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| 1 | Acoustic radiation force impulse imaging for assessing liver fibrosis in alcoholic liver disease显示文摘AIM: To evaluate the performance of elastography by ultrasound with acoustic radiation force impulse(ARFI) in determining fibrosis stage in patients with alcoholic liver disease(ALD) undergoing alcoholic detoxification in relation to biopsy.METHODS: Eighty-three patients with ALD undergoing detoxification were prospectively enrolled. Each patient underwent ARFI imaging and a liver biopsy onthe same day. Fibrosis was staged according to the METAVIR scoring system. The median of 10 valid ARFI measurements was calculated for each patient.RESULTS: Sixty-nine males and thirteen females(one patient excluded due to insufficient biopsy size) were assessed with a mean alcohol consumption of 132.4 ± 128.8 standard drinks per week and mean cumulative year duration of 17.6 ± 9.5 years. Sensitivity and specificity were respectively 82.4%(0.70-0.95) and 83.3%(0.73-0.94)(AUROC = 0.87) for F ≥ 2 with a cut-off value of 1.63m/s; 82.4%(0.64-1.00) and 78.5%(0.69-0.89)(AUROC = 0.86) for F ≥ 3 with a cut-off value of 1.84m/s; and 92.3%(0.78-1.00] and 81.6%(0.72-0.90)(AUROC = 0.89) for F = 4 with a cut-off value of 1.94 m/s.CONCLUSION: ARFI is an accurate, non-invasive and easy method for assessing liver fibrosis in patients with ALD undergoing alcoholic detoxification. | Anita Kiani Vanessa Brun Fabrice Lainé Bruno Turlin Jeff Morcet Sophie Michalak Antonia Le Gruyer Ludivine Legros Edouard Bardou-Jacquet Yves Gandon Romain Moirand | 2016 | World Journal of Gastroenterology2016，22，20： | 6 |
| 2 | Prokineticin 2/Bv8 is expressed in Kupffer cells in liver and is down regulated in human hepatocellular carcinoma显示文摘AIM: To study the implication of prokineticin 1 (PK1/EG- VEGF) and prokineticin 2 (PK2/Bv8) in hepatocellular carcinoma angiogenesis. METHODS: The gene induction of PK1/EG-VEGF and PK2/Bv8 was investigated in 10 normal, 28 fibrotic and 28 tumoral livers by using real time PCR. Their expression was compared to the expression of VEGF (an angiogenesis marker), vWF (an endothelial cell marker) and to CD68 (a monocyte/macrophage marker). Furthermore, the mRNA levels of PK1/EG-VEGF, PK2/Bv8, prokineticin receptor 1 and 2 were evaluated by real time PCR in isolated liver cell populations. Finally, PK2/Bv8 protein was detected in normal liver paraffin sections and in isolated liver cells by immunohistochemistry and immunocytochemistry. RESULTS: PK2/Bv8 mRNA but not PK1/EG-VEGF was expressed in all types of normal liver samples examined. In the context of liver tumor development, we reported that PK2/Bv8 correlates only with CD68 and showed a significant decrease in expression as the pathology evolves towards cancer. Whereas, VEGF and vWF mRNA were significantly upregulated in both fibrosis and HCC,as expected. In addition, out of all isolated liver cells examined, only Kupffer cells (liver resident macrophages) express significant levels of PK2/Bv8 and its receptors, prokineticin receptor 1 and 2. CONCLUSION: In normal liver PK2/Bv8 and its receptors were specifically expressed by Kupffer cells. PK2/Bv8 expression decreased as the liver evolves towards cancer and did not correlate with HCC angiogenesis. | Justin Monnier Claire Piquet-Pellorce Jean-Jacques Feige Orlando Musso Bruno Clément Bruno Turlin Nathalie Théret Michel Samson | 2008 | World Journal of Gastroenterology2008，14，8： | 4 |
| 3 | Pathology of hepatic iron overload显示文摘尽管在成像和遗传的进步允许基因铁超载的大多数盒子的非侵略的诊断,肝病理仍然保持经常有用( 1 )联系了损害由分级纤维变性并且寻找估计预后并且( 2 )指导病因学的诊断,特别当没有分子的标记是可得到的时。然后,肝铁质沉着病的类型(实质的,间充质或混合) 并且它在整个腹片的分发和肝是为建议它的病原学的有用工具:连接 HLA 的 hemochromatosis 基因(HFE ) hemochromatosis 或另外的稀罕基因 hemochromatosis, nonhemochromatotic 基因铁超载(ferroportin 疾病, aceruloplasminemia ) ,或对过多的铁第二等的铁超载供应,煽动性的症候群,非肝脏硬化症的长期的肝疾病包括 dysmetabolic 铁超载症候群,肝硬化,和血混乱。 | Yves Deugnier Bruno Turlin | 2007 | World Journal of Gastroenterology2007，13，35： | 3 |
| 4 | Insulin resistance–associated hepatic iron overload显示文摘 | Michel-Henry Mendler Bruno Turlin Romain Moirand Anne-Marie Jouanolle Thierry Sapey Dominique Guyader Jean-Yves le Gall Pierre Brissot Véronique David Yves Deugnier | 1999 | Gastroenterology1999，，5： | 2 |
| 5 | Epithelial cell adhesion molecule is a prognosis marker for intrahepatic cholangiocarcinoma显示文摘 | Laurent Sulpice Michel Rayar Bruno Turlin Eveline Boucher Pascale Bellaud Mireille Desille Bernard Meunier Bruno Clément Karim Boudjema Cédric Coulouarn | 2014 | Journal of Surgical Research2014，，： | 1 |
| 6 | Clinical significance of cell proliferation, microvessel density, and CD44 adhesion molecule expression in renal cell carcinoma显示文摘 | Nathalie Rioux-Leclercq Jonathan I. Epstein Jean-Yves Bansard Bruno Turlin Jean-Jacques Patard Andr Manunta Theresa Chan Marie-Paule Ramee Bernard Lobel Jacques-Philippe Moulinoux | 2001 | Human Pathology2001，，11： | 1 |
| 7 | Pathology of Hepatic Iron Overload显示文摘 | Yves Deugnier Bruno Turlin | 2011 | Semin Liver Dis2011，，03： | 1 |
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