共被期刊论文引用了2次
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| 1 | 靶向整合素α_vβ_3药物的研究进展显示文摘整合素α_vβ_3是整合素家族中的重要成员,是促进血管生成的关键黏附分子。它在肿瘤细胞膜的外表高效表达,成为肿瘤细胞典型的特异性标志物,有可能成为抗肿瘤药物作用的靶点。本文对整合素α_vβ_3拮抗剂治疗肿瘤的研究进行综述。 | 刘莉 丁丽君 | 2017 | 中国新药与临床杂志2017，36，9： | 4 |
| 2 | Fluorescent silicon nanoparticles-based nanotheranostic agents for rapid diagnosis and treatment of bacteria-induced keratitis显示文摘Recommended as a medical emergency,infectious keratitis with an acute and rapid disease progression can lead to serious damage of vision and even blindness.Herein,we present a kind of theranostic agents,which are made of vancomycin(Van)-modified fluorescent silicon nanoparticles(SiNPs-Van),enabling rapid and non-invasive diagnosis and treatment of Gram-positive bacteria-induced keratitis in a simultaneous manner.Typically,the resultant SiNPs-Van nanoagents have an ability of imaging bacteria in a short time both in vitro(5 min)and in vivo(10 min),making them an efficacious diagnostic agent for the detection of bacterial keratitis.In addition,the SiNPs-Van feature distinct antimicrobial activity,with superior activity of 92.5%at a concentration of 0.5 ng/mL against Staphylococcus aureus(S.aureus);comparatively,the antimicrobial rate of free vancomycin is 23.3%at the same concentration.We further explore the SiNPs-Van agents as eye drops for therapy of S.aureus-induced bacterial keratitis on rat model.Represented by slit-lamp scores,the keratitis severity of SiNPs-Van-treated corneas is 3.4,which is 59.6%and 77.3%slighter than vancomycin-(8.2 score)and PBS-treated corneas(15.0 score),respectively.The infected corneas recover to normal(1 score)after 7-d of SiNPs-Van treatment.Above results suggest that the SiNPs-Van could serve as a new kind of high-quality nanotheranostic agents,especially suitable for simultaneous diagnosis and therapy of Gram-positive bacteria keratitis. | Lu Zhang Xiaoyuan Ji Yuanyuan Su Xia Zhai Hua Xu Bin Song Airui Jiang Daoxia Guo Yao He | 2021 | Nano Research2021，14，1： | 2 |
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