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| 1 | Effect of alcohol consumption on liver stiffness measured by transient elastography显示文摘AIM:To determine the evolution of transient elastography(TE) in patients with alcoholic liver disease according to alcohol cessation or continuation.METHODS:We retrospectively selected in our local database all patients who had two TE between June 2005 and November 2010 with chronic alcohol excessive consumption and excluded those with associated cause of liver disease.TE was performed at least one week apart by senior operator.TE examinations with less than ten successful measures or with an interquartile range above 30% were excluded.We retrospectively reviewed file of all patients to include only patient followed up by trained addictologist and for which definite information on alcohol consumption was available.Concomitant biological parameters [aspartate amino transferase(AST),alanine amino transferase and gamma-glutamyl transpeptidase(GGT)] within 4 wk of initial and final TE were recorded.Putative fibrosis score according to initial and final TE were determined with available cut-off for alcoholic liver disease and hepatitis C.Initial and final putative fibrosis score were compared according to alcohol consumption during follow-up.RESULTS:During the study period 572 patients had TE examination for alcoholic liver disease and 79 of them had at least two examinations.Thirty-seven patients met our criteria with a median follow-up of 32.5 wk.At the end of the study,13(35%) were abstinent,and 24(65%) relapsers.Eight patients had liver biopsy during follow-up.TE decreased significantly during follow-up in 85% of abstinent patients [median(range):-4.9(-6.1,-1.9)],leading to a modification of the putative fibrosis stage in 28%-71% of patient according to different cut-off value.In relapsers TE increased in 45% and decreased in 54% of patient.There was no statistical difference between initial and final TE in relapsers.In the overall population,using 22.6 kPa as cut-off for cirrhosis,4 patients had cirrhosis at initial TE and 3 patients had cirrhosis at final TE.Using 19.5 kPa as cut-off for cirrhosis,7 patients had cirrhosis at initial TE and 5 patients had cirrhosis at final TE.Using 12.5 kPa as cut-off for cirrhosis,16 patients had cirrhosis at initial TE and 15 patients had cirrhosis at final TE.Evolution of biological data was in accordance with the relapse or abstinent status:abstinence ratio(duration of abstinence/duration follow-up) was correlated with AST ratio(r =-0.465,P = 0.007) and GGT ratio(r =-0.662,P<0.0001).GGT was correlated with initial(r = 0.488,P = 0.002) and final TE(r = 0.49,P<0.005).Final TE was correlated with AST(r = 0.362,P<0.05).Correlation between TE ratio and AST ratio(r = 0.44,P = 0.01) revealed that TE varied proportionally to AST for all patients irrespective of their alcohol status.The same relationship was observed between TE ratio and GGT ratio(r = 0.65,P<0.0001).Evolution of TE was significantly correlated with the ratio of time of abstinence to observation time(r =-0.387,P = 0.016) and the evolution of liver enzymes.CONCLUSION:TE significantly decreased with abstinence.Results of TE in alcoholic liver disease cannot be interpreted without taking into account alcohol consumption and liver enzymes. | Edouard Bardou-Jacquet Ludivine Legros Draman Soro Marianne Latournerie Anne Guillygomarc'h Caroline Le Lan Pierre Brissot Dominique Guyader Romain Moirand | 2013 | World Journal of Gastroenterology2013，19，4： | 20 |
| 2 | Acoustic radiation force impulse imaging for assessing liver fibrosis in alcoholic liver disease显示文摘AIM: To evaluate the performance of elastography by ultrasound with acoustic radiation force impulse(ARFI) in determining fibrosis stage in patients with alcoholic liver disease(ALD) undergoing alcoholic detoxification in relation to biopsy.METHODS: Eighty-three patients with ALD undergoing detoxification were prospectively enrolled. Each patient underwent ARFI imaging and a liver biopsy onthe same day. Fibrosis was staged according to the METAVIR scoring system. The median of 10 valid ARFI measurements was calculated for each patient.RESULTS: Sixty-nine males and thirteen females(one patient excluded due to insufficient biopsy size) were assessed with a mean alcohol consumption of 132.4 ± 128.8 standard drinks per week and mean cumulative year duration of 17.6 ± 9.5 years. Sensitivity and specificity were respectively 82.4%(0.70-0.95) and 83.3%(0.73-0.94)(AUROC = 0.87) for F ≥ 2 with a cut-off value of 1.63m/s; 82.4%(0.64-1.00) and 78.5%(0.69-0.89)(AUROC = 0.86) for F ≥ 3 with a cut-off value of 1.84m/s; and 92.3%(0.78-1.00] and 81.6%(0.72-0.90)(AUROC = 0.89) for F = 4 with a cut-off value of 1.94 m/s.CONCLUSION: ARFI is an accurate, non-invasive and easy method for assessing liver fibrosis in patients with ALD undergoing alcoholic detoxification. | Anita Kiani Vanessa Brun Fabrice Lainé Bruno Turlin Jeff Morcet Sophie Michalak Antonia Le Gruyer Ludivine Legros Edouard Bardou-Jacquet Yves Gandon Romain Moirand | 2016 | World Journal of Gastroenterology2016，22，20： | 6 |
| 3 | Accumulation of Flavonoids in an ntra ntrb Mutant Leads to Tolerance to UV-C显示文摘NADPH 依赖的 thioredoxin reductases (NTR ) 是决定 thioredoxins 的氧化还原作用状态的关键规章的酶。有二基因,把 NTR (NTRA 和 NTRB ) 编码为 Arabidopsis 染色体,编码 cytosolic 的各个和 mitochondrial isoform。双 ntra ntrb 异种最近被描绘了并且出现更慢的植物生长,稍微起皱的种子和显著超敏性到 buthionine sulfoximine (BSO ) ,谷胱甘肽生合成的一个特定的禁止者。在这份报纸,我们证明这异种也积累 flavonoids 的高水平。transcriptome 数据的分析证明 flavonoid 小径的几基因是在 ntra ntrb 异种的 overexpressed。flavonoids 的累积通常被认为植物应力的一个特点。不过,编码 ROS-detoxification 酶的基因的表示的举起都没被观察,建议 ntra ntrb 植物不患氧化疾病。另一个假设建议 flavonoids 明确地在 ntra ntrb 异种被综合以便救 NTR 的 inactivation。测试这, ntra ntrb 异种与透明种皮被穿过(tt4 ) 4 在把第一酶编码为 flavonoid 生合成的基因与一个变化种。因为 ntra ntrb 植物比野类型的植物对 UV-C 处理更抵抗,这个更高的电阻在 ntra ntrb tt4 异种被废除,建议在 ntra ntrb 异种的 flavonoids 的累积保护植物免于紫外光。 | Talaat Bashandy Ludivine Taconnat Jean-Pierre Renou Yves Meyer Jean-Philippe Reichheld | 2009 | Molecular Plant2009，2，2： | 3 |
| 4 | Relationship between texture and pectin composition of two apple cultivars during storage显示文摘 | Ludivine Billy Emira Mehinagic Ga?lle Royer Catherine M.G.C. Renard Ga?lle Arvisenet Carole Prost Frédérique Jourjon | 2007 | Postharvest Biology and Technology2007，，3： | 3 |
| 5 | Iron metabolism imbalance at the time of listing increases overall and infectious mortality after liver transplantation显示文摘BACKGROUND Liver transplantation(LT)is the best treatment for patients with liver cancer or end stage cirrhosis,but it is still associated with a significant mortality.Therefore identifying factors associated with mortality could help improve patient management.The impact of iron metabolism,which could be a relevant therapeutic target,yield discrepant results in this setting.Previous studies suggest that increased serum ferritin is associated with higher mortality.Surprisingly iron deficiency which is a well described risk factor in critically ill patients has not been considered.AIM To assess the impact of pre-transplant iron metabolism parameters on posttransplant survival.METHODS From 2001 to 2011,553 patients who underwent LT with iron metabolism parameters available at LT evaluation were included.Data were prospectively recorded at the time of evaluation and at the time of LT regarding donor and recipient.Serum ferritin(SF)and transferrin saturation(TS)were studied as continuous and categorical variable.Cox regression analysis was used to determine mortality risks factors.Follow-up data were obtained from the local and national database regarding causes of death.RESULTS At the end of a 95-mo median follow-up,196 patients were dead,38 of them because of infections.In multivariate analysis,overall mortality was significantly associated with TS>75%[HR:1.73(1.14;2.63)],SF<100μg/L[HR:1.62(1.12;2.35)],hepatocellular carcinoma[HR:1.58(1.15;2.26)],estimated glomerular filtration rate(CKD EPI Cystatin C)[HR:0.99(0.98;0.99)],and packed red blood cell transfusion[HR:1.05(1.03;1.08)].Kaplan Meier curves show that patients with low SF(<100μg/L)or high SF(>400μg/L)have lower survival rates at 36 mo than patients with normal SF(P=0.008 and P=0.016 respectively).Patients with TS higher than 75%had higher mortality at 12 mo(91.4%±1.4%vs 84.6%±3.1%,P=0.039).TS>75%was significantly associated with infection related death[HR:3.06(1.13;8.23)].CONCLUSION Our results show that iron metabolism imbalance(either deficiency or overload)is associated with post-transplant overall and infectious mortality.Impact of iron supplementation or depletion should be assessed in prospective study. | Elodie Fallet Michel Rayar Amandine Landrieux Christophe Camus Pauline Houssel-Debry Caroline Jezequel Ludivine Legros Thomas Uguen Martine Ropert-Bouchet Karim Boudjema Dominique Guyader Edouard Bardou-Jacquet | 2020 | World Journal of Gastroenterology2020，26，16： | 2 |
| 6 | Synthesis, structure and morphology of poly(dimethylsiloxane) networks filled with in situ generated silica particles显示文摘 | DEWIMILLE LUDIVINE BRESSON BRUNO BOKOBZA LILIANE | 2005 | Polymer2005，46，12： | 1 |
| 7 | Antiinflammatory and antiatherogenic effects of the NF-kB inhibitor Acetyl-11-Keto- β-boswellic acid in LPS-challenged ApoE-/-mice 显示文摘 | Clarisse CP Ludivine B Eric B | 2008 | Arterioscler Thromb Vasc Biol2008，28，2： | 1 |
| 8 | Coupled DTA–TGA–FT-IR investigation of pyrolytic decomposition of EVA, PVC and cellulose显示文摘 | Yannick Soudais Ludivine Moga Jaroslav Blazek Florent Lemort | 2006 | Journal of Analytical and Applied Pyrolysis2006，，1： | 1 |
| 9 | Synthesis, structure and morphology of poly ( demethylsiloxane) networks filled with in situ generated silica particles显示文摘 | LUDIVINE DEWIMILLE BRUNO BRCSSON LJLIANE BOKOBZA | 2005 | Polymer2005，，46： | 1 |
| 10 | Mitochondrial control of caspase-dependent and -independent cell death显示文摘 | Ludivine A. Pradelli Marie Bénéteau Jean-Ehrland Ricci | 2010 | Cellular and Molecular Life Sciences2010，，10： | 1 |
| 11 | Relationship between texture and pectin composition of two apple cultivars during storage显示文摘 | Ludivine B Emira M Ga(e)lle | 2008 | Post harvest Biol Tec2008，47，3： | 1 |
| 12 | Probing heat - stable water - soluble proteins from barley to malt and beer显示文摘 | Ludivine Perrocheau Helene Rogniaux Patrick Boivin | 2005 | Proteomics2005，，5： | 1 |
| 13 | Modification of wood wettability by plasma and corona treatments 显示文摘 | Laurence Podgorski Bnmo Chevet Ludivine Onic | 2000 | Internatianal Journal of Adhesion and Adhesives2000，20，2： | 1 |
| 14 | A polypyrrole protein microarray for antibody–antigen interaction studies using a label-free detection process显示文摘 | Ludivine Grosjean Boutheina Cherif Emilie Mercey André Roget Yves Levy Patrice Noel Marche Marie-Bernadette Villiers Thierry Livache | 2005 | Analytical Biochemistry2005，，2： | 1 |
| 15 | Involvement of toll-like receptor 5 in mouse model of colonic hypersensitivity induced by neonatal maternal separation显示文摘BACKGROUND Chronic abdominal pain is the most common cause for gastroenterology consultation and is frequently associated with functional gastrointestinal disorders including irritable bowel syndrome and inflammatory bowel disease. These disorders present similar brain/gut/microbiota trialogue alterations, associated with abnormal intestinal permeability, intestinal dysbiosis and colonic hypersensitivity(CHS). Intestinal dysbiosis can alter colon homeostasis leading to abnormal activation of the innate immunity that promotes CHS, perhaps involving the toll-like receptors(TLRs), which play a central role in innate immunity.AIM To understand the mechanisms between early life event paradigm on intestinal permeability, fecal microbiota composition and CHS development in mice with TLRs expression in colonocytes.METHODS Maternal separation model(NMS) CHS model, which mimics deleterious events in childhood that can induce a wide range of chronic disorders during adulthood were used. Colonic sensitivity of NMS mice was evaluated by colorectal distension(CRD) coupled with intracolonic pressure variation(IPV) measurement. Fecal microbiota composition was analyzed by 16S rRNA sequencing from weaning to CRD periods. TLR mRNA expression was evaluated in colonocytes.Additionally, the effect of acute intrarectal instillation of the TLR5 agonist flagellin(FliC) on CHS in adult naive wildtype mice was analyzed.RESULTS Around 50% of NMS mice exhibited increased intestinal permeability and CHS associated with intestinal dysbiosis, characterized by a significant decrease of species richness, an alteration of the core fecal microbiota and a specific increased relative abundance of flagellated bacteria. Only TLR5mRNA expression was increased in colonocytes of NMS mice with CHS. Acute intrarectal instillation of FliC induced transient increase of IPV, reflecting transient CHS appearance.CONCLUSION Altogether, these data suggest a pathophysiological continuum between intestinal dysbiosis and CHS, with a role for TLR5. | Geoffroy Mallaret Amandine Lashermes Mathieu Meleine Ludivine Boudieu Julie Barbier Youssef Aissouni Agathe Gelot Benoit Chassaing Andrew T Gewirtz Denis Ardid Frederic Antonio Carvalho | 2022 | World Journal of Gastroenterology2022，28，29： | 1 |
| 16 | The surface antigen SAG3 mediates the attachment of Toxoplasma gondii to cell-surface proteogly-cans显示文摘 | Alain J Ludivine C Joel DN | 2001 | Mol Biochem Parasitol2001，116，： | 1 |
| 17 | A polypyrrole protein microarray for antibody-antigen interaction studies using a label-free detection process显示文摘 | Boutheina Cherif Emilie Mercey | 2005 | Analytical Biochemistry2005，347，： | 1 |
| 18 | Dynamic changes in the date palm fruit proteome during development and ripening显示文摘Date palm(Phoenix dactylifera)is an economically important fruit tree in the Middle East and North Africa and is characterized by large cultivar diversity,making it a good model for studies on fruit development and other important traits.Here in gel comparative proteomics combined with tandem mass spectrometry were used to study date fruit development and ripening.Total proteins were extracted using a phenol-based protocol.A total of 189 protein spots were differentially regulated(pf0.05).The identified proteins were classified into 14 functional categories.The categories with the most proteins were‘disease and defense’(16.5%)and‘metabolism’(15.4%).Twenty-nine proteins have not previously been identified in other fleshy fruits and 64 showed contrasting expression patterns in other fruits.Abundance of most proteins with a role in abiotic stress responses increased during ripening with the exception of heat shock proteins.Proteins with a role in anthocyanin biosynthesis,glycolysis,tricarboxylic acid cycle and cell wall degradation were upregulated particularly from the onset of ripening and during ripening.In contrast,expression of pentose phosphate-and photosynthesis-related proteins decreased during fruit maturation.Although date palm is considered a climacteric species,the analysis revealed downregulation of two enzymes involved in ethylene biosynthesis,suggesting an ethylene-independent ripening of‘Barhi’fruits.In summary,this proteomics study provides insights into physiological processes during date fruit development and ripening at the systems level and offers a reference proteome for the study of regulatory mechanisms that can inform molecular and biotechnological approaches to further improvements of horticultural traits including fruit quality and yield. | Claudius Marondedze Christoph Gehring Ludivine Thomas | 2014 | Horticulture Research2014，1，1： | 1 |
| 19 | Payments for ecosystem services in Amazonia. The challenge of land use heterogeneity in agricultural frontiers near Cruzeiro do Sul (Acre,Brazil)显示文摘 | Ludivine Eloy Philippe Méral Thomas Ludewigs GustavoTosello Pinheiro Benjamin Singer | 2012 | Journal of Environmental Planning and Management2012，，： | 1 |
| 20 | Synthesis,stru-cture and morphology of poly (demethylsiloxane) networks filled with in situ generated silica particles显示文摘 | Ludivine Dewimille | 2005 | Polymer2005，46，： | 1 |
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