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| 1 | Nonalcoholic fatty liver disease, metabolic risk factors, and hepatocellular carcinoma: An open question显示文摘Non-alcoholic liver disease(NAFLD) defines liver abnormalities ranging from simple steatosis to nonalcoholic steatohepatitis with or without cirrhosis development, occurring in the absence of significant alcohol consumption, use of teratogenic medication, or hereditary disorders.The association between NAFLD and metabolic syndrome is well documented and widely recognized.Obesity, type 2 diabetes mellitus(T2DM), and dyslipidemia are the most common metabolic risk factors associated with NAFLD.Among the components of metabolic syndrome, current evidence strongly indicates obesity and diabetes as hepatocellular carcinoma(HCC) risk factors.There is also growing evidence that suggests an increased risk of HCC in NAFLD patients, even surpassing other etiologies in some high-income countries.Epidemiologic data demonstrate a parallel rise in prevalence of obesity, diabetes, NAFLD, and HCC.As obesity and its related diseases have steadily afflicted larger populations, HCC incidence is expected to increase in the future.Pathophysiologic mechanisms that underlie NAFLD development and subsequent progression to nonalcoholic steatohepatitis and cirrhosis(insulin resistance and hyperinsulinemia, oxidative stress, hepatic stellate cell activation, cytokine/adipocytokine signaling pathways, and genetic and environmental factors) appear to play a significant role in the development of NAFLD-related HCC.However, a comprehensive view of molecular mechanisms linking obesity, T2 DM, and NAFLD-related HCC, as well as the exact sequence of molecular events, is still not understood in its entirety.Good-quality data are still necessary, and efforts should continue towards better understanding the underlying carcinogenic mechanisms of NAFLD-related HCC.In this paper, we aimed to centralize the most important links supporting these relationships, focusing on obesity, T2 DM, and NAFLD-related HCC, as well as point out the major gaps in knowledge regarding the underlying molecular mechanisms behind them. | Letitia Adela Maria Streba Cristin Constantin Vere Ion Rogoveanu Costin Teodor Streba | 2015 | World Journal of Gastroenterology2015，21，14： | 15 |
| 2 | Psychosocial stress and liver disease status显示文摘'Psychosocial stress' is an increasingly common concept in the challenging and highly-demanding modern society of today. Organic response to stress implicates two major components of the stress system, namely the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. Stress is anamnestically reported by patients during the course of disease, usually accompanied by a decline in their overall health status. As the mechanisms involving glucocorticoids and catecholamines have been deciphered, and their actions on immune cell function deeper understood, it has become clear that stress has an impact on hepatic inflam-matory response. An increasing number of articles have approached the link between psychosocial stress and the negative evolution of hepatic diseases. This article reviews a number of studies on both human populations and animal models performed in recent years, all linking stress, mainly of psychosocial nature, and the evolution of three important liver-related pathological entities: viral hepatitis, cirrhosis and hepatocellular carcinoma. | Cristin Constantin Vere Costin Teodor Streba Letitia Maria Streba Alin Gabriel Ionescu Felix Sima | 2009 | World Journal of Gastroenterology2009，15，24： | 7 |
| 3 | Hypoxia Inducible Factor 1 Mediates Hypoxia-Induced TRPC Expression and Elevated Intracellular Ca2+ in Pulmonary Arterial Smooth Muscle Cells显示文摘 | Jian Wang Letitia Weigand Wenju Lu J T. Sylvester Gregg L. Semenza Larissa A. Shimoda | 2006 | Circulation Research2006，，12： | 1 |
| 4 | The Im-pact of Social Roles on Stereotypes of Gay Men显示文摘 | Fingerhut Letitia Anne Peplau | 2006 | Sex Roles2006，55，： | 1 |
| 5 | An interaction between S * tag and S * protein derived from human ribonuclease 1 allows site-specific conjugation of an enzyme to an antibody for targeted drug delivery显示文摘 | Tsuneaki Asai Letitia A Wims Sherie L Morrison | 2005 | Journal of Immunological Methods2005，299，12： | 1 |
| 6 | A model to de- sign a national high-speed rail network for freight distri- bution显示文摘 | Jennifer A P Russell D M Letitia M P | 2010 | Transportation Research Part A2010，44，： | 1 |
| 7 | Segmentation of urban road network from satellite images using fuzzy mathematical morphology显示文摘 | Letitia S Elwin Chandramonie | 2008 | ICGST-GVIP2008，8，4： | 1 |
| 8 | Experimental characterrization of multi-point corona discharge devices for direct ozonization of liquids显示文摘 | Letitia Ghizdavu | 2002 | J Electrostaics2002，54，： | 1 |
| 9 | Effect of complete epithelial debridement before riboflavin–ultraviolet-A corneal collagen crosslinking therapy显示文摘 | Sally Hayes David P. O’Brart Letitia S. Lamdin James Doutch Kostas Samaras John Marshall Keith M. Meek | 2008 | Journal of Cataract & Refractive Surgery2008，，4： | 1 |
| 10 | Mandarin learners use syntactic bootstrapping in verb acquisition显示文摘 | Joanne N. Lee Letitia R. Naigles | 2007 | Cognition2007，，2： | 1 |
| 11 | A New Geometric Algorithm to Generate Smooth Interpolation Curves on Riemannian Manifolds显示文摘 | Rui C Rodriguesa1 F Silva Letitia Janusz Jakubiak | 2005 | LMS Journal of Computational and Mathematics2005，，8： | 1 |
| 12 | Role of intrahepatic innervation in regulating the activity of liver cells显示文摘Liver innervation comprises sympathetic,parasympathetic and peptidergic nerve fibers,organized as either afferent or efferent nerves with different origins and roles.Their anatomy and physiology have been studied in the past 30 years,with different results published over time.Hepatocytes are the main cell population of the liver,making up almost 80%of the total liver volume.The interaction between hepatocytes and nerve fibers is accomplished through a wealth of neurotransmitters and signaling pathways.In this short review,we have taken the task of condensing the most important data related to how the nervous system interacts with the liver and especially with the hepatocyte population,how it influences their metabolism and functions,and how different receptors and transmitters are involved in this complex process. | Letitia Adela Maria Streba Cristin Constantin Vere Alin Gabriel Ionescu Costin Teodor Streba Ion Rogoveanu | 2014 | World Journal of Hepatology2014，6，3： | 1 |
| 13 | Chronic hypoxia inhibits Kv channel gene expression in rat distal pulmonary artery显示文摘 | Jian W Letitia W Wenqian W | 2005 | Am J Physiol Lung Cell Mol PhysioI2005，288，6： | 1 |
| 14 | Prostate angiogenesis in development and inflammation显示文摘 | Letitia Wong Jerry Gipp Jason Carr Christopher J. Loftus Molly Benck Sanghee Lee Vatsal Mehta Chad M. Vezina Wade Bushman | 2014 | Prostate2014，，4： | 1 |
| 15 | Novel vectors for the expression of antibody molecules using variable regions generated by polymerase chain reaction显示文摘 | Coloma M.J Letitia A Morrison S.L | | 0，，： | 1 |
| 16 | Local Alendronic Acid Elution Increases Net Periimplant Bone Formation: A Micro-CT Analysis显示文摘 | J. Dennis Bobyn Rebecca Thompson Letitia Lim Jenny Ann Pura Kristian Bobyn Michael Tanzer | 2014 | Clinical Orthopaedics and Related Research?2014，，2： | 1 |
| 17 | Colorectal cancer: epidemiology and health services research显示文摘 | Letitia BH Jessica B Clifford YK | 2006 | Surg Oncol Clin N Am2006，15，1： | 1 |
| 18 | Multilaboratory evaluation of disk diffusion antimicrobial susceptibility testing of Neisseria meningitidis isolates显示文摘 | James H J Sharon A C Letitia C F | 2006 | J Clin Microbiol2006，44，： | 1 |
| 19 | 汉语孤独谱系障碍儿童早期特殊疑问句习得的眼动研究显示文摘本研究采用多通道优先注视范式眼动实验对比了36名3~6岁孤独谱系障碍(ASD)儿童和28名1~3岁典型发展(TD)儿童的早期特殊疑问句习得。结果表明TD儿童可高效稳定地理解宾语特殊疑问句和主语特殊疑问句,而ASD儿童对特殊疑问句的理解比TD儿童显著延迟,且仅理解了宾语特殊疑问句,对主语特殊疑问句的理解存在困难。跨语言对比研究表明汉语ASD儿童与英语ASD儿童早期特殊疑问句的习得模式相似,对宾语特殊疑问句的习得均比主语特殊疑问句更具优势。研究结果表明不同语言ASD儿童的特殊疑问句习得遵循典型发展轨迹,受到普遍语法WH-移位原则和参数的制约,提示人类语言习得机制对ASD儿童核心语法习得的可能贡献。同时,研究也为多通道优先注视眼动装置在汉语学龄前ASD儿童语言评估中的应用提供了依据。 | 苏怡 肖洁 Letitia R.Naigles | 2022 | 现代外语2022，45，2： | 1 |
| 20 | Novel Vectors for the expression of antibody molecules using variable regions generated by polymerase chain reaction显示文摘 | Coloma MJ Hastings A Letitia A | 1992 | J Immunol Methods1992，152，： | 1 |
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