng Zhou Le Yu Zhengtu Li Xu Zhang Huihua Cai Juntao Gao | 2023 | Quantitative Biology2023，11，3： | 0 |
| 18 | Jamming Monitoring Technology of the Space Situational Awareness Facilities:A Comprehensive Survey显示文摘Complicated electromagnetic environments of the space situational awareness facilities(i.e.,satellite navigation systems,radar)would significantly impact normal operations.Effective monitoring and the corresponding diagnosis of the jamming signals are essential to normal opera-tions and the innovations in anti-jamming equipment.This paper demonstrates a comprehensive survey on jamming monitoring algorithms and applications.The methods in dealing with jamming signals are summarized primarily.Subsequently,the jamming detection,identification,and direc-tion finding techniques are addressed separately.Based on the established studies,we also provide some potential trends of the demonstrated jamming monitoring issues. | Sitian Liu Chunli Zhu Chen Yang Liyang Chen Kun Fang Kuo Li Xing He Zhipeng Wang Liheng Bian | 2022 | Journal of Beijing Institute of Technology2022，31，2： | 0 |
| 19 | Restoring Polarization Angle Map for High- Fidelity Underwater Imaging显示文摘Obtaining polarization information enables researchers to enhance underwater imaging quality by removing backscattering effect and to distinguish targets of different materials.However,due to the simplified assumption of unpolarized target light,most of the existing underwater polari-metric methods lose part of the polarization information,resulting in degraded imaging quality.In this work,a novel underwater polarimetric method is reported,which obtains the angle of polariza-tion(AOP)map to improve imaging quality.Specifically,the Stokes vectors were exploited to re-move the backscattering effect by obtaining two pairs of orthogonal polarization sub-images of the underwater scene.The target reflected light and the angle between the polarization directions of the target reflected light and the backscattered light were computed through the two groups of the or-thogonal polarized sub-images.The AOP map of the target light could be derived from the Stokes vectors.Then,the transmission map of the target light was estimated by using the non-local color priorly combined with the properties of light propagating underwater.Experiments show that the reported technique enables distinguishing different targets when the colors are similar.The quantit-ative metrics validate that the reported technique produces state-of-the-art performance for under-water imaging. | Yiming Li Liheng Bian | 2022 | Journal of Beijing Institute of Technology2022，31，2： | 0 |
| 20 | A new capacitive borehole tiltmeter for crustal deformation measurement and its performance analysis显示文摘Borehole inclinometers are important observation instruments used to measure ground tilt movement and monitor crustal deformation of solid tides and geological landslide disasters.They are widely used in oil exploration,mineral resource drilling,well logging,exploration and other fields.There is potential for development of rock stress strain monitoring tools.Many types of tiltmeters have been installed,such as SQ-7,FSQ,VS and JB.However,these tiltmeters are generally installed in a deep cave to avoid the interference of temperature,humidity,and human activities.With the urbanization of human society,suitable installation locations are difficult to find.To solve the problem,a two-component borehole tiltmeter,named the CBT-type tiltmeter,is proposed in this paper.It can be installed in a borehole less than500 m deep to eliminate environmental influences.The tiltmeter is composed of two sophisticated gravitational swing and two capacitive transducers.From preliminary theory and experiment analysis,its linear correlation coefficient is higher than 0.99,its co-seismic response is rapid and its noise level is up to 10 4arc seconds in practice. | Wu Liheng Li Tao Chen Zheng Li Hong | 2015 | International Journal of Mining Science and Technology2015，25，2： | 0 |
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