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| 1 | A study of preoperative methionine-depleting parenteral nutrition plus chemotherapy in gastric cancer patients显示文摘AIM To investigate the interference ofmethionine.free parenteral nutrition plus 5-Fu(-MetTPN+5-Fu)in gastric cancer cell kineticsand the side effects of the regimen.METHODS Fifteen patients with advancedgastric cancer were randomly divided into twogroups,7 patients were given preoperatively aseven-day course of standard parenteralnutrition in combination with a five-day courseof chemotherapy(sTPN+5-Fu),while the other8 patients were given methionine-deprivedparenteral nutrition and 5-Fu(-MetTPN+5-Fu).Cell cycles of gastric cancer and normal mucosawere studied by flow cytometry(FCM).Bloodsamples were taken to measure the serumprotein,methionine(Met)and cysteine(Cys)levels,and liver and kidney functions.RESULTS As compared with the resultsobtained before the treatment,the percentage ofG0/G1 tumor cells increased and that of S phasedecreased in the-MetTPN+5-Fu group,while thecontrary was observed in the sTPN+5-Fu group.Except that the ALT,AST and AKP levels wereslightly increased in a few cases receiving-MetTPN+5-Fu,all the other biochemicalparameters were within normal limits.Serum Cys level decreased slightly after the treatmentin both groups.Serum Met level of patientsreceiving sTPN+5-Fu was somewhat higher aftertreatment than that before treatment;however,no significant change occurred in the -MetTPN+5-Fu group,nor operative complications in bothgroups.CONCLUSION -MetTPN+5-Fu exerted asuppressive effect on cancer cell proliferation,probably through a double mechanism ofcreating a state of'Met starvation'adverse tothe tumor cell cycle,and by allowing 5-Fu to killspecifically cells in S phase.Preoperative short-term administration of -MetTPN+5-Fu had littleundesirable effect on host metabolism. | Cao WX Cheng QM Fei XF Li SF Yin HR Lin YZ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 2 | DSA analysis of hepatic arteriovenous fistula concurrent with hepatic cancer and its clinical significance显示文摘INTRODUCTIONIntervention therapy has become one of the maintherapies of hepatic cancer.Theintroduction of hepatic arterial perfusion andembolization has provided opportunities for asecondary operation on patients with intermediateand advanced cancer,thus | Guo WP Zhang HX Wang ZM Wang YQ Ni DH Li WX Guan Y | 2000 | World Journal of Gastroenterology2000，6，6： | 11 |
| 3 | Sedation and safety of propofol for therapeutic endoscopic retrograde cholangiopancreatography显示文摘Endoscopic retrograde cholangiopancrea tography(ERCP) is the most complex gastrointestinal procedure,which needs patients’ cooperation. The aim of this study was to observe the quality and safey of sedation with propofol in patients undergoing therapeutic ERCP. METHODS:Seventy patients who had undergone therapeutic ERCP were randomly divided into two groups.One group, given intravenously propofol, and the other sedated with routine method, served as the control. Blood pressure, heart rate,oxygen saturation were monitored and cardiorespiratory event was observed. Patient cooperation,performance, recovery time and amnesia served as variables postoperation. RESULTS:Blood pressure elevated in four patients in the propofol group, less than in the control group(P<0.01). Seven patients showed decreased blood pressure after administration of propofol,but none in the control group (P<0.01). Twelve patients in the control group showed mild or significant resistance, but none in the propofol group (P<0.01). The time for performance in the propofol group(P<0.05) was shorter than in the control group. Patient recovery was quicker in the propofol group than in the control group (P<0.01). The degree of amnesia better in the propofol group than in the control group ( P<0.01). The degree of amnesia was also better in the propofol group than in the control group (P<0.01). CONCLUSIONS:Propofol proves to be an excellent sedative for therapeutic ERCP. Being effective and safe, it shows a shorter ERCP duration but quick recovery and better amnesia. It is better than other routine sedatives. | Digestive Department (Chen WX, Lin HJ, Gu Q, Zhong XQ, Yu CH, Li YM and Gu ZY) and Department of Intensive Care Unit (Zhang WF), First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003 , China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 10 |
| 4 | Numb通过舌癌中的RBP-Jκ依赖性Notch1/PTEN/FAK信号传导途径抑制上皮-间质转化显示文摘景:口腔癌已被估计为全世界第六最常见的实体癌,其中舌鳞状细胞癌(TSCC)是最常见的口腔癌类型。然而,TSCC转移到淋巴结和远处部位的机制尚未完全了解。方法:本研究利用RT-qPCR方法检测Numb、PTEN和Notch1基因以及EMT相关基因的m RNA水平,利用蛋白质印迹分析检测这些基因的蛋白质水平。 | Li JY Huang WX Zhou X 赵泽亮 | 2019 | 中国口腔颌面外科杂志2019，17，4： | 6 |
| 5 | Autophagy reduces acute ethanol- induced hepatotoxicity and steatosis in rnice显示文摘 | Ding WX Li M Chen X | 2010 | Gastroenterology2010，139，： | 1 |
| 6 | Analysis of the fungi community in multiple- and single-grains Zaopeifrom a Luzhou-flavor liquor distillery in western China 显示文摘 | Shi S Zhang L Wu ZY Zhang WX Deng Y Zhong FD Li JM | 2011 | World JMicrobiol Biotechnol2011，27，： | 1 |
| 7 | Biological leaching of heavy metals from a contaminated soil by Aspergillus niger 显示文摘 | Ren WX Li PJ Geng Y Li XJ | 2009 | J Hazard Mater2009，167，： | 1 |
| 8 | Assay of T-and NK-cell subsets and the expression of NKG2A and NKG2D in patients with new-onset systemic lupus erythematosus显示文摘 | Li WX Pan HF Hu JL | 2010 | Clin Rheumatol2010，29，3： | 1 |
| 9 | Updated morphology, histopathology and molecular phylogeny of Myxobolus hearti , cardiac myxosporea in gibel carp, Carassius gibelio (Bloch)显示文摘 | LT Ye WX Li WW Wang SG Wu GT Wang | 2014 | J Fish Dis2014，，1： | 1 |
| 10 | Assay of T- and NK-cell subsets and the expression of NKG2A and NKG2D in patients with new-onset systemic lupus erythematosus显示文摘 | Li WX Pan HF Hu JL | 2010 | Clin R_heumatol2010，29，3： | 1 |
| 11 | Effects of taurine on aortic rings i-solated from fructose-fed insulin resistance and normal rat aorticrings are different显示文摘 | Xue WX Zhang MS Li J | 2008 | Cardiovasc Drug Ther2008，22，： | 1 |
| 12 | Polymorphisms of the TIM-1 and TIM-3 genes are not associated with systemic lupus erythe- matosus in a Chinese population显示文摘 | Li WX Chen GM Yuan H | 2011 | Mutagenesis2011，26，4： | 1 |
| 13 | Accelerated flap prefabrication with vascular endothelial growth factor 显示文摘 | Li QF Reis ED Zhang WX | 2000 | J Reconstr Microsurg2000，16，： | 1 |
| 14 | Exercise preconditioning upreg- ulates cerebral integrins and enhances cerebrovascular integrity in ischemic rats 显示文摘 | Ding YH Li J Yao WX | 2006 | Acta Neuropathol2006，112，1： | 1 |
| 15 | Molecular Alterations Underlie Nodal and Paranodal Degeneration in Type 1 Diabetic Neuropathy and Are Prevented by C-peptide显示文摘 | SIMA AAF ZHANG WX LI ZG | 2004 | Diabetes(S0012-1797)2004，53，： | 1 |
| 16 | Role of osteopontin in induction of monocyte chemoattractant protein 1 and macrophage inflammatory protein 1 through the NF-k 1 B and MAPK pathways in rheumatoid arthritis 显示文摘 | Zheng WX Li RS Pan H | 2009 | Arthritis Rheum2009，60，7： | 1 |
| 17 | cADP-ribose activates reconstituted ryanodine receptors from coronary arterial smooth muscle显示文摘 | Li PL Tang WX Valdivia HH | 2001 | Am J Physiol Heart Circ Physiol2001，280，1： | 1 |
| 18 | Ginkgolides protect PC12 cells against hypoxia-induced injury by p42/p44 MAPK pathwaydependent upregulation of HIF-1 alpha expression and HIF-1DNA- binding activity显示文摘 | Li Z Ya K Mei WX | 2008 | J Cell Biechem2008，103，2： | 1 |
| 19 | Interaction of a calcium channel blocker with noise in cochlear function in guinea pig显示文摘 | Liu J Niu YG Li WX | 2012 | Acta Otolaryngol2012，132，： | 1 |
| 20 | A novel naturally occurring hybrid gene encoded by a plant RNA virus facilitates long distance virus movement显示文摘 | Li WX Symons RH | 1995 | EMBO J1995，14，： | 1 |
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