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| 1 | Codon 249 mutations of p53 gene in development of hepatocellular carcinoma显示文摘Codon249mutationsofp53geneindevelopmentofhepatocelularcarcinomaPENGXiaoMou,PENGWenWeiandYAOJiLuSubjectheadingsliverneopla... | Peng, XM Peng, WW Yao, JL | 1998 | World Journal of Gastroenterology1998，4，2： | 18 |
| 2 | 塞来昔布治疗骨关节炎的随机对照试验显示文摘目的 :比较塞来昔布、萘普生以及安慰剂在治疗膝关节骨关节炎时的疗效、安全性。方法 :10 0 3名有症状的膝关节骨关节炎患者随机接受塞来昔布 5 0 ,10 0 ,2 0 0mg ,bid ;萘普生 5 0 0mg ,bid或安慰剂 12周。患者在停用既往NSAID药或止痛治疗后 2~ 7d以及服用受试药物治疗后 2 ,6 ,12周 ,根据标准疗效判定方法进行评估。结果 :塞来昔布在改善骨关节炎的症状和体征上有显著效果。在治疗后的 2d内疼痛明显缓解 ,最大抗炎和镇痛作用出现在 2周内并持续至 12周。各剂量的塞来昔布与安慰剂比较均有效 ,但 5 0mg ,bid的剂量效果较差 ;较大剂量的塞来昔布 (10 0和 2 0 0mg ,bid)疗效相似 ,所观察到的改善程度与萘普生 5 0 0mg ,bid相当。各剂量的塞来昔布和萘普生均有良好的耐受性。结论 :COX 2抑制剂塞来昔布是治疗骨关节炎的有效药物 ,对骨关节炎临床症状和体征的改善与萘普生相当。 | Bensen WG Fiechtner JJ Mcmillen JI Zhao WW Yu SS Woods EM Hubbard RC Isakson PC Verburg KM Geis GS | 2000 | 中国新药杂志2000，9，8： | 17 |
| 3 | A long-term follow-up study on hepatitis B surface antigen-positive patients undergoing allogeneic hematopoietic stem cell transplantation显示文摘 | Hui CK Lie A Au WY Leung YH Ma SY Cheung WW Zhang HY Chim CS Kwong YL Liang R Lau GK | 2006 | 中国生物学文摘2006，20，5： | 10 |
| 4 | A CLASS OF MODIFIED BROYDEN ALGORITHMS显示文摘In this paper we discuss the convergence of the modified Broyden algorithms.We prove that the algorithms are globally convergent for the colltinuous differen tiable function and the rate of convergence of the algorithms is one-step superlinear and n-step second-order for the uniformly convex objective function. From the dis-cussion of this paper, we may get some convergence properties of the Broyden | PU, DG TIAN, WW | 1994 | Journal of Computational Mathematics1994，12，4： | 6 |
| 5 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 6 | Gravity field and crustal structure of Gyirong-Lugu Region in western Xizang (Tibet) Plateau显示文摘THE Gyirong-Lugu gravity profile in western Xizang Plateau was carried out by Institute ofGeophysics,Chinese Academy of Sciences in 1994—1995.The data of this gravity profile fillthe gaps in the research of gravity field of western Xizang Plateau and provide basic informa-tion for the study of the whole structure and dynamical mechanism of Xizang Plateau. | Wang, QS Wu, CZ Jiang, WW | 1997 | Chinese Science Bulletin1997，42，8： | 3 |
| 7 | 确定以问题为基础的课程的问题显示文摘20世纪医学知识的急剧增长导致了医学教育中以问题为基础的课程的发展,自1950年代以来,为了向每一医学专科提供必要的课时,课程委员会面临着越来越大的压力,为拓宽课程的范围,采取的办法之一是采用以问题为基础的课程、降低课程内容的重要性,把重点放在解决问题的过程。还有一种办法是把课程内容建立在社区常见的、重要的卫生保健问题上。 | Ross.,WW 梅人朗 | 1996 | 国外医学(医学教育分册)1996，17，4： | 3 |
| 8 | 医学发展趋势:避免肥胖显示文摘 | Gibbs,WW 胡天其 | 1996 | 科学(中文版)1996，，12： | 3 |
| 9 | Simulation of stochastic wind field for large complex structures based on modified Fourier spectrum显示文摘Simulation for stochastic wind field is very important in analyzing dynamic responses of large complex structures due to strong wind.The typical simulation method is the spectrum representation method (SRM),but the SRM has drawbacks of inferior precision in lower frequency and slow calculating speed.In view of this,the modified Fourier spectrum method (MFSM) is introduced into the simulation of stochastic wind field in this paper.In this method,phase information of wind velocity time history is determined by cross power spectral density (CPSD) between adjacent points,and the wind velocity time history with time and space correlation is generated by iterative modification for CPSD considering auto power spectral density (APSD).Simulation of the wind field for a long-span bridge is undertaken to verify the effectiveness of the MFSM.Simulation results of the SRM and the MFSM are compared.It can be concluded that the MFSM is more accurate and has higher calculation speed than the SRM. | Zhao-dong XU | 2011 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2011，12，3： | 3 |
| 10 | Theophylline inhibits the late asthmatic response to nighttime antigen challenge in patients with mild atopic asthma显示文摘 | Jarjiour NN Lacouture PG Busse WW | 1998 | Ann Allergy Asth ma Immunol1998，81，3： | 2 |
| 11 | Combining SSH and cDNA microarrays for rapid identification of differentially expressed genes显示文摘 | Yang GP Ross DT Kuang WW | | 0，，： | 2 |
| 12 | Differential screening and suppression subtractive hybridization identified genes differentially expressed in an estrogen receptor positive breast carcinoma cell line显示文摘 | Kuang WW Thompson DA Hoch RV | | 0，，： | 2 |
| 13 | 充血性心力衰竭的病理生理和治疗现况显示文摘充血性心力衰竭(心衰)是临床常见的综合征,代偿过度促成恶性循环。正性肌力药物、利尿剂和血管扩张剂均可作为第一线治疗药物,合并用药具协同作用,血管扩张剂已被证实能延长患者生存期,应作为治疗心衰的常规药物,抗心律失常治疗在心衰治疗中的意义尚不肯定。预防为主将更利于降低心衰的致残率和病死率。 | Parmley WW 施海明 | 1989 | 国际心血管病杂志1989，32，5： | 2 |
| 14 | 虚拟细胞显示文摘 | Gibbs,WW 谢正祥 | 2001 | 科学(中文版)2001，，11： | 2 |
| 15 | Effect of simvastatin on left ventricular hypertrophy and function in rat with aortic stenosis显示文摘 | Lou JD Zhang WW Zhang GP | 1999 | Aata Pharmcol Sinica1999，20，4： | 2 |
| 16 | Simvastatin inhibits noradrenaline-induced hypertrophy of cultured neonatal rat cardiomyocytes显示文摘 | Lou JD Xie F Zhang WW | 2001 | British J Pharmacol2001，132，1： | 2 |
| 17 | 探测铀矿的瞬变中子测井显示文摘 | Give.,WW 霍全明 | 1990 | 国外测井技术1990，5，2： | 2 |
| 18 | Pathophysiology of severe asthma显示文摘 | Busse WW Banks Schlegel S Wenzel SE | | 0，，： | 2 |
| 19 | 新型高温酸化缓蚀剂显示文摘 | Fren.,WW 胥尚湘 | 1992 | 油气田开发工程译丛1992，，11： | 2 |
| 20 | Hyperglycaemia after glucose loading is a major predictor of preclinical atherosclerosis in nondiabetic subjects 显示文摘 | Zhang YF Hong J Zhan WW | 2006 | Clin Endocrinol (Oxf)2006，64，2： | 1 |
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