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| 1 | Discovery of the Early Paleozoic post-collisional granites in northern margin ofthe Erguna massif and its geological significance显示文摘The Luoguhe intrusion, located in MoheCounty, Heilongjiang Province, is mainly composed of mon-zogranite, quartz diorite and granodiorite, with minor dio-rite, tonalite, quartz monzodiorite, quartz monzonite, syeno-granite and alkali-feldspar granite. The intrusion can bedivided into two lithological units, i.e. quartz diorite andmonzogranite units, with affinities to high-K calc-alkalineseries. The quartz diorite unit (SiO2: 54.79%―58.30%Na2O/CaO: 0.79―1.53 and Shand index: 0.77―0.82) belongsto metaluminous rocks. And the monzogranite unit (SiO2:65.29%―66.45%, Na2O/CaO: 1.73―3.43 and Shand index<1.05) can be considered as weakly peraluminous rocks. Theintrusion is characterized by high REE abundance (∑REE =180.2―344.3 μg/g), medium-strong negative Eu anomalies(δ Eu = 0.33―0.82), weak REE fractionation [(La/Yb)N =4.12―10.45], enrichments in Rb, Th, U, K, La, Ce, Nd, HfZr and Sm, but strong depletions of Ba, Nb, Ta, Sr, P and TiThese characteristics of major, REE and trace elements in-dicate that the intrusion was formed in a transitional tectonicsetting from compressional to extensional regime, which canbe classified as post-collisional granitoids. SHRIMP U-Pbzircon analyses yield ages of 517±9 and 504±8 Ma for thequartz diorite and monzogranite units, respectively. The dis-covery of Early Paleozoic post-collisional granites in thenorthern margin of the Erguna massif indicates that thenorthern branch of Paleo-Asian Ocean between Siberianplate and Erguna massif was closed in the Early Paleozoicand the Salair orogeny ended ca. 500 Ma ago. | WU Guang SUN Fengyue ZHAO Caisheng LI Zhitong ZHAO Ailin PANG Qingbang LI Guangyuan | 2005 | Chinese Science Bulletin2005，50，23： | 69 |
| 2 | On the timing and duration of the destruction of the North China Craton显示文摘The timing and duration of the destruction of the North China Craton, which is pivotal to understanding the destruction mechanism and its geodynamic controlling factors, still remain controversial. On the basis of the principles of magma genesis and evolution, first we outline magmatic expressions that can be related to cratonic destruction, then use magmatic and basin evolution trends to constrain the timescale of the lithospheric thinning in North China. The main conclusions include: (1) the thinning of the lithosphere beneath the North China Craton might have started, at least locally, since late Carboniferous-late Triassic, attained its climax during the late Jurassic-early Cretaceous, and continued till the end of late Cretaceous-early Cenozoic. The destruction of the North China Craton was a relatively slow, rather than a dramatic process. (2) The weakened lithospheric zones along the margins and interiors of the craton played an important role in cratonic destruction, partly accounting for the heterogeneous pattern of cratonic destruction. (3) The tectonic factors that controlled the destruction of the North China Craton may be multiple. The late Carboniferous southward subduction of the Paleo-Asian plate and the late Triassic collision between North China and South China may have re-activated the craton by influencing the thermal and integral structure of the craton. The Pacific subduction underneath the eastern Asian continent played a determinant role in the cratonic destruction, governing the distribution patterns of post-Mesozoic basins and major tectonic configuration, temporal change of magmatism and formation of the North-South gravity lineament. | XU YiGang LI HongYan PANG ChongJin HE Bin | 2009 | Chinese Science Bulletin2009，54，19： | 70 |
| 3 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 4 | Cold-chain food contamination as the possible origin of COVID-19 resurgence in Beijing显示文摘COVID-19,caused by SARS-CoV-2[1,2],has been contained in China through stringent non-pharmaceutical interventions.Border control and quarantine have effectively prevented the virus from being spread by infected travellers,but the risk of resurgence caused by other routes of introduction and transmission remains unclear,and current strategies to prevent resurgence could be flawed.Since July,SARS-CoV-2 RNA contaminations in frozen food imported from countries with ongoing epidemics have been reported in nine provinces in China[3,4].However,there is no robust evidence of COVID-19 outbreaks initiated by environmentto-human transmission.Here we add to evidence of such transmission by investigating the recent COVID-19 resurgence in Beijing. | Xinghuo Pang Lili Ren Shuangsheng Wu Wentai Ma Jian Yang Lin Di Jie Li Yan Xiao Lu Kang Shichang Du Jing Du Jing Wang Gang Li Shuguang Zhai Lijuan Chen Wenxiong Zhou Shengjie Lai Lei Gao Yang Pan Quanyi Wang Mingkun Li Jianbin Wang Yanyi Huang Jianwei Wang COVID-19 Field Response Group COVID-19 Laboratory Testing Group | 2020 | National Science Review2020，7，12： | 51 |
| 5 | Deep water bottom current deposition in the northern South China Sea显示文摘There are some active bottom currents on the northern continental slope of the South China Sea (SCS). Reflection seismic profiles show that the bottom current channels occur in the water depth range of 1000 to 2700 m,extending from the NE to the SW,leading to accumulation of discontinuous drifts with higher sedimentation rates on the eastern side of the channel. The stacking pattern of the layers sug-gests that these drifts propagated southwestward,following the direction of the bottom currents. One sedimentary drift to the southeast of the Dongsha Islands has the highest sedimentation rate of 97cm/ka in the last 12 ka. The sedimentary characteristics of the sediment layers indicate that these bottom currents are most likley caused by the water movement of a branch of the West Pacific Ocean Current,which enters the northern SCS via the Bashi Strait. Once formed,the bottom currents trans-port sediments along the northern slope of SCS southwestward and finally disappear into the central basin of the SCS. Due to the bottom current activity,the deep-sea sedimentary process in the northern SCS is complex. | SHAO Lei LI XueJie GENG JianHua PANG Xiong LEI YongChang QIAO PeiJun WANG LiaoLiang WANG HongBin | 2007 | Science China Earth Sciences2007，50，7： | 43 |
| 6 | Straw return and appropriate tillage method improve grain yield and nitrogen efficiency of winter wheat显示文摘Straw return is an important management tool for tackling and promoting soil nutrient conservation and improving crop yield in Huang-Huai-Hai Plain, China. Although the incorporation of maize straw with deep plowing and rotary tillage practices are widespread in the region, only few studies have focused on rotation tillage. To determine the effects of maize straw return on the nitrogen(N) efficiency and grain yield of winter wheat(Triticum aestivum L.), we conducted experiments in this region for 3 years. Five treatments were tested:(i) rotary tillage without straw return(RT);(ii) deep plowing tillage without straw return(DT);(iii) rotary tillage with total straw return(RS);(iv) deep plowing tillage with total straw return(DS);(v) rotary tillage of 2 years and deep plowing tillage in the 3rd year with total straw return(TS). Treatments with straw return increased kernels no. ear^(–1), thousand-kernel weight(TKW), grain yields, ratio of dry matter accumulation post-anthesis, and nitrogen(N) efficiency whereas reduced the ears no. ha^(–1) in the 2011–2012 and 2012–2013 growing seasons. Compared with the rotary tillage, deep plowing tillage significantly increased the grain yield, yield components, total dry matter accumulation, and N efficiency in 2013–2014. RS had significantly higher straw N distribution, soil inorganic nitrogen content, and soil enzymes activities in the 0–10 cm soil layer compared with the DS and TS. However, significantly lower values were observed in the 10–20 and 20–30 cm soil layers. TS obtained approximately equal grain yield as DS, and it also reduced the resource costs. Therefore, we conclude that TS is the most economical method for increasing grain yield and N efficiency of winter wheat in Huang-Huai-Hai Plain. | CHEN Jin ZHENG Meng-jing PANG Dang-wei YIN Yan-ping HAN Ming-ming LI Yan-xia LUO Yong-li XU Xu LI Yong WANG Zhen-lin | 2017 | Journal of Integrative Agriculture2017，16，8： | 42 |
| 7 | Trends in Lipids Level and Dyslipidemia among Chinese Adults, 2002-2015显示文摘Objective To investigate the trends of lipid profiles and dyslipidemia among Chinese adults from 2002 to 2015.Methods Data were collected from three nationally representative cross-sectional surveys.Fasting venous blood samples were collected and serum lipids were tested by biochemical analysis and enzymatic determination.Lipid levels and the prevalence of dyslipidemia among adults were analyzed with complex sampling weighting adjustment for age and gender.Results The weighted means of TC, TG, and LDL-c significantly increased linearly from 3.93, 1.12, and 2.12 mmol/L in 2002 to 4.59, 1.41, and 2.78 mmol/L in 2010 and then to 4.63, 1.47, and 2.87 mmol/L in 2015, respectively;by contrast, HDL-c levels decreased significantly from 1.30 mmol/L to 1.26 mmol/L over the same period.Similar trends in mean non-HDL-c and lipid-related ratios were observed.The weighted dyslipidemia prevalence linearly increased;in particular, hypercholesterolemia increased from 1.6% to 5.6% and then to 5.8%, hypertriglyceridemia increased from 5.7% to 13.6% and then to 15.0%, low HDL-c increased from 18.8% to 35.5% and then to 24.9%, and high LDL-c increased from 1.3% to 5.6% and then to 7.2%(P for trend <0.001).Conclusion Dyslipidemia increased among Chinese adults from 2002 to 2015.Development of a comprehensive strategy to decrease lipid levels in this population is urgently required. | SONG Peng Kun MAN Qing Qing LI Hong PANG Shao Jie JIA Shan Shan LI Yu Qian HE Li ZHAO Wen Hua ZHANG Jian | 2019 | Biomedical and Environmental Sciences2019，32，8： | 45 |
| 8 | Enhanced secondary pollution offset reduction of primary emissions during COVID-19 lockdown in China显示文摘To control the spread of the 2019 novel coronavirus(COVID-19),China imposed nationwide restrictions on the movement of its population(lockdown)after the Chinese New Year of 2020,leading to large reductions in economic activities and associated emissions.Despite such large decreases in primary pollution,there were nonetheless several periods of heavy haze pollution in eastern China,raising questions about the well-established relationship between human activities and air quality.Here,using comprehensive measurements and modeling,we show that the haze during the COVID lockdown was driven by enhancements of secondary pollution.In particular,large decreases in NOx emissions from transportation increased ozone and nighttime NO_(3)radical formation,and these increases in atmospheric oxidizing capacity in turn facilitated the formation of secondary particulate matter.Our results,afforded by the tragic natural experiment of the COVID-19 pandemic,indicate that haze mitigation depends upon a coordinated and balanced strategy for controlling multiple pollutants. | Xin Huang Aijun Ding Jian Gao Bo Zheng Derong Zhou Ximeng Qi Rong Tang Jiaping Wang Chuanhua Ren Wei Nie Xuguang Chi Zheng Xu Liangduo Chen Yuanyuan Li Fei Che Nini Pang Haikun Wang Dan Tong Wei Qin Wei Cheng Weijing Liu Qingyan Fu Baoxian Liu Fahe Chai Steven JDavis Qiang Zhang Kebin He | 2021 | National Science Review2021，8，2： | 47 |
| 9 | Urotensin Ⅱ accelerates cardiac fibrosis and hypertrophy of rats induced by isoproterenol显示文摘目的:学习是否 urotensin II ( UII ),有势力 vasoconstrictive 肽,在心脏的肥大的发展和老鼠的 fibrogenesis 的 isinvolved 由 isoproterenol ( ISO )导致了 .Methods :三十只男 Wistar 老鼠随机被划分成 1 是的 3 groups.Group healthycontrol 组,组 2 是 ISO 组,并且组 3 是 ISO+UTI group.In 组 2 和 3 , ISO ( 5mg 中心点kg^(-1)中心点d^(-1))被给( sc )为 3 也是的 7 d.Group 从前每日在第一天内的 givenUTI [ 3 nmol/kg ( 5 ug/kg )。 | Yong-gang ZHANG Yu-guang LI Bao-guo LIU Rui-hong WEI Dong-ming WANG Xue-rui TAN Ding-fang BU Yong-zheng PANG Chao-shu TANG | 2007 | Acta Pharmacologica Sinica2007，28，1： | 36 |
| 10 | Assessment of candidate plant DNA barcodes using the Rutaceae family显示文摘DNA barcoding is a rapidly developing frontier technology that is gaining worldwide attention.Here,seven regions (psbA-trnH,matK,ycf5,rpoC1,rbcL,ITS2,and ITS) with potential for use as DNA barcodes were tested for their ability to identify 300 samples of 192 species from 72 genera of the family Rutaceae.To evaluate each barcode’s utility for species authentication,PCR amplification efficiency,genetic divergence,and barcoding gaps were assessed.We found that the ITS2 region exhibited the highest inter-specific divergence,and that this was significantly higher than the intra-specific variation in the 'DNA barcoding gap' assessment and Wilcoxon two-sample tests.The ITS2 locus had the highest identification efficiency among all tested regions.In a previous study,we found that ITS2 was able to discriminate a wide range of plant taxa,and here we confirmed that ITS2 was also able to discriminate a number of closely related species.Therefore,we propose that ITS2 is a promising candidate barcode for plant species identification. | LUO Kun1,2,CHEN ShiLin1,CHEN KeLi2,SONG JingYuan1,YAO Hui1,MA XinYe1,ZHU YingJie3,PANG XiaoHui1,YU Hua1,LI XiWen1,4 & LIU Zhen2 1Institute of Medicinal Plant Development,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100193,China 2College of Pharmacy,Hubei University of Chinese Medicine,Wuhan 430061,China 3School of Bioscience and Engineering,Southwest Jiaotong University,Chengdu 610031,China 4Department of Chemistry,Tsinghua University,Beijing 100084,China | 2010 | Science China(Life Sciences)2010，53，6： | 32 |
| 11 | New incompatible pair of TCM:Epimedii Folium combined with Psoraleae Fructus induces idiosyncratic hepatotoxicity under immunological stress conditions显示文摘Epimedii Folium(EF)combined with Psoraleae Fructus(PF)is a common modern preparation,but liver injury caused by Chinese patent medicine preparations containing EF and PF has been frequently reported in recent years.Zhuangguguanjiewan pills(ZGW),which contain EF and PF,could induce immune idiosyncratic liver injury according to clinical case reports and a nonhepatotoxic dose of lipopolysaccharide(LPS)model.This present study evaluated the liver injury induced by EF or PF alone or in combination and investigated the related mechanism by using the LPS model.Liver function indexes and pathological results showed that either EF or PF alone or in combination led to liver injury in normal rats;however,EF or PF alone could lead to liver injury in LPS-treated rats.Moreover,EF combined with PF could induce a greater degree of injury than that caused by EF or PF alone in LPS-treated rats.Furthermore,EF or PF alone or in combination enhanced the LPS-stimulated inflammatory cytokine production,implying that IL-1β,which is processed and released by activating the NLRP3 inflammasome,is a specific indicator of EF-induced immune idiosyncratic hepatotoxicity.Thus,EF may induce liver injury through enhancing the LPS-mediated proinflammatory cytokine production and activating the NLRP3 inflammasome.In addition,the metabolomics analysis results showed that PF affected more metabolites in glycerophospholipid and sphingolipid metabolic pathways compared with EF in LPS model,suggesting that PF increased the responsiveness of the liver to LPS or other inflammatory mediators via modulation of multiple metabolic pathways.Therefore,EF and PF combination indicates traditional Chinese medicine incompatibility,considering that it induces idiosyncratic hepatotoxicity under immunological stress conditions. | Yuan Gao Zhilei Wang Jinfa Tang Xiaoyi Liu Wei Shi Nan Qin Xiaoyan Wang Yu Pang Ruisheng Li Yaming Zhang Jiabo Wang Ming Niu Zhaofang Bai Xiaohe Xiao | 2020 | Frontiers of Medicine2020，14，1： | 32 |
| 12 | Acupuncture's Role in Solving the Opioid Epidemic: Evidence, Cost-Effectiveness, and Care Availability for Acupuncture as a Primary, Non-Pharmacologic Method for Pain Relief and Management-White Paper 2017显示文摘The United States(U.S.) is facing a national opioid epidemic, and medical systems are in need of nonpharmacologic strategies that can be employed to decrease the public's opioid dependence. Acupuncture has emerged as a powerful, evidence-based, safe, cost-effective, and available treatment modality suitable to meeting this need. Acupuncture has been shown to be effective for the management of numerous types of pain conditions, and mechanisms of action for acupuncture have been described and are understandable from biomedical, physiologic perspectives. Further, acupuncture's cost-effectiveness can dramatically decrease health care expenditures, both from the standpoint of treating acute pain and through avoiding addiction to opioids that requires costly care, destroys quality of life, and can lead to fatal overdose. Numerous federal regulatory agencies have advised or mandated that healthcare systems and providers offer non-pharmacologic treatment options for pain. Acupuncture stands out as the most evidence-based, immediately available choice to fulfil these calls. Acupuncture can safely, easily, and cost-effectively be incorporated into hospital settings as diverse as the emergency department, labor and delivery suites, andneonatal intensive care units to treat a variety of commonly seen pain conditions. Acupuncture is already being successful y and meaningfully utilized by the Veterans Administration and various branches of the U.S. Military, in some studies demonstrably decreasing the volume of opioids prescribed when included in care. | arthur yin fan david w.miller bonnie bolash matthew bauer john mcdonald sarah faggert hongjian he yong ming li amy matecki lindy camardella mel hopper koppelman jennifer a.m.stone lindsay meade john pang | 2017 | Journal of Integrative Medicine2017，15，6： | 29 |
| 13 | Development of single row automatic transplanting device for potted vegetable seedlings显示文摘In China,low degree of automation seriously affects the working efficiency and quality in vegetable transplanting.As one of the most important vegetables in China even in the world,tomato was taken as the research object in this study.An automatic single-row transplanting device was designed,based on the statistical analysis of the physical and mechanical properties of tomato seedlings of a typical variety.Based on the technology of mechatronics,the device integrated the functions of transporting seedling tray,automatic seedling extraction and mechanical planting.The kinematics orthogonality solution combined with the dynamic sequence solution method was used to optimize and analyze the kinematic parameters of the automatic seeding mechanism,and the“sickle”trajectory was obtained.According to the position and movement requirement for taking and dropping seedling,the mechanical conditions and the working parameters of key execution parts were obtained by using analytic drawing method to analyze the mechanical condition of seedling collecting mechanism.The transplanting experiment was conducted at room temperature of 25°C,and the age and moisture content of the seedlings were 40 d and 55%,respectively.The results showed that the highest success rate was 92.59%,and the lowest rate of leakage was 23.13%,when the transplanting frequency was 60 plants/min.The lowest success rate was 77.78%,and the highest rate of leakage was 38.75%,when transplanting frequency was 120 plants/min.When the transplanting frequency is between 60-90 plants/min,the device can meet the requirement of high speed transplanting for potted vegetable seedling. | Xin Jin Daoyi Li Hao Ma Jiangtao Ji Kaixuan Zhao Jing Pang | 2018 | International Journal of Agricultural and Biological Engineering2018，11，3： | 27 |
| 14 | Prognostic values of serum cystatin C and β2 microglobulin, urinary β2 microglobulin and N-acetyl-β-D-glucosaminidase in early acute renal failure after liver transplantation显示文摘在肝移植以后的背景尖锐肾的失败(ARF ) 与高死亡和病态被联系。早治疗学或预防的干预被早有效的预示的因素的缺乏妨碍。最近的研究显示那浆液 cystatin 铺平 C 和 2-microglobulin (132 MG ) 象一样尿 2 MG 和 N 乙酰 --D- glucosaminidase (唠叨) 将与早、温和的肾的缺陷在病人增加。在这研究,这些因素在接受了 orthotopic 肝移植( OLT )的病人在不同阶段期间被检测,并且他们在 OLT 以后预言早 ARF 的可行性也是 analyzed.Methods 没有,接待了的有正常的血脲氮(甜面包)和浆液 creatinine ( SCr )的六十个病人修改了骑在背肩上的肝移植veno静脉绕过有希望地被学习。血样品为浆液 2 MG (n=60 ) 的决心从病人被拉, SCr (n=60 ) 和在跟随 5 间隔的浆液 Cystatin C (n=39 ) :在操作前(到) ,在 anhepatic 阶段(T1 ) 前的 20 分钟,在 anhepatic (T2 ) 的 25 分钟,在 repeffusion (T3 ) 以后并且在操作(T4 ) 的结束的 60 分钟。尿 2 MG (n=-60 ) 并且唠叨(n=60 ) 也在跟随 3 间隔被检验:在操作前(到) ,在灌注(T3 ) 以后并且在操作(T4 ) 的结束的 60 分钟。根据 Rimola 在在操作以后的 24 个小时的 ARF 的 A 标准,所有病人被划分成二个组:ARF 组和 non-ARF 组。数据统计上被分析评估在六十个盒子中的十个显示出的 operation.Results 前与正常 SCr 和甜面包在病人在肝移植以后为早 ARF 认为这些因素是预示的因素的 feasibiliy ARF (16.7%) 。逻辑回归分析证明浆液的层次并且尿在操作前的 2 MG 以及浆液 cystatin C 在肝移植以后与早 ARF 被相关( P < 0.05 ),当仅仅浆液 cystatin 铺平时,在操作的结束的 C 和 Cr 与早 ARF 相关( P < 0.05 , P < 0.01 )在肝移植以后。浆液 2 MG, Cystatin C, SCr 并且尿在 ARF 组的 2 个 MG 层次在 non-ARF 组比那更多高(P < 0.05, P < 0.01 ) 。浆液 cystatin C 的正确、假的预兆的积极比率之间有重要差别,浆液并且尿在操作前的 2 个 MG 层次( P < 0.05 , P < 0.01 ),当仅仅 SCr 在手术的结束显示出这些组之间的重要差别时( P < 0.01 )结果揭示了的 .Conclusions 在在手术,和那肝移植前表明了正常 SCr 和甜面包的那些病人之中有潜在的肾的损坏,这能加重这损坏并且引起 ARF 。这里,我们提供了浆液 Cystatin C 的预示的价值, 2 MG,尿 2 MG 并且在肝移植以后与早尖锐的肾的失败在病人唠叨。 | HEI Zi-qing LI Xiao-yun SHEN Ning PANG Hong-yu ZHOU Shao-li GUAN Jian-qiang | 2008 | Chinese Medical Journal2008，，14： | 26 |
| 15 | Xyloketal B alleviates cerebral infarction and neurologic deficits in a mouse stroke model by suppressing the ROS/TLR4/NF-KB inflammatory signaling pathway显示文摘Xyloketal B (Xyl-B ) 是从红树属植物真菌 Xylaria sp 孤立的新奇海洋的混合物。我们以前证明有 Xyl-B 的那个预告的处理施加了 neuroprotective 效果并且在新生的老鼠稀释了 hypoxic-ischemic 大脑损害。在现在的学习,我们调查了预告的处理的 neuroprotective 效果并且与在用短暂中间的成年老鼠的 Xyl-B 处理以后服的动脉吸藏(tMCAO ) 模型,并且探索了内在的机制。成年男 C57 老鼠受到 tMCAO 外科。为预告的处理, Xyl-B 经由多重注射被给(12.5, 25,和 50 mg ?@ | Ni PAN Liu-yi LU Mei LI Guo-hao WANG Fang-yu n SUN Hong-shuo SUN Xue-jun WEN Jian-ding CHENG Jian- wen CHEN Ji-yan PANG Jie LIU Yong-yuan GUAN Li-yan ZHAO Wen-liang CHEN Guan-lei WANG | 2017 | Acta Pharmacologica Sinica2017，38，9： | 24 |
| 16 | Relationship between DNA Barcoding and Chemical Classification of Salvia Medicinal Herbs显示文摘Objective To make the identification of medicinal herbs in Salvia L.quickly and accurately.Methods In this work,DNA barcoding and chemical fingerprint were compared for the identification of herbs in Salvia L.First,the nucleotide sequences of the internal transcribed spacer region two amplified from 48 medicinal plants in Salvia L.,and three other groups of medicinal plants in Lamiaceae were sequenced.A molecular phylogeny was constructed using the minimum evolution and maximum parsimony methods according to their sequence diversity.Second,the water-solution bioactive components and lipid soluble components were tested by HPLC.Then a chemical phylogeny was built using HPLC fingerprint data.Comparing the molecular and chemical phylogenetic trees revealed many similarities.Results DNA barcoding was sequencing based and could therefore provide more accurate results within a shorter time especially in large-scale studies.Conclusion The results show that ITS2 region is a novel DNA barcode for the authentication of the species in Salvia L.This is the first work to show the relationship between DNA barcoding and chemical components. | HAN Jian-ping1,LIU Chang2,LI Min-hui1,3,SHI Lin-chun1,SONG Jing-yuan1,YAO Hui1,PANG Xiao-hui1,CHEN Shi-lin1,4 1.Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences,Beijing 100193,China 2.Molecular Chinese Medicine Laboratory,LKS Faculty of Medicine,The University of Hong Kong,Hong Kong,China 3.Baotou Medical College,Baotou 014040,China 4.Hubei University of Chinese Medicine,Wuhan 430065,China | 2010 | Chinese Herbal Medicines2010，2，1： | 23 |
| 17 | Deformation mechanism of roadways in deep soft rock at Hegang Xing’an Coal Mine显示文摘Engineering geomechanics characteristics of roadways in deep soft rock at Hegang Xing'an Coal Mine were studied and the nature of clay minerals of roadway surrounding rock was analyzed. This paper is to solve the technical problems of high stress and the difficulty in supporting the coal mine, and provide a rule for the support design. Results show that mechanical deformation mechanisms of deep soft rock roadway at Xing'an Coal Mine is of ⅠABⅡABCⅢABCD type, consisting of molecular water absorption (the ⅠAB -type), the tectonic stress type + gravity deformation type + hydraulic type (the ⅡABC -type), and the ⅢABCD -type with fault, weak intercalation and bedding formation. According to the compound mechanical deformation mechanisms, the corresponding mechanical control measures and conversion technologies were proposed, and these technologies have been successfully applied in roadway supporting practice in deep soft rock at Xing'an Coal Mine with good effect. Xing'an Coal Mine has the deepest burial depth in China, with its overburden ranging from Mesozoic Jurassic coal-forming to now. The results of the research can be used as guidance in the design of roadway support in soft rock. | Yang Xiaojie Pang Jiewen Liu Dongming Liu Yang Tian Yihong Ma Jiao Li Shaohua | 2013 | International Journal of Mining Science and Technology2013，23，2： | 21 |
| 18 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 19 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 20 | Liproxstatin-1 is an effective inhibitor of oligodendrocyte ferroptosis induced by inhibition of glutathione peroxidase 4显示文摘Our previous studies showed that ferroptosis plays an important role in the acute and subacute stages of spinal cord injury.High intracellular iron levels and low glutathione levels make oligodendrocytes vulnerable to cell death after central nervous system trauma.In this study,we established an oligodendrocyte(OLN-93 cell line)model of ferroptosis induced by RSL-3,an inhibitor of glutathione peroxidase 4(GPX4).RSL-3 significantly increased intracellular concentrations of reactive oxygen species and malondialdehyde.RSL-3 also inhibited the main antiferroptosis pathway,i.e.,SLC7A11/glutathione/glutathione peroxidase 4(xCT/GSH/GPX4),and downregulated acyl-coenzyme A synthetase long chain family member 4.Furthermore,we evaluated the ability of several compounds to rescue oligodendrocytes from ferroptosis.Liproxstatin-1 was more potent than edaravone or deferoxamine.Liproxstatin-1 not only inhibited mitochondrial lipid peroxidation,but also restored the expression of GSH,GPX4 and ferroptosis suppressor protein 1.These findings suggest that GPX4 inhibition induces ferroptosis in oligodendrocytes,and that liproxstatin-1 is a potent inhibitor of ferroptosis.Therefore,liproxstatin-1 may be a promising drug for the treatment of central nervous system diseases. | Bao-You Fan Yi-Lin Pang Wen-Xiang Li Chen-Xi Zhao Yan Zhang Xu Wang Guang-Zhi Ning Xiao-Hong Kong Chang Liu Xue Yao Shi-Qing Feng | 2021 | Neural Regeneration Research2021，16，3： | 19 |
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