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| 1 | Response of the sediment geochemistry of the Changjiang River(Yangtze River) to the impoundment of the Three Gorges Dam显示文摘Based on the measurement of major and trace elements in suspended sediments in the low reaches of the Changjiang River during throughout a whole hydrologic year, the origins, seasonal variations, and fluxes of multielements and the human impacts on multielements transport processes have been analyzed along with the influence of weathering in the Changjiang River basin. The results show that most element contents were high in both autumn and winter and low in summer, which was largely caused by the dilution of discharge. Weathering detritus in the Changjiang River basin is the main source of most elements in suspended sediments. However, riverine pollution could bring more loadings of Cd, Pb, As and Zn into river water than it did a few decades ago. The annual average fluxes of Cd, Pb and Zn, which are major contamination elements, to the sea were 179 ± 21 tons/year, 7810 ± 675 tons/year, and 12,000 ± 1320 tons/year,respectively, in which approximately 8.7%, 11.9% and 2.7% of their loadings, respectively,were contributed by pollution inputs. Element exports mainly occurred in the summer(44.4%–57.4%) in the lower part of the Changjiang River. A general relationship between sediment retention and element content suggests a positive feedback mechanism for the decreased number of particles, in which element riverine loadings are reduced due to the enhanced trapping effect by the Three Gorges Dam(TGD). Compared to those in 1980,current element shares of the Changjiang River compared to the global budget have declined due to the construction of the TGD. | Hao Wang Xiangbin Ran Jingxi Li Jun Liu Wentao Wu Menglu Li Jiaye Zang | 2019 | Journal of Environmental Sciences2019，31，9： | 6 |
| 2 | Preliminary Analysis of Diesel-Degrading Bacteria Immobilized on Organic Carriers in Seawater显示文摘Oil pollution in marine environment is becoming increasingly serious. Oil bioremediation by immobilization technology has been widely studied. However, the effect of bacteria immobilization was limited because of lack of nutrients. In this paper, the organic materials(corn straw, corn cob and corn leaf) were used as carriers. The diesel removal rate achieved by the immobilized bacteria was studied, and the effects of nutrients(e.g. nitrogen and phosphorus) released from organic carriers to the immobilized bacteria were analyzed. Test results indicated that a certain amount of nutrients was released from organic carriers. Additionally, the diesel removal rates achieved by different immobilized bacteria were all higher than those achieved by free bacteria. And, the diesel removal rates achieved by bacteria decreased in the following order: bacteria immobilized on corn straw(79%), bacteria immobilized on corn leaf(70%) and bacteria immobilized on corn cob(43%). These findings indicated two aspects, viz.: the carriers porous structure and the nutrients, which were favorable to biodegradation. Finally, the changes in nitrogen and phosphorus contents that were released from different carriers during biodegradation were studied. The results showed that the rate of diesel biodegradation was fast in the initial phase because of the sufficient nutrients released from carriers. Meanwhile, in the final phase, the rate of diesel biodegradation was relatively slow because of few nutrients released from carriers. | Liu Zhixiu Xue Jianliang Wu Yanan Li Menglu Sun Xiyu Cui Hao Cheng Lijie Gao Yu Xiao Xinfeng | 2017 | China Petroleum Processing & Petrochemical Technology2017，19，2： | 4 |
| 3 | Porcine FcεRI Mediates Porcine Reproductive and Respiratory Syndrome Virus Multiplication and Regulates the Inflammatory Reaction显示文摘Porcine reproductive and respiratory syndrome virus(PRRSV) shows characteristic antibody-dependent enhancement(ADE) of infection and causes porcine systemic inflammation, which is similar to a type I allergic reaction; however, the role of porcine FceεRI in ADE is still unclear. In this study, the expression of different Fc receptors(Fc Rs) on macrophages was investigated in a PRRSV 3D4/21 cell infection model in the presence or absence of PRRSV antibody. The transcription level of Fcc II and FceεRI was significantly up-regulated under PRRSV-antibody complex infection. Internalization and proliferation of PRRSV were promoted by the ADE mechanism when FceεRI was expressed in permissive 3D4/21 cells and the non-permissive cell line HEK 293T. Transcriptome sequencing data showed that the expression levels of AKT,ERK and other signal molecules in the anti-inflammatory pathway were significantly increased, especially in the cells infected with the PRRSV-antibody immune complex. Inflammatory regulatory molecules such as PLA2G6, LOX, TRPM8 and TRPM4 were significantly up-regulated following PRRSV infection but significantly down-regulated in the cells infected with the PRRSV-antibody immune complex. Our results demonstrated that FceεRI could be involved in PRRSV ADE, the antigen presenting process and regulation of the inflammatory response during PRRSV infection, which provides new insights into PRRSV infection mediated by FceεRI and the PRRSV-antibody immune complex. | Peidian Shi Lilin Zhang Jiashun Wang Dong Lu Yi Li Jie Ren Menglu Shen Lei Zhang Jinhai Huang | 2018 | Virologica Sinica2018，33，3： | 3 |
| 4 | Surpassing electrocatalytic limit of earth-abundant Fe^(4+)embedded in N-doped graphene for(photo)electrocatalytic water oxidation显示文摘Developing highly active,cost-effective,and environmental friendly oxygen evolution reaction(OER)electrocatalysts facilitates various(photo)electrochemical processes.In this work,Fe3N nanoparticles encapsulated into N-doped graphene nanoshells(Fe_(3)N@NG)as OER electrocatalysts in alkaline media were reported.Both the experimental and theoretical comparison between Fe_(3) N@NG and Fe_(3)N/NG,specifically including in situ Mossbauer analyses,demonstrated that the NG nanoshells improved interfacial electron transfer process from Fe_(3)N to NG to form high-valence Fe^(4+)ions(Fe^(4+)@NG),thus modifying electronic properties of the outer NG shells and subsequently electron transfer from oxygen intermediate to NG nanoshells for OER catalytic process.Meanwhile,the NG nanoshells also protected Fe-based cores from forming OER inactive and insulated Fe_(2)O_(3),leading to high OER stability.As a result,the as-formed Fe^(4+)@NG shows one of the highest electrocatalytic efficiency among reported Fe-based OER electrocatalysts,which can as well highly improve the photoelectrochemical water oxidation when used as the cocatalysts for the Fe_(2)O_(3) nanoarray photoanode. | Wenjia Xue Feng Cheng Menglu Li Wenjian Hu Congping Wu Bing Wang Kuowei Liao ZhenTao Yu Yingfang Yao Wenjun Luo Zhigang Zou | 2021 | Journal of Energy Chemistry2021，30，3： | 2 |
| 5 | ADMETNet:The knowledge base of pharmacokinetics and toxicology network显示文摘A good drug or drug candidate should not only interact with its target molecule effectively and specifically,but also be absorbed into the body,distributed to the right location,metabolized into right compounds,and eliminated out of the body in proper manner.The processes of drug getting into and out of the body involve Absorption,Distribution,Metabolism,and Excretion(ADME),which | Quan Xu Ke Liu Xingming Lin Yangmei Qin Linshan Chen Jiao Cheng Mindong Zhong Qiushun He Yinbo Li Tingwu Wang Jianbo Pan Menglu Peng Lixia Yao Zhiliang Ji | 2017 | Journal of Genetics and Genomics2017，44，5： | 2 |
| 6 | Mapping Domain- and Age-Specific Functional Brain Activity for Children’s Cognitive and Affective Development显示文摘The human brain undergoes rapid development during childhood,with significant improvement in a wide spectrum of cognitive and affective functions.Mapping domain-and age-specific brain activity patterns has important implications for characterizing the development of children’s cognitive and affective functions.The current mainstay of brain templates is primarily derived from structural magnetic resonance imaging(MRI),and thus is not ideal for mapping children’s cognitive and affective brain development.By integrating task-dependent functional MRI data from a large sample of 250 children(aged 7 to 12)across multiple domains and the latest easy-to-use and transparent preprocessing workflow,we here created a set of age-specific brain functional activity maps across four domains:attention,executive function,emotion,and risky decision-making.Moreover,we developed a toolbox named Developmental Brain Functional Activity maps across multiple domains that enables researchers to visualize and download domain-and age-specific brain activity maps for various needs.This toolbox and maps have been released on the Neuroimaging Informatics Tools and Resources Clearinghouse website(http://gffzza9adc041c78b4b3bhqkpq0uxx0okc65xw.ffgz.tsg.suse.edu.cn/projects/dbfa).Our study provides domain-and age-specific brain activity maps for future developmental neuroimaging studies in both healthy and clinical populations. | Lei Hao Lei Li Menglu Chen Jiahua Xu Min Jiang Yanpei Wang Linhua Jiang Xu Chen Jiang Qiu Shuping Tan Jia-Hong Gao Yong He Sha Tao Qi Dong Shaozheng Qin | 2021 | Neuroscience Bulletin2021，37，6： | 1 |
| 7 | Band degeneracy enhanced thermoelectric performance in layered oxyselenides by first-principles calculations显示文摘Band degeneracy is effective in optimizing the power factors of thermoelectric(TE)materials by enhancing the Seebeck coefficients.In this study,we demonstrate this effect in model systems of layered oxyselenide family by the density functional theory(DFT)combined with semi-classical Boltzmann transport theory.TE transport performance of layered LaCuOSe and BiCuOSe are fully compared.The results show that due to the larger electrical conductivities caused by longer electron relaxation times,the n-type systems show better TE performance than p-type systems for both LaCuOSe and BiCuOSe.Besides,the conduction band degeneracy of LaCuOSe leads to a larger Seebeck coefficient and a higher optimal carrier concentration than n-type BiCuOSe,and thus a higher power factor.The optimal figure of merit(ZT)value of 1.46 for n-type LaCuOSe is 22%larger than that of 1.2 for n-type BiCuOSe.This study highlights the potential of wide band gap material LaCuOSe for highly efficient TE applications,and demonstrates that inducing band degeneracy by cations substitution is an effective way to enhance the TE performance of layered oxyselenides. | Ning Wang Menglu Li Haiyan Xiao Zhibin Gao Zijiang Liu Xiaotao Zu Sean Li Liang Qiao | 2021 | npj Computational Materials2021，，1： | 1 |
| 8 | Vibration Control of Jacket Platforms with Magnetorheological Damper and Experimental Validation~显示文摘 | 嵇春艳 Chen Menglu Li Shanshan | 2010 | High Technology Letters2010，16，2： | 1 |
| 9 | The Anatomy of Shallow Water Sandy Braided River Reservoir Architecture显示文摘1 Introduction Reservoir architecture refers to pattern,scale,direction and overlapping relationship of different levels of architecture units.The research of architecture in fluvial phase began in the 1980s(Miall,1985).The braided | CHEN Liang YIN Taiju SU Yangling WANG Mengmeng SHEN Chunsheng LI Menglu | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 0 |
| 10 | Exploration of the contributing factors to the walking and biking travel frequency using multi-level joint models with endogeneity显示文摘The enormous advantages of active transportation lead the transportation research focus towards enhancing the walking and biking trips.The present study explored the influential factors to the walking and biking travel frequency based on data obtained from the National Household Travel Survey California add-on survey.The study features some highlights.First,bivariate models were used to account for the common unobserved heterogeneity shared at both household and personal levels.Second,endogeneity was explicitly considered.Third,both variable importance ranking and correlation analysis are employed to determine the different features to be fed into each of the joint models.The results illustrated that the models developed with endogeneity performed better than the models without endogeneity.Four influential variables which includes mode to work by bicycle,public transit usage,count of household members,and multiple race responses,tend to have statistically significant impacts on walking and biking trips. | Mankirat Singh Wen Cheng Ranjithsudarshan Gopalakrishnan Yihua Li Menglu Cao | 2022 | Journal of Traffic and Transportation Engineering(English Edition)2022，9，6： | 0 |
| 11 | Whisker of biphasic calcium phosphate ceramics: Osteoimmunomodulatory behaviors显示文摘Immune systems play a critical role in the regulation of bone formation and homeostasis,which arouses a growing interest in the development of biomaterials that can modulate both immune response and osteogenesis.In this study,biphasic calcium phosphate(BCP)ceramics were modified with different whiskered surface,and their effects on macrophage polarization and functional status were investigated.The results showed that compared to BCP-W ceramics with long and solid whiskers,BCPHW ceramics with short and hollow whiskers surface were conducive to protein adsorption and macrophage elongation.Furthermore,BCP-HW ceramics down-regulated the expression of M1 macrophage markers(Il1β,Tnfα,and iNos),promoted the expression of M2 macrophage markers(Il10 and Arg)and growth factors(Tgfβ1 and Bmp2),which might be attributed to the differential integrin expression regulated by different whisker structures.The conditioned medium derived from the supernatant of macrophage/whiskered ceramic co-culture was further used to culture MC3T3-E1 pre-osteoblasts to evaluate the effects of whiskered ceramic-mediated macrophage secretion on osteogenesis in vitro.Compared with BCP-W ones,the secretion pattern induced by BCP-HW ceramics could promote the expression of bone markers in pre-osteoblasts,which might due to the activation of intracellular signaling cascades like BMP/Smad and TGF-β/Smad signaling pathways.A murine intramuscular implantation model suggested that after implantation for 1,2,and 3 weeks,BCP-HW ceramics drove the switch of macrophages to ARG+wound-healing M2 phenotype,while BCP-W ceramics increased the proportion of iNOS+M1 inflammatory macrophages.At 2 months,only BCP-HW could induce ectopic bone formation.Taken together,these results indicated that BCP ceramics with hollow whiskers were capable of creating a proper inflammatory microenvironment to induce bone formation.These whiskered BCP ceramics with good osteo-immunomodulatory capacity hold promise in serving as bone grafts to achieve desired bone repair and regeneration. | Jinjie Wu Cong Feng Menglu Wang Hongfeng Wu Xiangdong Zhu Xiangfeng Li Xuening Chen Xingdong Zhang | 2022 | Nano Research2022，15，10： | 0 |
| 12 | Simvastatin Blocks Reinstatement of Cocaine-induced Conditioned Place Preference in Male Mice with Brain Lipidome Remodeling显示文摘Drug-associated reward memories are conducive to intense craving and often trigger relapse.Simvastatin has been shown to regulate lipids that are involved in memory formation but its influence on other cognitive processes is elusive.Here,we used a mass spectrometry-based lipidomic method to evaluate the impact of simvastatin on the mouse brain in a cocaine-induced reinstatement paradigm.We found that simvastatin blocked the reinstatement of cocaine-induced conditioned place preference(CPP)without affecting CPP acquisition.Specifically,only simvastatin administered during extinction prevented cocaine-primed reinstatement.Global lipidome analysis showed that the nucleus accumbens was the region with the greatest degree of change caused by simvastatin.The metabolism of fatty-acids,phospholipids,and triacylglycerol was profoundly affected.Simvastatin reversed most of the effects on phospholipids induced by cocaine.The correlation matrix showed that cocaine and simvastatin significantly reshaped the lipid metabolic pathways in specific brain regions.Furthermore,simvastatin almost reversed all changes in the fatty acyl profile and unsaturation caused by cocaine.In summary,pre-extinction treatment with simvastatin facilitates cocaine extinction and prevents cocaine relapse with brain lipidome remodeling. | Wei Xu Yuman He Jiamei Zhang Hongchun Li Xuemei Wan Menglu Li Yonghai Wang Rui Xu Haoluo Zhang Yanping Dai Haxiaoyu Liu Linhong Jiang Ying Zhao Xiaobo Cen | 2021 | Neuroscience Bulletin2021，37，12： | 0 |
| 13 | Histone deacetylase 8 regulates NF-κB-related inflammation in asthmatic mice through H3K9 acetylation显示文摘To the Editor:Bronchial asthma is a respiratory disease with pathological features that mainly comprise changes in airway inflammation,airway remodeling,and airway hyperresponsiveness. | Yuan Ren Menglu Li Shiyao Bai Xinming Su | 2022 | Chinese Medical Journal2022，135，17： | 0 |
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