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| 1 | Cell membrane-based nanoparticles: a new biomimetic platform for tumor diagnosis and treatment显示文摘Taking inspiration from nature, the biomimetic concept has been integrated into drug delivery systems in cancer therapy. Disguised with cell membranes, the nanoparticles can acquire various functions of natural cells. The cell membrane-coating technology has pushed the limits of common nano-systems(fast elimination in circulation) to more effectively navigate within the body. Moreover, because of the various functional molecules on the surface, cell membrane-based nanoparticles(CMBNPs) are capable of interacting with the complex biological microenvironment of the tumor. Various sources of cell membranes have been explored to camouflage CMBNPs and different tumor-targeting strategies have been developed to enhance the anti-tumor drug delivery therapy. In this review article we highlight the most recent advances in CMBNP-based cancer targeting systems and address the challenges and opportunities in this field. | Ruixiang Li Yuwei He Shuya Zhang Jing Qin Jianxin Wang | 2018 | Acta Pharmaceutica Sinica B2018，8，1： | 36 |
| 2 | Effect of temperature,salinity and irradiance on growth and photosynthesis of Ulva prolifera显示文摘Intensive Pyropia aquaculture in the coast of southwestern Yellow Sea and its subsequent waste, including disposed Ulva prolifera, was speculated to be one of the major sources for the large-scale green tide proceeding in the Yellow Sea since 2007. It was, however, unclear how the detached U. prolifera responded and resumed growing after they detached from its original habitat. In this study, we investigated the growth and photosynthetic response of the detached U. prolifera to various temperature, salinity and irradiance in the laboratory. The photosynthetic rate of the detached U. prolifera was significantly higher at moderate temperature levels(14–27°C)and high salinity(26–32), with optimum at 23°C and 32. Both low(<14°C) and highest temperature(40°C), as well as low salinity(8) had adverse effects on the photosynthesis. Compared with the other Ulva species, U. prolifera showed higher saturated irradiance and no significant photoinhibition at high irradiance, indicating the great tolerance of U. prolifera to the high irradiance. The dense branch and complex structure of floating mats could help protect the thalli and reduce photoinhibition in field. Furthermore, temperature exerted a stronger influence on the growth rate of the detached U. prolifera compared to salinity. Overall, the high growth rate of this detached U. prolifera(10.6%–16.7% d^(–1)) at a wide range of temperature(5–32°C) and salinity(14–32) implied its blooming tendency with fluctuated salinity and temperature during floating. The environmental parameters in the southwestern Yellow Sea at the beginning of green tide were coincident with the optimal conditions for the detached U. prolifera. | XIAO Jie ZHANG Xiaohong GAO Chunlei JIANG Meijie LI Ruixiang WANG Zongling LI Yan FAN Shiliang ZHANG Xuelei | 2016 | Acta Oceanologica Sinica2016，35，10： | 14 |
| 3 | Menthol-modified casein nanoparticles loading 10-hydroxycamptothecin for glioma targeting therapy显示文摘Chemotherapy outcomes for the treatment of glioma remains unsatisfactory due to the inefficient drug transport across the blood–brain barrier(BBB) and insufficient drug accumulation in the tumor region. Although many approaches, including various nanosystems, have been developed to promote the distribution of chemotherapeutics in the brain tumor, the delivery efficiency and the possible damage to the normal brain function still greatly restrict the clinical application of the nanocarriers.Therefore, it is urgent and necessary to discover more safe and effective BBB penetration and gliomatargeting strategies. In the present study, menthol, one of the strongest BBB penetration enhancers screened from traditional Chinese medicine, was conjugated to casein, a natural food protein with brain targeting capability. Then the conjugate self-assembled into the nanoparticles to load anti-cancer drugs.The nanoparticles were characterized to have appropriate size, spheroid shape and high loading drug capacity. Tumor spheroid penetration experiments demonstrated that penetration ability of mentholmodified casein nanoparticles(M-CA-NP) into the tumor were much deeper than that of unmodified nanoparticles. In vivo imaging further verified that M-CA-NPs exhibited higher brain tumor distribution than unmodified nanoparticles. The median survival time of glioma-bearing mice treated with HCPT-MCA-NPs was significantly prolonged than those treated with free HCPT or HCPT-CA-NPs. HE staining ofthe organs indicated the safety of the nanoparticles. Therefore, the study combined the advantages of traditional Chinese medicine strategy with modern delivery technology for brain targeting, and provide a safe and effective approach for glioma therapy. | Caifang Gao Jianming Liang Ying Zhu Chengli Ling Zhekang Cheng Ruixiang Li Jing Qin Weigen Lu Jianxin Wang | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 12 |
| 4 | Interspecies competition for nutrients between Prorocentrum donghaiense Lu and Skeletonema costatum(Grev.) Cleve in mesocosm experiments显示文摘Three mesocosm experiments were conducted in the East China Sea during blooms of Prorocentrum donghaiense Lu in May of 1998,2002 and 2003 to examine the role of nutrients in the formation of these harmful algae blooms(HABs).The results showed that there was interspecies competition between P.donghaiense and Skeletonema costatum(Grev.) Cleve.The cell number of P.donghaiense and S.costatum accounted for about 85% and 11% of the total cell number of phytoplankton respectively at the beginning of the experiment in May 1998.In May 2002,at the beginning of the experiment,the cell number of P.donghaiense accounted for 55%-66% of the total and S.costatum accounted for 32%-42%.The density of P.donghaiense and S.costatum was over 95% and 1%-5% respectively in May 2003.The results of these three mesocosm experiments showed that the dominant species in this specific community varied with different nutrient availability.Under low-phosphate conditions,the dominant species was P.donghaiense,while S.costatum became dominant in phosphate-replete cases.The average growth rate(1.08 d-1) of S.costatum in exponential growth phase was higher than that(0.39 d-1) of P.donghaiense.In the mesocosm,S.costatum predominated in the mesocosm by its rapid growth.When phosphorus was depleted,the cell number of S.costatum dropped rapidly,while P.donghaiense Lu decreased more slowly.The results from mesocosm experiment may explain why:(1) P.donghaiense bloom usually occurs in May,when phosphate concentration is low;(2) the bloom of S.costatum appears in early spring and summer time,when nutrients increase with increasing Changjiang River(Yangtze River) runoff;(3) the bloom of S.costatum is short and that of P.donghaiense Lu can last more than a month in the East China Sea. | ZHU Mingyuan XU Zongjun LI Ruixiang WANG Zongling SHI Xiaoyong | 2009 | Acta Oceanologica Sinica2009，28，1： | 10 |
| 5 | Drug targeting through platelet membrane-coated nanoparticles for the treatment of rheumatoid arthritis显示文摘The effective drug treatment of rheumatoid arthritis (RA) is hindered by poordelivery efficiency to the diseased site and the serious side effects caused bywide-spread drug distribution. Traditional drug-targeting strategies, such asligand modification, are complex, laborious, and inefficient. Inspired by theintrinsic relationship between platelets and RA, platelet-mimetic nanoparticles(PNPs) were developed for targeted drug delivery in RA. Through plateletreceptor-mediated adhesion, an intact platelet membrane was coated onto poly(lactic-co-glycolic add) nanopartides, endowing the resulting PNPs with variousfunctional receptors. By coating with platelet membranes, the nanoparticleswere stabilized and had a better circulation profile, providing a benefit forpassive targeting. In vitro binding of PNPs to inflamed endothelium, and in vivoaccumulation in joints of a collagen-induced arthritis (CIA) mouse model of RAwere significantly improved via P-selectin and GVPI recognition, indicating thatthe PNPs could effectively target to RA tissues through multiple mechanisms,similar to natural platelets. Moreover, FK506, a model drug, was loaded into thePNPs and used to treat RA. Pharmacodynamic studies demonstrated that theFK506-PNPs had a notable anti-arthritic effect in CIA mice. This study provides anew biomimetic targeting strategy with great potential for the treatment of RA. | Yuwei He Ruixiang Li Jianming Liang Ying Zhu Shuya Zhang Zicong Zheng Jing Qin Zhiqing Pang Jianxin Wang | 2018 | Nano Research2018，11，11： | 9 |
| 6 | Remarkable anisotropic phonon response in uniaxially strained few-layer black phosphorus显示文摘黑磷(BP ) 是一个好候选人因为学习紧张在 graphene 和转变金属 dichalcogenides 以外在 twodimensional (2D ) 上完成材料。这因为它支撑高紧张和源于它的唯一的皱起的结构的显著地各向异性的机械性质的特别能力。我们这里调查格子的依赖在由在原处做作的拉曼的单轴地做作的很少层 BP 的结晶的取向上的震动的频率光谱学。out-of-plane A 1 而, g 模式对沿着近扶手椅的方向的单轴的紧张敏感在里面飞机 B 2g 和 A 2 g 模式是敏感的在近之字形的方向拉紧。为使用离开这些方向的单轴的种类,所有三个声子模式是线性地 redshifted。我们的试验性的观察被对 BP 的结构的性质的单轴的张力的紧张的各向异性的影响用密度解释功能的理论。这研究表明由单轴的紧张的在 BP 的在里面飞机和 out-of-plane 声子模式的选择调节的可能性并且使紧张工程成为一条有希望的大街为广泛地 modulating 2D 材料的光、机械的性质。 | Yanlong Wang Chunxiao Cong Ruixiang Fei Weihuang Yang Yu Chen Bingchen Cao Li Yang Ting Yu | 2015 | Nano Research2015，8，12： | 9 |
| 7 | Carbon Materials Reinforced Aluminum Composites:A Review显示文摘Carbon materials, including carbon fibers, graphite, diamond, carbon foams, carbon nanotubes, and graphene, are attractive reinforcements for aluminum matrix composites due to their excellent mechanical and/or physical properties as well as light weight. Carbon materials reinforced aluminum(C/Al) composites are promising materials in many areas such as aerospace, thermal management, and automobile. However, there are still some challenging problems that need to be resolved,such as interfacial reactions, low wettability, and anisotropic properties. These problems have limited the use of these composites. This review mainly focuses on the categories, fabrication processes, existing problems and solutions, coatings and interfaces, challenges and opportunities of C/Al composites so as to provide a useful reference for future research. | Yu Huang Qiubao Ouyang Di Zhang Jing Zhu Ruixiang Li Hong Yu | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，5： | 8 |
| 8 | Community structure and controlled factor of attached green algae on the Porphyra yezoensis aquaculture rafts in the Subei Shoal, China显示文摘This study analyzes the community structure, the quantity changes of the algae and the effect of important environmental factors and estimates the total biomass of the attached green algae in the survey areas. The study uses data from surveys of the attached green algae on the Porphyra yezoensis aquaculture rafts and data regarding the environmental factors from October 2010 to April 2011 in the Subei Shoal. The attached green algae on the rafts included Ulva prolifera, Capsosiphon groenlandicus, U. linza, U. intestinalis, U. clathrata, and U. compressa.The biomass changes of the attached green algae exhibited an inverted parabola: the biomass was the highest(14 898 t) in April, and was the second highest(2 034 t) in November; it was lowest in February(only 729 t) and increased sharply from March to April. The species diversity differed significantly among the seasons. In September and October, when the P. yezoensis aquaculture rafts were initially set up, the attached green algae had a high biodiversity, while from December to the next February, a variety of green algae species coexisted on the rafts, although the biomass was low, and from March to April, as the biomass increased sharply, the species diversity dropped to the minimum. During this time, C. groenlandicus was apparently dominant with the maximum biomass proportion up to 80%, while the U. prolifera proportion increased exponentially to 20% to 40%.The water temperature had a direct regulating effect on the biomass and the species succession of the attached green algae. The estimation of the community dynamics and the biomass of the green algae provided the evidence needed to track the origin of the large-scale green tide in the southern Yellow Sea. | LI Yan XIAO Jie DING Lanping WANG Zongling SONG Wei FANG Song FAN Shiliang LI Ruixiang ZHANG Xuelei | 2015 | Acta Oceanologica Sinica2015，34，8： | 6 |
| 9 | A new distinct geminivirus causes soybean stay-green disease显示文摘Dear Editor,Plant viruses make up almost half of the plant disease-causing pathogens,affecting crop yields and the global economy(Savary et al.,2019).Soybean(Glycine max)is one of the most valuable legume crops in the world,supplying 25%of the global edible oil and two-thirds of the global concentrated protein for livestock feeding.Recently,the outbreak of soybean stay-green syndrome with delayed leaf senescence(stay-green),flat pods,and increased number of abnormal seeds has swept the soybean production in the Huang-Huai-Hai region of China,resulting in huge yield losses(Xu et al.,2019).This disease has become an epidemic and prominent problem in soybean production and is still expanding its geography,including North America,posing a serious threat to soybean production(Harbach et al.,2016;Zhang et al.,2016;Li et al.,2019).However,the cause of soybean stay-green syndrome remains obscure. | Ruixiang Cheng Ruoxin Mei Rong Yan Hongyu Chen Dan Miao Lina Cai Jiayi Fan Gairu Li Ran Xu Weiguo Lu Yu Gao Wenwu Ye Shuo Su Tianfu Han Junyi Gai Yuanchao Wang Xiaorong Tao Yi Xu | 2022 | Molecular Plant2022，15，6： | 6 |
| 10 | Nozzle test system for droplet deposition characteristics of orchard air-assisted sprayer and its application显示文摘In order to obtain nozzle droplet deposition characteristics for sprayer mechanical design and variable spraying control algorithms,a nozzle droplet deposition characteristics test system for air-assisted spraying was designed.The test system can supply a stable wind site with precisely controlled air speed whose speed control ranges from 2 m/s to 16 m/s with maximum relative error of 4.5%.It can spray out a certain amount of liquid pesticide with adjustable spraying pressure which can be controlled with high precision while the maximum relative error is only 1.33%.The distribution of droplet deposition can be collected and measured by using the acquisition device and a pesticide deposition optical measurement system.The experiment of two-dimensional nozzle flow measurement was carried out.The results show that nozzle flow distribution is uniform and symmetric with“double-hump”shape in the spray range.Multi-nozzle overlapped droplet deposition ranges from 85%to 116%relative to the average.The nozzle droplet deposition experiment was completed.The experiment results show that in air-assisted spraying,the higher the wind speed,the less droplet deposition is affected by gravity.When the wind speed is higher than 12 m/s and spraying distance is 0.80 m,droplet deposition is concentrated on the originally designated point and hardly affected by gravity.The horizontal spray width becomes smaller with higher wind speed.When the wind speed is high,it can be considered that nozzle deposition only focuses on the nozzle center,if the position requirement is not very high in orchard spraying. | Zhai Changyuan Zhao Chunjiang Wang Xiu Li Wei Li Wei Zhu Ruixiang | 2014 | International Journal of Agricultural and Biological Engineering2014，7，2： | 4 |
| 11 | The application and progress of bioelectrochemical systems (BESs) in soil remediation: A review显示文摘Soil pollution endangers human health and ecological balance,which is why finding a highly efficient way to deal with pollutants is necessary.Biological method is an environmentally friendly treatment method.Bioelectrochemical systems(BESs),which combine electrochemistry with biological methods,have been widely used to remediate polluted environments,including wastewater,sludge,sediment,and soil.In BESs,redox reactions occur on electrodes with electroactive bacteria,which convert pollutants into low-polluting or nonpolluting substances.With BESs being a promising technology in the remediation field,the decontamination mechanisms and applications in soil conducted by BESs have attracted much attention.Therefore,to better understand the research progress of BESs,this paper mainly summarizes the mechanism of different classified BESs.The applications of microbial fuel cells(MFCs)in four pollutants(petroleum,heavy metals,pesticides,antibiotics)and the possible applications of microbial electrolysis cells(MECs)in soil are discussed.The main problems in BESs and possible future development directions are also evaluated. | Tian Li Ruixiang Li Qixing Zhou | 2021 | Green Energy & Environment2021，6，1： | 4 |
| 12 | A novel tumor-targeting treatment strategy uses energy restriction via co-delivery of albendazole and nanosilver显示文摘尽管纳米技术很快在指向的肿瘤被开发了并且适用,化疗的结果仍然保持极大地在正常纸巾和房间由细胞毒素的药的毒性限制了。因此,与在正常房间的很少副作用,其他的交货系统的开发吸引了增加的注意。精力限制是癌症治疗的一条新奇、有希望的途径,它能经由细胞的精力新陈代谢的抑制限制肿瘤生长。在这研究,指向系统的一个新奇肿瘤,基于叶酸结合牛的浆液白朊(BSA ) ,被开发到共同交付 albendazole 和 nanosilver 同时,制止肿瘤房间的精力新陈代谢。没有 folic 酸修正, nanosilver,或 albendazole,这 nanosystem 用 nanoparticles 比那些显示出更强壮的反肿瘤功效,在 vitro 并且在 vivo。这 nanosystem 弄空经由 glycolytic 酶和 mitochondrial 损坏的直接抑制的细胞的 ATP,导致肿瘤房间的增长,房间周期拘捕,和 apoptosis 的抑制。提高的反肿瘤活动贡献了这个系统的指向肿瘤的能力,导致在肿瘤房间的特定的精力抑制。毒性评估被执行证实这个系统的安全。这 nanosystem 为肿瘤治疗提供有效、安全的策略。 | Jianming Liang Ruixiang Li Yuwei He Chengli Ling Qi Wang Yongzhuo Huang Jing Qin Weigen Lu Jianxin Wang | 2018 | Nano Research2018，11，9： | 3 |
| 13 | Construction of the Chinese Veteran Clinical Research (CVCR) Platform for the assessment of non-communicable diseases显示文摘 | Tan Jiping Li Nan Gao Jing Guo Yuhe Hu Wei Yang Jinsheng Yu Baocheng Yu Jianmin Du Wei Zhang Wenjun Cui Lianqi Wang Qingsong Xia Xiangnan Li Jianjun Zhou Peiyi Zhang Baohe Liu Zhiying Zhang Shaogang Sun Lanying Liu Nan Deng Ruixiang Dai Wenguang Yi Fang Chen Wenjun Zhang Yongqing Xue Shenwu Cui Bo Zhao Yiming Wang Luning | 2014 | Chinese Medical Journal2014，，3： | 3 |
| 14 | The Distribution of Green Algal Micro-Propagules and Macroalgae at the Early Stage of Green Tide in the Coastal Area of South Jiangsu Province in 2014显示文摘An integrated investigation was carried out during late April to late May of 2014 in the coastal area of South Jiangsu Province to understand the early development of green tide in the Yellow Sea and discover the temporal and spatial distribution of green algal micro-propagules and macroalgae at the early stage of green tide. The results showed that green algal micro-propagules distributed in all stations from late April to late May, and micro-propagules of high density(> 300 ind. L^(-1)) concentrated in the adjacent Porphyra aquaculture area. Floating macroalgae were initially observed in the northern survey areas, and increased gradually. The dominant species was U. prolifera in the floating macroalgae, ranging between 90% and 100%. The seawater surface temperature and salinity in the above mentioned time period were suitable for the growth of macroalgae. This work can help government to strengthen management to reduce the blooms of macroalgae in the coastal area of South Jiangsu Province and also facilitate the decision-making for managers at the early stage of green tide. | LIU Xiangqing WANG Zongling FAN Shiliang ZHANG Xuelei LI Ruixiang LI Yan | 2017 | Journal of Ocean University of China2017，16，1： | 3 |
| 15 | Structure and seasonal variability of fronts in the Southeast Indian Ocean along sections from Fremantle, Australia to Antarctic Zhongshan Station显示文摘Four sections of expendable conductivity-temperature-depth(XCTD) profiles from Fremantle, Australia to Antarctic Zhongshan Station and Moderate Resolution Imaging Spectroradiometer-Aquarius(MODIS-A) sea surface temperature(SST) products were used to study the structure and seasonal variability of Southeast Indian Ocean fronts. Water mass analysis showed that surface water masses in the Southeast Indian Ocean were less salty in March than in November. Compared with November, the subtropical front(STF) moved southward about one degree of latitude in March, whereas seasonal variability of the subantarctic front(SAF) and polar front(PF) locations was not obvious. In March, the saline front moved northward about two degrees of latitude relative to the thermal front in the upper 100 m at the SAF, which was the northern boundary of subAntarctic surface water(SASW). Analysis of climatological SST gradients from the satellite data showed that regions of enhanced sea surface temperature(SST) gradients were collocated with frontal locations identified with the XCTD data using water mass criteria. The surface expression of the PF identified by the SST gradient was further south by about one degree of latitude relative to the subsurface expression of the PF identified by the northern boundary of cold water. | YANG Wei GAO Libao LI Ruixiang LIU Changjian YAN Jinhui | 2016 | Advances in Polar Science2016，27，1： | 2 |
| 16 | The morphological identification of Protoperidinium(Peridiniales, Dinophyceae) species on the coasts of China显示文摘The classification and identification for Protoperidinium species are the most difficult work during its taxonomic study. In this research, taxonomic status of Protoperidinium was clarified by tracing its taxonomic history, 23 species belong to genus Protoperidinium on the coasts of China were preliminarily identified, and morphological description and plate patterns were given for each species. The key differences of similar species were also discussed in this study, we believe that P. oceanicum and P. murry, P. tumidum and P. fatulipes, P. globules and P.majus are separate species; P. diabolum should be treated as the valid name instead of the reported names Peridinium globosum or Peridinium longipes; the taxonomic relationship between P. punctulatum and P.subinerme requires further study. | LI Ruixiang PAN Yulong SUN Huiying LI Yan MA Xin WANG Yan | 2016 | Acta Oceanologica Sinica2016，35，4： | 2 |
| 17 | Numerical experiments of HAB inducement in Qingdao adjacent coastal area显示文摘A three-dimension ecological dynamic model was established to numerically study the relationship of HAB and environmental conditions.The numerical experiments showed that the growth of diatom,the dominant HAB specie,was mainly restricted by phosphate and silicate.If the concentrations of phosphate and silicate reach 17-25 μg/L and 300-375 μg/L respectively,the water is in a state of eutrophication.When phosphate and silicate up to 26-32 μg/L and 350-500 μg/L respectively,HAB could be induced.The major regions of HAB occurrence are Jiaozhou Bay mouth,coastal bays,and coastal area from Maidao to Shilaoren.To avoid HAB occurrence,concentration of phosphate and silicate should not exceed 17-20 μg/L and 300 μg/L as a whole.Reasonable control of pollutant discharge is a key point to prevent water eutrophication and HAB occurrence. | LIU Xuehai LI Ruixiang YUAN Yeli | 2010 | Acta Oceanologica Sinica2010，29，5： | 2 |
| 18 | The prognosis and clinicopathology of CXCR4 in gastric cancer patients: a meta-analysis显示文摘 | Mingzhi Han Shunzeng Lv Ya Zhang Ruiyang Yi Bin Huang Hanhui Fu Ruixiang Bian Xingang Li | 2014 | Tumor Biology2014，，5： | 1 |
| 19 | Comparison of essential oils of clove buds extracted with supercriti-cal carbon dioxide and other three traditional extraction methods显示文摘 | Guan Wenqiang Li Shufen Yan Ruixiang | 2007 | Food Chem2007，101，： | 1 |
| 20 | Comparison of essential oils of clove buds extracted with supercritical carbon di- oxide and other three traditional extraction methods显示文摘 | Guan Wenqiang Li Shufen Yan Ruixiang | 2007 | Food Chemistry2007，101，4： | 1 |
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