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| 1 | Relationship between head and neck cancer therapy and some genetic endpoints显示文摘Head and neck cancer(HNC) is the sixth most common human malignancy worldwide. The main forms of treat ment for HNC are surgery, radiotherapy(RT) and che motherapy(CT). However, the choice of therapy de pends on the tumor staging and approaches, which are aimed at organ preservation. Because of systemic RT and CT genotoxicity, one of the important side effects is a secondary cancer that can result from the activity of radiation and antineoplastic drugs on healthy cells Ionizing radiation can affect the DNA, causing single and double-strand breaks, DNA-protein crosslinks and oxidative damage. The severity of radiotoxicity can be directly associated with the radiation dosimetry and the dose-volume differences. Regarding CT, cisplatin is stil the standard protocol for the treatment of squamous cell carcinoma, the most common cancer located in theoral cavity. However, simultaneous treatment with cisplatin, bleomycin and 5-fluorouracil or treatment with paclitaxel and cisplatin are also used. These drugs can interact with the DNA, causing DNA crosslinks, double and single-strand breaks and changes in gene expression. Currently, the late effects of therapy have become a recurring problem, mainly due to the increased survival of HNC patients. Herein, we present an update of the systemic activity of RT and CT for HNC, with a focus on their toxicogenetic and toxicogenomic effects. | Eliana Maria Minicucci Glenda Nicioli da Silva Daisy Maria Fávero Salvadori | 2014 | World Journal of Clinical Oncology2014，5，2： | 2 |
| 2 | Treament for persistent chronic neuralgia after inguinal hemioplasty显示文摘 | Palumbo P Minicucci A Nasti AG | 2007 | Hernia2007，11，6： | 1 |
| 3 | Insulin pump therapy in patients with type 1 diabetes 显示文摘 | Minicucci WJ | 2008 | Arq Bras Endocrinol Metabol2008，52，2： | 1 |
| 4 | Self-determination, smoking, diet and health 显示文摘 | Williams GC Minicucci DS Kouides RW | 2002 | Health Education Research2002，17，： | 1 |
| 5 | Experimental myocardium infarction in rats:analysis of the model显示文摘 | Zornoff L A Paiva S A Minicucci M F | 2009 | Arq Bras Cardiol2009，93，9： | 1 |
| 6 | Oro-genital lichen planus:report of two cases显示文摘 | Minicucci EM Weber SA Stolf HO | 2008 | Maturitas2008，59，2： | 1 |
| 7 | Periostin as a modulator of chronic cardiac remodeling after myocardial infarction显示文摘 | Minicucci MF dos Santos PP Rafacho BP | 2013 | Clinics (Sao Pan- lo)2013，68，10： | 1 |
| 8 | Heart failure after myocardial infarction: clinical implications and treatment显示文摘 | MINICUCCI M F AZEVEDO P S POLEGATO B F | 2011 | Clin Cardiol2011，34，： | 1 |
| 9 | Energy metabo- lism in cardiac remodeling and heart failure 显示文摘 | Azevedo PS Minicucci MF Santos PP | 2013 | Cardiol Rev2013，21，3： | 1 |
| 10 | Energy metabolism in cardiac remodeling and heart failure显示文摘 | Azevedo PS Minicucci MF Santos PP | 2013 | Cardiol Rev2013，21，3： | 1 |
| 11 | Tobacco smoke-induced left ventricular remodelling is not associated with metalloproteinase-2 or -9 activation 显示文摘 | Castardeli Edson Duarte Daniella R Minicucci Marcos F | 2007 | European Journal of Heart Failure2007，9，2： | 1 |
| 12 | Effects of VE and selenium on antioxidant defense in rat hearts显示文摘 | SCHOLZ R W MINICUCCI L A REDDY C C | 1997 | Biochem Mol Biol Int1997，42，5： | 1 |
| 13 | Taurine attenuates cardiac remodeling after myocardial infarction显示文摘 | Lidiane P. Ardisson Bruna P.M. Rafacho Priscila P. Santos Heloísa Assalin Andréa F. Gon?alves Paula S. Azevedo Marcos F. Minicucci Bertha F. Polegato Katashi Okoshi Julio Sergio Marchini Luis F. Barbisan Ana Angélica H. Fernandes Fabio R.F. Seiva Sergio A | 2013 | International Journal of Cardiology2013，，： | 1 |
| 14 | Echocardiographic predictors of ventricular remodeling after acute myocardial infarction in rats显示文摘 | Minicucci MF Azevedo PS Santos DF | 2011 | Arq Bras Cardiol2011，97，： | 1 |
| 15 | Remodeling pattern and ventricular function in rats exposed to cigarette smoke显示文摘 | Azevedo PS Minicucci MF Matsubara BB | | 0，，： | 1 |
| 16 | Treatment of status epilepticus in adults: Guidelines of Italian League against epilepsy显示文摘 | Minicucci F Muscas G Perucca E | 2006 | Epilepsia2006，47，5： | 1 |
| 17 | Energy metabolism in cardiac remodeling and heart failure显示文摘 | Azevedo PS Minicucci MF Santos PP | 2013 | Cardiology in Review2013，，3： | 1 |
| 18 | The role of oxida-tive stress and lipid peroxidation in ventricular remodeling inducedby tobacco smoke exposure after myocardial infarction 显示文摘 | Duarte DR Minicucci MF Azevedo PS | 2009 | Clinics(Sao Paulo)2009，64，7： | 1 |
| 19 | Myxedema Ascites with Elevated Serum CA125 Concentration 显示文摘 | Duarte DR Chang CV Minicucci MF | 2006 | Am J Med Sci2006，331，2： | 1 |
| 20 | The Role of Green Tea and Oxidative Stress in Heart RemodelingInduced by Tobacco Smoke Exposure 显示文摘 | PEREIRA E J MINICUCCI M POLEGATO B | 2012 | The FASEB Journal2012，26，： | 1 |
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