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| 1 | Crohn’s and colitis in children and adolescents显示文摘Crohn's disease and ulcerative colitis can be grouped as the inflammatory bowel diseases(IBD).These conditions have become increasingly common in recent years,including in children and young people.Although much is known about aspects of the pathogenesis of these diseases,the precise aetiology is not yet understood,and there remains no cure.Recent data has illustrated the importance of a number of genes-several of these are important in the onset of IBD in early life,including in infancy.Pain,diarrhoea and weight loss are typical symptoms of paediatric Crohn's disease whereas bloody diarrhoea is more typical of colitis in children.However,atypical symptoms may occur in both conditions:these include isolated impairment of linear growth or presentation with extra-intestinal manifestations such as erythema nodosum.Growth and nutrition are commonly compromised at diagnosis in both Crohn's disease and colitis.Consideration of possible IBD and completion of appropriate investi-gations are essential to ensure prompt diagnosis,thereby avoiding the consequences of diagnostic delay.Patterns of disease including location and progression of IBD in childhood differ substantially from adultonset disease.Various treatment options are available for children and adolescents with IBD.Exclusive enteral nutrition plays a central role in the induction of remission of active Crohn's disease.Medical and surgical therapies need to considered within the context of a growing and developing child.The overall management of these chronic conditions in children should include multi-disciplinary expertise,with focus upon maintaining control of gut inflammation,optimising nutrition,growth and quality of life,whilst preventing disease or treatment-related complications. | Andrew S Day Oren Ledder Steven T Leach Daniel A Lemberg | 2012 | World Journal of Gastroenterology2012，18，41： | 4 |
| 2 | Groundwater flow in a compressible un- confined aquifer with uniform circular recharge 显示文摘 | Zlotnik V Ledder | 1992 | Water Resource Research1992，28，6： | 1 |
| 3 | Molecular analysisof the subgingival microbiota in health and disease 显示文摘 | Ledder RG Gilbert P Huws SA | 2007 | ApplEnviron Microbiol2007，73，2： | 1 |
| 4 | Interracial catalysis by phosphoinositide 3' - hydroxykinase显示文摘 | Barnett S F Ledder L M Stirdivant S M | 1995 | Biochemistry1995，34，14： | 1 |
| 5 | Development and characterization of a simple perfused oral microcosm 显示文摘 | McBain AJ Sissons C Ledder RG | 2005 | J Appl Microbiol2005，98，3： | 1 |
| 6 | Pancreatic trauma in children显示文摘 | Sutherland I Ledder 0 CrameriJ | 2010 | Pediatr Surg Int2010，26，12： | 1 |
| 7 | Integral equation for the planar ablation problem显示文摘 | LEDDER N | 1997 | International Journal of Engineering Science1997，35，9： | 1 |
| 8 | Molecular analysis of the subgingival microbiota in health and disease 显示文摘 | LEDDER RG GILBERT P HUWS SA | 2007 | Appl Environ Microbiol2007，73，2： | 1 |
| 9 | Molecular a- nalysis of the subgingival microbiota in health and disease显示文摘 | Ledder RG Gilbert P Huws SA | 2007 | Appl Environ Microbiol2007，73，2： | 1 |
| 10 | Development and characterization of a simple perfused oral microcosm显示文摘 | McBain AJ Sissons C Ledder RG | 2005 | J Appl Microbiol2005，98，3： | 1 |
| 11 | Regeneration of myenteric plexus in the mouse colon after experimental denervation with benzalkonium chloride显示文摘 | Hanani M Ledder O Yutkin V | 2003 | J Comp Neurol2003，462，3： | 1 |
| 12 | Combination of oral antibiotics may be effective in severe pediatric ulcerative colitis: A preliminary report显示文摘 | Dan Turner Arie Levine Kaija-Leena Kolho Ron Shaoul Oren Ledder | 2014 | Journal of Crohn’s and Colitis2014，，： | 1 |
| 13 | Molecular analysisof the subgingival microbiota in health and disease显示文摘 | Ledder RG Gilbert P Huws SA | 2007 | ApplEnviron Microbiol2007，73，2： | 1 |
| 14 | Individual miroflora be- get unique oral microcosms 显示文摘 | Ledder RG Gilbert P Pluen A | 2006 | J Appl Microbiol2006，100，5： | 1 |
| 15 | Pancreatic trauma in children显示文摘 | Ingrid Sutherland Oren Ledder Joe Crameri Andrew Nydegger Anthony Catto-Smith Timothy Cain Mark Oliver | 2010 | Pediatric Surgery International2010，，12： | 1 |
| 16 | Development and charac- terization of a simple perfused oral microcosm显示文摘 | McBain AJ Sissons C Ledder RG | 2005 | J Appl Microbi- ol2005，98，3： | 1 |
| 17 | Development and characterization of a simple perfused oral microcosm 显示文摘 | McBain A J Sissons C Ledder RG | 2005 | J ApplMicrobiol2005，98，3： | 1 |
| 18 | Regeneration of myenteric Plexus in the mouse colon after experinental denervation with benzalkonium chloride显示文摘 | Hanani M Ledder O | 2003 | J of comparative neuroology2003，462，： | 1 |
| 19 | Molecular analysis of the subgingival microbiota in health and disease显示文摘 | Ledder RG Gilbert P Huws SA | | 0，，02： | 1 |
| 20 | Feasibility of a psychosocial rehabilitation to enhance the involvement of relatives in cancer rehabilitation:Pilot study for a random- ized controlled trial显示文摘 | Ledderer L La Cour K Mogensen O er al | 2013 | Patient2013，6，3： | 1 |
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