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| 1 | Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors显示文摘Multipotent 神经干细胞为房间治疗保持大诺言。到导致的 pluripotent 干细胞以及成熟神经原的成纤维细胞的 reprogramming 建议可能性没有首先建立 pluripotency,把一个严重地区分的体的房间变换成一个 multipotent 状态。这里,我们证明房间从中层导出的那 Sertoli 能直接被变换成拥有神经干细胞性质的一个 multipotent 状态。导致的神经干细胞(iNSCs ) 表示多重 NSC 特定的标记,展出类似于正常 NSC 的全球基因表示侧面,并且能够自强并且区分功能的神经原进神经胶质并且 electrophysiologically。为酷氨酸 hydroxylase (TH ) 积极的导出 iNSC 的神经原污点, γ -aminobutyric 酸,和胆碱 acetyltransferase。另外, iNSCs 能熬过并且产生跟随移植进有牙齿的回转的触处。iNSCs 的产生可以为疾病建模和再生药有重要含意。 | Chao Sheng Qinyuan Zheng Jianyu Wu Zhen Xu Libin Wang Wei Li Haijiang Zhang Xiao-Yang Zhao Lei Liu Ziwei Wang Changlong Guo Hua-Jun Wu Zhonghua Liu Liu Wang Shigang He Xiu-Jie Wang Zhiguo Chen Qi Zhou | 2012 | Cell Research2012，22，1： | 31 |
| 2 | Generation of dopaminergic neurons directly from mouse fibroblasts and fibroblast-derived neural progenitors显示文摘 | Chao Sheng Qinyuan Zheng Jianyu Wu Zhen Xu Lisi Sang Libin Wang Changlong Guo Wanwan Zhu Man Tong Lei Liu Wei Li Zhong-Hua Liu Xiao-Yang Zhao Liu Wang Zhiguo Chen Qi Zhou | 2012 | Cell Research2012，22，4： | 12 |
| 3 | Fault plane parameters of Sanhe-Pinggu M8 earthquake in 1679 determined using present-day small earthquakes显示文摘The great Sanhe-Pinggu M8 earthquake occurred in 1679 was the largest surface rupture event recorded in history in the northern part of North China plain. This study determines the fault geometry of this earthquake by inverting seismological data of present-day moderate-small earthquakes in the focal area. We relocated those earthquakes with the double-difference method.Based on the assumption that clustered small earthquakes often occur in the vicinity of fault plane of large earthquake, and referring to the morphology of the long axis of the isoseismal line obtained by the predecessors, we selected a strip-shaped zone from the relocated earthquake catalog in the period from 1980 to 2009 to invert fault plane parameters of this earthquake. The inversion results are as follows: the strike is 38.23°, the dip angle is 82.54°,the slip angle is-156.08°, the fault length is about 80 km,the lower-boundary depth is about 23 km and the buried depth of upper boundary is about 3 km. This shows that the seismogenic fault is a NNE-trending normal dip-slip fault,southeast wall downward and northwest wall uplift, with the right-lateral strike-slip component. Moreover, the surface rupture zone, intensity distribution of the earthquake and seismic-wave velocity profile in the focal area all verified our study result. | Xiaoshan Wang Xiangdong Feng Xiwei Xu Guiling Diao Yongge Wan Libin Wang Guangqing Ma | 2014 | Earthquake Science2014，27，6： | 9 |
| 4 | Treatment of multiple sclerosis by transplantation of neural stem cells derived from induced pluripotent stem cells显示文摘Multiple sclerosis(MS) is an autoimmune disease of the central nervous system(CNS), with focal T lymphocytic infiltration and damage of myelin and axons. The underlying mechanism of pathogenesis remains unclear and there are currently no effective treatments. The development of neural stem cell(NSC) transplantation provides a promising strategy to treat neurodegenerative disease. However, the limited availability of NSCs prevents their application in neural disease therapy. In this study, we generated NSCs from induced pluripotent stem cells(iPSCs) and transplanted these cells into mice with experimental autoimmune encephalomyelitis(EAE), a model of MS. The results showed that transplantation of iPSC-derived NSCs dramatically reduced T cell infiltration and ameliorated white matter damage in the treated EAE mice. Correspondingly, the disease symptom score was greatly decreased, and motor ability was dramatically rescued in the iPSC-NSC-treated EAE mice, indicating the effectiveness of using iPSC-NSCs to treat MS. Our study provides pre-clinical evidence to support the feasibility of treating MS by transplantation of iPSC-derived NSCs. | Chao Zhang Jiani Cao Xiaoyan Li Haoyu Xu Weixu Wang Libin Wang Xiaoyang Zhao Wei Li Jianwei Jiao Baoyang Hu Qi Zhou Tongbiao Zhao | 2016 | Science China(Life Sciences)2016，59，9： | 9 |
| 5 | Revisiting ovarian cancer microenvironment: a friend or a foe?显示文摘 | Boyi Zhang Fei Chen Qixia Xu Liu Han Jiaqian Xu Libin Gao Xiaochen Sun Yiwen Li Yan Li Min Qian Yu Sun | 2018 | Protein & Cell2018，9，8： | 6 |
| 6 | Pharmacological Activation of RXR-a Promotes Hematoma Absorption via a PPAR-y-dependent Pathway After Intracerebral Hemorrhage显示文摘Endogenously eliminating the hematoma is a favorable strategy in addressing intracerebral hemorrhage(ICH).This study sought to determine the role of retinoid X receptor-ot(RXR-a)in the context of hematoma absorption after ICH.Our results showed that pharmacologically activating RXR-a with bexarotene significantly accelerated hematoma clearance and alleviated neurological dysfunction after ICH.RXR-ot was expressed in microglia/macro-phages,neurons,and astrocytes.Mechanistically,bexarotene promoted the nuclear translocation of RXR-a and PPAR-y,as well as reducing neuroinflammation by modulating microglia/macrophage reprograming from the Ml into the M2 phenotype.Furthermore,all the beneficial effects of RXR-a in ICH were reversed by the PPAR-y inhibitor GW9662.In conclusion,the pharmacological activation of RXR-a confers robust neuroprotection against ICH by accelerating hematoma clearance and repolarizing microglia/macrophages towards the M2 phenotype through PPAR-y-related mechanisms.Our data support the notion that RXR-ot might be a promising therapeutic target for ICH. | Chaoran Xu Huaijun Chen Shengjun Zhou Chenjun Sun Xiaolong Xia Yucong Peng Jianfeng Zhuang Xiongjie Fu Hanhai Zeng Hang Zhou Yang Cao Qian Yu Yin Li Libin Hu Guoyang Zhou Feng Yan Gao Chen Jianru Li | 2021 | Neuroscience Bulletin2021，37，10： | 4 |
| 7 | Overview of research on agricultural robots in China显示文摘As the representation of new concept agricultural machinery,agricultural robots possess great advantages of improving agricultural productivity,enhancing production environment and solving the problem of labor shortage.Therefore,the strategy for application of agricultural robots and precision agriculture to improve the intelligence and information level of agriculture is the inevitable trend for China’s agriculture in the twentieth century.Based on the developmental status of agricultural robots in China,the agricultural robots are categorized and the performances,structures and characteristics of various agricultural robots such as vegetable grafting robots,transplanting robots,spraying robots,mowing robots,harvesting robots,grading and detecting robots are amply introduced.It can be seen that vegetable grafting robots,spraying robots,harvesting robots,grading and detecting robots have already been put into production while others are still at experimental stage.At present,there are several problems such as low popularization,great limitations,high cost and low intelligence,which greatly restrict the development of agricultural robots in China.Thus,open agricultural robot system with good expansibility,generality and flexibility should be developed and adopted to decrease its cost and shorten developing cycle.The mechanical structure of robots should also be designed as simply as possible.Finally,multi-robot system would become another important development direction of agricultural robots in the future. | Zhang Libin Yang Qinghua Bao Guanjun Wang Yan Qi Liyong Gao Feng Xu Fang | 2008 | International Journal of Agricultural and Biological Engineering2008，1，1： | 4 |
| 8 | STRUCTURE DESIGN OF THE BEIJING SPECTROMETERⅢBEAM PIPE显示文摘The Beijing spectrometerⅢ(BESⅢ)beam pipe is in the center of the BESⅢ,which is the detector of the upgrade project of Beijing electron and positron collider(BEPCⅡ).Electrons and positrons collide in the BESⅢbeam pipe.According to the demands of the BEPCⅡ,a key program of Chinese Academy of Sciences,the BESⅢbeam pipe is designed based on the finite elements analysis.The BESⅢbeam pipe is installed in the inner cylinder of the BESⅢdrift chamber.As a vacuum tube,the BESⅢbeam pipe is designed as 1000 mm in length,63 mm in inner diameter and 114 mm in outer diameter,respectively.The BESⅢbeam pipe consists of a central beryllium pipe cooled by EDM-1,the oil No.1 for electric discharge machining,and two extended copper pipes cooled by deionized water(DW).The three parts are jointed by vacuum welding.Factors taken into account in the design are as follows.①The wall thickness of the central beryllium pipe should be designed as small as possible to reduce the multi-scattering and improve the particle momentum resolution.And the wall thickness of the extended copper pipe should be designed as large as possible to protect the detectors from the backgrounds.②The BESⅢbeam pipe must be sufficiently cooled to avoid the damage and prevents its influence to the BESⅢdrift chamber(DC)operation.The inner surface temperature of the DC inner cylinder must be maintained at 293±2 K.③The magnetic permeability of the materials used in the BESⅢbeam pipe must be less than 1.05 H/m to avoid large magnetic field distortions.④The static pressure of the vacuum chamber of the BESⅢbeam pipe must be less than 800μPa.The simulating results show that the designed structure oftbe BESⅢbeam pipe satisfies the requirements mentioned above.The structure design scheme is evaluated and adopted by the headquarters of BEPCⅡ. | ZHENG Lifang JI Quan WANG Li LI xunfeng XU Shaowang DONG Sujun ZHAO Libin LIU Jianping | 2008 | Chinese Journal of Mechanical Engineering2008，21，3： | 3 |
| 9 | Effects of heat treatment on mechanical properties and microstructure of tungsten fiber reinforced grey cast iron matrix composites显示文摘In this study,grey cast iron matrix composites reinforced by different volume fractions of tungsten fibers(Vr=0.95%,1.90%,2.85%,3.80%)were investigated in as-cast and under the heat treatment temperatures of 1,000℃and 1,100℃.The microstructure and mechanical properties of the composites were analyzed and tested by means of SEM,micro-hardness tester and three-point bend testing.The results show that with increasing of the volume fraction of tungsten fibers,the composites reinforced by the tungsten fiber have higher flexural strength and modulus than that of cast iron without reinforcement,and the flexural strength increases with the increasing of heat treatment temperatures.Due to diffusion reaction between matrix and reinforcing phases,the process of heat treatment,the number of graphite flakes in the matrix seemingly becomes lower;and some hard carbide particles are formed around the residual tungsten fibers.Not only does the hardness of both matrix and reinforcement change tremendously,but also the region of reinforcement is also extended from the original 0.11 mm to 0.19 mm in radius. | Niu Libin Xu Yunhua Peng jianHong Wu Hong | 2009 | China Foundry2009，6，4： | 3 |
| 10 | Study on in-situ WC particles/tungsten wire reinforced iron matrix composites under electromagnetic field显示文摘By applying electromagnetic field to a system consisting of tungsten wires and grey cast iron melt,the grey cast iron matrix composite reinforced by either in-situ WC particles or the combination ofin-situ WC particles and the residual tungsten wire was obtained.By means of differential thermal analysis(DTA),the pouring temperature ofiron melt was determined at 1,573 K.The microstructures of the composites were analyzed by using of X-ray diffraction(XRD),scanning electron microscopy(SEM) equipped with an energy dispersive spectrum(EDS) and pin-on-disc abrasive wear test.The obtained results indicated that,with the enhancing frequency of electromagnetic field,the amount ofin-situ WC particles gradually increases,leading to continuous decrease of the residual tungsten wires.When the electromagnetic field frequency was up to 4 kHz,tungsten wires reacted completely with carbon atoms in grey cast iron melt,forming WC particals.The electromagnetic field appeared to accelerate the elemental diffusion in the melt,to help relatively quick formation of a series of small FeW-C ternary zones and to improve the kinetic condition ofin-situ WC fabrication.As compared with the composite prepared without the electromagnetic field,the composite fabricated at 4 kHz presented good wear resistance. | Niu Libin Xu Yunhua Wu Hong | 2010 | China Foundry2010，7，2： | 2 |
| 11 | RGB WGM lasing woven in fiber braiding cavity显示文摘It is critical to realize woven and wearable red-green-blue(RGB) whispering gallery mode(WGM)lasing that is tunable and flexible in the fiber braiding cavity. However, it is still a challenge to achieve tunable full-color lasing with the large color gamut by a facile approach. Here, we design the braiding cavity to realize RGB WGM lasing with high performance. The braiding cavity consists of three optical fibers coated with dye-doped polymer. Each fiber therein serves as a resonant cavity to support multiple lasing modes. There is no interference owing to the air gap between them;therefore, we can achieve full-color WGM lasing. The lasing emission in our fiber braiding cavity covers a color gamut of 86.7% larger than standard RGB space.Our work may provide a platform for potential applications in white laser and integrated optoelectronic devices. | Kun GE Zhiyang XU Dan GUO Ben NIU Jun RUAN Libin CUI Tianrui ZHAI | 2022 | Science China(Information Sciences)2022，65，8： | 2 |
| 12 | Change of Organic δ^(13)C in Ornithogenic Sediments of the Xisha Archipelago,South China Sea and its Implication for Ecological Development显示文摘Organic carbon isotopes in sediments have been frequently used to identify the source of organic matter.Here we present a study of organic δ^(13)C on two sediment profiles influenced by guano from Guangjin and Jinqing islands in the Xisha Archipelago,South China Sea.Organic matter from ornithogenic coral sand sediments has two main sources,guano pellets and plant residues,and their organic δ^(13)C(δ^(13)C_(OM)) are significantly different.Organic carbon δ^(13)C_(guano) is much higher thanδ^(13)C_(plants),and δ^(13)C_(OM)of bulk samples is intermediate.Based on a two-end-member mixing model,the proportions of guano-and plant-derived organic matter in the bulk samples were reconstructed quantitatively.The results showed that seabirds began to inhabit the islands around approximately1200-1400 AD,and that guano pellets have been an important source of soil organic matter since then.With the accumulation of guano-derived nutrients,plants began to develop prosperously on the islands in the last 200 years,which is reflected by the significant increase of plant-derived organic matter in the upper sediment layer.However,guano-derived organic matter decreased greatly in recent decades,indicating a rapid decrease in seabird population.Our results show that organic δ^(13)C can be effectively used to quantitatively determine different source contributions of OM to bulk ornithogenic coral sand sediments. | WU Libin LIU Xiaodong XU Liqiang | 2017 | Acta Geologica Sinica(English Edition)2017，91，3： | 2 |
| 13 | Coupled biodegradation of p-nitrophenol and p-aminophenol in bioelectrochemical system:Mechanism and microbial functional diversity显示文摘Biodegradation mechanisms and microbial functional diversity during coupled pnitrophenol(PNP)and p-aminophenol(PAP)degradation were studied in a bioelectrochemical system.PNP in the biocathode and PAP in the bioanode were almost completely removed within 28 hr and 68 hr respectively.The degradation followed the steps including hydrating hydroxyalkylation,dehydrogenating carbonylation,and hydrolating ring cleavage,etc.Metagemomic analysis based on the KEGG and egg NOG database annotations revealed the microbial composition and functional genes/enzymes related to phenol degradation in the system.The predominant bacteria genera were Lautropia,Pandoraea,Thiobacillus,Ignavibacterium,Truepera and Hyphomicrobium.The recognized biodegradation genes/enzymes related to pollutant degradation were as follows:pmo,hbd,&ppo for phenol degradation,nzba,amie,&badh for aromatic degradation,and CYP&p450 for xenobiotics degradation,etc.The co-occurrence of ARGs(antibiotic resistant genes),such as ade F,Mex J,Erm F,PDC-93 and Escherichiacolimdf A,etc.,were annotated in CARD database during the biodegradation process.The Proteobacteria&Actinobacteria phylum was the primary host of both the biodegradation genes&ARGs in this system.The microbial functional diversity ensured the effective biodegradation of the phenol pollutants in the bioelectrochemical system. | Jianjun Luo Yuxi Xu Jing Wang Libin Zhang Xinbai Jiang Jinyou Shen | 2021 | Journal of Environmental Sciences2021，33，10： | 2 |
| 14 | Thermodynamic database of multi-component Mg alloys and its application to solidification and heat treatment显示文摘An overview about one thermodynamic database of multi-component Mg alloys is given in this work.This thermodynamic database includes thermodynamic descriptions for 145 binary systems and 48 ternary systems in 23-component(Mg–Ag–Al–Ca–Ce–Cu–Fe–Gd–K–La–Li–Mn–Na–Nd–Ni–Pr–Si–Sn–Sr–Th–Y–Zn–Zr)system.First,the major computational and experimental tools to establish the thermodynamic database of Mg alloys are briefly described.Subsequently,among the investigated binary and ternary systems,representative binary and ternary systems are shown to demonstrate the major feature of the database.Finally,application of the thermodynamic database to solidification simulation and selection of heat treatment schedule is described. | Guanglong Xu Ligang Zhang Libin Liu Yong Du Fan Zhang Kai Xu Shuhong Liu Mingyue Tan Zhanpeng Jin | 2016 | Journal of Magnesium and Alloys2016，4，4： | 2 |
| 15 | Dramatic reduction of liver cancer incidence in young adults: 28 year follow-up of etiological interventions in an endemic area of China显示文摘 | Zongtang Sun Taoyang Chen Snorri S. Thorgeirsson Qimin Zhan Jianguo Chen Ju-Hyun Park Peixin Lu Chu Chieh Hsia Nengjin Wang Libin Xu Lingling Lu Fei Huang Yuanrong Zhu Jianhua Lu Zhengping Ni Qinan Zhang Yuying Wu Guoting Liu Zhiyuan Wu Chunfeng Qu Mitche | 2013 | Carcinogenesis2013，，8： | 1 |
| 16 | A 1 V 450 nW fully integrated programmable biomedical sen- sor interface chip显示文摘 | Zou Xiaodan Xu Xiaoyuan Yao Libin | 2009 | IEEE Journal of Solid-state Cir- cuits2009，44，4： | 1 |
| 17 | Three-dimensional CFD modeling and simulation on the performance of steam ejector heat pump for dryer section of the paper machine显示文摘 | Yuejin Yuan Libin Tan Yingying Xu Yueding Yuan | 2015 | Vacuum2015，，： | 1 |
| 18 | All-fiber Norrow-band grating assisted Sagnae Transmission Filter显示文摘 | Fu Libin An Honglin Xu Wanjjin | 2000 | Chinese Journal of Lasers B2000，9，4： | 1 |
| 19 | Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression显示文摘 | Zhengzhao Liu Peng Chen Hong Gao Yu Gu Jiao Yang Hong Peng Xingxing Xu Haifeng Wang Meiqiang Yang Xiaoying Liu Libin Fan Shiyao Chen Jian Zhou Yihong Sun Kangchen Ruan Shuqun Cheng Masaaki Komatsu Eileen White Lin Li Hongbin Ji Daniel Finley Ronggui Hu | 2014 | Cancer Cell2014，，： | 1 |
| 20 | A 1-V 450-nW fully integrated programmable biomedical sensor interface chip显示文摘 | ZOU Xiaodan XU Xiaoyuan YAO Libin | 2009 | IEEE Journal of Solid-State Circuits2009，44，4： | 1 |
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