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| 1 | Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury显示文摘The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan,Hubei province,and rapidly spread to many provinces in China as well as other countries.Here we report the epidemiological,clinical,laboratory,and radiological characteristics,as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen,China.All 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS).The most common laboratory abnormalities were hypoalbuminemia,lymphopenia,decreased percentage of lymphocytes (LYM) and neutrophils (NEU),elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH),and decreased CD8 count.The viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease severity.ALB,LYM,LYM (%),LDH,NEU (%),and CRP were highly correlated to the acute lung injury.Age,viral load,lung injury score,and blood biochemistry indexes,albumin (ALB),CRP,LDH,LYM (%),LYM,and NEU (%),may be predictors of disease severity.Moreover,the Angiotensin Ⅱlevel in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung injury.Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection. | Yingxia Liu Yang Yang Cong Zhang Fengming Huang Fuxiang Wang Jing Yuan Zhaoqin Wang Jinxiu Li Jianming Li Cheng Feng Zheng Zhang Lifei Wang Ling Peng Li Chen Yuhao Qin Dandan Zhao Shuguang Tan Lu Yin Jun Xu Congzhao Zhou Chengyu Jiang Lei Liu | 2020 | Science China(Life Sciences)2020，63，3： | 157 |
| 2 | Practice guidelines for the pathological diagnosis of primary liver cancer: 2015 update显示文摘In 2010, a panel of Chinese pathologists reported the first expert consensus for the pathological diagnosis of primary liver cancers to address the many contradictions and inconsistencies in the pathological characteristics and diagnostic criteria for PLC. Since then considerable clinicopathological studies have been conducted globally, prompting us to update the practice guidelines for the pathological diagnosis of PLC. In April 18, 2014, a Guideline Committee consisting of 40 specialists from seven Chinese Societies(including Chinese Society of Liver Cancer, Chinese Anti-Cancer Association; Liver Cancer Study Group, Chinese Society of Hepatology, Chinese Medical Association; Chinese Society of Pathology, Chinese Anti-Cancer Association; Digestive Disease Group, Chinese Society of Pathology, Chinese Medical Association; Chinese Society of Surgery, Chinese Medical Association; Chinese Society of Clinical Oncology, Chinese Anti-Cancer Association; Pathological Group of Hepatobiliary Tumor and Liver Transplantation, Chinese Society of Pathology, Chinese Medical Association) was created for the formulation of the first guidelines for the standardization of the pathological diagnosis of PLC, mainly focusing on the following topics: gross specimen sampling, concepts and diagnostic criteria of small hepatocellular carcinoma(SHCC), microvascular invasion(MVI), satellite nodules,and immunohistochemical and molecular diagnosis. The present updated guidelines are reflective of current clinicopathological studies, and include a novel 7-point baseline sampling protocol, which stipulate that at least four tissue specimens should be sampled at the junction of the tumor and adjacent liver tissues in a 1:1 ratio at the 12, 3, 6 and 9 o'clock reference positions. For the purposes of molecular pathological examination, at least one specimen should be sampled at the intratumoral zone, but more specimens should be sampled for tumors harboring different textures or colors. Specimens should be sampled at both adjacent and distant peritumoral liver tissues or the tumor margin in order to observe MVI, satellite nodules and dysplastic foci/nodules distributed throughout the background liver tissues. Complete sampling of whole SHCC ≤ 3 cm should be performed to assess its biological behavior, and in clinical practice, therapeutic borders should be also preserved, even in SHCC. The diagnostic criteria of MVI and satellite nodules, immunohistochemical panels, as well as molecular diagnostic principles, such as clonal typing, for recurrent HCC and multinodule HCC were also proposed and recommended. The standardized process of pathological examination is aimed at ensuring the accuracy of pathological PLC diagnoses as well as providing a valuable frame of reference for the clinical assessment of tumor invasive potential, the risk of postoperative recurrence, long-term survival, and the development of individualized treatment regimens. The updated guidelines could ensure the accuracy of pathological diagnoses of PLC, and provide a valuable frame of reference for its clinical assessment. | Wen-Ming Cong Hong Bu Jie Chen Hui Dong Yu-Yao Zhu Long-Hai Feng Jun Chen 无 | 2016 | World Journal of Gastroenterology2016，22，42： | 81 |
| 3 | Development and progress on hydrogen metallurgy显示文摘Hydrogen metallurgy is a technology that applies hydrogen instead of carbon as a reduction agent to reduce CO2 emission,and the use of hydrogen is beneficial to promoting the sustainable development of the steel industry.Hydrogen metallurgy has numerous applications,such as H2reduction ironmaking in Japan,ULCORED and hydrogen-based steelmaking in Europe;hydrogen flash ironmaking technology in the US;HYBRIT in the Nordics;Midrex H2TM by Midrex Technologies,Inc.(United States);H2FUTURE by Voestalpine(Austria);and SALCOS by Salzgitter AG(Germany).Hydrogen-rich blast furnaces(BFs)with COG injection are common in China.Running BFs have been industrially tested by AnSteel,XuSteel,and BenSteel.In a currently under construction pilot plant of a coal gasification–gas-based shaft furnace with an annual output of 10000 t direct reduction iron(DRI),a reducing gas composed of 57 vol%H2 and 38 vol%CO is prepared via the Ende method.The life cycle of the coal gasification–gas-based shaft furnace–electric furnace short process(30 wt%DRI+70 wt%scrap)is assessed with 1 t of molten steel as a functional unit.This plant has a total energy consumption per ton of steel of 263.67 kg standard coal and a CO2 emission per ton of steel of 829.89 kg,which are superior to those of a traditional BF converter process.Considering domestic materials and fuels,hydrogen production and storage,and hydrogen reduction characteristics,we believe that a hydrogen-rich shaft furnace will be suitable in China.Hydrogen production and storage with an economic and large-scale industrialization will promote the further development of a full hydrogen shaft furnace. | Jue Tang Man-sheng Chu Feng Li Cong Feng Zheng-gen Liu Yu-sheng Zhou | 2020 | International Journal of Minerals,Metallurgy and Materials2020，27，6： | 34 |
| 4 | The Chromosome-Level Reference Genome of Tea Tree Unveils Recent Bursts of Nonautonomous LTR Retrotransposons in Driving Genome Size Evolution显示文摘Dear Editor,The tea tree Camellia sinensis,a member of the genus Camellia in the Theaceae family,includes two major cultivated varieties,C.sinensis var.assamica(CSA\Assam type)and C.sinensis var.sinensis(CSS;Chinese type)(Ming and Bartholomew,2007).Due to the high economic importance of the tea tree,considerable efforts have been made to explore genetic basis of the biosynthesis of natural metabolites that determine health benefits and diverse tea flavors(Shi et al.,2011;Li et al.,2011;Li et al.,2015;Xia et aL,2017;Liu et al.,2019). | Qun-Jie Zhang Wei L i Kui Li Hong Nan Cong Shi Yun Zhang Zhang-Yan Dai Yang-Lei Lin Xiao-Lan Yang Yan Tong Dan Zhang Cui Lu Li-Ying Feng Chen-Feng Wang Xiao-Xin Liu Jian-An Huang Wen-Kai Jiang Xing-Hua Wang Xing-Cai Zhang Evan E.Eichler Zhong-Hua Liu and Li-Zhi Gao | 2020 | Molecular Plant2020，13，7： | 27 |
| 5 | Magma mixing of granites at Lianghe:In-situ zircon analysis for trace elements, U-Pb ages and Hf isotopes显示文摘In this paper, we report an integrated study of trace element, U-Pb age and Hf isotopic composition of zircons from alkali feldspar granites, granodiorites and diorite enclaves in a recently discovered ring complex at Lianghe in western Yunnan, Chi na. The granitoids showed identical U-Pb ages of 127, 115 and 122 Ma, from felsic to mafic, but had different zircon trace el ements and Hf isotopic compositions. Trace element content decreased with a gradual increase in εHf(t) values of ?9.1 to ?5.4, ?4.5 to 0, and 3.6 to 6.2, respectively. Results indicate that changes in zircon trace elements generally correlate with changes in Hf isotope signatures within single samples and among various granitoids. These relationships reflect the mixing of felsic and mafic magmas. Evidence indicates that depleted mantle-derived mafic magma underplating caused ancient crustal melting, and then formed large-scale granites in Lianghe during the Early Cretaceous. These granodiorites were formed mainly by the mix ing of mafic magma and granitic magma. | CONG Feng LIN ShiLiang ZOU GuangFu LI ZaiHui XIE Tao PENG ZhiMin LIANG Ting | 2011 | Science China Earth Sciences2011，54，9： | 26 |
| 6 | Pilose antler aqueous extract promotes the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells by stimulating the BMP-2/Smad1, 5/Runx2 signaling pathway显示文摘Peptides from Pilose antler aqueous extract(PAAE) have been shown to stimulate the proliferation and differentiation of bone marrow mesenchymal stem cells(BMSCs). However, the underlying molecular mechanisms are not well understood. Here, PAAE was isolated and purified to explore the molecular mechanisms underlying PAAE’s effects on BMSCs as well as its osteoprotective effects in ovariectomized rats. Our results showed that PAAE promoted proliferation and differentiation of BMSCs to become osteoblasts by enhancing ALP activity and increasing extracellular matrix mineralization. The trabecular microarchitecture of ovariectomized rats was also found to be protected by PAAE. Quantitative reverse transcription-polymerase chain reaction(Quantitative RT-PCR) results suggest that PAAE also increased the expression of osteogenic markers including, alkaline phosphatase(ALP), runt-related transcription factor 2(Runx2), osteocalcin(OCN), bone morphogenetic protein-2(BMP-2), and collagen I(COL-I). Immunoblotting results indicated that PAAE upregulated the levels of BMP-2 and Runx2 and was associated with Smad1/5 phosphorylation. PAAE A at the concentration of 200μg·mL^-1 showed the strongest effect on proliferation and osteogenic differentiation of BMSCs after 48 h. Using matrix-assisted laser desorption/ionization time of flight mass spectrometry(MALDI-TOF MS), we identified the molecular weight of PAAE A and found that it is less than 3000 Da and showed several significant peaks. In conclusion, PAAE activates the BMP-2/Smad1, 5/Runx2 pathway to induce osteoblastic differentiation and mineralization in BMSCs and can inhibit OVX-induced bone loss. These mechanisms are likely responsible for its therapeutic effect on postmenopausal osteoporosis. | REN Cong GONG Wei LI Feng XIE Ming | 2019 | Chinese Journal of Natural Medicines2019，17，10： | 25 |
| 7 | In vitro differentiation of adipose-derived stem cells and bone marrow-derived stromal stem cells into neuronal-like cells显示文摘Adipose-derived stem cells and bone marrow-derived stromal stem cells were co-cultured with untreated or Aβ1-40-treated PC12 cells, or grown in supernatant derived from untreated or Aβ1-40-treated PC12 cells. Analysis by western blot and quantitative real-time PCR showed that protein levels of Nanog, Oct4, and Sox2, and mRNA levels of miR/125a/3p were decreased, while expression of insulin-like growth factor-2 and neuron specific enolase was increased. In comparison, the generation of neuron specific enolase-positive cells was most successful when adipose-derived stem cells were co-cultured with Aβ1-40-treated PC12 cells. Our results demonstrate that adipose-derived stem cells and bone marrow-derived stromal stem cells exhibit trends of neuronal-like cell differentiation after co-culture with Aβ1-40-treated PC12 cells. This process may relate to a downregulation of miR-125a-3p mRNA expression and increased levels of insulin-like growth factor-2 expression. | Jin Zhou Guoping Tian Jing'e Wang Xuefeng Cong Xingkai Wu Siyang Zhang Li Li Bing Xu Feng Zhu Xuedan Luo Jian Han Fengjie Hu | 2011 | Neural Regeneration Research2011，6，19： | 21 |
| 8 | Research on in-situ condition preserved coring and testing systems显示文摘As shallow resources are increasingly depleted,the mechanics'theory and testing technology of deep insitu rock has become urgent.Traditional coring technologies obtain rock samples without retaining the in-situ environmental conditions,leading to distortion of the measured parameters.Herein,a coring and testing systems retaining in-situ geological conditions is presented:the coring system that obtains in-situ rock samples,and the transfer and testing system that stores and analyzes the rocks under a reconstructed environment.The ICP-Coring system mainly consists of the pressure controller,active insulated core reactor and insulation layer and sealing film.The ultimate bearing strength of 100 MPa for pressurepreservation,temperature control accuracy of 0.97%for temperature-retained are realized.CH_(4)and CO permeability of the optimized sealing film are as low as 3.85 and 0.33 ppm/min.The average tensile elongation of the film is 152.4%and the light transmittance is reduced to 0%.Additionally,the pressure and steady-state temperature accuracy for reconstructing the in-situ environment of transfer and storage system up to 1%and±0.2 is achieved.The error recorded of the noncontact sensor ring made of lowdensity polymer is less than 6%than that of the contact test.The system can provide technical support for the deep in-situ rock mechanics research,improving deep resource acquisition capabilities and further clarifying deep-earth processes. | He-Ping Xie Tao Liu Ming-Zhong Gao Ling Chen Hong-Wei Zhou Yang Ju Feng Gao Xiao-Bo Peng Xiong-Jun Li Rui-Dong Peng Ya-Nan Gao Cong Li Zhi-Qiang He Ming-Qing Yang Zhi-Yu Zhao | 2021 | Petroleum Science2021，18，6： | 19 |
| 9 | Intestinal immune barrier integrity in rats with nonalcoholic hepatic steatosis and steatohepatitis显示文摘背景不含酒精的脂肪肝疾病( NAFLD )作为在这篇文章的 NAFLD.The 目的 pathogenis 的一个重要角色是完全在 NAFLD.Methods 的发展期间估计肠的有免疫力的障碍功能的长期的肝 injury.Intestinal 障碍戏的主要原因出现了 60 只男 Sprague-Dawley ( SD )老鼠被划分成 2 groups:normal 食谱( ND )组和高脂肪的饮食( HFD ) group.NAFLD 老鼠模型在 HFD 老鼠 group.Portal 血内毒素水平被建立被 li | Su Lin Wang Jian-hua Cong Xu Wang Li-hong Liu Feng Xie Xing-wang Zhang Heng-hui Wang Jiang-hua Fei Ran Liu Yu-lan | 2012 | Chinese Medical Journal2012，，2： | 18 |
| 10 | Asperosaponin VI promotes angiogenesis and accelerates wound healing in rats via up-regulating HIF-1α/VEGF signaling显示文摘创伤治疗由于愈合的病理的复杂性和完成功能、审美上令人满意的疤的高需求仍然是临床的挑战。自从他们能与营养和氧在创伤地点支持房间,最新形成的血容器为织物修理是必要的。在这研究,我们调查了从繁体中文药孤立的 Asperosaponin VI (ASA VI ) 的效果, Dipsacus asper 墙的根在支持 angiogenesis,以及它在创伤治疗学的功能。有 ASA VI (20-80 g/mL ) 的人的脐的静脉 endothelial 房间(HUVEC ) 的处理 dose-dependently 支持了增长,移植并且在 vitro 提高了他们的 angiogenic 能力,它与起来调整的 HIF-1/VEGF 发信号被联系。完整厚度的皮肤的创伤模型老鼠与 ASA VI 被注射(20 mg ????????????????? | Cheng-gui WANG Yi-ting LOU Min-ji TONG Li-lian ZHANG Zeng-jie ZHANG Yong-zeng FENG Shi LI Hua-zi XU Cong MAO | 2018 | Acta Pharmacologica Sinica2018，39，3： | 18 |
| 11 | Geochronology and Petrogenesis for the Protolith of Biotite Plagioclase Gneiss at Lianghe,Western Yunnan显示文摘在这份报纸,我们在西方的云南在 Lianghe 从黑云母斜长石片麻岩报导 U-Pb 年龄的综合研究和锆石的 Hf 同位素作文。锆石保存了继承核心和边界质地。火的锆石谷物和边界产出 120.4 的加权的吝啬的 206Pb/238U 年龄 ????晈 吗?? | CONG Feng LIN Shiliang ZOU Guangfu XIE Tao LI Zaihui TANG Fawei PENG Zhimin | 2011 | Acta Geologica Sinica(English Edition)2011，85，4： | 16 |
| 12 | Few-layer Tellurium:one-dimensional-like layered elementary semiconductor with striking physical properties显示文摘Few-layer Tellurium, an elementary semiconductor, succeeds most of striking physical properties that black phosphorus(BP) offers and could be feasibly synthesized by simple solution-based methods. It is comprised of non-covalently bound parallel Te chains, among which covalent-like feature appears.This feature is, we believe, another demonstration of the previously found covalent-like quasi-bonding(CLQB) where wavefunction hybridization does occur. The strength of this inter-chain CLQB is comparable with that of intra-chain covalent bonding, leading to closed stability of several Te allotropes. It also introduces a tunable bandgap varying from nearly direct 0.31 eV(bulk) to indirect 1.17 eV(2L) and four(two) complex, highly anisotropic and layer-dependent hole(electron) pockets in the first Brillouin zone.It also exhibits an extraordinarily high hole mobility(~10~5 cm^2/Vs) and strong optical absorption along the non-covalently bound direction, nearly isotropic and layer-dependent optical properties, large ideal strength over 20%, better environmental stability than BP and unusual crossover of force constants for interlayer shear and breathing modes. All these results manifest that the few-layer Te is an extraordinary-high-mobility, high optical absorption, intrinsic-anisotropy, low-cost-fabrication, tunable bandgap, better environmental stability and nearly direct bandgap semiconductor. This ‘‘one-dimen sion-like' few-layer Te, together with other geometrically similar layered materials, may promote the emergence of a new family of layered materials. | Jingsi Qiao Yuhao Pan Feng Yang Cong Wang Yang Chai Wei Ji | 2018 | Science Bulletin2018，63，3： | 12 |
| 13 | Current status and development trends of innovative blast furnace ironmaking technologies aimed to environmental harmony and operation intellectualization显示文摘Blast furnace(BF)ironmaking is dominant for reducing pollution emission and energy consumption in iron and steel industry.Under the increasingly strict environmental pressure,some innovative technologies of BF ironmaking for environmental protection have been developed and applied in actual operating facilities.The current state of BF ironmaking in Europe,America,Japan,and China were briefly overviewed.Moreover,some innovative BF ironmaking technologies aiming at environmental harmony and operation intellectualization in the world,such as waste gas recycling sintering,BF operation with coke oven gas injection,ferro-coke,lime coating coke,BF visualization and intellectualization,were roundly summarized.Finally,some discussion on the technologies was carried out and the development trends of BF ironmaking were pointed out.The review could provide references and supports for the progress of environment-friendly technologies of BF ironmaking,thereby promoting their practical applications and achieving sustainable development of BF ironmaking,especially for Chinese ironmaking industry. | Hong-tao Wang Wei Zhao Man-sheng Chu Cong Feng Zheng-gen Liu Jue Tang | 2017 | Journal of Iron and Steel Research(International)2017，24，8： | 9 |
| 14 | Synthesis of NaYF_4:Nd@NaLuF_4@SiO_2@PS colloids for fluorescence imaging in the second biological window显示文摘Nd doped nanoparticles is commonly used as bioimaging agents but presents poor stability. Here, a polymer coating is applied to NaYF4:Nd nanoparticles using a versatile step-by-step coating strategy. The as-synthesized NaYF_4:Nd@NaLuF_4@SiO_2@PS colloids show good stability in various polar solvent and are very stable in water at least for 6 months. These NaYF_4:Nd@NaLuF_4@SiO_2@PS colloids can exhibit strong down converting photoluminescence when excited by 808 nm lasers. Moreover, these NaYF_4:Nd@NaLuF_4@SiO_2@PS colloids accumulate in liver of mice when used as bio-imaging agents. which exhibit strong fluorescence luminescence in NIR Ⅱ window. | Dongpeng Yang Cong Cao Wei Feng Chunhui Huang Fuyou Li | 2018 | Journal of Rare Earths2018，36，2： | 9 |
| 15 | First total synthesis of two nematicidal prenylated flavanones显示文摘全部的合成(±)-8-(3-methylbut-2-enyl)-2-phenyl-2,3-dihydrochromen-4-one 并且(±)-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one 首先通过 C-prenylation,酉分的氢氧根组的保护,丁间醇醛冷凝作用,环合和从便宜 benzaldehyde, 4-hydroxybenzaldehyde 和 2-hydroxyacetophenone 开始的 deprotection 被完成,与 20 和 16.3% 的全部的产量。新混合物的所有结构被红外证实, 1 H NMR 和 MS。 | Jin Hui Yang Shi Zhi Jiang Yan Min Zhao Yun Feng Li Cong Bin Ji Wan Yi Liu | 2009 | Chinese Chemical Letters2009，20，9： | 9 |
| 16 | Association of a SLC30A8 Genetic Variant with Monotherapy of Repaglinide and Rosiglitazone Effect in Newly Diagnosed Type 2 Diabetes Patients in China显示文摘Objective To investigate a potential relationship between Solute carrier family 30 (zinc transporter) member 8 (SLC30A8) rs13266634 variant and efficacy of rosiglitazone or repaglinide in treating newly diagnosed Chinese type 2 diabetes patients.Methods A total of 209 diabetic patients without any antihyperglycemic history were recruited and treated with repaglinide or rosiglitazone randomly for 48 weeks (104 and 105 patients,respectively).Anthropometric measurements and clinical laboratory tests were carried out before and after the treatment.An non-synonymous variant rs13266634 was genotyped by matrix-assisted laser desorption ionization-time of flight mass spectroscopy.Results Ninety-one patients in repaglinide group and ninety-three patients in rosiglitazone group completed the study.Δ value of homeostasis model assessment of beta cell function (HOMA-B)and Δ value of fasting proinsulin levels were statistically significant between three genotype groups (P=0.0149 and 0.0246,respectively) after rosiglitazone treatment.However,no genotype association was observed in the repaglinide or rosiglitazone group with other parameters.Conclusion The SLC30A8 variant was associated with the efficacy of insulin sensitizer monotherapy on insulin secretion in patients with newly diagnosed type 2 diabetes mellitus in Shanghai,China. | JIANG Feng LI Qing HU Cheng ZHANG Rong WANG Cong Rong YU Wei Hui LU Jing Yi TANG Shan Shan BAO Yu Qian XIANG Kun San JIA Wei Ping | 2012 | Biomedical and Environmental Sciences2012，25，1： | 8 |
| 17 | Malnutrition and Quality of Life in Chinese Cancer Patients: a Clinical Study of 23,994 Subjects显示文摘Background Malnutrition is common in patients with cancer,and can negatively impact their quality of life(QoL)and even survival.However,there is currently no large data available on the prevalence of malnutrition in Chinese cancer patients.This study evaluated the prevalence of malnutrition and the QoL of Chinese patients with locoregional,recurrent or metastatic cancer.Methods We conducted a nationwide observational,multi-center,hospital-based cross-sectional study within the Chinese Society of Nutritional Oncology(CSNO)Network.All of the patients were diagnosed with one of the following 18 different types of malignant tumors:lung cancer,gastric cancer,liver cancer,colorectal cancer,breast cancer,esophageal cancer,cervical cancer,endometrial cancer,nasopharyngeal carcinoma,malignant lymphoma,leukemia,pancreatic cancer,ovarian cancer,prostate cancer,bladder cancer,brain cancer,biliary tract malignant tumors or gastrointestinal stromal tumors.These patients were enrolled from 72 hospitals located in different regions of China.The patients’nutritional status was evaluated based on the body mass index(BMI),loss of bodyweight,laboratory measurements and patient generated-subjective global assessment(PG-SGA)scores.The cancer patients’physical status and QoL were assessed by the Karnofsky Performance Status(KPS)questionnaire and the European Organization for Research and Treatment of Cancer(EORTC)QLQ-C30 questionnaire,respectively.Results From December 2013 to April 2016,23,994 patients hospitalized for cancer treatment(such as surgery,chemotherapy or radiotherapy)were enrolled in the study.The patients included 12,494(52.9%)males and 11,124(47.1%)females.The mean age was 55.8±13.7 years.The proportions of patients in cancer stagesⅠ,Ⅱ,Ⅲ,Ⅳand uncertain were 11.5%,20.3%,27.5%,30.2%and 10.5%,respectively.Among the 23,994 inpatients,the proportions of patients who were underweight(BMI<18.5 kg/m2),normal(18.5 kg/m2 | Hong Xia Xu Chun Hua Song Zhen Ming Fu Chang Wang Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Jiu Wei Cui Wei Li Han Ping Shi the Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2021 | Journal of Nutritional Oncology2021，6，1： | 8 |
| 18 | Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis显示文摘Curcumenol,an effective ingredient of Wenyujin,has been reported that exerted its antitumor potential in a few cancer types.However,the effect and molecular mechanism of curcumenol in lung cancer are largely unknown.Here,we found that curcumenol induced cell death and suppressed cell proliferation in lung cancer cells.Next,we demonstrated that ferroptosis was the predominant method that contributed to curcumenol-induced cell death of lung cancer in vitro and vivo for the first time.Subsequently,using RNA sequencing,we found that the long non-coding RNA H19(lncRNA H19)was significantly downregulated in lung cancer cells treated with curcumenol,when compared to untreated controls.Overexpression of lncRNA H19 eliminated the anticancer effect of curcumenol,while lncRNA H19 knockdown promoted ferroptosis induced by curcumenol treatment.Mechanistically,we showed that lncRNA H19 functioned as a competing endogenous RNA to bind to miR-19b-3p,thereby enhanced the transcription activity of its endogenous target,ferritin heavy chain 1(FTH1),a marker of ferroptosis.In conclusion,our data show that the natural product curcumenol exerted its antitumor effects on lung cancer by triggering ferroptosis,and the lncRNA H19/miR-19b-3p/FTH1 axis plays an essential role in curcumenol-induced ferroptotic cell death.Therefore,our findings will hopefully provide a valuable drug for treating lung cancer patients. | Ruonan Zhang Ting Pan Yu Xiang Mingming Zhang Han Xie Zimao Liang Bi Chen Cong Xu Jing Wang Xingxing Huang Qianru Zhu Ziming Zhao Quan Gao Chengyong Wen Wencheng Liu Weirui Ma Jiao Feng Xueni Sun Ting Duan Elaine Lai-Han Leung Tian Xie Qibiao Wu Xinbing Sui | 2022 | Bioactive Materials2022，7，7： | 8 |
| 19 | Research on Water-Exit and Take-off Process for Morphing Unmanned Submersible Aerial Vehicle显示文摘This paper presents a theoretic implementation method of Morphing Unmanned Submersible Aerial Vehicle(MUSAV),which can both submerge in the water and fly in the air.Two different shapes are put forward so that the vehicle can suit both submergence and flight,considering the tremendous differences between hydrodynamic configuration and aerodynamic configuration of a vehicle.The transition of the two shapes can be achieved by using morphing technology.The water-to-air process,including water-exit,morphing,take-off and steady flight,is analyzed.The hydrodynamic and aerodynamic model of the vehicle exiting the water surface obliquely and then taking off into the air has been founded.The control strategy after morphing is analyzed and the control method is given.Numerical method is used to validate the motion model of the water-exit process.Results of simulations show the validity of the proposed model and the feasibility of MUSAV in theory. | HU Jun-hua XU Bao-wei FENG Jin-fu QI Duo YANG Jian WANG Cong | 2017 | China Ocean Engineering2017，31，2： | 8 |
| 20 | 3-year Treatment of Tenofovir Alafenamide vs.Tenofovir Disoproxil Fumarate for Chronic HBV Infection in China显示文摘Background and Aims:Tenofovir alafenamide(TAF)has similar efficacy to tenofovir disoproxil fumarate(TDF)but with improved renal and bone safety in chronic hepatitis B patients studied outside of China.We report 3-year results from two phase 3 studies with TAF in China(Clinicaltrials.gov:NCT02836249 and NCT02836236).Methods:Chinese hepatitis B e antigen(HBeAg)-positive and-negative chronic hepatitis B patients with viremia and elevated alanine aminotransferase were randomized 2:1 to TAF or TDF treatment groups and treated in a double-blind fashion for 144 weeks(3 years).Efficacy responses were assessed by individual study while safety was assessed by a pooled analysis.Results:Of the 334 patients(180 HBeAg-positive and 154 HBeAg-negative)randomized and treated,baseline characteristics were similar between groups.The overall mean age was 38 years and 73%were male.The mean HBV DNA was 6.4 log10 IU/mL.The median alanine aminotransferase was 88 U/L,and 37%had a history of antiviral use.At week 144,the proportion with HBV DNA<29 IU/mL was similar among the two groups,with TAF at 83%vs.TDF at 79%,and TAF at 93%vs.TDF at 92%for the HBeAg-positive and-negative patients,respectively.In each study,higher proportions of TAF than TDF patients showed normalized alanine aminotransferase(via the American Association for the Study of Liver Diseases and the China criteria)and showed loss of HBsAg;meanwhile,the HBeAg seroconversion rates were similar.Treatment was well-tolerated among the TAF patients,who showed a smaller median decline in creatinine clearance(−0.4 vs.−3.2 mL/min;p=0.014)and less percentage change in bone mineral density vs.TDF at hip(−0.95%vs.−1.93%)and spine(+0.35%vs.−1.40%).Conclusions:In chronic hepatitis B patients from China,TAF treatment provided efficacy similar to TDF but with better renal and bone safety at 3 years. | Jinlin Hou Qin Ning Zhongping Duan You Chen Qing Xie Fu-Sheng Wang Lunli Zhang Shanming Wu Hong Tang Jun Li Feng Lin Yongfeng Yang Guozhong Gong John FFlaherty Anuj Gaggar Shuyuan Mo Cong Cheng Gregory Camus Chengwei Chen Yan Huang Jidong Jia Mingxiang Zhang GS-US-320-0110 and GS-US-320-0108 China Investigators | 2021 | Journal of Clinical and Translational Hepatology2021，9，3： | 7 |
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