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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | Simulation of phase transition process using lattice Boltzmann method显示文摘A new lattice Boltzmann model based on SC model, is proposed to describe the liquid-vapor phase transitions. The new model is validated through the simulation of the one-component phase transition process. Compared with the simulation results of van der Waals gas and the Maxwell equal-area construction, the results of the new model have a better agreement with the analytical solutions than those of SC and Zhang models. Since the obtained temperature range and the maximum density ratio in this model are expanded, and the magnitude of maximum spurious current is only between those of SC and Zhang models, it is believed that this new model has better stability than SC and Zhang models. Consequently, the application scope of this new model is expanded compared with the existing phase transition models. According to the principle of the corresponding states in engineering thermodynamics, the simulations of ammonia and water phase transition process were implemented using this new model with different equations of state. Compared with the experimental data of ammonia and water, the results show that the Peng-Robinson is the best equation of state to describe the phase transition process of ammonia and water. Especially, the simulation results of ammonia with Peng-Robinson equation of state have an excellent agreement with its experimental data. Therefore these simulation results have a significant influence on the real engineering applications. | ZENG JianBang LI LongJian LIAO Quan CUI WenZhi CHEN QingHua PAN LiangMing | 2009 | Chinese Science Bulletin2009，54，24： | 8 |
| 3 | Molecular Cytogenetic Characterization of a Wheat-Leymus mollis 3D(3Ns) Substitution Line with Resistance to Leaf Rust显示文摘Leymus mollis(Trin.)Pilger(NsNsXmXm,2n?28),a wild relative of common wheat,possesses many potentially valuable traits that could be transferred to common wheat during breeding programs.In this study,the karyotypic constitution of a wheat e L.mollis 3D(3Ns#1)disomic substitution line isolated from the F5progeny of octoploid Tritileymus M842-16 Triticum durum cv.D4286,which was designated as 10DM57,was determined using genomic in situ hybridization(GISH),fluorescent in situ hybridization(FISH),SSR markers,and ESTSTS markers.Screening of mitosis and meiosis showed that 10DM57 had a chromosome karyotype of 2n?42?21II.GISH indicated that10DM57 was a line with 40 chromosomes from wheat and two of the Ns chromosomes from L.mollis,which formed a ring bivalent in pollen mother cells at metaphase I.FISH analysis showed that the chromosome 3D may be replaced by 3Ns#1 in 10DM57.DNA markers,including SSR and EST-STS primers,showed that the pair of wheat chromosome 3D in 10DM57 was substituted by the pair of chromosome 3Ns#1from L.mollis.Evaluation of the agronomic traits showed that,compared with its common wheat relative 7182,10DM57 was resistant to leaf rust while the spike length and number of spikes per plant were improved significantly,which correlated with a higher wheat yield.The new germplasm,10DM57,could be exploited as an intermediate material in wheat genetic and breeding programs. | Yuhui Pang Xinhong Chen Jixin Zhao Wanli Du Xueni Cheng Jun Wu Yanli Li Liangming Wang Jing Wang Qunhui Yang | 2014 | Journal of Genetics and Genomics2014，41，4： | 6 |
| 4 | Prediction and mitigation analysis of ground vibration caused by running high-speed trains on rigid-frame viaducts显示文摘In this study a 3D numerical analysis approach is developed to predict the ground vibration around rigid-frame viaducts induced by running high-speed trains.The train-bridge-ground interaction system is divided into two subsystems:the train-bridge interaction and the soil-structure interaction.First,the analytical program to simulate bridge vibration with consideration of train-bridge interaction is developed to obtain the vibration reaction forces at the pier bottoms.The highspeed train is described by a multi-DOFs vibration system and the rigid-frame viaduct is modeled with 3D beam elements.Second,applying these vibration reaction forces as input external excitations,the ground vibration is simulated by using a general-purpose program that includes soil-structure interaction effects.The validity of the analytical procedure is confirmed by comparing analytical and experimental results.The characteristics of high-speed train-induced vibrations,including the location of predominant vibration,are clarified.Based on this information a proposed vibration countermeasure using steel strut and new barrier is found effective in reducing train-induced vibrations and it satisfies environmental vibration requirements.The vibration screening efficiency is evaluated by reduction VAL based on 1/3 octave band spectral analysis. | Liangming Sun Weiping Xie Xingwen He Toshiro Hayashikawa | 2016 | Earthquake Engineering and Engineering Vibration2016，15，1： | 5 |
| 5 | Hydrogel Microneedle Arrays for Transdermal Drug Delivery显示文摘Stratum corneum is the main obstacle for drugs to pass through the skin. Microneedles are composed of arrays of micro-projections formed with different materials, generally ranging from 25-2000 μm in height. Microneedles straightly pierce the skin with its short needle arrays to overcome this barrier. Microneedles can be divided into several categories, for instance, solid microneedles, coated microneedles, and hollow microneedles and so on. However, all these types have their weak points related to corresponding mechanisms.In recent years, pioneering scientists have been working on these issues and some possible solutions have been investigated. This article will focus on the microneedle arrays consisting of hydrogels. Hydrogels are commonly used in drug delivery field. Hydrogel microneedles can be further divided into dissolving and degradable microneedles and phase transition microneedles. The former leaves drug with matrix in the skin. The latter has the feature that drugs in the matrix are delivered while the remaining ingredients can be easily removed from the skin after usage. For drugs which are required to be used every day, the phase transition microneedles are more acceptable. This article is written in order to summarize the advantages of these designs and summarize issues to be solved which may hinder the development of this technology. | Xiaoyun Hong Zaozhan Wu Lizhu Chen Fei Wu Liangming Wei Weien Yuan | 2014 | Nano-Micro Letters2014，6，3： | 5 |
| 6 | Microstructure evolution of Al-Zn-Mg-Cu-Zr alloy during hot deformation显示文摘Compression tests of the Al-Zn-Mg-Cu-Zr(7055) alloy were performed at various strains and temperatures from 300 to 450℃ under a constant strain rate between 10-2 s-1 and 1 s-1.Microstructures during hot deformation were studied by transmission electron microscopy(TEM).Dislocation density,dislocation cells and subgrains of the deformed samples were investigated in detail and compared to make a better understanding of the microstructure evolution.The results showed that stress-strain curves under the experimental conditions belonged to the type of dynamic recovery.When the alloy deformed at various strains and 300℃,the microstructure underwent a process of disordered dislocations to cell structure,subgrain structure and subgrain coarsening.With the temperature increasing,subgrains grew and dislocation density in the interior decreased at a strain rate of 1 s-1.At the temperature of 350℃,the average diameter of subgrains decreased,sub-boundaries broadened and dislocation density in the interior decreased when the strain rate was increased.The deformed samples of 7055 alloy had smaller subgrains than that of 7005 alloy at the same compression condition because of high alloy content. | YAN Liangming,SHEN Jian,LI Zhoubing,LI Junpeng,and YAN Xiaodong General Research Institute for Nonferrous Metals,Beijing 100088,China | 2010 | Rare Metals2010，29，4： | 4 |
| 7 | Wind Wave Characteristics and Engineering Environment of the South China Sea显示文摘Wave simulation was conducted for the period 1976 to 2005 in the South China Sea(SCS) using the wave model, WAVEWATCH-III. Wave characteristics and engineering environment were studied in the region. The wind input data are from the objective reanalysis wind datasets, which assimilate meteorological data from several sources. Comparisons of significant wave heights between simulation and TOPEX/Poseidon altimeter and buoy data show a good agreement in general. By statistical analysis, the wave characteristics, such as significant wave heights, dominant wave directions, and their seasonal variations, were discussed. The largest significant wave heights are found in winter and the smallest in spring. The annual mean dominant wave direction is northeast(NE) along the southwest(SW)-NE axis, east northeast in the northwest(NW) part of SCS, and north northeast in the southeast(SE) part of SCS. The joint distributions of wave heights and wave periods(directions) were studied. The results show a single peak pattern for joint significant wave heights and periods, and a double peak pattern for joint significant wave heights and mean directions. Furthermore, the main wave extreme parameters and directional extreme values, particularly for the 100-year return period, were also investigated. The main extreme values of significant wave heights are larger in the northern part of SCS than in the southern part, with the maximum value occurring to the southeast of Hainan Island. The direction of large directional extreme Hs values is focus in E in the northern and middle sea areas of SCS, while the direction of those is focus in N in the southeast sea areas of SCS. | WANG Zhifeng ZHOU Liangming DONG Sheng WU Lunyu LI Zhanbin MOU Lin WANG Aifang | 2014 | Journal of Ocean University of China2014，13，6： | 4 |
| 8 | Cu_2O nanowires as anode materials for Li-ion rechargeable batteries显示文摘Li-ion batteries are a key technology for multiple clean energy applications.In this study,Cu2O nanowires were obtained by the reduction of cupric acetate with pyrrole.The resulting Cu2O nanowires exhibited excellent reversible capacities of 470mAh g-1 at rate of 1 C after 100 cycles.The results show that the Cu2O nanowires had more capacity than materials previously reported.No fading was observed over 100 cycles of charging and discharging.The compound metal Cu and incorporation of the conducting polymer polypyrrole(PPy)improved the conductivity of Cu2O and enhanced the stability of the electrode during cycling.The results from this study imply that Cu2O nanowires with high capacity and good cycle retention could be excellent candidates as anode materials for Li-ion rechargeable batteries. | CHEN Rui WANG Ying NULI YanNa YU Yuan GAO PengFei CHEN Qiang WEI LiangMing HU NaTao YANG Zhi GAO RunGang ZHANG LiLing ZHANG YaFei | 2014 | Science China(Technological Sciences)2014，57，6： | 3 |
| 9 | Down-regulation of heparanase leads to the inhibition of invasion and proliferation of A549 cells in vitro and in vivo显示文摘Heparanase 是降级的哺乳动物的 endoglycosidase 在房间表面并且在细胞外的矩阵的 heparan 硫酸盐。heparanase 的表示在许多人的恶意的肿瘤被检测并且仔细把侵略,转移,和 angiogenesis 与肿瘤联系了。然而, heparanase 的特定的角色和它调整非小的房间肺癌症(NSCLC ) 的恶意的潜力的机制房间仍然保持不清楚。在现在的学习, heparanase 的表示在由 antisense oligodeoxynucleotide 的 NSCLC 房间线是下面调整的。结果证明 heparanase 的下面规定导致了重要抑制侵略并且在 vitro 并且在 vivo 的 A549 房间的 proliferative 潜力。进一步的研究证明 heparanase 的下面规定显著地禁止了 A549 房间的 angiogenic 潜力,它可能是为在在 vivo 的 BALB/c 裸体老鼠的 A549 房间增长的抑制负责的机制。这些调查结果证明 heparanase 在调整 A549 房间的侵略,增长,和 angiogenesis 起必要作用。 | Zhitao Chen Liangming Zhu Xiaohua Li Hui Tian Yusong Fang Haibo Liu Shuhai Li Lin Li Weiming Yue Wenjun Li | 2013 | Acta Biochimica et Biophysica Sinica2013，45，3： | 3 |
| 10 | A framework design for the Chinese National Disaster Reduction System of Systems(CNDRSS)显示文摘China is one of the most disaster-prone countries in the world.Currently,the disaster prevention and relief mechanism in China is mainly based on single disaster types and is implemented by different ministries and divisions in single administrative regions.Subsequently,the available resources,including data,services,materials,and human resources,cannot be shared and used effectively.Based on the idea of an observation system of systems and a business system of systems,this paper presents an integrated framework for a Chinese National Disaster Reduction System of Systems(CNDRSS)to address this issue.The CNDRSS framework aims to achieve data sharing and collaboration among different disaster-related ministries/institutions by providing one-stop services for all phases of disaster management and linking together existing and planned disaster-related business systems and observation systems.The key technologies use federated databases and a web service to integrate multiple disaster management systems among different ministries/institutions and a sensor web to integrate airborne,space-borne,and in-situ observations through the web service.These event-driven focused-services connecting the various observations,processing,and mapping processes can meet the requirements for complex disasterchain systems. | Deren Li Linglin Zeng Nengcheng Chen Jie Shan Liangming Liu Yida Fan Wei Li | 2014 | International Journal of Digital Earth2014，7，1： | 3 |
| 11 | Efiect of surface waves on air-sea momentum fiux in high wind conditions for typhoons in the South China Sea显示文摘The WAVEWATCH-Ⅲ wave model is implemented in the South China Sea to investigate the air-sea momentum fiux in high wind conditions during 23 passages of typhoon occurred in 2005.The wave model is driven by the reanalyzed surface winds assimilated by several meteorologic data sources.The friction velocity was calculated and the relationships between difierent air-sea momentum param-eters were studied.The results show that the drag coeficient decreases with the wave age generally and levels ofi for wind speeds higher than 35 m/s under typhoon wind forcing.The spatial variations of air-sea momentum fiux parameters in high wind conditions forced by typhoons are completely difierent from those at weak wind speeds and significantly depend on the relative position from the typhoon center. | Liangming Zhou Aifang Wang Peifang Guo Zhifeng Wang | 2008 | Progress in Natural Science:Materials International2008，18，9： | 2 |
| 12 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5hpob5nbfxxkkb6qfc.ffgz.tsg.suse.edu.cn/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 13 | EFFECTIVE NUMERICAL METHODS FOR ELASTO-PLASTIC CONTACT PROBLEMS WITH FRICTION显示文摘Several effective numerical methods for solving the elasto-plastic contact problems with friction are pres-ented.First,a direct substitution method is employed to impose the contact constraint conditions on condensed finite ele-ment equations,thus resulting in a reduction by half in the dimension of final governing equations.Second,an algorithmcomposed of contact condition probes and elasto-plastic iterations is utilized to solve the governing equation,whichdistinguishes two kinds of nonlinearities,and makes the solution unique.In addition,Positive-Negative Sequence Modifica-tion Method is used to condense the finite element equations of each substructure and an analytical integration is intro-duced to determine the elasto-plastic status after each time step or each iteration,hence the computational efficiency is en-hanced to a great extent.Finally,several test and practical examples are pressented showing the validity and versatility ofthese methods and algorithms. | Wang Xucheng Chang Liangming Cen Zhangzhi (Department of Engineering Mechanics,Tsinghua University) | 1990 | Acta Mechanica Sinica1990，6，4： | 2 |
| 14 | Asymptomatic patients and asymptomatic phases of Coronavirus Disease 2019(COVID-19):a population-based surveillance study显示文摘In this population-based study,we identified 307 confirmed COVID-19 cases from massive surveillance,including 129551 individuals screened at fever clinics or returning from Hubei and 3710 close contacts of confirmed COVID-19 patients.Among them,17 patients were asymptomatic at initial clinical assessment.These asymptomatic patients on admission accounted for a small proportion of all patients(5.54%)with relatively weak transmissibility,and the detection rate was 0.35 per 100 close contacts.Moreover,the dynamics of symptoms of the 307 patients showed that the interval from symptom remission to the final negativity of viral nucleic acid was 5.0 days(interquartile range 2.0 to 11.0 days),with 14 patients(4.56%)having re-detectable viral RNA after discharge.Overall;our findings suggested asymptomatic carriers and presymptomatic patients only accounted for a small proportion of COVID-19 patients.Also,the asymptomatic phase during recovery from COVID-19 implied that negativity in viral RNA is necessary as a de-isolation criterion and follow-up is recommended. | Xueying Zheng Sihui Luo Yong Sun Mingfeng Han Jian Liu Liangye Sun Liangming Zhang Ping Ling Yu Ding Tengchuan Jin Zhirong Liu Jianping Weng | 2020 | National Science Review2020，7，10： | 2 |
| 15 | Design and analysis of recurrent neural network models with non-linear activation functions for solving time-varying quadratic programming problems显示文摘A special recurrent neural network(RNN),that is the zeroing neural network(ZNN),is adopted to find solutions to time-varying quadratic programming(TVQP)problems with equality and inequality constraints.Howevet,there are some weaknesses in activation functions of traditional ZNN models,including convex restriction and redundant formulation.With the aid of different activation functions,modified ZNN models are obtained to overcome the drawbacks for solving TVQP problems.Theoretical and experimental research indicate that the proposed models are better and more effective at solving such TVQP problems. | Xiaoyan Zhang Liangming Chen Shuai Li Predrag Stanimirovic Jiliang Zhang Long Jin | 2021 | CAAI Transactions on Intelligence Technology2021，6，4： | 2 |
| 16 | ChemicalcompositionsinDictyophoraechinovolvataextractedwithacetoneandtheantibacterialactivityextractedwithacetone ethanolandwater显示文摘 | LiangM(梁鸣) TangDF(檀东飞) | 2005 | 菌物学报2005，24，： | 1 |
| 17 | Heat Transfer and Bubble Movement of Two-Side and One-Side Heating Subcooled Flow Boiling in Vertical Narrow Channels显示文摘 | Pan LiangMing | 2006 | Journal of Heat Transfer2006，128，： | 1 |
| 18 | Synthesis, biodegrad- ability and cytotoxicity of water soluble isobutyl chitosan 显示文摘 | Li Donghong Liu Liangming Tian Kunlun | 2007 | Carbo- hydrate Polym2007，67，1： | 1 |
| 19 | Fermentative biohydrogen production from lactate and acetate 显示文摘 | WU Chaowei WHANG Liangming CHENG Haihsuan | 2012 | Bioresource Technology2012，113，： | 1 |
| 20 | Synthesis,biodegradability and cytotoxicity of water-soluble isobutylchitosan显示文摘 | Li Donghong Liu Liangming Tian Kunlun | 2007 | Carbohydr Polym2007，67，1： | 1 |
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