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| 1 | Quercus yangyiensis sp. nov. from the Late Pliocene of Baoshan, Yunnan and Its Paleoclimatic Significance显示文摘A new Quercus(Fagaceae) morphospecies is described based on well-preserved fossil leaves. The fossils were collected from Yangyi Formation of the Upper Pliocene at the Yangyi coalmine, Baoshan, western Yunnan, China. Details of the microstructure of mesophyll tissue are preserved because lithification of the fossils was not complete. The fossil laminas possess typical characteristics of Quercus sect. Heterobalanus: quite thick and coriaceous cuticle; secondary veins bifurcating near the margin in the middle and top of the leaf; and upper epidermis with adaxial hypodermis. Based on a detailed morphological and anatomical comparison with all living and fossil species of Quercus sect. Heterobalanus, the fossil leaves prove to be different in their sparse and garland-shaped multicellular trichomes on the lower epidermis, and so it is described as a new species Quercus yangyiensis He, Li et Sun sp. nov. The much sparser trichomes of our fossils compare well with those of living Quercus sect. Heterobalanus and indicate a more humid climate during the deposition of the Yangyi Formation in the Late Pliocene. | HE Yuli LI Na WANG Zixi WANG Haofei YANG Guolin XIAO Liang WU Jingyu SUN Bainian | 2014 | Acta Geologica Sinica(English Edition)2014，88，3： | 6 |
| 2 | Purification and Characterization of an Antibacterial Protein from the Cultured Mycelia of Cordyceps sinensis显示文摘抗菌剂蛋白质从 Cordycepssinensi.f 的有教养的 mycelia 被孤立,并且被指定为 Cordyceps sinensis 抗菌剂蛋白质(CSAP ) 。CSAP 锁住 wassingle,与 35 x 10 ~ 的一个明显的分子的团, 3 由 SDS 页和新奇恐水病的 N 终端顺序 N-ALATQHGAP 揭示了。抗菌剂试金证明 CSAP 能对真菌或酵母禁止克积极、克否定的细菌而是没有重要抑制的生长。而且, CSAP 的抗菌剂活动不杀菌却细菌抑制。抗菌剂蛋白质在 Cordyceps 种类被描述的 Itwas 第一次,它可能在主人的化学防卫机制包含。 | HU Zheng YE Maoqing XIA Liqiu TU Wenjuan LI Liang ZOU Guolin | 2006 | Wuhan University Journal of Natural Sciences2006，11，3： | 5 |
| 3 | Mitochondrial fusion/fission process involved in the improvement of catalpol on high glucose- induced hepatic mitochondrial dysfunction显示文摘Catalpol, iridoid glycoside,被显示了由 rescuing mitochondrial 功能,而是详细机制遗体施加血糖过低的效果不清楚还。在这研究,在糖尿病的条件下面的肝的线粒体上的 catalpol 的效果和机制进一步被检验。catalpol 的口头的管理显著地在高脂肪的导致食谱、导致 streptozotocin 的糖尿病的老鼠减少了血葡萄糖, triglyceride,和胆固醇层次。另外, catalpol 在源于糖尿病的肝 mitochondrial ATP 内容稀释了减少。而且,拥有一种长尺寸的线粒体的数字在对待 catalpol 的老鼠被增加。有趣地, mitochondrial 功能的导致 catalpol 的恢复与减少的分裂蛋白质 1 被联系并且 dynamin 相关的蛋白质象增加的 mitofusin 一样的 1 个表达式在肝的 1 个表达式。在 HepG2 房间, catalpol 减轻了 ATP 内容和 mitochondrial 膜潜力的减少,并且反应的氧种类形成的增加由高葡萄糖导致了。当房间与 catalpol 被对待时,线粒体的管状的特征被维持的米托特拉克·格林污点表演。Catalpol 也减少了分裂蛋白质 1 并且 dynamin 相关的蛋白质 1 表情和增加的 mitofusin 在 HepG2 房间的 1 表情。现在的结果建议 catalpol 能改善在一名糖尿病患者下面的肝的 mitochondrial 机能障碍状态,和这可能与它 mitochondrial 的规定有关熔化和分裂事件。 | Zhimeng Xu Luyong Zhang Xiaojie Li Zhenzhou Jiang Lixin Sun Guolin Zhao Guohua Zhou Heran Zhang Jing Shang Tao Wang | 2015 | Acta Biochimica et Biophysica Sinica2015，47，9： | 4 |
| 4 | Non-anthracycline-containing docetaxel and cyclophosphamide regimen is associated with sustained worse outcome compared with docetaxel, anthracycline and cyclophosphamide in neoadjuvant treatment of triple negative and HER2-positive breast cancer patients:显示文摘Objective: A previous study demonstrated that non-anthracycline-containing docetaxel plus cyclophosphamide(TC) regimen was inferior to docetaxel, anthracycline and cyclophosphamide(TAC) in neoadjuvant treatment of triple-negative breast cancer(TNBC) and human epidermal growth factor receptor-2-(HER2)-positive breast cancer in a short-term follow-up. Herein, long-term follow-up survival outcomes have been investigated.Methods: TNBC or HER2-positive patients were randomized to receive 6 cycles of TC or TAC neoadjuvant treatment. The primary endpoint was pathological complete remission(p CR). Secondary endpoints included clinical response rate, event-free survival(EFS), and overall survival(OS).Results: A cohort of 96 patients consisted of 45 in TC and 51 in TAC arm. With a median follow-up period of53(range, 8–76) months, the patients achieving p CR post neoadjuvant chemotherapy exhibited superior EFS and OS than patients without p CR(P<0.05). TAC treatment resulted in consistently better EFS than TC treatment:the estimated 5-year EFS was 66.1% vs. 29.8%(P=0.002). Moreover, the estimated 5-year OS was also in favor of TAC: 88.4% vs. 51.6%(P<0.001). Multivariable analysis demonstrated that the treatment regimen was an independent prognostic factor, and patients treated with TAC had a superior EFS [hazard ratio(HR), 0.48; 95%confidence interval(95% CI), 0.26–0.90; P=0.021] and OS(HR, 0.20; 95% CI, 0.08–0.60; P=0.003).Conclusions: The updated long-term follow-up data demonstrated a sustained benefit in EFS and OS from anthracycline-containing TAC treatment, indicating that anthracycline is an essential and effective drug in this clinical trial. | Xiaosong Chen Guolin Ye Chenfang Zhang Xinzheng Li Kunwei Shen | 2016 | Chinese Journal of Cancer Research2016，28，6： | 4 |
| 5 | Standard pancreatoduodenectomy versus extended pancreatoduodenectomy with modified retroperitoneal nerve resection in patients with pancreatic head cancer:a multicenter randomized controlled trial显示文摘Background:The extent of pancreatoduodenectomy for pancreatic head cancer remains controversial,and more high-level clinical evidence is needed.This study aimed to evaluate the outcome of extended pancreatoduodenectomy(EPD)with retroperitoneal nerve resection in pancreatic head cancer.Methods:This multicenter randomized trial was performed at 6 Chinese highvolume hospitals that enrolled patients between October 3,2012,and September 21,2017.Four hundred patients with stage I or II pancreatic head cancer and without specific pancreatic cancer treatments(preoperative chemotherapy or chemoradiation)within three months were randomly assigned to undergo standard pancreatoduodenectomy(SPD)or EPD,with the latter followed by dissection of additional lymph nodes(LNs),nerves and soft tissues 270◦on the right side surrounding the superior mesenteric artery and celiac axis.The primary endpoint was overall survival(OS)by intention-to-treat(ITT).The secondary endpoints were disease-free survival(DFS),mortality,morbidity,and postoperative pain intensity.Results:TheR1 ratewas slightly lower with EPD(8.46%)thanwith SPD(12.56%).The morbidity and mortality rates were similar between the two groups.The median OS was similar in the EPD and SPD groups by ITT in the whole study cohort(23.0 vs.20.2 months,P=0.100),while the median DFS was superior in the EPD group(16.1 vs.13.2 months,P=0.031).Patients with preoperative CA19–9<200.0 U/mL had significantly improved OS and DFS with EPD(EPD vs.SPD,30.8 vs.20.9 months,P=0.009;23.4 vs.13.5 months,P<0.001).The EPD group exhibited significantly lower locoregional(16.48%vs.35.20%,P<0.001)andmesenteric LNrecurrence rates(3.98%vs.10.06%,P=0.022).The EPD group exhibited less back pain 6 months postoperation than the SPD group.Conclusions:EPD for pancreatic head cancer did not significantly improve OS,but patients with EPD treatment had significantly improved DFS.In the subgroup analysis,improvements in bothOS and DFS in the EPD armwere observed in patients with preoperative CA19–9<200.0 U/mL.EPD could be used as an effective surgical procedure for patients with pancreatic head cancer,especially those with preoperative CA19–9<200.0 U/mL. | Qing Lin Shangyou Zheng Xianjun Yu Meifu Chen Yu Zhou Quanbo Zhou Chonghui Hu Jing Gu Zhongdong Xu LinWang Yimin Liu Qingyu Liu MinWang Guolin Li He Cheng Dongkai Zhou Guodong Liu Zhiqiang Fu Yu Long Yixiong Li Weilin Wang Renyi Qin Zhihua Li Rufu Chen | 2023 | Cancer Communications2023，43，2： | 3 |
| 6 | Genome-wide identification and expression analysis of NIN-like Protein(NLP)genes reveals their potential roles in the response to nitrate signaling in watermelon显示文摘To balance the relationship between high yield and low nitrogen supply,the nitrogen utilization efficiency of watermelon needs to be improved urgently.Nodule inception-like Protein(NLP)transcription factors play a key node role in nitrate response and growth and development of plant,however,comprehensive analysis of the NLP gene family in watermelon is unclear.This study explored the functional classification,evolutionary characteristics,and expression profile of the ClNLP gene family.Three ClNLPs were categorized into three groups according to their gene structure and phylogeny.All of them contained the conserved RWP-RK and PB1 domains.Evolutionary analysis of ClNLPs revealed that ClNLP1 and ClNLP3 underwent strong purified selection.In addition,cis-acting elements related to plant hormones and abiotic stresses were present in the ClNLP promoter.According to tissue-specific analysis ClNLP was widely expressed in roots,stems,leaves,flowers and fruits,and ClNLP1 was significantly induced in the roots of different nitrogen utilization varieties under different nitrate nitrogen supply.The SRTING functional protein association network suggested that ClNLP1 is associated with most genes,such as NRT1.1,NRT2.1,NIA1,and NIR1,and the dual-luciferase reporter assay found that ClNLP1 positively regulates the expression of ClNRT2.1.We speculated that ClNLP1 might play a central role in regulating the response of watermelon to nitrate nitrogen. | Gaopeng Yuan Dexi Sun Yifan Wang Guolin An Weihua Li Wenjing Si Junpu Liu Yingchun Zhu | 2022 | Horticultural Plant Journal2022，8，5： | 2 |
| 7 | A Role for Transmembrane Protein 16C/Slack Impairment in Excitatory Nociceptive Synaptic Plasticity in the Pathogenesis of Remifentanil-induced Hyperalgesia in Rats显示文摘Remifentanil is widely used to control intraoperative pain. However, its analgesic effect is limited by the generation of postoperative hyperalgesia. In this study, we investigated whether the impairment of transmembrane protein 16C(TMEM16C)/Slack is required for a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic receptor(AMPAR) activation in remifentanil-induced postoperative hyperalgesia. Remifentanil anesthesia reduced the paw withdrawal threshold from 2 h to 48 h postoperatively,with a decrease in the expression of TMEM16C and Slack in the dorsal root ganglia(DRG) and spinal cord.Knockdown of TMEM16C in the DRG reduced the expression of Slack and elevated the basal peripheral sensitivity and AMPAR expression and function. Overexpression of TMEM16C in the DRG impaired remifentanilinduced ERK1/2 phosphorylation and behavioral hyperalgesia. AMPAR-mediated current and neuronal excitability were downregulated by TMEM16C overexpression in the spinal cord. Taken together, these findings suggest that TMEM16C/Slack regulation of excitatory synaptic plasticity via GluA1-containing AMPARs is critical in the pathogenesis of remifentanil-induced postoperative hyperalgesia in rats. | Yize Li Linlin Zhang Jing Li Chunyan Wang Yi Chen Yuan Yuan Keliang Xie Guolin Wang Yonghao Yu | 2021 | Neuroscience Bulletin2021，37，5： | 2 |
| 8 | Resolution Analysis of the First Stage in the High Precision Pipelined ADCs显示文摘 | WANG Hongmei LI Fule LI Guolin WANG Zhihua | 2006 | Chinese Journal of Electronics2006，15，1： | 2 |
| 9 | Phenylpropanoid glycosides from Lamiophlomis rotate显示文摘 | Yi Jinhai Zhang Guolin Li Bogang | 1999 | Phytochemistry1999，51，6： | 1 |
| 10 | Identification and fine-mapping of quantitative trait loci(QTL) conferring rice false smut resistance in rice显示文摘Rice false smut(RFS) is a rice fungal disease caused by the biotrophic fungus Ustilaginoidea virens(Cooke) Takahashi. The pathogenic fungus specifically infects rice spikelets at the booting stage and coverts the infected spikelets into false smut balls consisting of hyphae and chlamydospores(Ashizawa et al., 2012);Sun et al. | Yifeng Huang Kaixuan Cui Zhen Zhang Rongyao Chai Hongguang Xie Jianyao Shou Junru Fu Guolin Li Jiyun Liu Shuangqing Wu Guochang Sun Jianfu Zhang Yiwen Deng Zuhua He | 2023 | Journal of Genetics and Genomics2023，50，4： | 1 |
| 11 | A diplexer for gigawatt class high power microwaves显示文摘 | Li Guolin Yuan Chengwei Zhang Jiayan | 2008 | Laser and Particle Beams2008，26，： | 1 |
| 12 | Combining microwave beams with high peak power and long pulse duration显示文摘 | Li Guolin Shu Ting Yuan Chengwei | 2010 | Physics of Plasmas2010，17，03： | 1 |
| 13 | Pro/E and AD- AMS, the way of data exchange between studies 显示文摘 | Ning Li Guolin Duan Gongjing Xu | 2012 | Me- chanical design2012，29，9： | 1 |
| 14 | The Investigation on Wear Resistance of Fe-based Alloy Coating by Argon Arc Cladding 显示文摘 | Guo Guolin Li Yang | 2012 | Applied Mechanics and Materials2012，，： | 1 |
| 15 | Characterization of a rabbit osteoporosis model induced by ovariectomy and glucocorticoid显示文摘 | Li Baofeng Yuan Zhi Chen Bei Meng Guolin Yin Qingshui Liu Jian | 2010 | Acta Orthopaedica2010，，3： | 1 |
| 16 | Step adap- tive normalization blind source separation algorithm显示文摘 | YIN HONGWEI LI GUOLIN LU CUIHUA | 2014 | Modern Technologies in Materials Mechanics and Intelli- gent Systems2014，51，3： | 1 |
| 17 | Shear Wave Speed Dispersion Characteristics of Seafloor Sediments in the Northern South China Sea显示文摘To accurately characterize the shear wave speed dispersion of seafloor sediments in the northern South China Sea,five types of sediments including silty clay,clayey silt,sandy silt,silty sand,and clayey sand were selected,on which the measurements of the shear wave speed at 0.5-2.0 kHz and related physical properties were performed.Results reveal that the shear wave speed of sediments increases as the frequency increases,and the dispersion enhanced in the sediments in the order of silty clay,clayey silt,sandy silt,silty sand,and clayey sand,at a linear change rate of 0.727,0.787,3.32,4.893,and 6.967 m s−1 kHz−1,respectively.Through regression analysis,linear and logarithmic regression equations for the correlation between shear wave speed and frequency were established for each sediment type and the determination coefficients of regression equations indicate that the correlation is closer to a logarithmic relationship.The Grain-Shearing(GS)and Biot-Stoll models were used to calculate the shear wave speed dispersion of the five sediment types,and the comparison between theoretical prediction and measured results of shear wave speeds shows that the GS model can more accurately describe the shear wave speed dispersion characteristics of these sediments in the frequency band of 0.5-2.0 kHz.In the same band,the predictions obtained by using the Biot-Stoll model are significantly different from the measured data. | KAN Guangming MENG Xiangmei WANG Jingqiang CAO Guolin LI Guanbao LIU Baohua ZHI Pengyao | 2022 | Journal of Ocean University of China2022，21，1： | 1 |
| 18 | Efficient Feature Extraction Using Apache Spark for Network Behavior Anomaly Detection显示文摘Extracting and analyzing network traffic feature is fundamental in the design and implementation of network behavior anomaly detection methods. The traditional network traffic feature method focuses on the statistical features of traffic volume. However, this approach is not sufficient to reflect the communication pattern features. A different approach is required to detect anomalous behaviors that do not exhibit traffic volume changes,such as low-intensity anomalous behaviors caused by Denial of Service/Distributed Denial of Service(Do S/DDo S)attacks, Internet worms and scanning, and Bot Nets. We propose an efficient traffic feature extraction architecture based on our proposed approach, which combines the benefit of traffic volume features and network communication pattern features. This method can detect low-intensity anomalous network behaviors and conventional traffic volume anomalies. We implemented our approach on Spark Streaming and validated our feature set using labelled real-world dataset collected from the Sichuan University campus network. Our results demonstrate that the traffic feature extraction approach is efficient in detecting both traffic variations and communication structure changes.Based on our evaluation of the MIT-DRAPA dataset, the same detection approach utilizes traffic volume features with detection precision of 82.3% and communication pattern features with detection precision of 89.9%. Our proposed feature set improves precision by 94%. | Xiaoming Ye Xingshu Chen Dunhu Liu Wenxian Wang Li Yang Gang Liang Guolin Shao | 2018 | Tsinghua Science and Technology2018，23，5： | 1 |
| 19 | Robust transport of charge carriers in in-plane 1T′-2H MoTe_(2) homojunctions with ohmic contact显示文摘Metal-semiconductor ohmic contacts are required to reduce the energy dissipation for two-dimensional (2D) electronic devices, and phase engineering of 2D transition-metal dichalcogenides (TMDCs) is a promising approach for building ohmic contacts. Here, 2D in-plane 1T′-2H MoTe2 homojunctions were prepared by direct epitaxy via vapor deposition. The interface properties of in-plane 1T′-2H MoTe2 homojunction were investigated in detail by combining experiments, calculations and theories. The ohmic contact properties of 1T′-2H MoTe2 homojunction were proved according to Kelvin force probe microscopy and density functional theory calculations. The charge carriers robust transport in in-plane 1T′-2H MoTe2 homojunction without Fermi-level pinning can be well described by Poisson equation and band alignment. These results indicate that phase engineering of 2D TMDCs is promising to construct ohmic contacts for device applications. | Donglin Lu Zhenqing Li Congsheng Xu Siwei Luo Chaoyu He Jun Li Gang Guo Guolin Hao Xiang Qi Jianxin Zhong | 2021 | Nano Research2021，14，5： | 1 |
| 20 | A novel observation: melatonin's interaction with malondiadehyde显示文摘 | LI Guolin LI Li YIN Dazhong | 2005 | Neuroendocrinology Letters2005，26，1： | 1 |
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