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| 1 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 2 | 钠-葡萄糖共转运蛋白-2抑制剂或胰高血糖素样肽-1受体激动剂治疗成人2型糖尿病:临床实践指南显示文摘临床问题对于存在不同心血管风险及肾脏结局的2型糖尿病患者,在原有生活方式干预和/或其他降糖药物的基础上加用钠-葡萄糖共转运蛋白2(SGLT-2)抑制剂和胰高血糖素样肽1(GLP-1)受体激动剂的获益及风险是什么?现行做法几十年来,2型糖尿病的治疗决策都以控制血糖为主导。SGLT-2抑制剂和GLP-1受体激动剂在传统观念中常被用于二甲双胍治疗后血糖仍控制不佳的患者。目前这一现状已经发生了改变,这得益于多项临床研究结果。研究显示SGLT-2抑制剂和GLP-1受体激动剂拥有独立于药物降糖作用之外的对于动脉粥样硬化性心血管病(CVD)和慢性肾脏病(CKD)的获益。建议本指南阐述了针对不同风险分层的成人2型糖尿病患者使用SGLT-2抑制剂或GLP-1受体激动剂的建议。•伴有3种或更少的心血管风险因素且不存在CVD或CKD:不建议启动SGLT-2抑制剂或GLP-1受体激动剂治疗。(推荐等级:弱)•伴有3种以上心血管风险因素且不存在CVD或CKD:建议启动SGLT-2抑制剂治疗,不建议启动GLP-1受体激动剂治疗。(推荐等级:弱)•已经存在CVD或CKD:建议启动SGLT-2抑制剂治疗和GLP-1受体激动剂治疗。(推荐等级:弱)•已经存在CVD和CKD:建议启动SGLT-2抑制剂治疗(推荐等级:强)和GLP-1受体激动剂治疗。(推荐等级:弱)•对于那些想要进一步降低CVD和CKD结局风险的患者:推荐优先启用SGLT-2抑制剂治疗而非GLP-1受体激动剂治疗。(推荐等级:弱)这项指南是如何制订的一个由患者、临床医生和方法学家共同组成的国际小组提出了这些推荐意见。这些推荐意见基于可信度较高的指南的标准,并使用GRADE分级方法进行评估。该小组采用了息者个体化的观点。证据一项关于获益与风险的系统综述和网络meta分析(764项随机对照研究,包括421346例参与者)发现SGLT-2抑制剂和GLP-1受体激动剂可以降低总体死亡率、心肌梗死发生率、终末期肾病或肾衰竭的发生率(中等至高等质量的证据)。在不同的亚组中这些药物对卒中、因心力衰竭所致住院和其他主要不良事件有不同的影响。药物绝对获益的程度因患者个体风险的不同有很大的差异。(例如,对于接受了超过5年药物治疗的1000例患者,在最低风险人群中死亡人数减少了5人,在最高风险人群中死亡人数减少了48人)。一项关于预后的综述确认了14种风险预测模型,其中一种(RECODe)在证据总结中报告了大部分基线风险评估数据,小组利用该模型以支持风险分层的建议。考虑到患者的价值观及个体差异,指南推荐的支撑证据包括一项对已发表论文的系统综述、一项患者焦点小组研究、一项临床问题总结,以及一项指南调查。指南解读我们依据不同的CVD和CKD风险水平,综合考虑获益、风险和其他因素的平衡,以及每一个风险组别的实际问题,来对推荐意见进行分层。本指南强烈建议CVD和CKD患者使用SGLT-2抑制剂治疗,这说明专家组认为其具有显著的获益。而对于其他成人2型糖尿病患者,推荐等级较弱,这说明专家组想要在获益、风险及治疗花费上取得一个更好的平衡。临床医生通过该指南可以使用可靠的风险计算模型,如RECODe,来明确其患者的个体心血管和肾脏疾病风险。医患交互式总结临床证据和制订决策有助于患者知晓治疗选择,包括进行共同决策。2型糖尿病人群(全球患病率不断增长1-2)正面临着不断增加的心血管疾病、肾脏病和其他并发症的风险3。数十年来,2型糖尿病的管理始终以控制血糖及糖化血红蛋白(HbA1c)为治疗目标4-5,但是,最近的高质量随机对照研究已经对这种以血糖为中心的治疗模式发起了挑战。研究结果显示,强化血糖控制未必会降低大血管不良事件,它还可能带来不利影响监管机构现在要求新型糖尿病药物必须证明其具有心血管和肾脏获益才能获得批准。对两类新药--钠-葡萄糖共转运蛋白2(SGLT-2)抑制剂和胰高血糖素样肽1(GLP-1)受体激动剂(见框图1)的临床试验结果显示,在现有治疗方案(常规治疗)之上加用这些药物,对死亡、心肌梗死、卒中、心力衰竭和肾脏的结局(如进展为终末期肾病)都有获益8-12。 | Sheyu Li Per Olav Vandvik Lyubov Lytvyn Gordon H Guyatt Suetonia C Palmer Rene Rodriguez-Gutierrez Farid Foroutan Thomas Agoritsas Reed A C Siemieniuk Michael Walsh Lawrie Frere David J Tunnicliffe Evi V Nagler Veena Manja Bjφrn Olav Asvold Vivekanand Jha Mieke Vermandere Karim Gariani Qian Zhao Yan Ren Emma Jane Cartwright Patrick Gee Alan Wickes Linda Fems Robin Wright Ling Li Qiukui Hao Reem A Mustafa 无 郭鹤鸣(译) | 2021 | 英国医学杂志中文版2021，24，9： | 7 |
| 3 | Economic transformation and the gender earnings gap in urban China显示文摘 | Bj?rn Gustafsson Shi Li | 2000 | Journal of Population Economics2000，，2： | 3 |
| 4 | High-throughput screening and machine learning for the efficient growth of high-quality single-wall carbon nanotubes显示文摘It has been a great challenge to optimize the growth conditions toward structure-controlled growth of single-wall carbon nanotubes(SWCNTs).Here,a high-throughput method combined with machine learning is reported that efficiently screens the growth conditions for the synthesis of high-quality SWCNTs.Patterned cobalt(Co)nanoparticles were deposited on a numerically marked silicon wafer as catalysts,and parameters of temperature,reduction time and carbon precursor were optimized.The crystallinity of the SWCNTs was characterized by Raman spectroscopy where the featured G/D peak intensity(IG/ID)was extracted automatically and mapped to the growth parameters to build a database.1,280 data were collected to train machine learning models.Random forest regression(RFR)showed high precision in predicting the growth conditions for high-quality SWCNTs,as validated by further chemical vapor deposition(CVD)growth.This method shows great potential in structure-controlled growth of SWCNTs. | Zhong-Hai Ji Lili Zhang Dai-Ming Tang Chien-Ming Chen Torbjörn EMNordling Zheng-De Zhang Cui-Lan Ren Bo Da Xin Li Shu-Yu Guo Chang Liu Hui-Ming Cheng | 2021 | Nano Research2021，14，12： | 3 |
| 5 | A sensitivity study of the WRF model in offshore wind modeling over the Baltic Sea显示文摘Accurate wind modeling is important for wind resources assessment and wind power forecasting. To improve the WRF model configuration for the offshore wind modeling over the Baltic Sea, this study performed a sensitivity study of the WRF model to multiple model configurations, including domain setup,grid resolution, sea surface temperature, land surface data, and atmosphere-wave coupling. The simulated offshore wind was evaluated against LiDAR observations under different wind directions, atmospheric stabilities, and sea status. Generally, the simulated wind profiles matched observations, despite systematic underestimations. Strengthening the forcing from the reanalysis data through reducing the number of nested domains played the largest role in improving wind modeling. Atmosphere-wave coupling further improved the simulated wind, especially under the growing and mature sea conditions.Increasing the vertical resolution, and updating the sea surface temperature and the land surface information only had a slight impact, mainly visible during very stable conditions. Increasing the horizontal resolution also only had a slight impact, most visible during unstable conditions. Our study can help to improve the wind resources assessment and wind power forecasting over the Baltic Sea. | Huidong Li Björn Claremar Lichuan Wu Christoffer Hallgren Heiner Körnich Stefan Ivanell Erik Sahlée | 2021 | Geoscience Frontiers2021，12，6： | 2 |
| 6 | A neurotrophin axis inmyeloma: TrkB and BDNF promote tumor cell Survival 显示文摘 | Pearse RN Swendeman S L Li Y | 2005 | Blood2005，105，11： | 1 |
| 7 | Economic transformation and the gender earnings gap in urban China显示文摘 | Bj?rn Gustafsson Shi Li | 2000 | Journal of Population Economics2000，，2： | 1 |
| 8 | Human metapneumovirus elicits weak IFN-gamma memory responses compared with respiratory syneytial virus 显示文摘 | Douviue RN Bastien N Li Y | 2012 | J Immunol2012，176，10： | 1 |
| 9 | Economic transformation and the gender earnings gap in urban China显示文摘 | Bj?rn Gustafsson Shi Li | 2000 | Journal of Population Economics2000，，2： | 1 |
| 10 | Economic transformation and the gender earnings gap in urban China显示文摘 | Bj?rn Gustafsson Shi Li | 2000 | Journal of Population Economics2000，，2： | 1 |
| 11 | In vitro evaluation of cytotoxicity of a naturally occurring crosslinking reagent for biological tissue fixation显示文摘 | Sung HW Huang RN Huang LI | 1999 | J Biomater Sci Polym Ed1999，10，1： | 1 |
| 12 | Economic transformation and the gender earnings gap in urban China显示文摘 | Bj?rn Gustafsson Shi Li | 2000 | Journal of Population Economics2000，，2： | 1 |
| 13 | Histopathology of the human retina in retinitis pigmentosa显示文摘 | Milam AH Li ZY Fariss RN | 1998 | Prog Retin Eye Res1998，17，2： | 1 |
| 14 | Human metapneumovirus elicits weak IFN-gamma memory responses compared with respiratory syncytial virus显示文摘 | Douviue RN Bastien N Li Y | 2012 | J Immunol2012，176，10： | 1 |
| 15 | Ataxin-3 is a histone-binding protein with two independent transcriptional corepressor activities显示文摘 | Li F Macfarlan T Pittman RN | 2002 | J Biol Chem2002，277，45： | 1 |
| 16 | Chronic kidney disease and the risk for cardiovascular disease, renal replacement, and death in the United States Medicare population, 1998 to 1999 显示文摘 | Foley RN Murray AM Li S | 2005 | J Am Soc Nephrol2005，16，： | 1 |
| 17 | Chronic kidney disease and the risk for cardiovascular disease, renal replacement, and death in the United States Medicare population, 1998 to 1999 显示文摘 | Foley RN Murray AM Li S | 2005 | J Am Soc Nephrol2005，16，： | 1 |
| 18 | The prevalence and endemic na- ture of dengue infections in Guangdong, South China: an epidemi- ological, serological, and etiological study from 2005-2011 显示文摘 | Guo RN Lin JY Li LH | 2014 | PLoS One2014，9，85： | 1 |
| 19 | Lung and Intestine: A Specific Link in an Ulcerative Colitis Rat Model显示文摘 | Yuan Liu Xin-Yue Wang Xue Yang Shan Jing Li Zhu Si-Hua Gao Bj?rn Moum | 2013 | Gastroenterology Research and Practice2013，，： | 1 |
| 20 | Economic transformation and the gender earnings gap in urban China显示文摘 | Bj?rn Gustafsson Shi Li | 2000 | Journal of Population Economics2000，，2： | 1 |
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