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| 1 | Alterations in metastatic properties of hepatocellular carcinoma cell following H-ras oncogene transfection显示文摘AIM To demonstrate the relationship betweenH-ras oncogene and hepatocellular carcinoma(HCC) metastasis.METHODS Activated H-ras oncogene wastransfected into SMMC 7721, a cell line derivedfrom human HCC, by calcium phosphatetransfection method. Some metastasis-relatedparameters were detected in vitro, includingadhesion assay, migration assay, expression ofcollagenase ⅣV (c ⅣV ase) and epidermal growthfactor receptor (EGFR).RESULTS The abilities of H-ras-transfected cellclones in adhesion to laminin (LN) or fibronectin(FN), migration, c Ⅳ ase secretion increasedmarkedly, and the expression of EGFR elevatedmoderately. More importantly, these alterationswere consistent positively with the expressionof p21, the protein product of H-ras oncogene.CONCLUSION H-ras oncogene could inducethe metastatic phenotype of HCC cell in vitro toraise its metastatic potential. | Qing Wang~1 Zhi Ying Lin~2 Xiao Li Feng~3 ~1Department of Microbiology,Medical Center of Fudan University.the former Shanghai Medical University,Shanghai 200032,China ~2Liver Cancer Institute,Zhongshan Hospital,Shanghai 200032,China ~3Shanghai Institute of Biochemistry,Academy Sinica,Shanghai 200031,ChinaQing Wang earned master degree from Shanghai Medical University in 1996,now a senior lecturer of microbiology,specialized in the role of oncogcncs on tumor metastasis,having 8 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 48 |
| 2 | Wave Forces on Submerged Semi-Circular Breakwater and Similar Structures显示文摘—The results of design and experiment of a submerged semi-circular breakwater at the Yangtzeestuary show that the submerged structure will be unsafe when the general empirical wave force formulafor semi-circular breakwater is used in design.Therefore,a new calculation method for the wave forces act-ing on a submerged semi-circular structure is given in this paper,in which the wave force acting on the in-side circumference of semi-circular arch is included,and the phase modification coefficient in the generalempirical formula is adjusted as well.The new wave force calculation method has been verified by the re-sults of seven related physical model tests and adopted in the design of the south esturary jetty of the firststage project of Deep Channel Improvement Project of the Yangtze River Estuary,the total jetty length be-ing 17.5km. | XIE Shileng Prof. Senior Engineer, The First Design Institute of Navigation Engineering, Ministry of Communications of China, Tianjin 300222, P. R. China. | 1999 | China Ocean Engineering1999，14，1： | 15 |
| 3 | Experimental Research on Sewage Outfall Diffusers显示文摘The influence of diffuser parameters, including the riser spacing, port number in a riser, injection angle, port arrangement, etc., on the surface initial dilution is experimentally investigated. The relative density difference between the effluent and the sea water in the model is the same as that in the prototype, and the effect of the cross current is simulated by an inverse model technique. Based on the result analysis, the arrangement with more ports in a riser and larger riser spacing is suggested to save construction cost. The relationship between the Reynolds number based on the port diameter and velocity, and the surface initial dilution is also explored, and the critical Reynolds number is proposed. | Jiang Chuanfeng , Yan Zhongmin , Zhou Chuntian and Liu Mingming Professor, Res. Inst. of Water Resources and Hydro-Electric Power, Hohai University, Nanjing 210024 Senior Engineer, Res. Inst. of Water Resources and Hydro-Electric Power, Hohai University, Nanjing 210024 Engineer, Res. Inst. of Water Resources and Hydro-Electric Power, Hohai University, Nanjing 210024 | 1995 | China Ocean Engineering1995，10，2： | 13 |
| 4 | Nonlinear Dynamics and Stability of Neural Networks with Delay-Time显示文摘In this paper we study the dynamic properties and stabilities of neural networks with delay-time (which includes the time-varying case) by differential inequalities and Lyapunov function approaches. The criteria of connective stability, robust stability, Lyapunov stability, asymptotic atability, exponential stability and Lagrange stability of neural networks with delay-time are established, and the results obtained are very useful for the design, implementation and application of adaptive learning neural networks. | L. C. Jiao, member, IEEE, and Zheng Bao, Senior member, IEEECenter for Neural Networks and Institute of Elec. Eng, Xidian University, Xian 710071, China | 1992 | Journal of Systems Engineering and Electronics1992，3，2： | 11 |
| 5 | The Forthcoming 30th International Geological Congress (Beijing)-Geological Olympic Grand Meeting显示文摘TheForthcoming30thInternationalGeologicalCongress(Beijing)-GeologicalOlympicGrandMeeting￥//YanDunshi(ViceChairmanoftheOrganiz... | (Vice Chairman of the Organization Committee of the 30th IGC the Chairman of Exhibition committee)Xu Baowen(Chairman of the Exhibition Commitiee of the 30th IGC.the Deputy director of Senior,Consultotation,Center of the Minisiry of Geology and Mineral Res | 1996 | China Oil & Gas1996，3，2： | 10 |
| 6 | Housing Wealth, Financial Wealth and Consumption in China显示文摘纸在城市的中国在财产财富和家庭消费的趋势运动调查在变化之间的关系。用向量错误修正 cointegration 模型,我们证明在城市的中国在家庭消费,可处理的收入,金融财富和住房财富之间有一种唯一的长期间 cointegrating 关系。当 cointegrated 系统被外部震动扰乱时,我们发现住房财富是恢复长期间平衡关系的唯一的因素。另外,我们的永久临时的变化分解分析都显示那在消费的运动的变化是永久的,支持消费行为的古典随机的散步假设。然而,在住房财富的短期的运动的变化的一个大比例被发现临时。 | Jie Chen Feng Guo Aiyong Zhu Associate Professor,School of Management,Fudan University,Shanghai,China. Senior Research Economist and Economics Lecturer,Haile/US Bank College of Business,Northern Kentucky University,Highland Heights,USA. Master Student,School of Economics,Fudan University,Shanghai,China. | 2009 | China & World Economy2009，17，3： | 10 |
| 7 | A MATHEMATICAL MODEL FOR RESERVOIR SEDIMENTATION AND FLUVIAL PROCESSES显示文摘This paper consists of two parts: mechanism of non-equilibrium transport of non-uniform sediment and its application in the mathematical model. Based on a statistic approach of sediment transport proposed by the authors, a 1 - D equation of non-e- quilibrium transport for various size group of sediment particles is developed. Then equations to predict change of sediment concentration and the corresponding changes in size distribution of suspended load and bed material are also derived. The conception that changes in size distribution are interrelated to sediment-carrying capacity is expounded. These results reveal the essence of sediment transport of non-uniform sediment particles. In the second part a mathematical model incorporating the mentioned equations to compute deposition and scouring in reservoirs as well as the fluvial processes of river channels has been developed. Verification of the model agrees well with field data. | Han Qiwei and He Mingmin (Senior Research Engineers, Dept. of Sedimentation Eng. Inst. of Water Conservancy and Hydroelectric Power Research.) (The English text is abridged, altered and edited by Ding Lianzhen) | 1990 | International Journal of Sediment Research1990，5，2： | 10 |
| 8 | NUMERICAL ANALYSIS OF THE MECHANICS OF SOIL REINFORCEMENT显示文摘Roots affect the soil stress and strain and contribute to soil reinforcement. An analysis of stress and strain in the root-soil composite is presented which combines roots, soils, and an interface element by using the Duncan-Chang E- model and a nonlinear-interface-element model. In this research, a finite element numerical analysis method was applied to simulate the stress field resulting in a composite of Pinus tabulaeformis roots and soils. Results show that roots can transmit the stress from surface soils to deep soils, and can reduce soil stress within the surface soil layer; results also show that the effect of soil reinforcement by roots is limited to surface soils. The Slope Safety Index of a pine slope becomes 10% higher than that of a natural slope, indicating that roots have a significant effect on soil reinforcement. | Weifeng SONG1, Lihua CHEN2 and Xiuping LIU3 1 PhD candidate, senior engineer, College of Water and Soil Conservation, Beijing Forestry University Key Laboratory of Soil and Water Conservation and Combating Desertification, Ministry of Education, Beijing 100083, China 2 Prof., Doctor, College of Water and Soil Conservation, Beijing Forestry University Key Laboratory of Soil and Water Conservation and Combating Desertification, Ministry of Education, Beijing 100083, China 3 Master, College of Water and Soil Conservation, Beijing Forestry University Key Laboratory of Soil and Water Conservation and Combating Desertification, Ministry of Education, Beijing 100083, China | 2006 | International Journal of Sediment Research2006，21，3： | 9 |
| 9 | Effect of Berm Width and Elevation on Irregular Wave Run-Up显示文摘This paper discusses the effect of berm width and elevation of composite slope on irregular wave run-up. Based on the data obtained from model tests, the formula and distribution of irregular wave run-up on composite slope are derived. The changing of wind speed, width and elevation of the berm are considered comprehensively. The wave run-up with various exceedance probability can be es-timated utilizing the distribution curves of irregular wave run-up. | Chen Guoping , Yu Kuang-ming and Zhang Jiachang Assistant Engineer, River and Harbour Department, Nanjing Hydraulic Research Institute, NanjingProf. and Senior Engineer, River and Harbour Department, Nanjing Hydraulic Research Institute, Nanjing Senior Engineer, River and Harbour Department, Nanjing Hydraulic Research Institute, Nanjing | 1991 | China Ocean Engineering1991，6，4： | 7 |
| 10 | 关于保障中国木材安全的研究显示文摘中国木材安全处于不安全的状态,主要表现为:森林资源经营粗放,木材自给能力弱;木材需求刚性增长,供需缺口扩大;对外贸易摩擦日益突出,国际木材贸易难度加大;木材产业自身发展层次低,资源利用效率不高。保障木材安全战略的基本点是:立足国内资源,加快速生丰产林基地建设;加强森林经营,提高森林资源总量和质量;科学利用木材资源,提高木材综合利用效率。对策:建立健全国有林管理机制,加快国有林改革步伐;全面实施森林经营工程;大力发展速生丰产林;充分挖掘平原林业的潜力,实现平原林业又好又快发展;加大对林业科技教育投入,培养不同层次科技人才,依靠科技进步提高森林资源培育的效率和木材工业的科技创新能力;重视国外木材资源供给战略研究,制定充分利用国际森林资源的长远规划;利用国家政策保障木材安全;赋予林业行政部门对林业产业和木材安全机制的管理职能。 | Timber Security Investigative Group,China Association of Senior Scientists and Technicians | 2010 | 林业资源管理2010，，1： | 7 |
| 11 | Coupled BEM-FEM Analysis of the Large-Diameter Cylinder Structure System显示文摘A method of coupled BEM-FEM analysis for the elastic spatial structure system is presented. It can be applied to the calculation of the stress and deformation of the large-diamater cylinder structure system and it is suitable for symmetric or non-symmetric structures under the distributed or concentrated load. Numerical examples show that the proposed method and computer program BEFEM are quite efficient in the analysis of the large-diameter cylinder structure problems in ocean engineering. | Zhou Xireng, Duan Xudong, Sang Xuezhu Zhang Rui and Dai Jialu 1 Professor, Tianjin University, Tianjin2 Engineer, Xiamen Port Office, Fujian3 Lecturer, Tianjin University, Tianjin4 Senior Engineer, Tianjin Port Office, Tianjin | 1992 | China Ocean Engineering1992，7，2： | 6 |
| 12 | Fractal Dimension and Fractals in Ocean Engineering显示文摘- This paper discusses the application of fractal dimension and fractals in ocean engineering. To handle some ocean environment problems, the existing fractal method, in which the fractal dimension is a constant, can be used. For some complicated problems in ocean engineering, this paper presents the concept of the variable dimension fractals (D = f(r)), i. e., the fractal dimension D is the function of characteristic scale r instead of a constant. By using variable dimension fractals, several deformation and stress states of offshore structures are described. | Fu Yuhua Senior Engineer, China Offshore Oil Engineering Corporation, P. O. Box 4709, Beijing, 100027 | 1994 | China Ocean Engineering1994，9，3： | 5 |
| 13 | Investigation on Settling Characteristics of Floes in the Changjiang Estuary, China显示文摘- Settling characteristics of floes, including relative settling velocity, relative flocculation coefficient and flocculation exponent, are obtained by the suspended load equations for different size fractions. Data of the Changjiang Estuary suggest that level of flocculation changes from river section, river mouth (turbidity maximum) to offshore area in sequence of low, very high and high. The settling characteristics of floes reflected by in situ estimation performs a similar feature as that obtained from still water experiment. | Li Yan, Wang Yaqin LinYian Associate Professor, Second Institute of Oceanography, State Oceanic Administration, Hangzhou, 310012 Senior Engineer, Second Institute of Oceanography, State Oceanic Administration, Hangzhou, 310012 | 1995 | China Ocean Engineering1995，10，3： | 5 |
| 14 | INHERENT DISTRIBUTION LAW OF TURBULENT INTENSITY IN SEDIMENT-LADEN FLOW显示文摘Turbulent intensity of longitudinal velocity in a two-dimension sediment-laden flow depends on two factors,velocity and its gradient. The experimental data obtained flume experiment has proved that there is a quantitative formula between turbulent intensity a and the product of velocity u and its gradient du/dy. Based on the formula, the relationship between o and the friction velocity u* has been derived and analyzed. | CHEN Li Assoc.Prof.Wuhan University of Hydraulic and Electric engneering, China LIU Qingquan Assoc.Research Fellow. Institute of Mechanics of Chinese Academy of Sciences Beijing, China ZHANG Shuofu Senior Eingeer. Department of Water Conservancy and Pow | 1997 | International Journal of Sediment Research1997，12，3： | 5 |
| 15 | Computational Techniques of 2D Tidal Flow in Estuaries and Bays显示文摘- Some problems in the numerical calculation of tidal flow in estuaries and bays, such as distribution bed roughness, relationship between model moving boundary and water volume balance, remedy of certain shortage under open boundary conditions, smooth transfer of the controlling message for the inner boundaries of nested model, can not be solved usually by means of the fundamental equations and computing mode adopted in the numerical model, but can be done by the measures which not only satisfy the physical features but also are convenient for operation. Based on the calculated samples of some areas of Modaomen, Lingdingyang and Huangmaohai of the Pearl River Estuary, and Shuidong Bay (a typical barrier- lagoon tidal channel) in Guangdong Province, method and process of calculation for the above mentioned problems are briefly presented in this paper. | Xin Wenjie Senior Engineer, River and Harbour Department, Nanjing Hydraulic Research Institute, Nanjing 210024 | 1995 | China Ocean Engineering1995，10，4： | 4 |
| 16 | 澳大利亚人乳头状瘤病毒疫苗计划实施5年对年轻人群生殖器疣患病情况的影响:国家调查数据分析显示文摘目的评估2007年中开始的澳大利亚人乳头状瘤病毒(HPV)疫苗计划对生殖器疣患病情况的影响。设计国家调查数据趋势分析。数据来源数据收集于2004--2011年度澳大利亚8所性健康服务机构;其中2所最大的临床中心收集了自我报告的本中心2009年度HPV疫苗现状。研究对象2004--2011年度首次就诊的85770名澳大利亚出生的国民;其中7686(9.0%)名患生殖器疣。主要结局测量比较前疫苗时期(2004—2007年中)和疫苗时期(2007年中-2001年末)不同人群生殖器疣新发病率变化趋势。结果疫苗时期21岁以下和21~30岁女性诊断患有生殖器疣的比例明显下降,发病率分别从2007年度的11.5%和11.3%下降至2011年度的0.85%和3.1%,P均〈0.001。在30岁以上的女性中未发现发病率的明显下降。在21岁以下和21~30岁异性恋男性人群中疫苗时期生殖器疣的发病率较前疫苗时期明显下降,分别由2007年度12.1%和18.2%下降至2011年度2.2%和8.9%,P均〈0.001。30岁以上的异性恋男性人群中发病率无明显下降。2011年235名21岁以下女性在使用HPV疫苗后无新发生殖器疣病例。结论年轻女性生殖器疣发病率的显著下降和2011年度部分年轻女性使用疫苗后的零发病率,说明HPV疫苗获得实验室外的良好功效。异性恋男性生殖器疣发病率的显著下降可能是由于群体免疫所致。 | Hammad Ali,lecturer Basil Donovan, professor HandanWand,senior lecturer Tim R H Read, sexual health physician David G Regan,senior lecturer Andrew E Grulich, professor Christopher K FaMey, professor Rebecca J Guy, associate professor 尹婕(译) 潘凌亚(校) | 2013 | 英国医学杂志中文版2013，16，4： | 4 |
| 17 | Leukocyte populations and IL-6 in the tumor microenvironment of an orthotopic colorectal cancer model显示文摘Colorectal 癌症(CRC ) 是世界范围的一个主要健康问题。它经常由于它的无征状的性质晚被诊断。就象所有癌症,有免疫力的反应被包含;在 CRC,如果这有免疫力的回答为疾病前进有利或相反,然而,它是未知的。在这研究,在 mesenteric 淋巴节点(MLN ) 和 Peyers 补丁的有免疫力的反应在一个 orthotopic 鼠标模型在 CRC 的开发期间被调查。CRC 被把 CT26 房间注入 BALB/c 老鼠的盲肠墙导致。流动 cytometry 被用来分析在 MLN 和 Peyers 补丁涉及肿瘤免疫的白血球人口。为 immunohistochemistry 的低温恒温器节从盲肠和冒号被准备从导致 CRC 并且假冒操作动物。老鼠 CT26 房间线生产的 Cytokines 在 vitro 并且在 vivo 被测量。房间在 CRC 组在 MLN 和 Peyers 补丁被发现的 CD8 +/TCR+ 和 CD49b +/TCR( 生来的杀手) 的数字的重要增加。另外, T 房间在从假冒操作老鼠的冒号纸巾的薄板 propria 是在场的,但是与 CRC 从老鼠在冒号纸巾不在。肿胀的纸巾的 Immunohistochemical 分析显示出嗜曙红血球, CD69 + T 房间,和 CD11b + 房间渗入。在 vitro 并且在 vivo CT26 肿瘤,房间是 interleukin (IL )-6 积极。另外,渗入肿瘤的 CD45 + 房间也是 IL-6 积极。在摘要,对 CRC 和在肿瘤免疫被含有的关键受动器淋巴细胞的有免疫力的反应的动力学被表明。而且, IL-6 是在肿瘤微型环境以内在场的关键 cytokine。 | Sarah Miller Paul V. Senior Monica Prakash Vasso Apostolopoulos Samy Sakkal Kulmira Nurgali | 2016 | Acta Biochimica et Biophysica Sinica2016，48，4： | 4 |
| 18 | Analysis on Residents’ Travel Characteristics and Transport Policies: A Case Study on Tianjin显示文摘The history of city development in China and other countries proves that the residents’ travel demand and characteristics apparently change in both time and space terms along with the process of rapid urbanization and motorization.In recent years, | MA Keping,Engineer,Research Center of Transport,Tianjin Urban Planning & Design Institute,Tianjin,P.R.China.CAO Bohu,Senior Engineer,Research Center of Transport,Tianjin Urban Planning & Design Institute,Tianjin,P.R.China.FAN Xiaoyong,Engineer,Research Center of Transport,Tianjin Urban Planning & Design Institute,Tianjin,P.R.China. | 2008 | China City Planning Review2008，17，1： | 4 |
| 19 | 指南儿童毛细支气管炎:NICE指南概要显示文摘本文是英国医学杂志发布的基于现有最佳证据得出的系列新指南概要之一。它们重点对临床实践提供重要建议,尤其是尚无定论或存有争议的领域。 | Valentina Ricci research fellow Vanessa Delgado Nunes senior research fellow and guideline lead M Stephen Murphy clinical director for children's guidelines Steve Cunningham consultant and honorary reader in paediatric respiratory medicine 许菲 梁志欣 | 2015 | 英国医学杂志中文版2015，0，12： | 4 |
| 20 | VERTICAL HEREDITY VS. HORIZONTAL GENE TRANSFER: A CHALLENGE TO BACTERIAL CLASSIFICATION显示文摘The diversity and classification of microbes has been a long-standing issue.Molecular phylogeny of the prokaryotes based on comparison of the 16S rRNA sequences of the small ribosomal subunit has led to a reasonable tree of life in the late 1970s. How-ever, the availability of more and more complete bacterial genomes has brought about complications instead of refinement of the tree. In particular, it turns out that different choice of genes may tell different history. This might be caused by possible horizontal gene transfer (HGT) among species. There is an urgent need to develop phylogenetic methods that make use of whole genome data. We describe a new approach in molecular phylogeny,namely, tree construction based on K-tuple frequency analysis of the genomic sequences.Putting aside the technicalities, we emphasize the transition from randomness to determin-ism when the string length K increases and try to comment on the challenge mentioned in the title. | HAO Bailin(Institute of Theoretical Physics, Academy of Chinese Sciences, Beijing 100080, China Senior International Fellow of the Santa Fe Institute T-Life Research Center, Fudan University,Shanghai 200433, China)QI Ji(Institute of Theoretical Physics, Beijing 100080, China) | 2003 | Journal of Systems Science & Complexity2003，16，3： | 3 |
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