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| 1 | Effects of tachyplesin on the morphology and ultrastructure of human gastric carcinoma cell line BGC-823显示文摘AIM To investigate the morphological andultrastructural changes in the human gastriccarcinoma cell line BGC-823 after being treatedwith tachyplesin.METHODS Tachyplesin was isolated from acidextracts of Chinese horseshoe crab(Tachypleustridentatus)hemocytes.BGC-823 cells and thecells treated with 2.0mg/L tachyplesin wereexamined respectively under light microscope,scanning and transmission electron microscope.RESULTS BGC-823 cells had undergone therestorational alteration in morphology andultrastructure after tachyplesin treatment.Thechanges were as follows:the shape of cells wasunanimous,the volume enlarged and cellsturned to be flat and spread,the nucleo-cytoplasmic ratio lessened and nuclear shapebecame rather regular,the number of nucleolusreduced and its volume lessened,heter-chromatin decreased while euchromatinincreased in nucleus.In the cytoplasm,mitochondria grew in number with consistentstructure relatively,Golgi complex turned to betypical and well-developed,rough endoplasmicreticulum increased and polyribosomedecreased.The microvilli at cellular surfacewere rare and the filopodia reduced whilelamellipodia increased at the cell edge.CONCLUSION Tachyplesin could alter themalignant morphological and ultrastructuralcharacteristics of human gastric carcinoma cellseffectively and have a certain inducing differen-tiation effect on human gastric carcinoma cells. | Li QF Ou Yang GL Li CY Hong SG | 2000 | World Journal of Gastroenterology2000，6，5： | 19 |
| 2 | Thermodynamic Aspect in Synthesis of AlN Powders by Carbothermal Reduction and Nitridation Process显示文摘A thermodynamical calculation shows that AlN powders were synthesized in the process bythe overall reaction Al2O3(s)+3C(s)+N2(g)=2AlN(s)+3CO(g) and its minimum reaction tem-perature T0=1852 K, if all reactants and products were in standard states. ln the practicalexperiments, AlN phase appeared obviously at only 1300℃, the major reasons are related to thepartial pressure of its gaseous product pco and the mixed free energy. The synthesis temperaturecould be lowered by either increasing N2 flow rate or elevating N2 pressure. On the other hand,as the temperature decreases, the equilibrium constant Km also reduces, and the reducing ratestrongly depends on the temperature: the lower the temperature, the higher the rate. | Dai, XM Li, QF Ding, MQ Tian, JM | 1999 | Journal of Materials Science & Technology1999，15，1： | 2 |
| 3 | Differential expression of three hypoxia-indueible factor- alpha subunits in pulmonary arteries of rat with hypoxig-induced hyper- tension显示文摘 | Li QF Dai AG | 2005 | Acta Biochim Biophys Sin2005，37，10： | 1 |
| 4 | Potential association of DRD2 and DAT1 genetic variation with heroin dependence显示文摘 | Hou QF Li SB | 2009 | Neuroscience Letters2009，464，2： | 1 |
| 5 | Genetic analysis of chikungunya vi- ruses imported to mainland China in 2008显示文摘 | Zheng K Li JD Zhang QF | 2010 | Virology Journal2010，7，8： | 1 |
| 6 | Drought tolerance through over-expression of expansin gene TaEXPB23 in transgenic tobacco 显示文摘 | Li F Xing SC Guo QF | 2011 | Plant Physiol2011，168，： | 1 |
| 7 | Effects of dl-3-n-butylphthalideon expression of VEGF and b FGF in rat brain with permanent for calcerebral ischemia显示文摘 | Li QF Kong SY Deji QZ | 2008 | Sichuan Da Xue Xue Bao Yi Xue Ban2008，39，1： | 1 |
| 8 | An integrated fat grafting tech?nique for cosmetic facial contouring显示文摘 | Xie Y Zheng DN Li QF | 2010 | J Plast Reconstr Aesth Surg2010，63，2： | 1 |
| 9 | Accelerated flap prefabrication with vascular endothelial growth factor 显示文摘 | Li QF Reis ED Zhang WX | 2000 | J Reconstr Microsurg2000，16，： | 1 |
| 10 | Controlled gelation temperature,pore diameter and degradation of a highly porous chitosanbased hydrogel显示文摘 | Dang QF Yan JQ Li JJ | 2011 | CarbohydPolym2011，83，1： | 1 |
| 11 | Selective fraction of Scutellaria baicalensis and its chemopreventive effects on MCF-7 human breast cancer cells显示文摘 | Wang CZ Li XL Wang QF | 2010 | Phytomedicine2010，17，1： | 1 |
| 12 | Development and full vali- dation of a sensitive quantitative assay for the determination of clemastine in human plasma by liquid chromatography-tandem mass spectrometry显示文摘 | XIE ZY LIAO QF LI ZJ | 2007 | J Pharm Biomed Anal2007，44，4： | 1 |
| 13 | MicroRNA Detection in cervical exfoliated cells as atriage for human papillomavir- us-positive women显示文摘 | Tian QF Li Y Wang FF | 2014 | J Natl Cancer Ins2014，，： | 1 |
| 14 | Tranilast attenuates TGF-β1-induced epithelial-mesenchymal transition in the NRK-52E cells显示文摘 | Li SS Liu QF He AL Wu FR | 2014 | Pak J Pharm Sci2014，27，1： | 1 |
| 15 | Anticancer effects of ginsenoside Rgl ,cinnamic acid,and tanshinone IIA in osteosarcoma MG-63 cells : nuclear matrix downregulation and cytoplasmic trafficking of nucleophosmin显示文摘 | Li QF Shi SL Liu QR | 2008 | Int J Biochem Cell B2008，40，9： | 1 |
| 16 | Nasal reconstruction using a split-forehead flap显示文摘 | LI QF XIE F GU B | 2006 | Plast Reconstr Surg2006，118，7： | 1 |
| 17 | The efect of centrifugation on viability of fat grafts: an evaluation with the glucose transport te st显示文摘 | Xie Y Zheng DN Li QF | 2010 | J Plast Reconstr Aesthetic Surg2010，63，48： | 1 |
| 18 | Isolated nocturnal hypertension and arterial stiffness in a Chinese population 显示文摘 | Li LH Li Y Huang QF | 2008 | Blood Press Monit2008，13，3： | 1 |
| 19 | Isoflurane preconditioning activates HIF1alpha,iNOS and Erk1/2 and protects against oxygen-glucose deprivatian neuronal injury显示文摘 | Li QF Zhu YS Jiang H | 2008 | Brain Res2008，1245，： | 1 |
| 20 | Activation of sphingosine kinase mediates suppressive effect of interleukin-6 on human multiple myeloma cell apoptosis显示文摘 | Li QF Wu CT Duan HF | 2007 | Br J Haematol2007，138，5： | 1 |
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