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| 1 | Hypoglycemic effect of catalpol on high-fat diet/streptozotocin-induced diabetic mice by increasing skeletal muscle mitochondrial biogenesis显示文摘Catalpol, iridoid glycoside,在根值 Rehmanniae 的根存在。一些研究证明了 catalpol 为这效果在导致 streptozotocin 的糖尿病的模型,而是内在的机制有显著血糖过低的效果充分没被阐明。因为 mitochondrial 机能障碍在糖尿病的病理起一个重要作用并且因为改善 mitochondrial 功能可以为糖尿病的处理提供一条新途径,这研究被设计。Catalpol 口头上地予导致的高脂肪的 diet/streptozotocin (HFD/STZ ) 和 metformin 被以为 4 个星期的糖尿病的老鼠日报。身体重量(BW )(IPGTT ) , fasting 血葡萄糖(FBG ) 水平,和葡萄糖处理被测量在期间或在处理以后。结果整个 catalpol 管理的四个连续星期在 BW 没有明显的变化显示出 FBG 水平的剂量依赖者减小。Catalpol 治疗实质地在糖尿病的老鼠减少了浆液总数胆固醇和 triglyceride 层次。另外, catalpol 高效地增加了 mitochondrial ATP 生产并且在骨胳的肌肉织物颠倒了 mitochondrial 膜潜力和 mtDNA 拷贝数字的减少。而且, catalpol (200 mg/kg ) 在骨胳的肌肉救了 mitochondrial 超微结构,与传播电子显微镜学检测了。peroxisome 的相对 mRNA 水平(PGC1 ) 当这效果被 catalpol 颠倒时,激活 proliferator 的受体 gamma 激活剂 1 显著地在糖尿病的老鼠的肌肉组织被减少,导致一条剂量依赖者起来规定。一起拿,我们发现 catalpol 能够经由在 HFD/STZ-induced 糖尿病的老鼠的骨胳的肌肉改进 mitochondrial 功能的阴沉的 FBG 水平。 | Xia Li Zhimeng Xu Zhenzhou Jiang Lixin Sun Jinzi Ji Jingshan Miao Xueji Zhang Xiaojie Li Shan Huang Tao Wang Luyong Zhang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，9： | 16 |
| 2 | Mitochondrial fusion/fission process involved in the improvement of catalpol on high glucose- induced hepatic mitochondrial dysfunction显示文摘Catalpol, iridoid glycoside,被显示了由 rescuing mitochondrial 功能,而是详细机制遗体施加血糖过低的效果不清楚还。在这研究,在糖尿病的条件下面的肝的线粒体上的 catalpol 的效果和机制进一步被检验。catalpol 的口头的管理显著地在高脂肪的导致食谱、导致 streptozotocin 的糖尿病的老鼠减少了血葡萄糖, triglyceride,和胆固醇层次。另外, catalpol 在源于糖尿病的肝 mitochondrial ATP 内容稀释了减少。而且,拥有一种长尺寸的线粒体的数字在对待 catalpol 的老鼠被增加。有趣地, mitochondrial 功能的导致 catalpol 的恢复与减少的分裂蛋白质 1 被联系并且 dynamin 相关的蛋白质象增加的 mitofusin 一样的 1 个表达式在肝的 1 个表达式。在 HepG2 房间, catalpol 减轻了 ATP 内容和 mitochondrial 膜潜力的减少,并且反应的氧种类形成的增加由高葡萄糖导致了。当房间与 catalpol 被对待时,线粒体的管状的特征被维持的米托特拉克·格林污点表演。Catalpol 也减少了分裂蛋白质 1 并且 dynamin 相关的蛋白质 1 表情和增加的 mitofusin 在 HepG2 房间的 1 表情。现在的结果建议 catalpol 能改善在一名糖尿病患者下面的肝的 mitochondrial 机能障碍状态,和这可能与它 mitochondrial 的规定有关熔化和分裂事件。 | Zhimeng Xu Luyong Zhang Xiaojie Li Zhenzhou Jiang Lixin Sun Guolin Zhao Guohua Zhou Heran Zhang Jing Shang Tao Wang | 2015 | Acta Biochimica et Biophysica Sinica2015，47，9： | 4 |
| 3 | A Survey of Wi-Fi Sensing Techniques with Channel State Information显示文摘A review of signal processing algorithms employing Wi-Fi signals for positioning and recognition of human activities is presented.The principles of how channel state information(CSI)is used and how the Wi-Fi sensing systems operate are reviewed.It provides a brief introduction to the algorithms that perform signal processing,feature extraction and recognitions,including location,activity recognition,physiological signal detection and personal identification.Challenges and future trends of Wi-Fi sensing are also discussed in the end. | MICHEN Liangqin TIAN Liping XU Zhimeng CHEN Zhizhang | 2020 | ZTE Communications2020，18，3： | 1 |
| 4 | Magnetically accelerated thermal energy storage within Fe_(3)O_(4)-anchored MXene-based phase change materials显示文摘Inherent weak photon-capturing ability is a long-standing bottleneck for pristine phase change materials(PCMs)in photothermal conversion application.To conquer this difficulty,herein,magnetic Fe_(3)O_(4) nanoparticles were in situ anchored between the layers and the surface of two-dimensional MXene for the infiltration of myristic acid(MA)by an in situ chemical anchoring strategy.Benefiting from the synergistic localized surface plasmon resonance effect of MXene and Fe_(3)O_(4) nanoparticles,our designed MXene@Fe_(3)O_(4)-MA composite PCMs harvested an ultrahigh photothermal conversion efficiency of 97.7%.During the photothermal conversion process,MXene can capture photons and convert solar energy into heat energy efficiently,and the in situ anchored Fe_(3)O_(4) nanoparticles further enhanced the photothermal conversion efficiency.Moreover,the introduction of Fe_(3)O_(4) nanoparticles improved the thermal energy storage density(144.17 J/g)of MXene-MA composite PCMs since Fe_(3)O_(4) nanoparticles provided more heterogeneous nucleation sites for MA.Simultaneously,MXene@Fe_(3)O_(4)-MA composite PCMs were endowed with excellent paramagnetism,and realized efficient magnetic-thermal conversion.Additionally,MXene@Fe_(3)O_(4)-MA composite PCMs exhibited excellent energy conversion stability,thermal stability,and reliability after undergoing multiple thermal cycles.Therefore,high-performance MXene@Fe_(3)O_(4)-based energy conversion composite PCMs are promising candidates to accelerate efficient utilization of the practical solar energy and magnetic energy. | Yan Gao Zhaodi Tang Xiao Chen Jiamin Yan Yu Jiang Jianhang Xu Zhang Tao Lei Wang Zhimeng Liu Ge Wang | 2023 | Aggregate2023，4，1： | 0 |
| 5 | Explore the dominant factor in prime editing via a view of DNA processing显示文摘Prime editing is a revolutionary gene-editing method that is capable of introducing insertions,deletions and base substitutions into the genome.However,the editing efficiency of Prime Editor(PE)is limited by the DNA repair process.Here,we show that overexpression of the flap structure-specific endonuclease 1(FEN1)and the DNA ligase 1(LIG1)increases the efficiency of prime editing,which is similar to the dominant negative mutL homolog 1(MLH1dn).In addition,MLH1 is still the dominant factor over FEN1 and LIG1 in prime editing.Our results help to further understand the relationship of proteins involved in prime editing and envisage future directions for the development of PE. | Zhimeng Xu Dacheng Ma Houzhen Su Xiaodong Jia Yinqing Li Yinying Lu Zhen Xie | 2023 | Synthetic and Systems Biotechnology2023，8，3： | 0 |
| 6 | On the Sum-Rate Capacity of Poisson Multiple Access Channel with Non-Perfect Photon-Counting Receiver显示文摘We investigate two-user sum-rate capacity for Poisson channel considering practical photon-counting receiver,including finite sampling rate and dead time.The sum-rate capacity reduction due to photon-counting loss is characterized and compared with that of continuous Poisson channel.We show that the sum-rate capacity with non-perfect receiver approaches the capacity of continuous time Poisson channel as the sampling time and dead time both approach zero.For optimal transmission strategy,we demonstrate three possible transmission strategies,including only one active user and two active users.In addition,we study the special case of identical peak power constraint for each user.We adopt majorization method to demonstrate that the optimal duty cycle for the two users must be the same and unique.Furthermore,we analyze the sum-rate capacity for multiple input single output(MISO)multiple-access channel(MAC).We propose a sufficient condition on dead time where the sum-rate capacity of the Poisson MISO-MAC is equivalent to that of single input single output,and the equivalence would not hold for sufficient large peak power or dead time.The theoretical capacity results are validated by numerical results. | Zhimeng Jiang Chen Gong Guanchu Wang Zhengyuan Xu | 2020 | Journal of Communications and Information Networks2020，5，3： | 0 |
| 7 | A Study of Cognition and Demand of Pharmacy Services in Hospitals from the Views of Doctors,Pharmacists and Patients显示文摘Objective To study the cognition and demand of pharmacy services in hospitals from the views of doctors,pharmacists and patients and to provide references for improving the quality of pharmacy services.Methods 3 level 2 hospitals and 3 level 3 hospitals in Beijing were selected and questionnaires for doctors,pharmacists and patients were distributed and collected.Results and Conclusion Cognitively speaking,69.85% of doctors and 75.36% of pharmacists believe that pharmacy services are necessary,and 81.1% of patients believe it is helpful for pharmacists being involved in the process of treatment plans.Doctors and pharmacists themselves believe that the current pharmacist’s service ability is still insufficient,mainly due to the lack of clinical knowledge and the knowledge of medication combination.In terms of demand,doctors and patients have higher demand for pharmacy services,which is mainly involved in designing patient treatment plans,providing drug information and giving medication advice,and providing medication counseling.Doctors,pharmacists and patients all recognize and support the development of pharmacy services.However,in the understanding of the meaning of pharmacy services,doctors are better than pharmacists.Doctors and patients have greater demand for pharmacy services,but the supply of pharmacy services is still far from enough.It is recommended to strengthen the construction of related systems,incorporate pharmacy service work into hospital performance appraisal;attach importance to pharmacy professional talent training,improve pharmacy service ability,explore new hospital pharmacy service mode and to promote hospital pharmacy development. | Xu Zhimeng Dong Li | 2019 | Asian Journal of Social Pharmacy2019，14，2： | 0 |
| 8 | The effects of amino groups and open metal sites of MOFs on polymer-based electrolytes for all-solid-state lithium metal batteries显示文摘Metal-organic frameworks(MOFs) are becoming more and more popular as the fillers in polymer electrolytes in recent years. In this study, a series of MOFs(NH_(2)-MIL-101(Fe), MIL-101(Fe), activated NH_(2)-MIL-101(Fe) and activated MIL-101(Fe)) were synthesized and added to PEO-based solid composite electrolytes(SCEs). Furthermore, the role of the —NH_(2) groups and open metal sites(OMSs) were both examined. Different ratios of MOFs vs polymers were also studied by the electrochemical characterizations. At last, we successfully designed a novel solid composite electrolyte containing activated NH_(2)-MIL-101(Fe),PEO, Li TFSI and PVDF for the high-performance all-solid-state lithium-metal batteries. This work might provide new insight to understand the interactions between polymers and functional groups or OMSs of MOFs better. | Jiahao Lu Zhimeng Wang Qi Zhang Cheng Sun Yanyan Zhou Sijia Wang Xiangyun Qiu Shoudong Xu Rentian Chen Tao Wei | 2023 | Chinese Journal of Chemical Engineering2023，60，8： | 0 |
| 9 | Comparison of Seismic Design Codes between China and the United States for Reinforced Soil Retaining Walls显示文摘Because of its excellent seismic performance, reinforced soil retaining walls are increasingly used in civil engineering. Although many countries have published corresponding design codes, the differences between them are still relatively large. Using the FHWA Code and the Code for Seismic Design of Railway Engineering(CSDRE), stability calculations of reinforced soil retaining walls were carried out and the similarities and differences between these two design codes were analyzed. According to the comparative analysis, the following conclusions are drawn: the inertia force, the earth pressure and the tensile force of reinforcements calculated from the CSDRE are less than those from the FHWA Code, and the safety factor calculated from the former is larger. Although the M-O method is recommended to calculate the dynamic earth pressure, the FHWA Code suggests a higher action point as compared to the CSDRE. | XU Peng TIAN Hongcheng JIANG Guanlu WANG Zhimeng | 2019 | Earthquake Research in China2019，33，1： | 0 |
| 10 | MUC1 vaccines usingβ-cyclodextrin grafted chitosan(CS-g-CD)as carrier via host-guest interaction elicit robust immune responses显示文摘We construct MUC1 vaccines usingβ-cyclodextrin grafted chitosan(CS-g-CD)as carrier via host-guest interaction.These vaccines based on non-covalent assembling can provoke robust immune responses,including high level of specific antibodies and cytokines.The induced antibodies can specifically recognize tumor cells and mediate cytotoxicity against tumor cells.These results indicate that CS-g-CD with strong immunostimulatory activities can be a straightforward platform for peptide-based vaccine construction. | Hangyan Yu Han Lin Yuntian Xie Mengyuan Qu Min Jiang Jie Shi Haofei Hong Hongrui Xu Ling Li Guochao Liao Zhimeng Wu Zhifang Zhou | 2022 | Chinese Chemical Letters2022，33，11： | 0 |
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