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| 1 | 根治性手术与短程放疗后行经肛门内镜显微手术(TEM)保留器官治疗早期直肠癌(TREC):一项随机、开放标签的可行性研究显示文摘背景:基于全直肠系膜切除(total mesorectal excision,TME)的根治性手术可能不是早期直肠癌的最佳一线治疗。选择性TME保留器官的策略可以减少治疗的不良反应,又不会显著影响肿瘤结果。该临床随机研究通过与TME比较,探讨器官保留策略的可行性。方法:TREC是一项在英国21个三级转诊中心进行的随机、开放标签的可行性研究。符合条件的受试者年龄≥18岁,分期为T2期或更早,最大直径不超过30 mm;排除淋巴结受累或转移的患者。患者按计算机随机分配(1:1)接受短程放疗保留器官,8~10周后行经肛门内镜显微手术(transanal endo⁃scopic microsurgery,TEM)或TME术。当TEM标本组织病理学特征提示局部复发风险增加时,患者被考虑计划早期转为TME。一项非随机前瞻性登记收集了认为不适合随机化的患者,因为每例患者都是按临床指征治疗的。主要终点为12、18和24个月的累积随机分组。次要结局为应用欧洲癌症研究与治疗组织(EORTC)QLQ C30和CR29量表对意向治疗人群的安全性、有效性和健康相关生活质量进行了评价。该研究已在ISRCTN注册中心注册,ISRCTN14422743。 | 佟伟华 BACH S P GILBERT A BROCK K | 2021 | 结直肠肛门外科2021，27，3： | 9 |
| 2 | Bacterial coaggregation: an integral process in the development of multi-species biofilms 显示文摘 | Rickard AH Gilbert P High NJ | 2003 | Trends Microbiol2003，11，2： | 1 |
| 3 | Sensitivity and specificity of clinical, histologic and immunologic features in the diagnosis of paraneoplastic pemphigus 显示文摘 | Joly P Richard C Gilbert D | 2000 | J Am Acad Dermatol2000，43，4： | 1 |
| 4 | Indicators for transboundary river management显示文摘 | Lorenz C M Gilbert A J Cofino W P | 2001 | Environmental Management2001，28，1： | 1 |
| 5 | Gold and trace element zonation in pyrite using a laser imaging technique: Implications for the timing of gold in orogenic and Carlin- style sediment- hosted deposits 显示文摘 | R R Large L Danyushevsky C Hollit V Maslennikov S Meffer S Gilbert S Bull R Scott P Emsbo H Thomas B Singh J Foster | 2009 | Economic Geology2009，104，5： | 1 |
| 6 | Determinants of portfolio performance Ⅱ: An update 显示文摘 | BRINSON G P SINGER B D GILBERT L BEE- BOWER G L | 1991 | Financial Analysis Journal1991，47，3： | 1 |
| 7 | Podocytes in glomerulus of rat kidney express a characteristic 44 kD protein显示文摘 | Mundel P Gilbert P Kriz W | 1991 | J Histochem Cytochem1991，39，8： | 1 |
| 8 | Sparse recovery using sparse matrices 显示文摘 | Gilbert A Indyk P | 2010 | Proceedings of the IEEE2010，98，6： | 1 |
| 9 | Risk factors for outbreaks of infectious intestinal disease linked to domestic catering显示文摘 | RYAN M J WALL P G GILBERT R J | 1996 | Commun Dis Rep CDR Rev1996，6，13： | 1 |
| 10 | Characterization and comparative sequence analysis of replication origins from three large Bacillus thuringiensis plasmids显示文摘 | BAUM J A COYLE D M GILBERT M P | 1991 | J Bacteriol1991，173，17： | 1 |
| 11 | Matrix effects affecting headspace-gas chromatographic method used for dissolved gas analysis in dielectric liquids显示文摘 | Jalbert J Gilbert R Tetreault P the indirect calibration of the static | 2003 | Anal Chem2003，75，19： | 1 |
| 12 | Chamcterisation of stearate/stearic acid coated fillers显示文摘 | Gilbert M Petiraksakul P Mathieson I | 2001 | MATERIALS SCIENCE AND TECHNOLOGY2001，17，11： | 1 |
| 13 | Re- cent trends on the development of photobiological pro- cesses and photobioreactors for the improvement of hy- drogen production显示文摘 | DASGUPTA NC GILBERT JJ LINDBLAD P | 2010 | lnternational Journal of Hydro- gen Energy2010，35，10： | 1 |
| 14 | Biomarker distributions in Australian oil predominantly derived from terrigenous source material 显示文摘 | Philp R P Gilbert T D | 1986 | Ad- vances in Organic Geochemistry1986，10，13： | 1 |
| 15 | TaintDroid: An Information- Flow Tracking System for Realtime Privacy Monitoring on Smartphones 显示文摘 | ENCK W GILBERT P | 2014 | ACM Transactions on Computer Systems2014，，2： | 1 |
| 16 | Cerebral radiation necrosis 显示文摘 | Giglio P Gilbert MR | 2003 | Neurologist2003，9，： | 1 |
| 17 | Management of primary hypot- hyroidism: statement by the British Thyroid Association Executive Com- mittee 显示文摘 | Okosieme O Gilbert J Abraham P | 2016 | Clin Endocrinol (Oxf)2016，84，6： | 1 |
| 18 | The effects of hardpan layers on the water chemistry, from the leaching of pyrrhotite-rich tailings material 显示文摘 | GILBERT S E COOKE D R HOLLINGS P | 2003 | Environmental Geology2003，44，： | 1 |
| 19 | Biomarker distributions in Australia oils predominantly derived from terrigenous source material 显示文摘 | Philp R P Gilbert T D | 1986 | Organic Geochemistry1986，10，： | 1 |
| 20 | Influence of shellfish farming activities on nitrification,nitrate reduction to ammonium and denitrification at the water-sediment interface of the Thau lagoon,France显示文摘 | Gilbert F Souchu P Bianchi M B | 1997 | Marine Ecology Progress Series1997，151，： | 1 |
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