|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Antimicrobial resistance in Acinetobacter baumannii : From bench to bedside显示文摘Acinetobacter baumannii(A. baumannii) is undoubtedly one of the most successful pathogens in the modern healthcare system. With invasive procedures, antibiotic use and immunocompromised hosts increasing in recent years, A. baumannii has become endemic in hospitals due to its versatile genetic machinery, which allows it to quickly evolve resistance factors, and to its remarkable ability to tolerate harsh environments. Infections and outbreaks caused by multidrugresistant A. baumannii(MDRAB) are prevalent and have been reported worldwide over the past twenty or more years. To address this problem effectively, knowledge of species identification, typing methods, clinical manifestations, risk factors, and virulence factors is essential. The global epidemiology of MDRAB is monitored by persistent surveillance programs. Because few effective antibiotics are available, clinicians often face serious challenges when treating patients with MDRAB. Therefore, a deep understanding of the resistance mechanisms used by MDRAB can shed light on two possible strategies to combat the dissemination of antimicrobial resistance: stringent infection control and antibiotic treatments, of which colistin-based combination therapy is the mainstream strategy. However, due to the current unsatisfying therapeutic outcomes, there is a great need to develop and evaluate the efficacy of new antibiotics and to understand the role of other potential alternatives, such as antimicrobial peptides, in the treatment of MDRAB infections. | Ming-Feng Lin Chung-Yu Lan | 2014 | World Journal of Clinical Cases2014，2，12： | 55 |
| 2 | Peripheral T-lymphocyte subpopulations in different clinical stages of chronic HBV infection correlate with HBV load显示文摘AIM: To characterize the peripheral T-cell subpopulation profiles and their correlation with hepatitis B virus (HBV) replication in different clinical stages of chronic HBV infection.METHODS: A total of 422 patients with chronic HBV infection were enrolled in this study. The patients were divided into three stages: immune-tolerant stage, immune active stage, and immune-inactive carrier stage. Composition of peripheral T-cell subpopulations was determined by flow cytometry. HBV markers were detected by enzyme-linked immunosorbent assay. SerumHBV DNA load was assessed by quantitative real-time polymerase chain reaction.RESULTS: CD8+ T-cells were significantly higher in patients at the immune-tolerant stage than in patients at the immune-active and -inactive carrier stages (36.87 ± 7.58 vs 34.37 ± 9.07, 36.87 ± 7.58 vs 28.09 ± 5.64, P < 0.001). The peripheral blood in patients at the immune-tolerant and immune active stages contained more CD8+ T-cells than CD4+ T-cells (36.87 ± 7.58 vs 30.23 ± 6.35, 34.37 ± 9.07 vs 30.92 ± 7.40, P < 0.01), whereas the peripheral blood in patients at the immune-inactive carrier stage and in normal controls contained less CD8+ T-cells than CD4+ T-cells (28.09 ± 5.64 vs 36.85 ± 6.06, 24.02 ± 4.35 vs 38.94 ± 3.39, P < 0.01). ANOVA linear trend test showed that CD8+ T-cells were signif icantly increased in patients with a high viral load (39.41 ± 7.36, 33.83 ± 7.50, 31.81 ± 5.95 and 26.89 ± 5.71, P < 0.001), while CD4+ T-cells were signif icantly increased in patients with a low HBV DNA load (37.45 ± 6.14, 33.33 ± 5.61, 31.58 ± 6.99 and 27.56 ± 5.49, P < 0.001). Multiple regression analysis displayed that log copies of HBV DNA still maintained its highly signif icant coefficients for T-cell subpopulations, and was the strongest predictors for variations in CD3+, CD4+ and CD8+ cells and CD4+/CD8+ ratio after adjustment for age at HBV-infection, maternal HBV-infection status, presence of hepatitis B e antigen and HBV mutation.CONCLUSION: Differences in peripheral T-cell subpopulation profi les can be found in different clinical stages of chronic HBV infection. T-cell impairment is signifi cantly associated with HBV load. | Jing You Lin Zhuang Yi-Feng Zhang Hong-Ying Chen Hutcha Sriplung Alan Geater Virasakdi Chongsuvivatwong Teerha Piratvisuth Edward McNeil Lan Yu Bao-Zhang Tang .lun-Hua Huang | 2009 | World Journal of Gastroenterology2009，15，27： | 39 |
| 3 | Helicobacter pylori infection generated gastric cancer through p53-Rb tumor-suppressor system mutation and telomerase reactivation显示文摘AIM: To investigate the relationship between Helicobacterpylori (H. pylori) infection and the expressions of the p53,Rb, c-myc, bcl-2 and hTERT mRNA in a series of diseasesfrom chronic gastritis (CG), intestinal metaplasia type Ⅰ or Ⅱ(IMⅠ-Ⅱ), intestinal metaplasia type Ⅲ (IMⅢ), mild or modestdysplasia (DysⅠ-Ⅱ), severe dysplasia (DysⅢ) to gastric cancer(GC) and to elucidate the mechanism of gastriccarcinogenesis relating to H.pyloriinfection.METHODS: 272 cases between 1998 and 2001 wereavailable for the study including 42 cases of CG, 46 cases ofIMⅠ-Ⅱ, 25 cases of IMⅢ, 48 cases of DysⅠ-Ⅱ, 27 cases ofDysⅢ, 84 cases of GC.-H. pyloriinfection and the expressionsof p53, Rb, c-myc, bcl-2 were detected by means ofstreptavidin-peroxidase (SP) immunohistochemical method.HTERT mRNA was detected byin situ hybridization(ISH).RESULTS: The expressions of p53, Rb, c-myc, hTERT mRNAand bcl-2 were higher in the GC than in CG, IN, Dys. Theexpression of c-myc was higher in IMⅢ with-H.pyloriinfection(10/16) than that without infection (1/9) and the positive ratein DysⅠ-Ⅱ and DysⅢ with-H.pyloriinfection was 18/30 and 13/17, respectively, higher than that without infection (4/18 and3/10, respectively). In our experiment mutated p53 had noassociation with H.pyloriinfection, theexpression of Rb wasassociated with-H. pyloriinfection in GC, but the p53-Rb tumor-suppressor system abnormal in DysⅠ-Ⅱ cases, DysⅢⅡ and GCcases with H. pyloriinfection was 21/30, 15/17 and 48/48respecively, higher than non-infection groups (4/18, 3/10, 28/36). Furthermore the level of hTERT mRNA in GC with H. pyloriinfection (47/48) was higher than that without infection (30/36), however the relationship between bcl-2 and H. pyloriwasonly in IMⅢ. C-myc had a close association with hTERT mRNAin DysⅢ and GC (P=0.0 253,0.0 305 respectively).CONCLUSION: In the gastric carcinogenesis, H. pylorimightcause the severe imbalance of proliferation and apoptosisin the precancerous lesions (IMⅢ and GysⅢ) first, leadingto p53-Rb tumor-suppressor system mutation and telomerasereactivation, and finally causes gastric cancer. | Jing Lan Yong-Yan Xiong Yi-Xian Lin Bi-Cheng Wang Ling-Ling Gong Hui-Sen Xu Guang-Song Guo Department of Pathology,Zhongnan Hospital,Wuhan University,Wuhan city 430071,Hubei Province,China | 2003 | World Journal of Gastroenterology2003，9，1： | 39 |
| 4 | Does Helicobacter pylori infection play a role in iron deficiency anemia? A meta-analysis显示文摘AIM:To perform a meta-analysis of observational studies and randomized controlled trials(RCTs)on the association between Helicobacter pylori(H.pylori)and iron deficiency anemia(IDA).METHODS:A defined search strategy was used to search Medline,Embase,the Cochrane Library,Clinical Trials,Cochrane Central Register of Controlled Trials,Premedline and Healthstar.Odds ratio(OR)was used to evaluate observational epidemiology studies,and weighted mean difference(WMD)was used to demonstrate the difference between control and intervention groups.RESULTS:Fifteen observational studies and 5 RCTs were identified and used for calculation.The pooled OR for observational studies was 2.22(95%CI:1.52-3.24,P<0.0001).The WMD for hemoglobin(HB) was 4.06 g/L(95%CI:-2.57-10.69,P=0.01),and the WMD for serum ferritin(SF)was 9.47μg/L(95%CI:-0.50-19.43,P<0.0001).Results were heterogeneous for all comparisons.CONCLUSION:This meta-analysis on observational studies suggests an association between H.pylori and IDA.In RCTs,eradication of H.pylori can improve HB and SF levels but not significantly. | Qu, Xin-Hua Huang, Xiao-Lu Xiong, Ping Zhu, Cui-Ying Huang, You-Liang Lu, Lun-Gen Sun, Xu Rong, Lan Zhong, Liang Sun, Da-Yu Lin, Hai Cai, Ming-Ci Chen, Zhi-Wei Hu, Bing Wu, Lian-Ming Jiang, Yi-Bin Yan, Wei-Li | 2010 | World Journal of Gastroenterology2010，16，7： | 34 |
| 5 | Effect of viral load on T-lymphocyte failure in patients with chronic hepatitis B显示文摘AIM: To investigate peripheral T-lymphocyte sub-population profile and its correlation with hepatitis B virus (HBV) replication in patients with chronic hepatitis B (CHB).METHODS: Distribution of T-lymphocyte subpopulations in peripheral blood was measured by flow cytometry in 206 CHB patients. HBV markers were detected with ELISA. Serum HBV DNA load was assessed with quantitative real-time polymerase chain reaction (PCR). The relationship between HBV replication and variation in peripheral T-cell subsets was analyzed.RESULTS: CHB patients had significantly decreased CD3+ and CD4+ cells and CD4+/CD8+ ratio, and increased CD8+ cells compared with uninfected controls (55.44 ± 12.39 vs 71.07 ± 4.76, 30.92 ± 7.48 vs 38.94 ± 3.39, 1.01 ± 0.49 vs 1.67 ± 0.33, and 34.39 ± 9.22 vs 24.02 ± 4.35; P < 0.001, respectively). Univariate analysis showed a similar pattern of these parameters was significantly associated with high viral load, presence of serum hepatitis B e antigen (HBeAg) expression, liver disease severity, history of maternal HBV infection, and young age at HBV infection, all with P < 0.01. There was a significant linear relationship between viral load and these parameters of T-lymphocyte subpopulations (linear trend test P < 0.001). There was a negative correlation between the levels of CD3+ and CD4+ cells and CD4+/CD8+ ratio and serum level of viral load in CHB patients (r = -0.68, -0.65 and -0.75, all P < 0.0001), and a positive correlation between CD8+ cells and viral load (r = 0.70, P < 0.0001). There was a significant decreasing trend in CD3+ and CD4+ cells and CD4+/CD8+ ratio with increasing severity of hepatocyte damage and decreasing age at HBV infection (linear trend test P < 0.01). In multiple regression (after adjustment for age at HBV infection, maternal HBV infection status and hepatocyte damage severity) log copies of HBV DNA maintained a highly significant predictive coefficient on T-lymphocyte subpopulations, and was the strongest predictor of variation in CD3+, CD4+, CD8+ cells and CD4+/CD8+ ratio. However, the effect of HBeAg was not significant.CONCLUSION: T-lymphocyte failure was signifi-cantly associated with viral replication level. The substantial linear dose-response relationship and strong independent predictive effect of viral load on T-lymphocyte subpopulations suggests the possibility of a causal relationship between them, and indicates the importance of viral load in the pathogenesis of T cell hyporesponsiveness in these patients. | Jing You Hutcha Sriplung Alan Geater Virasakdi Chongsuvivatwong Lin Zhuang Hong-Ying Chen Lan Yu Bao-Zhang Tang Jun-Hua Huang | 2008 | World Journal of Gastroenterology2008，14，7： | 30 |
| 6 | The combined effects of the ENSO and the Arctic Oscillation on the winter climate anomalies in East Asia显示文摘With the warm/cold phases of the El Ni o and Southern Oscillation (ENSO) as a background, the impacts of monthly variation in the Arctic Oscillation (AO) on the winter climate anomalies in East Asia are studied with the NCEP/DOE Reanalysis 2 data and the Chinese station data regarding temperature and rainfall. The combined effects of ENSO and the AO indicate that the winter climate anomalies are mainly influenced by the AO in northern China and the ENSO in southern China, when an El Ni o couples with a negative AO month or a La Ni a couples with a positive AO month. These climate anomalies in China are consistent with the mechanisms proposed in previous studies. However, most of China presents a different pattern of climate anomalies if an El Ni o couples with a positive AO month or a La Ni a couples with a negative AO month, with the exception of the temperature anomalies in northern China, which are still affected dominantly by the AO. Further analysis suggests that the causes are attributed to the differences in both the stratosphere-troposphere interaction and the extratropics-tropics interaction. In the former cases, zonal symmetric circulation prevails in the winter and the extratropics-tropics interaction is weakened. Thus, the influences of the ENSO and the AO on the East Asian climate mainly present linear combination effects. On the contrary, an annular mode of atmospheric circulation is not favored in the latter cases and the extratropics-tropics interaction is strong. Hence, the combined effects of the ENSO and the AO on the winter climate in East Asia present nonlinear characteristics. | CHEN Wen LAN XiaoQing WANG Lin MA Yin | 2013 | Chinese Science Bulletin2013，58，12： | 30 |
| 7 | Type Ⅰ and type Ⅱ Helicobacter pylori infection status and their impact on gastrin and pepsinogen level in a gastric cancer prevalent area显示文摘BACKGROUND Type I Helicobacter pylori(H.pylori)infection causes severe gastric inflammation and is a predisposing factor for gastric carcinogenesis.However,its infection status in stepwise gastric disease progression in this gastric cancer prevalent area has not been evaluated;it is also not known its impact on commonly used epidemiological gastric cancer risk markers such as gastrin-17(G-17)and pepsinogens(PGs)during clinical practice.AIM To explore the prevalence of type I and type II H.pylori infection status and their impact on G-17 and PG levels in clinical practice.METHODS Thirty-five hundred and seventy-two hospital admitted patients with upper gastrointestinal symptoms were examined,and 523 patients were enrolled in this study.H.pylori infection was confirmed by both 13C-urea breath test and serological assay.Patients were divided into non-atrophic gastritis(NAG),nonatrophic gastritis with erosion(NAGE),chronic atrophic gastritis(CAG),peptic ulcers(PU)and gastric cancer(GC)groups.Their serological G-17,PG I and PG II values and PG I/PG II ratio were also measured.RESULTS A total H.pylori infection rate of 3572 examined patients was 75.9%,the infection rate of 523 enrolled patients was 76.9%,among which type I H.pylori infection accounted for 72.4%(291/402)and type II was 27.6%;88.4%of GC patients were H.pylori positive,and 84.2%of them were type I infection,only 11.6%of GC patients were H.pylori negative.Infection rates of type I H.pylori in NAG,NAGE,CAG,PU and GC groups were 67.9%,62.7%,79.7%,77.6%and 84.2%,respectively.H.pylori infection resulted in significantly higher G-17 and PG II values and decreased PG I/PG II ratio.Both types of H.pylori induced higher G-17 level,but type I strain infection resulted in an increased PG II level and decreased PG I/PG II ratio in NAG,NAGE and CAG groups over uninfected controls.Overall PG I levels showed no difference among all disease groups and in the presence or absence of H.pylori;in stratified analysis,its level was increased in GC and PU patients in H.pylori and type I H.pylori-positive groups.CONCLUSION Type I H.pylori infection is the major form of infection in this geographic region,and a very low percentage(11.6%)of GC patients are not infected by H.pylori.Both types of H.pylori induce an increase in G-17 level,while type I H.pylori is the major strain that affects PG I and PG IIs level and PG I/PG II ratio in stepwise chronic gastric disease.The data provide insights into H.pylori infection status and indicate the necessity and urgency for bacteria eradication and disease prevention in clinical practice. | Lin Yuan Jun-Bo Zhao Ying-Lei Zhou Ya-Bin Qi Qiong-Ya Guo Hai-Hui Zhang Muhammad Noman Khan Ling Lan Chang-He Jia Yan-Rui Zhang Song-Ze Ding | 2020 | World Journal of Gastroenterology2020，26，25： | 29 |
| 8 | Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress显示文摘癌症房间以他们的能力著名给新陈代谢的小径换新电线在各种各样的压力条件下面支持幸存和增长。尽管在肝生产了,酉同类身体没在正常的成年的肝房间被消费。我们这里发现酉同类分解代谢或 ketolysis 在 hepatocellular 被重新激活在营养剥夺条件下面的癌(HCC ) 房间。机械学地, 3-oxoacid CoA-transferase 1 (OXCT1 ) ,其表情在正常的成年的肝纸巾被压制的限制率的 ketolytic 酶,被浆液重新导致被触发饥饿的 mTORC2-AKT-SP1 在 HCC 房间发信号。而且,我们观察到在 HCC 的那提高的 ketolysis 为 AMPK 激活的压抑是批评的并且保护 HCC 房间免受过多的 autophagy 的伤害,从而提高肿瘤生长。重要地,临床的 HCC 样品的分析表明那增加的 OXCT1 表情预言更高耐心的死亡。一起拿,我们这里揭开剥夺营养的 HCC 房间为精力由采用酉同类身体的新奇新陈代谢的改编供应和癌症前进。 | De Huang Tingting Li Lin Wang Long Zhang Ronghui Yan Kui Li Songge Xing Gongwei Wu Lan Hu Weidong Jia Sheng-Cai Lin Chi V Dang Libing Song Ping Gao Huafeng Zhang | 2016 | Cell Research2016，26，10： | 27 |
| 9 | Measure theory of statistical convergence显示文摘The question of establishing measure theory for statistical convergence has been moving closer to center stage, since a kind of reasonable theory is not only fundamental for unifying various kinds of statistical convergence, but also a bridge linking the studies of statistical convergence across measure theory, integration theory, probability and statistics. For this reason, this paper, in terms of subdifferential, first shows a representation theorem for all finitely additive probability measures defined on the σ-algebra A of all subsets of N, and proves that every such measure can be uniquely decomposed into a convex combination of a countably additive probability measure and a statistical measure (i.e. a finitely additive probability measure μ with μ(k) = 0 for all singletons {k}). This paper also shows that classical statistical measures have many nice properties, such as: The set S of all such measures endowed with the topology of point-wise convergence on A forms a compact convex Hausdorff space; every classical statistical measure is of continuity type (hence, atomless), and every specific class of statistical measures fits a complementation minimax rule for every subset in N. Finally, this paper shows that every kind of statistical convergence can be unified in convergence of statistical measures. | CHENG LiXin LIN GuoChen LAN YongYi LIU Hui | 2008 | Science China Mathematics2008，51，12： | 26 |
| 10 | Microbial flocculant and its application in environmental protection显示文摘1IntroductionAlotofvariedflocculantshavebeenusedinwastewatertreatment,dredgingdownstreamprocessingandsomeindustrialfieldincl... | Zhang Tong, Lin Zhe Department of Environmental Engineering, East China University of Science and Technology, Shanghai 200237, China Zhu Huai lan Department of Environmental Science, East China Normal University, Shanghai 200062, China | 1999 | Journal of Environmental Sciences1999，11，1： | 25 |
| 11 | Expenditure and financial burden for the diagnosis and treatment of colorectal cancer in China:a hospital.based,multicenter,cross-sectional survey显示文摘Background: The increasing prevalence of colorectal cancer(CRC) in China and the paucity of information about relevant expenditure highlight the necessity of better understanding the financial burden and effect of CRC diagnosis and treatment. We performed a survey to quantify the direct medical and non-medical expenditure as well as the resulting financial burden of CRC patients in China.Methods: We conducted a multicenter, cross-sectional survey in 37 tertiary hospitals in 13 provinces across China between 2012 and 2014. Each enrolled patient was interviewed using a structured questionnaire. All expenditure data were inflated to the 2014 Chinese Yuan(CNY; 1 CNY = 0.163 USD). We quantified the overall expenditure and financial burden and by subgroup(hospital type, age at diagnosis, sex, education, occupation, insurance type, household income, clinical stage, pathologic type, and therapeutic regimen). We then performed generalized linear modeling to determine the factors associated with overall expenditure.Results: A total of 2356 patients with a mean age of 57.4 years were included, 57.1 % of whom were men; 13.9% of patients had stage I cancer; and the average previous-year household income was 54,525 CNY.The overall average direct expenditure per patient was estimated to be 67,408 CNY, and the expenditures for stage Ⅰ, Ⅱ, Ⅲ, and Ⅳ disease were 56,099 CNY, 59,952 CNY, 67,292 CNY, and 82,729 CNY, respectively. Non-medical expenditure accounted for 8.3%of the overall expenditure. The 1-year out-of-pocket expenditure of a newly diagnosed patient was 32,649 CNY, which accounted for 59.9% of their previous-year household income and caused 75.0% of families to suffer an unmanageable financial burden. Univariate analysis showed that financial burden and overall expenditure differed in almost all subgroups(P < 0.05), except for sex. Multivariate analysis showed that patients who were treated in specialized hospitals and those who were diagnosed with adenocarcinoma or diagnosed at a later stage were likely to spend more,whereas those with a lower household income and those who underwent surgery spent less(all P < 0.05).Conclusions: For patients in China, direct expenditure for the diagnosis and treatment of CRC seemed catastrophic,and non-medical expenditure was non-ignorable. The financial burden varied among subgroups, especially among patients with different clinical stages of disease, which suggests that, in China, CRC screening might be cost-effective. | Hui-Yao Huang Ju-Fang Shi Lan-Wei Guo Ya-Na Bai Xian-Zhen Liao Guo-iangLiu A-Yan Mao Jian-Song Ren Xiao-Jie Sun Xin-Yu Zhu Le Wang Bing-Bing Song Ling-Bin Du Lin Zhu Ji-Yong Gong Qi Zhou Yu-Qin Liu Rong Cao Ling Mai Li Lan Xiao-Hua Sun Ying Ren Jin-Yi Zhou Yuan-Zheng Wang Xiao Qi Pei-An Lou Dian Shi Ni Li Kai Zhang Jie He Min Dai | 2017 | Chinese Journal of Cancer2017，36，8： | 25 |
| 12 | Combined monitoring of evoked potentials during microsurgery for lesions adjacent to the brainstem and intracranial aneurysms显示文摘在外科期间监视的背景 Neurophysiologic 是阻止永久神经病学的损害源于外科的操作。改进 intraoperative neuromonitoring 的精确性和敏感, transcranial 监视电的刺激马达联合唤起了潜力( TES-MEPs ), somatosensory 唤起了潜力( SSEP )和 brainstem 听觉的唤起的潜力( BAEP )为邻近与 SSEP 联合 TES-MEPs 监视的 brainstem 和 intracranial aneurysms.Methods 的损害在 microsurgery 被尝试象 intracranial 一样与邻近 brainstem 的损害在 68 个连续病人被尝试一在他们之中, 31 个病人(31 个手术, 28 个以后的头部的窝肿瘤, 3 个以后的发行量动脉瘤) 也受到 BAEP 监视。监视结果和临床的结果的关联是 68 个病人的唤起的潜力(EP ) 监视联合在 64 被做的学习 prospectively.Results (94.1%) 。监视的 MEP 为 4 个病人(5.9%) 是不可能的。没有复杂并发症在在所有病人监视联合期间被观察。(66.2%) 在 45, 68 个病人,, EP 是稳定的,并且他们是神经病学地未经触动的。马达机能障碍被 MEP 在 4 在 8 个病人,在 5 的 SSEP ,和 BAEP 检测, respectively.Conclusions A 结束关系在手术后的马达功能之间存在, TES-MEPs monitoring.TES-MEPs 的结果在检测马达机能障碍,而是联合 EP 比 SSEP 和 BAEP 优异用作一只保险箱,为马达神经系统的功能监视的 intraoperative 的有效、侵略的方法。为邻近 brainstem 和 intracranial 动脉瘤的损害在 microsurgery 期间联合 EP 监视可以检测潜在地危险的演习并且改进随后的过程的安全。 | KANG De-zhi WU Zan-yi LAN Qing YU Liang-hong LIN Zhang-ya WANG Chen-yang LIN Yuan-xiang | 2007 | Chinese Medical Journal2007，，18： | 20 |
| 13 | Repurposing vitamin D for treatment of human malignancies via targeting tumor microenvironment显示文摘Tumor cells along with a small proportion of cancer stem cells exist in a stromal microenvironment consisting of vasculature, cancer-associated fibroblasts, immune cells and extracellular components.Recent epidemiological and clinical studies strongly support that vitamin D supplementation is associated with reduced cancer risk and favorable prognosis. Experimental results suggest that vitamin D not only suppresses cancer cells, but also regulates tumor microenvironment to facilitate tumor repression. In this review, we have outlined the current knowledge on epidemiological studies and clinical trials of vitamin D. Notably, wesummarized and discussed the anticancer action of vitamin D in cancer cells, cancer stem cells and stroma cells in tumor microenvironment, providing a better understanding of the role of vitamin D in cancer. We presently re-propose vitamin D to be a novel and economical anticancer agent. | Xu Wu Wei Hu Lan Lu Yueshui Zhao Yejiang Zhou Zhangang Xiao Lin Zhang Hanyu Zhang Xiaobing Li Wanping Li Shengpeng Wang Chi Hin Cho Jing Shen Mingxing Li | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 20 |
| 14 | Dynamic and Static Recrystallization Behavior of Low Carbon High Niobium Microalloyed Steel显示文摘The recrystallization behavior of a low carbon high niobium microalloyed steel was investigated using continuous and interrupted hot compression tests.The results showed that the initiation of dynamic recrystallization(DRX)could be detected from inflection in the plot of the strain hardening rate against stress regardless of the stress peak appearance.According to the Zener-Hollomon parameter equation,the activity energy of DRX(Qdef)was obtained and a new modified expression calculating Qdef was proposed in consideration of the chemical composition of experimental steel.Applying the 2% offset method,the static softening fraction was determined.The graphic representation of the softening fraction vs interruption time gave the information about the non-static recrystallization temperature(about 1000 ℃)and the relationship of precipitation-time-temperature.Static recrystallization kinetics followed the Avrami's law at high deformation temperature,and different values of the exponent m were given to illustrate the effect of niobium element on static recrystallization at different deformation temperatures. | LAN Liang yun QIU Chun lin ZHAO De-wen GAO Xiu hua DU Lin-xiu | 2011 | Journal of Iron and Steel Research(International)2011，18，1： | 16 |
| 15 | NMR-based damage characterisation of backfill material in host rock under dynamic loading显示文摘It is not uncommon that backfill material used in underground mining being exposed to repetitive dynamic stresses induced by blasting operations or rockburst events. Understanding the strength and fracture evolution of backfilled stopes is critical to maintain the long-term stope stability and ensure safe mining activities. This paper aims to study the damage evolution of the backfill material and its host rock behaviour under three-dimensional(3D) dynamic loading. Using a true-triaxial testing machine, multiple samples of backfill material enclosed by country rock were fabricated and tested under various dynamic loadings with different true-triaxial confining stress conditions. In addition, the nuclear magnetic resonance(NMR) measurement was conducted on the samples before and after exerting static and dynamic loading to obtain their porosity distribution changes. The experiment results suggested that with the increase of the dynamic loading, the porosity of the backfill sample goes through a two-stage process,which shows a slightly linear decrease and then followed by an exponential increase. The research findings can help understand the damage mechanism and fracture development of backfilled stopes and its host rock in deep underground mines, which are constantly subject to the combination of 3D static confining stress and dynamic loading. | Binglei Li Jiquan Lan Guangyao Si Guopeng Lin Liuqing Hu | 2020 | International Journal of Mining Science and Technology2020，30，3： | 16 |
| 16 | Genome sequences of horticultural plants:past,present,and future显示文摘Horticultural plants play various and critical roles for humans by providing fruits,vegetables,materials for beverages,and herbal medicines and by acting as ornamentals.They have also shaped human art,culture,and environments and thereby have influenced the lifestyles of humans.With the advent of sequencing technologies,there has been a dramatic increase in the number of sequenced genomes of horticultural plant species in the past decade.The genomes of horticultural plants are highly diverse and complex,often with a high degree of heterozygosity and a high ploidy due to their long and complex history of evolution and domestication.Here we summarize the advances in the genome sequencing of horticultural plants,the reconstruction of pan-genomes,and the development of horticultural genome databases.We also discuss past,present,and future studies related to genome sequencing,data storage,data quality,data sharing,and data visualization to provide practical guidance for genomic studies of horticultural plants.Finally,we propose a horticultural plant genome project as well as the roadmap and technical details toward three goals of the project. | Fei Chen Yunfeng Song Xiaojiang Li Junhao Chen Lan Mo Xingtan Zhang Zhenguo Lin Liangsheng Zhang | 2019 | Horticulture Research2019，6，1： | 16 |
| 17 | A human herpesvirus miRNA attenuates interferon signaling and contributes to maintenance of viral latency by targeting IKKε显示文摘类型我发信号的干扰素(IFN ) 是调停的主要反应抗病毒的天生的免疫。IFN 抄写依赖于抄写因素 IRF3/IRF7 和 NF-B 的激活。许多病毒的蛋白质作为能够防碍 IFN 发信号从主人便于避免被显示出天生的有免疫力的反应。这里,我们报导那病毒的 miRNA, miR-K12-11,由 Kaposi 的联系肉瘤的 herpesvirus (KSHV ) 编码了为 IFN 通过指向 I-kappa-B kinase epsilon (IKK ) 发信号和行为的调整是批评的。miR-K12-11 的宫外的表示导致了减少的 IKK 表示,当 miR-K12-11 的抑制被发现在感染 KSHV 的房间恢复 IKK 表示时。重要地, miR-K12-11 的表示稀释了由减少的调停 IKK 的 IRF3/IRF7 phosphorylation 并且由禁止刺激基因(ISG ) 的 IKK 依赖的 IFN 的激活发信号的 IFN,允许抗病毒的免疫的 miR-K12-11 抑制。我们的数据建议由 miR-K12-11 指向的 IKK 是 KSHV 利用调制在 KSHV 生命周期期间发信号的 IFN 的重要策略,特别在潜伏。我们也证明 IKK 能与 12-O-tetradecanoylphorbol 13 醋酸盐的处理 synergistically 提高 KSHV 复活。而且, miR-K12-11 的抑制提高了小囊的口炎病毒感染导致的 KSHV 复活。一起拿,我们的调查结果也建议 miR-K12-11 能由指向 IKK 贡献 KSHV 潜伏的维护。 | Deguang Liang Yuan Gao Xianzhi Lin Zhiheng He Qinglan Zhao Qiang Deng Ke Lan | 2011 | Cell Research2011，21，5： | 15 |
| 18 | A GPCR/secretase complex regulates β- and γ-secretase specificity for Aβ production and contributes to AD pathogenesis显示文摘尾 - 地点的 Dysregulation 劈开应用软件的酶(BACE ) 或纬 - secretase 导致异常生产淀粉 -- 尾肽(尾) 并且贡献 Alzheimer 的疾病(广告) 的病原学。自从这些 secretases,调停众多的蛋白质的解朊的处理,因为不可避免的不希望得到的副作用,小成功都没被获得由 secretase 禁止者对待广告。因此,解开具有重要性这些 secretases 的规章的机制。这里,我们证明那未 - opioid 受体(欧洲粪金龟子) 支持由 BACE1 和纬 - 处理尾先锋蛋白质(应用软件) secretase,然而并非槽口, N-cadherin 或 APLP 的。进一步的调查表明那只欧洲粪金龟子与 BACE1 和纬 - secretase 形成建筑群,并且欧洲粪金龟子的激活调停为应用软件 endoproteolysis secretases/receptor 建筑群排序的 co-endocytic。受体的机能障碍延迟 BACE1 和纬 - secretase 并且这样的 endocytosis 尾的生产。一致地,击倒或欧洲粪金龟子的 antagonization 减少 secretase 活动并且改善一个尾病理和 A 尾 - 依赖者行为的赤字,但是不影响在广告模型老鼠处理槽口, N-cadherin 或 APLP。我们的学习不仅揭开为为尾生产调整 secretase 的特性而且建议形成的那干预或 GPCR/secretase 建筑群的 trafficking 的 DOR/secretase 建筑群的形成的分子的机制能对广告导致新策略,潜在地与更少副作用。 | Lin Teng Jian Zhao Feifei Wang Lan Ma Gang Pei | 2010 | Cell Research2010，20，2： | 14 |
| 19 | Analysis of TLR4 and TLR2 polymorphisms in inflammatory bowel disease in a Guangxi Zhuang population显示文摘AIM: To study the polymorphisms of toll-like receptor 4 (TLR4) gene Asp299Gly, Thr399Ile and TLR2 gene Arg753Gln, Arg677Trp and susceptibility to inflammatory bowel disease (IBD) in the Zhuang population from Guangxi, China. METHODS: A case-control study was performed from February 2007 to October 2011 which included 146 Zhuang patients with IBD in the experimental group and 164 healthy Zhuang subjects who acted as the control group. All patients and healthy subjects were from the Guangxi Zhuang Autonomous Region of China. Genomic DNA was extracted from intestinal tissue by the phenol chloroform method. TLR4 gene Asp299Gly, Thr399Ile and TLR2 gene Arg753Gln, Arg677Trp were amplified by polymerase chain reaction (PCR), and then detected by PCR-restriction fragment length polymorphism (RFLP). RESULTS: The TLR4 gene Asp299Gly was digested using Nco Ⅰ restriction enzyme, and a single band of 249 bp was observed which showed that it was a wild type (AA). The TLR4 gene Thr399Ile was digested using Hinf Ⅰrestriction enzyme and only the wild type (CC) was detected. In addition, the TLR2 gene Arg-677Trp was digested using Aci Ⅰ restriction enzyme and only the wild type (CC) was detected. The TLR2 gene Arg753Gln was digested using Pst Ⅰ restriction enzyme. Only the wild type (GG) as a single band of 254 bp was observed during RFLP. Overall, no heterozygous or homozygous single nucleotide polymorphism mutations were found in patients with Crohn's disease and ulcerative colitis both in the TLR4 gene Asp299Gly, Thr399Ile and the TLR2 gene Arg677Trp, Arg753Gln in the Zhuang population from the Guangxi Zhuang Autonomous Region of China. CONCLUSION: The TLR4 gene Asp299Gly, Thr399Ile and TLR2 gene Arg753Gln, Arg677Trp polymorphisms may not be associated with IBD in the Zhuang population from the Guangxi Zhuang Autonomous Region of China. | Lan Chen Mei-Jiao Lin Ling-Ling Zhan Xiao-Ping Lv | 2012 | World Journal of Gastroenterology2012，18，46： | 14 |
| 20 | Sex- and region- specific alterations of basal amino acid and monoamine metabolism in the brain of aquaporin -4 knockout mice显示文摘 | Yi Fan Jing Zhang Xiu - Lan Sun Lin Gao Xiao - Ning Zeng Jian - Hua Ding Cong Cao Ling Niu Gang Hu | 2005 | 中国药理通讯2005，22，4： | 14 |
您所在的机构暂未开通此部分的功能，请联系管理员