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| 1 | Cenozoic Adakite-type Volcanic Rocks in Qiangtang,Tibet and Its Significance显示文摘Volcanic rocks in the study area, including dacite, trachyandesite and mugearite, belong to the intermediate-acid, high-K calc-alkaline series, and possess the characteristics of adakite. The geochemistry of the rocks shows that therocks are characterized by SiO2>59%, enrichment in Al2O3 (15.09-15.64%) and Na2O (>3.6%), high Sr (649-885 μg/g)and Sc, low Y contents (<17 μg/g), depletion in HREE (Yb<1.22 μg/g), (La/Yb)N>25, Sr/Y>40, MgO<3% (Mg#<0.35),weak Eu anomaly (Eu/Eu*=0.84-0.94), and lack of the high field strength elements (HFSE) (Nb, Ta, Ti, etc.). The Nd andSr isotope data (87Sr/86Sr=0.7062-0.7079, 143Nd/144Nd=0.51166-0.51253, εNd= -18.61-0.02), show that the magmaresulted from partial melting (10%-40%) of newly underplated basaltic lower crust under high pressure (1-4 GPa), and thepetrogenesis is obviously affected by the crust's assimilation and fractional crystallization (AFC). This research will givean insight into the uplift mechanism of the Tibetan plateau. | LIUShen HURuizhong FENGCaixia CHIXiaoguo LICai YANGRihong WANGTianwu JINWei | 2003 | Acta Geologica Sinica(English Edition)2003，77，2： | 11 |
| 2 | B, Sr, O and H Isotopic Compositions of Formation Waters from the Bachu Bulge in the Tarim Basin显示文摘以便阐明在 BachuBulge 的 basinal 盐水的起源和迁居, Tarim 盆,我们,在化学成分,和硼上执行了分析,和从 Paleozoicstrata 的粘土矿物的 XRD 的形成水的氢和氧同位素。水表演 Ca, B,李和 Sr 丰富和 SO_4 弄空在含碳并且奥陶纪和 K 丰富部分地相对海水的奥陶纪。在三角洲 D 和 delta^(18 ) 之间的关系 O 证明水的所有数据近与他们的交叉向全球 MeteoricWater 线衰退到今日的本地天落水,建议那现代天落水与蒸发的海水混合了。^(87 )Sr/^(86 ) Sr 比率范围 from0.7090 到 0.7011,比那些显著地高当代的海水。detla^(11 ) Hvalues 每千从 +19.7 到 +32.3,显示出有深度和 Bconcentrations 的减少。结果建议 isotopic 结盟不同 B, Sr 从外部来源被导出。然而,后来,伊利石的百分比被显示在学习区域在粘土矿物之中与深度增加,即,伊利石由于降水而非在更深的埋葬期间沥滤,它是不大可能的让伊利石作出贡献 B 的重要数量到水。因此,有 B 珍视的低 delta^(11 ) 的 B 被解释在寒武纪、更低的奥陶纪主要从热降级 ofkerogen 或暗岩被补充说。 | CAI Chunfang PENG Licai MEI Bowen XIAO Yingkai | 2006 | Acta Geologica Sinica(English Edition)2006，80，4： | 7 |
| 3 | Evaluation of three tracers for labeling distal cerebrospinal fluidcontacting neurons显示文摘It has been reported that distal cerebrospinal fluidcontacting neurons(dCSF-CNs)can be detected by immunohistochemical assay using cholera toxin subunit B-conjugated horseradish peroxidase(CBHRP).In the present study,another two methods with CB alone or CB-conjugated FITC(CB-FITC)were used,and the results from the three methods were compared.Adult Sprague-Dawley rats were randomly divided into three groups with CB-HRP,CB or CB-FITC.Tracers were diluted to 30%in artificial cerebrospinal fluid and injected separately(in a volume of 3μL)into the lateral ventricle.Animals from the CB-HRP and CB groups were perfused 48 h after surgery while animals from the CB-FITC group were perfused 1,3,6,12,24 or 48 h after surgery.The brain was sectioned(40μm)for immunofluorescence and five sections with positive neurons were selected from each rat for neuron counting.Three clusters of positive neurons in a'Y-like'distribution were detected ventral to the cerebral aqueduct of rats from the three groups.No significant difference was observed among the quantitative data.In the CB-FITC group,stable staining was detected even at 6 h after injection.Taken together,lateral ventricle injection of CB/CB-FITC is a useful method for labeling dCSFCNs in rats.The CB-FITC method makes dCSF-CNs labeling much simpler and more convenient. | Fang Zhou Jiayou Wang Hongxing Zhang He Liu Guangping Zhao Cuihua Zu Xiaoxing Lu Licai Zhang | 2013 | Neuroscience Bulletin2013，29，5： | 7 |
| 4 | Dynamic route guidance algorithm based onartificial immune system显示文摘To improve the performance of the K-shortest paths search in intelligent traffic guidance systems,this paper proposes an optimal search algorithm based on the intelligent optimization search theory and the metaphor mechanism of vertebrate immune systems.This algorithm,applied to the urban traffic network model established by the node-expanding method,can expediently realize K-shortest paths search in the urban traffic guidance systems.Because of the immune memory and global parallel search ability from artificial immune systems,K shortest paths can be found without any repeat,which indicates evidently the superiority of the algorithm to the conventional ones.Not only does it perform a better parallelism,the algorithm also prevents premature phenomenon that often occurs in genetic algorithms.Thus,it is especially suitable for real-time requirement of the traffic guidance system and other engineering optimal applications.A case study verifies the efficiency and the practicability of the algorithm aforementioned. | Licai YANG Jie LIN Dewei WANG Lei JIA | 2007 | 控制理论与应用(英文版)2007，5，4： | 7 |
| 5 | Fly ash-based geopolymer as a novel photocatalyst for degradation of dye from wastewater显示文摘The geopolymer synthesized by alkali-activated fly ash was firstly used as a novel photocatalyst for degradation of methylene blue(MB) dye from wastewater.The geopolymer is composed of nanoparticulates with an average particle size of about 50 nm.More than 90%of pore volume in the fly ash-based geopolymer predominately centralized on the pore size in the range of 17-700 nm.The degradation efficiency of MB dye by fly ash-based geopolymer catalyst was up to 92.79%under UV irradiation due to the synergistic effect of adsorption and semiconductor photocatalysis.The pseudo-first-order and pseudo-second-order rate equations as well as intra-particle diffusion rate equation were employed to correlate analysis for the adsorption kinetics of MB dye.The experimental data agreed well with pseudo-second-order rate equation in both cases of with UV and without UV irradiations.The intra-particle diffusion process is not the rate determining step.The photocatalytic degradation of MB dye in solution obeys third-order reaction kinetics. | Yaojun Zhang Licai Liu | 2013 | Particuology2013，11，3： | 5 |
| 6 | Application of Pore Evolution and Fracture Development Coupled Models in the Prediction of Reservoir 'Sweet Spots' in Tight Sandstones显示文摘<正>The Chang-6~3 reservoir in the Huaqing area has widely developed tight sandstone reservoirs characterized by'thick sand layers,but not rich in oil',and it is thus necessary to further study its oil and gas enrichment law.This study builds porosity and fracture development | ZHANG Linyan ZHUO Xizhun MA Licheng CHEN Xiaoshuai SONG Licai ZHOU Xingui | 2015 | Acta Geologica Sinica(English Edition)2015，89，3： | 3 |
| 7 | Applying HOSVD to Alleviate the Sparsity Problem in Context-aware Recommender Systems显示文摘 | WANG Licai | 2013 | Chinese Journal of Electronics2013，22，4： | 2 |
| 8 | Factors controlling geochemical and mineralogical compositions of coals preserved within marine carbonate successions: A case study from the Heshan Coalfield, southern China显示文摘 | Shifeng Dai Weiguo Zhang Vladimir V. Seredin Colin R. Ward James C. Hower Weijiao Song Xibo Wang Xiao Li Lixin Zhao Huan Kang Licai Zheng Peipei Wang Dao Zhou | 2013 | International Journal of Coal Geology2013，，： | 2 |
| 9 | A novel humanized MUC1 antibody–drug conjugate for the treatment of trastuzumab-resistant breast cancer显示文摘Mucin 1(MUC1)has been regarded as an ideal target for cancer treatment,since it is overexpressed in a variety of different cancers including the majority of breast cancer.However,there are still no approved monoclonal antibody drugs targeting MUC1.In this study,we generated a humanized MUC1(HzMUC1)antibody from our previously developed MUC1 mouse monoclonal antibody that only recognizes MUC1 on the surface of tumor cells.Furthermore,an antibody–drug conjugate(ADC)was generated by conjugating HzMUC1 with monomethyl auristatin(MMAE),&the efficacy of HzMUC1-MMAE on the MUC1-positive HER2+breast cancer in vitro&in‘Xenograft’model was tested.Results from western blot analysis&immunoprecipitation revealed that the HzMUC1 antibody did not recognize cell-free MUC1-N in sera from breast cancer patients.Confocal microscopy analysis showed that HzMUC1 antibody bound to MUC1 on the surface of breast cancer cells.Results from mapping experiments suggested that HzMUC1 may recognize an epitope present in the interaction region between MUC1-N and MUC1-C.Results from colony formation assay&flow cytometry demonstrated that HzMUC1-MMAE significantly inhibited cell growth by inducing G2/M cell cycle arrest&apoptosis in trastuzumab-resistant HER2-positive breast cancer cells.Meanwhile,HzMUC1-MMAE significantly reduced the growth of HCC1954 xenograft tumors by inhibiting cell proliferation&enhancing cell death.In conclusion,our results indicate that HzMUC1-ADC is a novel therapeutic drug that can overcome trastuzumab resistance of breast cancer.HzMUC1-ADC should also be an effective therapeutic drug for the treatment of different MUC1-positive cancers in clinic. | Guang Wu Lan Li Yuxin Qiu Wei Sun Tianhao Ren Yingshuai Lv Mengnan Liu Xiaoxia Wang Hongqun Tao Lingjie Zhao Jiawei Cao Licai He Hongzhi Li Haihua Gu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，12： | 2 |
| 10 | The effect of differential temperatures on the latent heat in the nucleation of CdSe quantum dots显示文摘This work studied the effect of differential temperatures on the latent heat in the nucleation of CdSe quantum dots(QDs).The result showed that,by the formula of phase change,with increasing the reaction temperature,the latent heat in the nucleation of QDs reduced.CdSe QDs with the size-dispersion from 2.7 to 3.6 nm were synthesized via oleic acid-paraffin liquid system by controlling the reaction temperature from 180 to 220℃.Synthesized QDs were characterized by UV-vis absorption spectra and X-ray diffraction(XRD).The result of UV-vis absorption spectra showed that with increasing of reaction temperature,the first absorption peak was red-shifted and the size of QD increased.The result of XRD showed that the synthesized QDs were zinc-blende structure. | Licai Hao Zhongchen Bai Shuijie Qin Zhengping Zhang | 2017 | Journal of Semiconductors2017，38，4： | 1 |
| 11 | LILRB4 ITIMs mediate the T cell suppression and infiltration of acute myeloid leukemia cells显示文摘We recently demonstrated that leukocyte Ig-like receptor 4(LILRB4)expressed by monocytic acute myeloid leukemia(AML)cells mediates T-cell inhibition and leukemia cell infiltration via its intracellular domain.The cytoplasmic domain of LILRB4 contains three immunoreceptor tyrosine-based inhibitory motifs(ITIMs);the tyrosines at positions 360,412,and 442 are phosphorylation sites.Here,we analyzed how the ITIMs of LILRB4 in AML cells mediate its function.Our in vitro and in vivo data show that Y412 and Y442,but not Y360,of LILRB4 are required for T-cell inhibition,and all three ITIMs are needed for leukemia cell infiltration.We constructed chimeric proteins containing the extracellular domain of LILRB4 and the intracellular domain of LILRB1 and vice versa.The intracellular domain of LILRB4,but not that of LILRB1,mediates T-cell suppression and AML cell migration.Our studies thus defined the unique signaling roles of LILRB4 ITIMs in AML cells. | Zunling Li Mi Deng Fangfang Huang Changzhu Jin Shuang Sun Heyu Chen Xiaoye Liu Licai He Ali HSadek Cheng Cheng Zhang | 2020 | Cellular & Molecular Immunology2020，17，3： | 1 |
| 12 | A Murine Model of?Hepatic?Veno- occlusive?Disease?Induced by Allogeneic Hematopoietic Stem Cell Transplantation显示文摘 | Lingyu Zeng Licai An Ting Fang etal | 2013 | Cell Biochemistry and Biophysics2013，67，3： | 1 |
| 13 | Preparation and identification of monoclonal antibody against fumonisin B 1 and development of detection by Ic-ELISA显示文摘 | Sumei Ling Jie Pang Jinjin Yu Rongzhi Wang Licai Liu Yanling Ma Yuming Zhang Ni Jin Shihua Wang | 2013 | Toxicon2013，，： | 1 |
| 14 | Glial Cell-Derived Neurotrophic Factor Attenuates Neuropathic Pain in a Mouse Model of Chronic Constriction Injury: Possible Involvement of E-cadherin/p120ctn Signaling显示文摘 | Cunjin Wang Hongjun Wang Jun Pang Li Li Suming Zhang Ge Song Na Li Junping Cao Licai Zhang | 2014 | Journal of Molecular Neuroscience2014，，2： | 1 |
| 15 | Dry-Sliding Tribological Properties of TiAl/Ti 2 AlC Composites显示文摘 | Jun Cheng Fei Li Licai Fu Zhuhui Qiao Jun Yang Weimin Liu | 2014 | Tribology Letters2014，，2： | 1 |
| 16 | Effect of TiB 2 on dry-sliding tribological properties of TiAl intermetallics显示文摘 | Jun Cheng Yuan Yu Licai Fu Fei Li Zhuhui Qiao Jinshan Li Jun Yang Weimin Liu | 2013 | Tribology International2013，，： | 1 |
| 17 | Tribological behavior of nanocrystalline Fe 88 Si 12 alloy in vacuum environment显示文摘 | Licai Fu Youyun Tang Yonghai Kang Jun Yang Weimin Liu | 2015 | Wear2015，，： | 1 |
| 18 | High temperature tribological behavior of a Ti-46Al-2Cr-2Nb intermetallics显示文摘 | Jun Cheng Jun Yang Xinghua Zhang Hong Zhong Jiqiang Ma Fei Li Licai Fu Qinling Bi Jinshan Li Weimin Liu | 2012 | Intermetallics2012，，： | 1 |
| 19 | The Tribological Behavior of a Ti-46Al-2Cr-2Nb Alloy Under Liquid Paraffine Lubrication显示文摘 | Jun Cheng Jun Yang Jiqiang Ma Qinling Bi Xinghua Zhang Licai Fu Fei Li Shengyu Zhu Weimin Liu | 2012 | Tribology Letters2012，，3： | 1 |
| 20 | Mineralogical and geochemical anomalies of late Permian coals from the Fusui Coalfield, Guangxi Province, southern China: Influences of terrigenous materials and hydrothermal fluids显示文摘 | Shifeng Dai Weiguo Zhang Colin R. Ward Vladimir V. Seredin James C. Hower Xiao Li Weijiao Song Xibo Wang Huan Kang Licai Zheng Peipei Wang Dao Zhou | 2013 | International Journal of Coal Geology2013，，： | 1 |
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