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| 1 | Study protocol of the Asian XELIRI ProjecT(AXEPT):a multinational,randomized,non-inferiority,phase Ⅲ trial of second-line chemotherapy for metastatic colorectal cancer, comparing the eicacy and safety of XELIRI with or without bevacizumab versus FOLFIRI w显示文摘Background: Capecitabine and irinotecan combination therapy(XELIRI) has been examined at various dose levels to treat metastatic colorectal cancer(m CRC). Recently, in the Association of Medical Oncology of the German Cancer Society(AIO) 0604 trial, tri?weekly XELIRI plus bevacizumab, with reduced doses of irinotecan(200 mg/m^2 on day 1) and capecitabine(1600 mg/m^2 on days 1–14), repeated every 3 weeks, has shown favorable tolerability and eicacy which were comparable to those of capecitabine and oxaliplatin(XELOX) plus bevacizumab. The doses of capecit?abine and irinotecan in the AIO trial are considered optimal. In a phase I/II study, XELIRI plus bevacizumab(BIX) as second?line chemotherapy was well tolerated and had promising eicacy in Japanese patients.Methods: The Asian XELIRI Projec T(AXEPT) is an East Asian collaborative, open?labelled, randomized, phase Ⅲ clinical trial which was designed to demonstrate the non?inferiority of XELIRI with or without bevacizumab versus standard FOLFIRI(5?fluorouracil, leucovorin, and irinotecan combination) with or without bevacizumab as second?line chemo?therapy for patients with m CRC. Patients with 20 years of age or older, histologically conirmed m CRC, Eastern Coop?erative Oncology Group performance status 0–2, adequate organ function, and disease progression or intolerance of the irst?line regimen will be eligible. Patients will be randomized(1:1) to receive standard FOLFIRI with or with?out bevacizumab(5 mg/kg on day 1), repeated every 2 weeks(FOLIRI arm) or XELIRI with or without bevacizumab(7.5 mg/kg on day 1), repeated every 3 weeks(XELIRI arm). A total of 464 events were estimated as necessary to show non?inferiority with a power of 80% at a one?sided α of 0.025, requiring a target sample size of 600 patients. The 95% conidence interval(CI) upper limit of the hazard ratio was pre?speciied as less than 1.3.Conclusion: The Asian XELIRI Projec T is a multinational phase III trial being conducted to provide evidence for XELIRI with or without bevacizumab as a second?line treatment option of mCRC. | Masahito Kotaka Ruihua Xu Kei Muro Young Suk Park Satoshi Morita Satoru Iwasa Hiroyuki Uetake Tomohiro Nishina Hiroaki Nozawa Hiroshi Matsumoto Kentaro Yamazaki Sae-Won Han Wei Wang Joong Bae Ahn Yanhong Deng Sang-Hee Cho Yi Ba Keun-Wook Lee Tao Zhang Taroh Satoh Marc E.Buyse Baek-Yeol Ryoo Lin Shen Junichi Sakamoto Tae Won Kim | 2016 | Chinese Journal of Cancer2016，35，12： | 3 |
| 2 | 男性C反应蛋白、纤维蛋白原和心肺适应性与高血压发生风险的相关性显示文摘在正常血压和高血压高危人群中,较高的心肺适应性(cardiorespiratory fitness)可预防高血压[1-2]。但高心肺适应性能否降低炎症水平升高的受试者发生高血压的风险,尚不清楚。本研究旨在探讨男性中,独立于肥胖,炎症与高血压发生的相关性;心肺适应性、炎症与高血压发生的联合相关性。研究者假设炎症与高血压发生相关,但高心肺适应性可降低这种相关性。 | Jae SY Kurl S Laukkanen JA Lee CD Choi YH Fernhall B Franklin BA | 2015 | 中华高血压杂志2015，23，9： | 2 |
| 3 | Sharkskin-Inspired Magnetoactive Reconfigurable Acoustic Metamaterials显示文摘Most of the existing acoustic metamaterials rely on architected structures with fixed configurations,and thus,their properties cannot be modulated once the structures are fabricated.Emerging active acoustic metamaterials highlight a promising opportunity to on-demand switch property states;however,they typically require tethered loads,such as mechanical compression or pneumatic actuation.Using untethered physical stimuli to actively switch property states of acoustic metamaterials remains largely unexplored.Here,inspired by the sharkskin denticles,we present a class of active acoustic metamaterials whose configurations can be on-demand switched via untethered magnetic fields,thus enabling active switching of acoustic transmission,wave guiding,logic operation,and reciprocity.The key mechanism relies on magnetically deformable Mie resonator pillar(MRP)arrays that can be tuned between vertical and bent states corresponding to the acoustic forbidding and conducting,respectively.The MRPs are made of a magnetoactive elastomer and feature wavy air channels to enable an artificial Mie resonance within a designed frequency regime.The Mie resonance induces an acoustic bandgap,which is closed when pillars are selectively bent by a sufficiently large magnetic field.These magnetoactive MRPs are further harnessed to design stimuli-controlled reconfigurable acoustic switches,logic gates,and diodes.Capable of creating the first generation of untethered-stimuli-induced active acoustic metadevices,the present paradigm may find broad engineering applications,ranging from noise control and audio modulation to sonic camouflage. | Kyung Hoon Lee Kunhao Yu Hasan Al Ba’ba’a An Xin Zhangzhengrong Feng Qiming Wang | 2020 | Research2020，，1： | 2 |
| 4 | Endoscopic skull base surgery显示文摘 | Lee SC Senior BA | | 0，，02： | 1 |
| 5 | A comparison of the systemic toxicity of lidocaine versus its quaternary derivative QX-314 in mice显示文摘 | Cheung HM Lee SM Macleod BA | 2011 | Can ] Anaesth2011，58，5： | 1 |
| 6 | Flow quantification using fast cine phase-contrast MR imaging,conventional cine phase-contrast MR imaging and Doppler sonography: in vitro and vivo validation显示文摘 | Lee VS Spritzer CE Carroll BA | 1997 | AJR1997，169，： | 1 |
| 7 | The role of the natural environment in the emergence of antibiotic resistance in Gram-negative bacteria显示文摘 | Elizabeth MH Wellington Alistair BA Boxall Paul Cross Edward J Feil William H Gaze Peter M Hawkey Ashley S Johnson-Rollings Davey L Jones Nicholas M Lee Wilfred Otten Christopher M Thomas A Prysor Williams | 2013 | The Lancet Infectious Diseases2013，，2： | 1 |
| 8 | A comparison of the systemic toxicity of lidocaine versus its quaternary derivative QX-314 in mice显示文摘 | Cheung HM Lee SM MacLeod BA | 2011 | Can J Anaesth2011，58，5： | 1 |
| 9 | Flow quantification using fast cine phase-contrast MR imaging,conventional cine phase-contrast MR imaging and Doppler sonography:in vitro and in vivo validation显示文摘 | Lee VS Spritzer CE Carroll BA | | 0，，04： | 1 |
| 10 | Ribozyme-mediated induction of apoptosis in human cancer cells by targeted repair of mutant p53 RNA显示文摘 | Sullenger BA Lee SW | 2004 | Mol Ther2004，10，2： | 1 |
| 11 | Death pathways in noise-damaged outer hair cells显示文摘 | Bohne BA Harding GW Lee SC | 2007 | Hear Res2007，223，12： | 1 |
| 12 | Trends in the incidence and treatment of parathyroid cancer in the United States 显示文摘 | Lee PK Jarosek SL Virnig BA | 2007 | Cancer2007，109，9： | 1 |
| 13 | Prospective early response imaging biomarker for neoadjuvant breast cancer chemotherapy显示文摘 | Lee KC Moffat BA Schott AF | 2007 | Clin Cancer Res2007，13，21： | 1 |
| 14 | Turnover of new graduate nurses in their first job using survival analysis显示文摘 | Cho SH Lee JY Mark BA | | 0，，1： | 1 |
| 15 | Modified open-door cervical expansive laminoplasty for spondylotic myelopathy: operative technique outcome, and predictors for gait improvement 显示文摘 | Lee TT Manzano GR Green BA | 1997 | J Neurosurg1997，86，1： | 1 |
| 16 | Surgical treatment of spinal ependymoma and post-operative radiotherapy显示文摘 | Lee TT Gromelski EB Green BA | 1998 | Acta Neurochir (Wien)1998，140，4： | 1 |
| 17 | Neuroprotective effects ofbasic fibroblast growth factor following spinal cord contusion injury inthe rat显示文摘 | Lee TT Green BA Dietrich WD | 1999 | J Neurotrauma1999，16，5： | 1 |
| 18 | The prognoses of metaplastic breast cancer patient compared to those of triple-negative breast cancer patient显示文摘 | Ba SY Lee SK Koo MY | 2011 | Breast Cancer Res Treat2011，126，2： | 1 |
| 19 | Prospective early response imaging biomarker for neoadjuvant breast cancer chemotherapy显示文摘 | Lee KC Moffat BA Schott AF | | 0，，2： | 1 |
| 20 | Prospective early response imaging biomarker for neoadjuvant breast cancer chemotherapy显示文摘 | LEE KC MOFFAT BA SCHOTY AF | 2007 | Clin Cancer Res2007，13，12： | 1 |
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