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| 1 | Aquaporins:Their role in cholestatic liver disease显示文摘This review focuses on current knowledge on hepato-cyte aquaporins(AQPs)and their significance in bile formation and cholestasis.Canalicular bile secretion results from a combined interaction of several solute transporters and AQP water channels that facilitate water flow in response to the osmotic gradients created. During choleresis,hepatocytes rapidly increase their canalicular membrane water permeability by modulating the abundance of AQP8.The question was raised as to whether the opposite process,i.e.a decreased canalicular AQP8 expression would contribute to the development of cholestasis.Studies in several experimental models of cholestasis,such as extrahepatic obstructive cholestasis,estrogen-induced cholestasis, and sepsis-induced cholestasis demonstrated that the protein expression of hepatocyte AQP8 was impaired. In addition,biophysical studies in canalicular plasma membranes revealed decreased water permeability associated with AQP8 protein downregulation.The combined alteration in hepatocyte solute transporters and AQP8 would hamper the efficient coupling of osmotic gradients and canalicular water flow.Thus cholestasis may result from a mutual occurrence of impaired solute transport and decreased water permeability. | Guillermo L Lehmann Maria C Larocca Leandro R Soria Raúl A Marinelli | 2008 | World Journal of Gastroenterology2008，14，46： | 8 |
| 2 | Efficacy and safety of once- weekly bortezomib in multiple myeloma patients 显示文摘 | Bringhen S Larocca A Rossi D | 2010 | Blood2010，116，23： | 1 |
| 3 | Efficacy and safety of once-weekly bortezomib in multiple myeloma patients 显示文摘 | Bringhen S Larocca A Rossi D | 2010 | Blood2010，116，23： | 1 |
| 4 | The water channel aquaporin-8 is mainly intracellular in rat hepatocytes,and its plasma membrane insertion is stimulated by cyclic AMP显示文摘 | Garcia F Kierbel A Larocca MC | 2001 | J Biol Chem2001，276，12： | 1 |
| 5 | Complete response correlates with long-term progression-free and overall survival in elderly myeloma treated with novel agents: analysis of 1175 patients显示文摘 | Gay F Larocca A Wijermans P | 2011 | Blood2011，117，11： | 1 |
| 6 | Current treatment strategies with lenalidomide in multiple myeloma and future perspectives 显示文摘 | Larocca A Cavallo F Mina R | 2012 | Future Oncol2012，8，10： | 1 |
| 7 | Complete response correlates with long-term progression-free and overall survival in elderly myeloma treated with novel agents: analysis of 1175patients 显示文摘 | Gay F Larocca A Wijermans P | 2011 | Bloodl2011，117，11： | 1 |
| 8 | Efficacy and safety of once -weekly bortezomib in multiple myeloma patients 显示文摘 | Bringhen S Larocca A Rossi D | 2010 | Blood2010，116，： | 1 |
| 9 | Toughening of poly(butylene terephthalate ) by AES lerpolymer 显示文摘 | LAROCCA N M HAGE Jr E PESSAN L A | 2004 | Polymer2004，45，： | 1 |
| 10 | Translational evidence that impaired autophagy contributes to arterial ageing 显示文摘 | LaRocca TJ Henson GD Thorburn A | 2012 | J Physiol2012，590，14： | 1 |
| 11 | Expression profile of MUM1/IRF4, BCL 6, and CD138/syndecan-1 defines novel histogenetic subsets of human immunodeficiency virus related lymphomas显示文摘 | Carbone A Gloghini A Larocca LM | 2001 | Blood2001，97，3： | 1 |
| 12 | The water channel aquaporin-8 is mainly intracellular in rat hepatocytes,and its plasma membrane insertion is stimulated by cyclic AMP显示文摘 | García F Kierbel A Larocca MC | 2001 | Biol Chem2001，76，12： | 1 |
| 13 | Toughening of poly (butylene-terephthalate) by AES terpolymer显示文摘 | LAROCCA N M HAGE E PESSAN L A | | 0，，15： | 1 |
| 14 | Current treatment strategies with lenalidomide in multiple mye-loma and future perspectives 显示文摘 | Larocca A Cavallo F blina R | 2012 | Future Oncol2012，8，10： | 1 |
| 15 | The molecular and phenotypic profile of primary nervous system lymphoma identifies distinct categories of the disease and is consistent with histogenetic derivation from germinal center-related B cells显示文摘 | Larocca LM Capello D Rinelli A | 1998 | Blood1998，92，3： | 1 |
| 16 | Current treatment strategies with lenalidomide in multiple myeloma and future perspectives 显示文摘 | Larocca A Cavallo F Mina R | 2012 | Future Oncol2012，8，10： | 1 |
| 17 | Natural history of small gallbladder polyps is benign: evidence from a clinical and pathogenetic study 显示文摘 | Colecchia A Larocca A Scaioli E | 2009 | Am J Gastroenterol2009，104，： | 1 |
| 18 | Natural history of small gallbladder polyps is benign: evidence from a clinical and path- ogenetic study 显示文摘 | Colecchia A Larocca A Scaioli E | 2009 | Am J Gastroenterol2009，104，3： | 1 |
| 19 | Complete response correlates withlong-term progression-free and overallsurvival in elderly myeloma treatedwith novel agents : analysis of 1175patients显示文摘 | Gay F Larocca A Wijermans P etal | 2011 | Blood2011，117，11： | 1 |
| 20 | Emcacy and safety of once - weekly bortezomib in multiple myeloma patients 显示文摘 | Bringhen S Larocca A Rossi D | 2010 | Blood2010，116，： | 1 |
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