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| 1 | Does progesterone show neuroprotective effects on traumatic brain injury through increasing phosphorylation of Akt in the hippocampus?显示文摘There are currently no federally approved neuroprotective agents to treat traumatic brain injury. Progesterone, a hydrophobic steroid hormone, has been shown in recent studies to exhibit neuroprotective effects in controlled cortical impact rat models. Akt is a protein kinase known to play a role in cell signaling pathways that reduce edema, inflammation, apoptosis, and promote cell growth in the brain. This study aims to determine if progesterone modulates the phosphorylation of Akt via its threonine 308 phosphorylation site. Phosphorylation at the threonine 308 site is one of several sites responsible for activating Akt and enabling the protein kinase to carry out its neuroprotective effects. To assess the effects of progesterone on Akt phosphorylation, C57BL/6 mice were treated with progesterone(8 mg/kg) at 1(intraperitonally), 6, 24, and 48 hours(subcutaneously) post closed-skull traumatic brain injury. The hippocampus was harvested at 72 hours post injury and prepared for western blot analysis. Traumatic brain injury caused a significant decrease in Akt phosphorylation compared to sham operation. However, mice treated with progesterone following traumatic brain injury had an increase in phosphorylation of Akt compared to traumatic brain injury vehicle. Our findings suggest that progesterone is a viable treatment option for activating neuroprotective pathways after traumatic brain injury. | Richard Justin Garling Lora Talley Watts Shane Sprague Lauren Fletcher David F.Jimenez Murat Digicaylioglu | 2014 | Neural Regeneration Research2014，9，21： | 6 |
| 2 | Biomarkers of Coagulation, Inflammation, and Angiogenesis are Independently Associated with Preeclampsia显示文摘 | Roland Boij Judit Svensson Kristina Nilsson‐Ekdahl Kerstin Sandholm Tomas L. Lindahl Elzbieta Palonek Mats Garle G?ran Berg Jan Ernerudh Maria Jenmalm Leif Matthiesen | 2012 | Am J Reprod Immunol2012，，3： | 2 |
| 3 | The role of Smad7 in oral mucositis显示文摘口头的 mucositis,严重口头的溃疡,是放射疗法或 chemoradio 治疗和一个限制因素的普通有毒的效果到为有效癌症治疗使用放射的最大的剂量。在癌症病人之中,与标准化疗政体或上面身体的放射对待的个人,至少 40% 和多达 70% 开发口头的 mucositis。迄今为止,没有食物及药品管理局在癌症病人对待口头的 mucositis 的同意的药。为口头的 mucositis 治疗的关键挑战是没有支持癌症房间生长,修理并且保护溃烂的口头的 mucosa。口头的 mucositis 是建筑群的结果, multifaceted pathobiology,包含一系列发信号的小径和在上皮和 submucosa 之间的相互作用的链。在那些小径和相互作用之中,原子 factor-kappa B (NF-B ) 的激活对口头的 mucositis 的发炎过程批评。我们最近发现发信号的 TGF (转变生长因素) 的激活与口头的 mucositis 的发展被联系。Smad7, TGF 发信号的否定管理者,禁止 NF-B 和 TGF 激活并且当支持上皮的移植时,因此由 attenuating 生长抑制, apoptosis,和发炎在口头的 mucositis 的预防和治疗起一个枢轴的作用。这评论的主要目的是评估 Smad7 的已知的功能,与它在堵住在口头的 mucositis 的多重病理学的过程的分子的机制和它的功能的一个特别焦点。 | Li Bian Gangwen Han Carolyn W. Zhao Pamela J. Garl Xiao-Jing Wang | 2015 | Protein & Cell2015，6，3： | 2 |
| 4 | Effects of dietary carbohydrate-to lipid ratios on growth and body composition of fingerling channel catfish 显示文摘 | Garling D Wilson R P | 1977 | Progressive Fish-Culturist1977，39，1： | 1 |
| 5 | Liquid storage of marrowstromal cells 显示文摘 | Lane TA Garls D Mackintosh E | 2009 | Transfusion2009，49，7： | 1 |
| 6 | The Acquisition and Use of an Internal Representation of the Spatial Layout of the Environment During Location显示文摘 | GARLING T BOOK A LINGDBERG E | 1979 | Man-Environment System1979，9，： | 1 |
| 7 | Environmental concern : Conceptual definitions, measurement methods and research findings 显示文摘 | Fransson N Garling T ( 1999 ) | 1999 | Journal of Environmental Psychology1999，19，4： | 1 |
| 8 | Pretreatment of soybean meal with phytase for salmonid diets to reduce phosphorus concentrations in hatchery effluents 显示文摘 | Cain K D Garling D | 1995 | Prog Fish Cult1995，57，： | 1 |
| 9 | Extended framework for mod- eling choice behavior 显示文摘 | Ben- Akiva M McFadden D Garling T | 1999 | Marketing Letters1999，10，3： | 1 |
| 10 | Belief-value Structures as Determinants of Consumer Behavior:A Study of Housing Preferences and Choices显示文摘 | LINDBERG ERIK GARLING TOMMY MONTGOMERY HENRY | 1989 | Journal of Consumer Policy1989，12，2： | 1 |
| 11 | Effects of dietary carbohy-drate-to-lipid ratio on growth and body composition of fin-gerling channel catfish显示文摘 | Garling D L Wilson R P | 1977 | Prog Fish-Cult1977，39，： | 1 |
| 12 | Perlecan Up-Regulation of FRNK Suppresses Smooth Muscle Cell Proliferation Via Inhibition of FAK Signaling显示文摘 | WALKER H A WHITELOCK J M GARL P J | 2003 | Mol Biol Cell2003，14，5： | 1 |
| 13 | External rota- tion stress imaging in syndesmotic injuries of the ankle: comparison of lateral radiography and radiostereometry in a cadaveric model显示文摘 | Beumer A Valstar ER Garling EH | 2003 | Acta Orthop Scand2003，74，2： | 1 |
| 14 | Unique, highly proliferative growth phenotype expressed by embryonic and nc;ointimat smooth muscle cells is driven by constitutive Akt, mTOR, and p70S6K signaling and is actively repressed by PTEN 显示文摘 | Mourani PM Garl PJ Wenzlau JM | 2004 | Circulation2004，109，10： | 1 |
| 15 | Pretreatment of soybean meal with phytase for salmonoid diets to reduce phosphorus concentrations in hatchery effluents显示文摘 | Cain K D Garling D L | 1995 | Progressive Fish-Culturist1995，57，： | 1 |
| 16 | Environmental Concern: Conceptual Definitions, Measurement Methods, and Research Findings显示文摘 | FRANSSON N GARLING T | 1999 | Journal of Environ mental Psychology1999，19，4： | 1 |
| 17 | Morphological control of mesoporous alumina nanostructures via template-free solvothermal synthesis显示文摘 | Garl Z H Ning G L Lin Y | 2007 | Mater Lett2007，61，： | 1 |
| 18 | Escalation of commitment with transparent future outcomes 显示文摘 | Karlsson N Garling T Bonini N | 2005 | Experimental Psychology2005，52，1： | 1 |
| 19 | The complex convexity of quasi-normed linear spaces 显示文摘 | Davis W J Garling D J H Tomczak-Jaegermann N | 1984 | J Func Anal1984，55，： | 1 |
| 20 | Pretreatment of soybean meal with phytase for salmonid diets to reduce phos- phorus concentrations in hatchery effluents 显示文摘 | CAIN K D GARLING D L | 1995 | The Progressive Fish-Culturist1995，57，： | 1 |
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