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| 1 | Autoimmune hepatitis and anti-tumor necrosis factor alpha therapy:A single center report of 8 cases显示文摘This article describes cases of anti-tumor necrosis factor(TNF)-α-induced autoimmune hepatitis and evaluates the outcome of these patients in relation to their immunosuppressive strategy. A retrospective analysis of medical records was performed in our center, in order to detect cases of autoimmune hepatitis(AIH) associated with anti-TNF biologic agents. We describe and analyze eight cases of AIH following anti-TNF therapy, 7 with infliximab and 1 with adalimumab. A distinction should be made between induction of autoimmunity and clinically evident autoimmune disease. Liver biopsy is useful in detecting the role of the TNF-α antagonist in the development of AIH. The lack of relapse after discontinuing immunosuppressive therapy favors, as in this case series, an immune-mediated drug reaction as most patients with AIH have a relapse after treatment is suspended. Although AIH related to anti-TNF therapy is rare, a baseline immunological panel along with liver function tests should be performed in all patients with autoimmune disease before starting biologics. | Susana Rodrigues Susana Lopes Fernando Magro Hélder Cardoso Ana Maria Horta e Vale Margarida Marques Eva Mariz Miguel Bernardes Joanne Lopes Fátima Carneiro Guilherme Macedo | 2015 | World Journal of Gastroenterology2015，21，24： | 9 |
| 2 | Minimal volume vitrification of epididymal spermatozoa results in successful in vitro fertilization and embryo development in mice显示文摘这研究在精子功能, IVF 结果,和胚胎开发上比较了三个 cryopreservation 协议。Epididymal 精子 cryopreserved 用慢凉下来(18% w/v 棉白糖, RS-C ) 与用 0.25 M 蔗糖(SV ) 或 18% w/v 棉白糖(RV ) 使成玻璃的精子相比。新鲜控制(FC ) 的活动性,活力,和 DNA 损坏(TUNEL 试金) 精子与 thawed 以后相比或温暖了 RS-C, RV,和 SV 样品。老鼠卵母细胞(n = 267 ) 随机为授精被分配进三个组:RV (n = 102 ) , RS-C (n = 86 ) ,并且 FC (n = 79 ) 。数字和从每个处理的二房间的胚胎和胚囊的比例被估计。精子活动性(P <0.01 ) 并且活力(P <0.05 ) 显著地与慢凉下来的精子相比在玻璃化以后被减少。然而, DNA 破碎显著地在用蔗糖使成玻璃的精子被减少(15 ±1.8%[SV ] 对 26 ±2.8%[RV ] 并且 27 ±1.2%[RS-C ] ;P <0.01 ) 。尽管 RS-C, RV,和 FC 精子生产的二房间的胚胎的数字不是显著地不同的,胚囊的数字用 RV 精子从二房间的胚胎生产了比 FC 精子显著地高(P = 0.0053 ) 。这个简单、小体积玻璃化协议和标准授精方法从 epididymal 精子的小数字允许成功的胚胎生产并且可以临床上被使用为 ICSI 围绕需要,它有绕过精子的劣势选择。 | Fabrizzio Horta Hamida Alzobi Sutthipat Jitanantawittaya Sally Catt Penny Chen Mulyoto Pangestu Peter Temple-Smith | 2017 | Asian Journal of Andrology2017，19，1： | 3 |
| 3 | The Association between Researchers’Conceptions of Research and Their Strategic Research Agendas显示文摘Purpose:In studies of the research process,the association between how researchers conceptualize research and their strategic research agendas has been largely overlooked.This study aims to address this gap.Design/methodology/approach:This study analyzes this relationship using a dataset of more than 8,500 researchers across all scientific fields and the globe.It studies the associations between the dimensions of two inventories:the Conceptions of Research Inventory(CoRI)and the Multi-Dimensional Research Agenda Inventory—Revised(MDRAI-R).Findings:The findings show a relatively strong association between researchers’conceptions of research and their research agendas.While all conceptions of research are positively related to scientific ambition,the findings are mixed regarding how the dimensions of the two inventories relate to one another,which is significant for those seeking to understand the knowledge production process better.Research limitations:The study relies on self-reported data,which always carries a risk of response bias.Practical implications:The findings provide a greater understanding of the inner workings of knowledge processes and indicate that the two inventories,whether used individually or in combination,may provide complementary analytical perspectives to research performance indicators.They may thus offer important insights for managers of research environments regarding how to assess the research culture,beliefs,and conceptualizations of individual researchers and research teams when designing strategies to promote specific institutional research focuses and strategies.Originality/value:To the best of the authors’knowledge,this is the first study to associate research agendas and conceptions of research.It is based on a large sample of researchers working worldwide and in all fields of knowledge,which ensures that the findings have a reasonable degree of generalizability to the global population of researchers. | João M.Santos Hugo Horta | 2020 | Journal of Data and Information Science2020，5，4： | 3 |
| 4 | Management of autoimmune hepatitis:Focus on pharmacologic treatments beyond corticosteroids显示文摘In autoimmune hepatitis, patients who are intolerant or with toxicity experience, non-responders, relapsers or refractory are challenging. Non-standard drugs are being tried to preemptively avoid corticosteroid-related side effects. Prognosis and quality of life of life rely on treatment optimization. Recently, emergence of powerful immunosuppressive agents, mainly from liver transplantation, challenged the supremacy of the corticosteroid regime and promise greater immunosuppression than conventional medications, offer site-specific actions and satisfactory patient tolerance. Successes in experimental models of related diseases have primed these molecular interventions. We performed a literature review on alternative treatments. Azatioprine intolerance is the principal indication for mycophenolate use butit can be used as a front-line therapy. Cyclosporine A and tacrolimus have been tested for non-responders or relapsers. Rituximab may be used as salvage therapy. Anti-tumor necrosis factor-alpha agents may be used for incomplete responses or non-responders. Methotrexate is possibly an alternative for induction of remission and maintenance in refractory patients. Cyclophosphamide has been included in the induction regimen with corticosteroids. Ursodeoxycholic acid action is mainly immunomodulatory. Non-standard treatments are coming slowly to the attention, but its use should be cautious performed by experienced centers. | Marta Casal Moura Rodrigo Liberal Hélder Cardoso Ana Maria Horta e Vale Guilherme Macedo | 2014 | World Journal of Hepatology2014，6，6： | 2 |
| 5 | The inhibit of epidural morphine -inducepruitus by epidural droperidol 显示文摘 | Horta ML Ramos L Goncalves ZR | 2000 | Anesth analg2000，90，3： | 1 |
| 6 | Role of human decay-accelerating factor in the evasion of Schistosoma mansoni from the complement-mediated killing in vitro显示文摘 | Ramalho-Pinto FJ Fatima M | 1991 | J Exp Med1991，174，6： | 1 |
| 7 | Prepregnancy BMI and the risk of gestational diabetes : a systematic review of the literature with meta-analysis显示文摘 | Torloni MR Betran AP Horta BL | 2009 | Obes Rev2009，10，2： | 1 |
| 8 | Association of age with sperm DNA fragmentation显示文摘 | Horta F Madariaga M Garcia A | 2011 | Rev Med Chil2011，139，3： | 1 |
| 9 | The worldwide preva- lence of ADHD: A systematic review and metaregression analysis 显示文摘 | Polanczyk G de Lima MS Horta BL | 2007 | Am J Psychiatry2007，164，6： | 1 |
| 10 | EFNS guidelines for the diagnosis and management of Alzheimer disease显示文摘 | Horta J O'Brienb JT Gainottic G | | 0，，： | 1 |
| 11 | Short-term stenting using fully covered self-expandable metal stents for treatment of refractory biliary leaks, postsphincterotomy bleeding, and perforations 显示文摘 | Canena J Liberato M Horta D | 2015 | Surg Endosc2015，27，1： | 1 |
| 12 | p53 and p21WAF1/CIP1 overexpression at the invasive front of lower lip squarnous cell carcinoma显示文摘 | de Assis LA de Souza AF | 2007 | J Oral Pathol Med2007，36，2： | 1 |
| 13 | The worldwide prevalence of ADHD: a systematic review and metaregression analysis显示文摘 | Polanczyk G de Lima MS Horta BL | 2007 | Am J Psychiatry2007，164，6： | 1 |
| 14 | The worldwide prev- alence of ADHD : a systematrie review and metaregression analy- sis显示文摘 | Polanczyk G De Lima MS Horta BL | 2007 | Am J Psychiatry2007，164，6： | 1 |
| 15 | Pattern of health services utilization by adults of the Pelo- tas birth cohort from 1982 to 2004 -5, Southern Brazil显示文摘 | Juvenal S Dias - da - Costa DeniseP Gigante Bernardo L Horta | 2008 | Rev Saude Publica2008，42，2： | 1 |
| 16 | Salt heaving in the Sahara显示文摘 | HORTA J C | 1985 | Geotechnique1985，35，： | 1 |
| 17 | The worldwide prevalence of ADHD: a systematic review and metaregres sion analysis显示文摘 | Polanczyk G de Lima MS Horta BL | 2007 | Am J Psychiatry2007，164，6： | 1 |
| 18 | The worldwide prevalence of ADHD: a systematic review and Meta regression analysis 显示文摘 | Polanczyk MD de Lima MS Horta BL | 2007 | Am J Psychiatry2007，164，6： | 1 |
| 19 | The worldwide prevalence of ADHD: a systematic review and metaregression analysis显示文摘 | Polanczyk G de Lima MS Horta BL | 2007 | Am J Psychiatry2007，164，6： | 1 |
| 20 | Fatty acid composition of porcine cumulus oocyte complexes (COC) during maturation: effect of the lipid modulators trans -10, cis -12 conjugated linoleic acid ( t 10, c 12 CLA) and forskolin显示文摘 | E. G. Prates S. P. Alves C. C. Marques M. C. Baptista A. E. M. Horta R. J. B. Bessa R. M. Pereira | 2013 | In Vitro Cellular & Developmental Biology - Animal2013，，5： | 1 |
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