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| 1 | Meta-analysis of subtotal stomach-preserving pancreaticoduodenectomy vs pylorus preserving pancreaticoduodenectomy显示文摘AIM: To investigate the differences in outcome following pylorus preserving pancreaticoduodenectomy(PPPD) and subtotal stomach-preserving pancreaticoduodenectomy(SSPPD).METHODS: Major databases including Pub Med(Medline), EMBASE and Science Citation Index Expanded and the Cochrane Central Register of Controlled Trials(CENTRAL) in The Cochrane Library were searched for comparative studies between patients with PPPD and SSPPD published between January 1978 and July 2014. Studies were selected based on specific inclusion and exclusion criteria. The primary outcome was delayed gastric emptying(DGE). Secondary outcomes included operation time, intraoperative blood loss, pancreatic fistula, postoperative hemorrhage, intraabdominal abscess, wound infection, time to starting liquid diet, time to starting solid diet, period of nasogastric intubation, reinsertion of nasogastric tube, mortality and hospital stay. The pooled odds ratios(OR) or weighted mean difference(WMD) with 95% confidence intervals(95%CI) were calculated using either a fixed-effects or random-effects model. RESULTS: Eight comparative studies recruiting 650 patients were analyzed, which include two RCTs, one non-randomized prospective and 5 retrospective trial designs. Patients undergoing SSPPD experienced significantly lower rates of DGE(OR = 2.75; 95%CI: 1.75-4.30, P < 0.00001) and a shorter period of nasogastric intubation(OR = 2.68; 95%CI: 0.77-4.58,P < 0.00001), with a tendency towards shorter time to liquid(WMD = 2.97, 95%CI:-0.46-7.83; P = 0.09) and solid diets(WMD = 3.69, 95%CI:-0.46-7.83; P = 0.08) as well as shorter inpatient stay(WMD = 3.92, 95%CI:-0.37-8.22; P = 0.07), although these latter three did not reach statistical significance. PPPD, however, was associated with less intraoperative blood loss than SSPPD [WMD =-217.70, 95%CI:-429.77-(-5.63); P = 0.04]. There were no differences in other parameters between the two approaches, including operative time(WMD =-5.30, 95%CI:-43.44-32.84; P = 0.79), pancreatic fistula(OR = 0.91; 95%CI: 0.56-1.49; P = 0.70), postoperative hemorrhage(OR = 0.51; 95%CI: 0.15-1.74; P = 0.29), intraabdominal abscess(OR = 1.05; 95%CI: 0.54-2.05; P = 0.89), wound infection(OR = 0.88; 95%CI: 0.39-1.97; P = 0.75), reinsertion of nasogastric tube(OR = 1.90; 95%CI: 0.91-3.97; P = 0.09) and mortality(OR = 0.31; 95%CI: 0.05-2.01; P = 0.22).CONCLUSION: SSPPD may improve intraoperative and short-term postoperative outcomes compared to PPPD, especially DGE. However, these findings need to be further ascertained by well-designed randomized controlled trials. | Wei Huang Jun-Jie Xiong Mei-Hua Wan Peter Szatmary Shameena Bharucha Ilias Gomatos Quentin M Nunes Qing Xia Robert Sutton Xu-Bao Liu | 2015 | World Journal of Gastroenterology2015，21，20： | 8 |
| 2 | American Gastroenterological Association Medical Position Statement on Constipation显示文摘 | Adil E. Bharucha Spencer D. Dorn Anthony Lembo Amanda Pressman | 2013 | Gastroenterology2013，，1： | 3 |
| 3 | 奈必洛尔和缬沙坦固定剂量联合治疗高血压的疗效与安全性研究显示文摘任意2类降压药物固定剂量联合降压作用强于单独增加一类药物剂量的作用。该研究评估β受体阻滞剂奈必洛尔(nebivolol)和血管紧张素受体拮抗剂缬沙坦(valsartan)固定剂量联合治疗成人高血压的疗效与安全性。方法:研究人员在美国401个医疗中心进行了为期8周、临床试验3期、多中心、随机、双盲、安慰剂平行对照试验。参与者均为≥18岁的高血压患者(但血压≤180/110mm Hg,1mm Hg=0.133kPa),以15例为一治疗组, | 刘莉 叶鹏 Giles TD Weber MA Basile J Gradman AH Bharucha DB Chen W Pattathil M | 2014 | 中华高血压杂志2014，22，8： | 2 |
| 4 | Differential effects of selective and non- selective musearinie antagonists on gastrointestinal transit and bowel function in healthy women 显示文摘 | Bharucha AE Isowa H Hiro S | 2013 | Neurogastroenterol Motil2013，25，01： | 1 |
| 5 | Slow transit constipation显示文摘 | Bharucha AE Philips SF | | 0，，01： | 1 |
| 6 | Conditions associated with Alzheimer's disease at death:case-control study显示文摘 | Chandra V Bharucha NE Schoenberg BS | 1986 | Neurology1986，36，2： | 1 |
| 7 | Human umbilical cord blood serum can replace fetal bovine serum in the culture of mesenchymal stem cel s显示文摘 | Shetty P Bharucha K Tanavde V | | 0，，03： | 1 |
| 8 | American Gastroenterological Association medical position statement on constipation显示文摘 | Bharucha AE Dorn SD | 2013 | Gastroenterology2013，144，6： | 1 |
| 9 | American Neurogastro- enterology and Motility Society consensus statement on intraluminal measurement of gastrointestinal and colonic motility in clinical practice 显示文摘 | Camilleri M Bharucha AE di Lorenzo C | 2008 | Neurogastroenterol Moti12008，20，12： | 1 |
| 10 | Functional Anorectal Disor-ders 显示文摘 | Bharucha AE Wald A Enck P | 2006 | Seminars in Gastrointestinal Disease2006，130，5： | 1 |
| 11 | Relationship between symptoms and disordered continence mechanisms in women with idi-opathic faecal incontinence显示文摘 | Bharucha AE Fletcher JG Harper CM | 2005 | Gut2005，54，： | 1 |
| 12 | Smad3 null mice display more rapid wound closure and reduced scar formation after a stab wound to the cerebral cortex显示文摘 | Wang Y Moges H Bharucha Y | 2007 | Experimental Neurology2007，1，203： | 1 |
| 13 | Effects of a serotonin 5-HT ( 4 ) receptor antagonist SB-207266 on gastrointestinal motor and sensory function in humans显示文摘 | Bharucha AE Camilleri M Haydock S | 2000 | Gut2000，47，5： | 1 |
| 14 | Drawing a blank in functional dyspepsia ? 显示文摘 | Camilleri M Bharucha AE | 2006 | Gastroenterology2006，130，： | 1 |
| 15 | Simplepractical approach provides a technique for calibratingtortuosity factors显示文摘 | LUO Y BHARUCHA K SAMUEL R | 2003 | Oil Gas2003，101，35： | 1 |
| 16 | Low-density ver- sus high-density thoracic pedicle screw constructs in adolescent idiopathic scoliosis: do more screws lead to a better outcome? 显示文摘 | Bharucha NJ Lonner BS Auerbach JD | 2013 | Spine J2013，13，4： | 1 |
| 17 | ANMS-ESNM position pa- per and consensus guidelines on biofeedback therapy for anorectal dis- orders 显示文摘 | Rao SS Benninga MA Bharucha AE | 2015 | Neurogastroenterol Motil2015，27，5： | 1 |
| 18 | Anaplatic large cell malignant lymphoma with extensive eosinophil or neutrophil infiltration 显示文摘 | Walsh MY Bharucha H | 1998 | Histopathology1998，32，： | 1 |
| 19 | Effects of a selective chloride channel activator, lubiprostone on gastrointestinal transit, gastric sensory', and motor functions in healthy volunteers 显示文摘 | Camilleri M Bharucha AE Ueno R | 2006 | Am J Physiol Gastrointest Liver Physiol2006，290，5： | 1 |
| 20 | Pituitary hyperplasia mimicking pituiatay tumor 显示文摘 | Dadachanji MC Bharucha NE Jhankaria BG | 1994 | Surg Nerrol1994，42，5： | 1 |
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