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| 1 | Abnormal Metabolic Connectivity in Rats at the Acute Stage of Ischemic Stroke显示文摘Stroke at the acute stage is a major cause of disability in adults, and is associated with dysfunction of brain networks. However, the mechanisms underlying changes in brain connectivity in stroke are far from fully elucidated. In the present study, we investigated brain metabolism and metabolic connectivity in a rat ischemic stroke model of middle cerebral artery occlusion(MCAO)at the acute stage using18 F-fluorodeoxyglucose positron emission tomography. Voxel-wise analysis showed decreased metabolism mainly in the ipsilesional hemisphere, and increased metabolism mainly in the contralesional cerebellum. We used further metabolic connectivity analysis to explore the brain metabolic network in MCAO.Compared to sham controls, rats with MCAO showed most significantly reduced nodal and local efficiency in the ipsilesional striatum. In addition, the MCAO group showed decreased metabolic central connection of the ipsilesional striatum with the ipsilesional cerebellum, ipsilesional hippocampus, and bilateral hypothalamus. Taken together,the present study demonstrated abnormal metabolic connectivity in rats at the acute stage of ischemic stroke, which might provide insight into clinical research. | Shengxiang Liang Xiaofeng Jiang Qingqing Zhang Shaofeng Duan Tianhao Zhang Qi Huang Xi Sun Hua Liu Jie Dong Weilin Liu Jing Tao Shujun Zhao Binbin Nie Lidian Chens Baoci Shan | 2018 | Neuroscience Bulletin2018，34，5： | 5 |
| 2 | Contrast-enhanced ultrasound is helpful in the differentiation of malignant and benign breast lesions显示文摘 | Hongjia Zhao Rong Xu Qiufang Ouyang Lidian Chen Baowei Dong Ye Huihua | 2009 | European Journal of Radiology2009，，2： | 4 |
| 3 | Research progress in rehabilitation treatment of stroke patients A bibliometric analysis显示文摘BACKGROUND: Stroke presents as a transient or chronic brain dysfunction and is associated with high morbidity and high mortality. The doctors and scientists would like to argue how to enhance the validity of the rehabilitation treatment and how to further improve the level of treatment on stroke. OBJECTIVE: The aim of this study was to quantitatively analyze the current worldwide progress in research on stroke rehabilitation treatment based on Web of Science database and ClinicalTrial.gov in the past 10 years. METHODS: We conducted a quantitative analysis of clinical trial articles regarding stroke rehabilitation published in English from 2003 to 2013 and indexed in the National Institutes of Health Clinical Trials registry and Web of Science databases. Data were downloaded on March 15, 2013. RESULTS: (1) From 2003 to 2013, 2 654 clinical trials investigating stroke were indexed in ClinicalTrials.gov. There were only 58 clinical trials registered in 2003, and there was a marked increase from 2005. A total of 605 clinical trials on the rehabilitation of stroke were conducted in the past 10 years. (2) The analysis showed that most of the trials in the field were registered by North American institutions. With respect to the Asian countries, China and Taiwan Region of China also published a reasonable proportion of the trials, but comparatively speaking, the number of trials is really rare. Most of the interventions were drugs, followed by the devices, and behavioral interventions were ranked third. (3) In the past 10 years, there were 4 052 studies on stroke indexed by Web of Science database. CONCLUSION: From perspective of research progress, we found that the number of clinical trials and papers on stroke rehabilitation has increased significantly in the past 10 years, between them a remarkable positive correlation exists. | Xiaodong Feng Chengmei Liu Qingchuan Guo Yanjie Bai Yafeng Ren Binbin Ren Junmin Bai Lidian Chen | 2013 | Neural Regeneration Research2013，8，15： | 3 |
| 4 | Electroacupuncture enhances hippocampal NSCs proliferation in cerebral ischemia-reperfusion injured rats via activation of notch signaling pathway显示文摘 | Jing Tao Bin Chen Yanling Gao Shanli Yang Jia Huang Xin Jiang Yayin Wu Jun Peng Zhenfeng Hong Lidian Chen | 2014 | International Journal of Neuroscience2014，，3： | 2 |
| 5 | Gua Lou Gui Zhi decoction suppresses LPS-induced activation of the TLR4/NF-κBpathway in BV-2 murine microglial cells显示文摘 | Haixia Hu Zuanfang Li Xiaoqin Zhu Ruhui Lin Jiumao Lin Jun Peng Jing Tao Lidian Chen | 2013 | International Journal of Molecular Medicine2013，，6： | 2 |
| 6 | Extraction of Lepidium apetalum Seed Oil Using Supercritical Carbon Dioxide and Anti-Oxidant Activity of the Extracted Oil显示文摘 | Wei Xu Kedan Chu Huang Li Lidian Chen Yuqin Zhang Xuchong Tang | | 0，，12： | 1 |
| 7 | Seasonal changes of ener- gy reserves in Bulimulus tenuissimus (d' Orbigny, 1835 )(Mollusca, Bulimulidae)显示文摘 | Lidiane S Liliane M Flavia OJ et ol | 2012 | Anim Bioi2012，62，1： | 1 |
| 8 | Early hearing protection by brain-derived neurotrophic factor 显示文摘 | Lidian A Stenkvist AM Linder B | 2013 | Acta Otolaryngol2013，133，1： | 1 |
| 9 | Promoter hypermethylation in primary squamous cell carcinoma of the oral cavity and ompharynx: A study of a Bra- zilian cohort显示文摘 | Melissa de Freitas Cordeiro Silva Elaine Stur Lidiane Pignaton Agostini | 2012 | Mol Biol Rep2012，39，10： | 1 |
| 10 | Effect of Dialysate Sodium Reduction on Body Water Volume, Blood Pressure, and Inflammatory Markers in Hemodialysis Patients — A Prospective Randomized Controlled Study显示文摘 | Gabriela Carvalho Beduschi Lidiane Silva Rodrigues Telini Jacqueline Costa Teixeira Caramori Luis Cuadrado Martin Pasqual Barretti* | 2013 | Renal Failure2013，，5： | 1 |
| 11 | Determination of Cd, Cr and Pb in phos- phate fertilizers by laser-induced breakdown spectrosco- py 显示文摘 | LIDIANE CRISTINA NUNES GABRIEL GUSTINEL- IA ARANTES de CARVALHO DARIO SANTOS JUNIOR | 2014 | Spectrochimica Acta Part B2014，，97： | 1 |
| 12 | Simultaneous optimization by neuro- genetic approach for analysis of plant materials by laser induced breakdown spectroscopy显示文摘 | Lidiane Cristina Nunes GilmareAnt6nia da Silva Lilian Cristina Trevizan | 2009 | Spectrochimica Acta Part B: Atomic Spectroscopy2009，64，6： | 1 |
| 13 | Extraction of Lepidium apet alum Seed Oil Using Supercritical Carbon Dioxide and Anti-Oxidant Activity of the Extracted Oil显示文摘 | Wei Xu Kedan Chu Huang Li Lidian Chen Yuqin Zhang Xuchong Tang | 2011 | Molecules2011，16，10： | 1 |
| 14 | Taurine attenuates cardiac remodeling after myocardial infarction显示文摘 | Lidiane P. Ardisson Bruna P.M. Rafacho Priscila P. Santos Heloísa Assalin Andréa F. Gon?alves Paula S. Azevedo Marcos F. Minicucci Bertha F. Polegato Katashi Okoshi Julio Sergio Marchini Luis F. Barbisan Ana Angélica H. Fernandes Fabio R.F. Seiva Sergio A | 2013 | International Journal of Cardiology2013，，： | 1 |
| 15 | Diversity and antifungal susceptibility of yeasts from tropical freshwater environments in Southeastern Brazil显示文摘 | Adriana O. Medeiros Lidiane M. Kohler Junia S. Hamdan Beatriz S. Missagia Francisco A.R. Barbosa Carlos A. Rosa | 2008 | Water Research2008，，： | 1 |
| 16 | Electroacupuncture exerts anti-inflammatory effects in cerebral ischemia-reperfusioninjured rats via suppression of the TLR4/NF-κB pathway显示文摘 | Lan Lan Jing Tao Azhen Chen Guanli Xie Jia Huang Jiumao Lin Jun Peng Lidian Chen | 2013 | International Journal of Molecular Medicine2013，，1： | 1 |
| 17 | Trypanocidal tetrahydrofuran lignans from Peperomia blanda 显示文摘 | Lidiane G F Debora C B Massuo J K | 2008 | Phytochemistry2008，69，： | 1 |
| 18 | Electroacupuncture ameliorates cognitive impairment through inhibitionof NF-κB-mediated neuronal cell apoptosis in cerebral ischemia-reperfusion injuredrats显示文摘 | Xiaodong Feng Shanli Yang Jiao Liu Jia Huang Jun Peng Jiumao Lin Jing Tao Lidian Chen | 2013 | Molecular Medicine Reports2013，，5： | 1 |
| 19 | Antioxidant properties and total phenolic contents of some tropical seaweeds of the Brazilian coast显示文摘 | Cintia D. Leal Martins Fernanda Ramlov Nathália Peixoto Nocchi Carneiro Lisia M. Gestinari Bruno F. dos Santos Lilian M. Bento Cintia Lhullier Lidiane Gouvea Eduardo Bastos Paulo A. Horta Angelica R. Soares | 2013 | Journal of Applied Phycology2013，，： | 1 |
| 20 | Optimization and validation of a LIBS method for the determination of macro and micronutri- ents in sugar cane leaves 显示文摘 | LIDIANE CRISTINA NUNES JEZ WILLIAN BATISTA BRAGA LILIAN CRISTINA TREVI- ZAN | 2010 | Journal of Analytical Spectrometry2010，，25： | 1 |
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